PIG:I3L6Y9

Species (Taxon ID)	Sus scrofa (Pig). (9823)
Gene Name(s)	DICER1 (ECO:0000313 with Ensembl:ENSSSCP00000019791)
Protein Name(s)	Uncharacterized protein (ECO:0000313 with Ensembl:ENSSSCP00000019791)
External Links
UniProt	I3L6Y9
EMBL	CU915626
STRING	9823.ENSSSCP00000019791
Ensembl	ENSSSCT00000022914
GeneTree	ENSGT00510000046789
InParanoid	I3L6Y9
OMA	ECTSGRT
OrthoDB	EOG78PV82
TreeFam	TF330258
Reactome	R-SSC-203927 R-SSC-426486
Proteomes	UP000008227
GO	GO:0005737 GO:0035068 GO:0005634 GO:0016442 GO:0070578 GO:0005524 GO:0004530 GO:0003725 GO:0004386 GO:0035198 GO:0070883 GO:0004525 GO:0003723 GO:0035197 GO:0001525 GO:0006309 GO:0048754 GO:0055013 GO:0061309 GO:0051216 GO:0021987 GO:0033168 GO:0051607 GO:0035116 GO:0061548 GO:0071335 GO:0031069 GO:0060119 GO:0060576 GO:0030324 GO:0035280 GO:0048255 GO:0035264 GO:0014835 GO:0060253 GO:0021889 GO:0010628 GO:2000630 GO:0031643 GO:0009791 GO:0031054 GO:0030422 GO:0051726 GO:0070173 GO:0010660 GO:0045664 GO:0048713 GO:0045069 GO:0048608 GO:0090501 GO:0035087 GO:0021522 GO:0051225 GO:0048536 GO:0019827 GO:0030423 GO:0010070
Gene3D	1.10.1520.10 3.40.50.300
InterPro	IPR011545 IPR005034 IPR014001 IPR001650 IPR027417 IPR003100 IPR000999
Pfam	PF00270 PF03368 PF00271 PF02170 PF00636
SMART	SM00487 SM00490 SM00949 SM00535
SUPFAM	SSF101690 SSF52540 SSF69065
PROSITE	PS51327 PS51192 PS51194 PS50821 PS50142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0039537	suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway	PMID:26512690^[1]	ECO:0000314			P	Figures 2 and 3 shows that Dicer is normally involved in the cellular defense against viruses. The expression of Dicer is shown in Figure 2 when the cell is placed under viral stress, and in Figure 3, the levels of the fragment of the porcine reproductive and respiratory syndrome virus (PRRSV) is shown to be lowered in the presence of Dicer. However, in Figure 1, PRRSV is shown to silence luciferase when gene that codes for luciferase is placed in the gene that codes for Dicer. In Figure 4, the PRRSV lowers the expression of Dicer and Ago-2 (both involved in the cellular defense mechanism against PRRSV) simultaneously when fully functional. The lowered expression is shown specifically in Figure 4.F.	complete CACAO 11121
involved_in	GO:0031054	pre-miRNA processing	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 MGI:MGI:2177178 PANTHER:PTN001029377 UniProtKB:Q9UPY3 WB:WBGene00000939	P	Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 MGI:MGI:2177178 PANTHER:PTN000383724 PomBase:SPCC188.13c UniProtKB:Q9LXW7 UniProtKB:Q9UPY3 WB:WBGene00000939	P	Seeded From UniProt	complete
part_of	GO:0016442	RISC complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 PANTHER:PTN000383724 UniProtKB:Q9UPY3	C	Seeded From UniProt	complete
involved_in	GO:0006309	apoptotic DNA fragmentation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001029377 WB:WBGene00000939	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 MGI:MGI:2177178 PANTHER:PTN000383724 PomBase:SPCC188.13c TAIR:locus:2092409 WB:WBGene00000939	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 PANTHER:PTN000383724 PomBase:SPCC188.13c TAIR:locus:2092409 UniProtKB:P84634 UniProtKB:Q9LXW7 UniProtKB:Q9SP32 WB:WBGene00000939	C	Seeded From UniProt	complete
enables	GO:0004530	deoxyribonuclease I activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001029377 WB:WBGene00000939	F	Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 MGI:MGI:2177178 PANTHER:PTN000383724 TAIR:locus:2092409 UniProtKB:Q9UPY3 WB:WBGene00000939	F	Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004525	P	Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016891	P	Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004525	P	Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004525	P	Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004525	P	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F	Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000999 InterPro:IPR036389	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F	Seeded From UniProt	complete
involved_in	GO:0006396	RNA processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000999 InterPro:IPR036389	P	Seeded From UniProt	complete
enables	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005034	F	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000401001	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Chen, J et al. (2015) Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Inhibits RNA-Mediated Gene Silencing by Targeting Ago-2. Viruses 7 5539-52 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26512690-1] Chen, J et al. (2015) Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Inhibits RNA-Mediated Gene Silencing by Targeting Ago-2. Viruses 7 5539-52 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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PIG:I3L6Y9

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