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User:Vvg0009

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CACAO Fall 2015

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
updatedbyinstructorMOUSE:STK42015-10-20 13:50:25 CDTGO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate (P)PMID:19073936ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4

challenge
updatedbyinstructorARATH:SCL232015-10-20 13:40:17 CDTGO:0001714 endodermal cell fate specification (P)PMID:26415082ECO:0000316 genetic interaction evidence used in manual assertion

SCL23 works with SCR to regulate endodermal cell fate. This is shown in Figure 2 where the mutant lacking SCL23 can differentiate cells to a certain extent.

challenge
unacceptablePIG:I3L6Y92015-11-03 16:01:11 CSTGO:0039537 suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway (P)PMID:26512690ECO:0000314 direct assay evidence used in manual assertion

Figures 2 and 3 shows that Dicer is normally involved in the cellular defense against viruses. The expression of Dicer is shown in Figure 2 when the cell is placed under viral stress, and in Figure 3, the levels of the fragment of the porcine reproductive and respiratory syndrome virus (PRRSV) is shown to be lowered in the presence of Dicer. However, in Figure 1, PRRSV is shown to silence luciferase when gene that codes for luciferase is placed in the gene that codes for Dicer. In Figure 4, the PRRSV lowers the expression of Dicer and Ago-2 (both involved in the cellular defense mechanism against PRRSV) simultaneously when fully functional. The lowered expression is shown specifically in Figure 4.F.

challenge

acceptable:0
unacceptable:1
requires_changes:0
flagged:0

Annotations challenged by Vvg0009

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
updatedbyinstructorChristin3sheets,
Team Hardy Weinburgers
STAA8:Q2G0W2GO:0045838 - positive regulation of membrane potential (P)PMID:25448817ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 5

fixed by Sandyl 27
updatedbyinstructorYeyuan,
Team Bob Ross
HUMAN:ITCHGO:0006511 - ubiquitin-dependent protein catabolic process (P)PMID:25518932ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 3

fixed by Dyd5192
unacceptableYeyuan,
Team Bob Ross
HUMAN:ITCHGO:2000060 - positive regulation of ubiquitin-dependent protein catabolic process (P)PMID:16387660ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 1

0 annotations fixed by Vvg0009

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