CACAO Spring 2016
My Annotations
| Status | Page | Date/Time | GO Term (Aspect) | Reference | Evidence | Notes | Links |
|---|
| unacceptable | ENTFC:VANA | 2016-02-21 13:00:29 CST | GO:0022607 cellular component assembly (P) | PMID:26678143 | ECO:0000317 genomic context evidence used in manual assertion | The vanA gene in Enterococcus faecium encodes for D-alanine D-lactate ligase which promotes ester bond formation producing a new peptidoglycan within the cell. This peptidoglycan inhibits vancomysin binding being it is a glycopeptide antibiotic. The GO ID shows the cellular component assembly pathaway which is what the formation of a new peptidoglycan is thus creating Vancomycin resistance. The Pubmed article shows the study showing that vanA has been proven to contain antibiotic resistant properties in animals and when included in our diet, further promotes antibiotic resistant bacterial strains in humans
| challenge |
| unacceptable | ENTFA:GELE | 2016-03-29 03:17:48 CDT | GO:0044085 cellular component biogenesis (P) | PMID:27013840 | ECO:0000314 direct assay evidence used in manual assertion | Table 3 shows the five vancomycin sensitive and resistant genes that were identified in this study using PCR and known genetic sequencing of eneterococci species both from clinical and fecal isolates. The gel E gene was found to be present in a high percentage of vancomysin resistant enterococci species both in clinical isolates (44.4%) and fecal isolates (29.2%) compared to lower percentage isolates being vancomysin sensitive enterococci species. In comparing these percentages they were considered statistical significant allowing these researchers to conclude that the gel E gene that encoded for gelatinase which, is considered a cellular constituent, significantly contributed to these species being vancomycin resistant when compared to enterococci species that didn't as regularly contain the gel E gene being more vancomycin sensitive.
| challenge |
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Annotations challenged by Mitchell.L.Kennedy
0 annotations fixed by Mitchell.L.Kennedy
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