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ENTFA:GELE
Contents
| Species (Taxon ID) | Enterococcus faecalis (strain ATCC 700802 / V583). (226185) | |
| Gene Name(s) | gelE (ECO:0000303 with PMID:1846126[1], ECO:0000312 with EMBL:ABL10087.1) | |
| Protein Name(s) | Gelatinase (ECO:0000303 with PMID:1846126[1], ECO:0000312 with EMBL:ACF74544.2)
Coccolysin (ECO:0000303 with PMID:8179636[2], ECO:0000312 with EMBL:AAO81586.1) | |
| External Links | ||
| UniProt | Q833V7 | |
| EMBL | M37185 D85393 EF105504 AE016830 EU862241 | |
| PIR | A43580 | |
| RefSeq | NP_815516.1 WP_002369251.1 | |
| ProteinModelPortal | Q833V7 | |
| IntAct | Q833V7 | |
| STRING | 226185.EF1818 | |
| MEROPS | M04.007 | |
| DNASU | 1200704 | |
| EnsemblBacteria | AAO81586 | |
| GeneID | 1200704 | |
| KEGG | efa:EF1818 | |
| PATRIC | 21853964 | |
| eggNOG | ENOG4105D4Y COG3227 | |
| KO | K08605 | |
| OMA | GTIMEKQ | |
| OrthoDB | EOG6H1PW1 | |
| BioCyc | EFAE226185:GHI1-1790-MONOMER | |
| PMAP-CutDB | A1E464 | |
| Proteomes | UP000001415 | |
| GO | GO:0005615 GO:0046872 GO:0004222 | |
| Gene3D | 3.10.170.10 | |
| InterPro | IPR011096 IPR023612 IPR001570 IPR013856 | |
| Pfam | PF07504 PF01447 PF02868 | |
| PRINTS | PR00730 | |
| PROSITE | PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044085 |
cellular component biogenesis |
ECO:0000314 |
P |
Table 3 shows the five vancomycin sensitive and resistant genes that were identified in this study using PCR and known genetic sequencing of eneterococci species both from clinical and fecal isolates. The gel E gene was found to be present in a high percentage of vancomysin resistant enterococci species both in clinical isolates (44.4%) and fecal isolates (29.2%) compared to lower percentage isolates being vancomysin sensitive enterococci species. In comparing these percentages they were considered statistical significant allowing these researchers to conclude that the gel E gene that encoded for gelatinase which, is considered a cellular constituent, significantly contributed to these species being vancomycin resistant when compared to enterococci species that didn't as regularly contain the gel E gene being more vancomycin sensitive. |
complete | |||||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Su, YA et al. (1991) Nucleotide sequence of the gelatinase gene (gelE) from Enterococcus faecalis subsp. liquefaciens. Infect. Immun. 59 415-20 PubMed GONUTS page
- ↑ Mäkinen, PL & Mäkinen, KK (1994) The Enterococcus faecalis extracellular metalloendopeptidase (EC 3.4.24.30; coccolysin) inactivates human endothelin at bonds involving hydrophobic amino acid residues. Biochem. Biophys. Res. Commun. 200 981-5 PubMed GONUTS page
- ↑ Biswas, PP et al. () Molecular Characterization of Virulence Genes in Vancomycin-Resistant and Vancomycin-Sensitive Enterococci. J Glob Infect Dis 8 16-24 PubMed GONUTS page
