GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:0044319 | wound healing, spreading of cells | PMID:11698262 | IDA: Inferred from Direct Assay | P | ||||
| This annotation made on page: HUMAN:IL4 By: Cwolterman (group Team Pinball Wizards) on 2013-02-08 21:37:38 CST. | ||||||||
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| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | Jbeasley, Team Everything Burrito | 2013-02-16 13:10:00 CST | A more appropriate GO term for this annotation is GO:0010633 : negative regulation of epithelial cell migration. Figure 7 shows that Interleukin-4 (IL-4) inhibits the migration of the Calu-3 epithelial cells, but it does not directly prove the inhibition of wound healing. | 5 |
| Challenge | Vthompsonui, Team GreyJoy | 2013-02-13 10:16:06 CST | The chosen GO term is incorrect, term GO:0061045 (negative regulation of wound healing) would be more suitable since IL-4 inhibits Calu-3 cell migration | 5 |
| Private Assessment | Bmcintosh | 2013-06-22 13:18:01 CDT | You need to be an instructor to view these notes. | Updated by Instructor ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
| Public Assessment | JimHu | 2013-02-19 13:56:12 CST | The original annotation is incorrect. Annotation to GO:0044319 wound healing, spreading of cells would be used when the gene product being annotated is involved in the process of cell spreading during wound healing. Here, IL-4 reduces the amount of healing/spreading, so a regulates term is more appropriate. The two challenges provide two possible corrected annotations for the regulation of wound healing and the regulation of cell spreading. Note also that there are opportunities to submit new term requests to GO based on this paper. GO is inconsistent in covering different cell types in the processes studied here. | Corrected Through Challenges ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
| Public Assessment | DanielRenfro | 2013-02-16 13:10:01 CST | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Private Assessment | Bmcintosh | 2013-02-13 13:41:46 CST | You need to be an instructor to view these notes. | Requires Changes ✗ Go term |
| Public Assessment | DanielRenfro | 2013-02-13 10:16:07 CST | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Private Assessment | Bmcintosh | 2013-02-13 09:36:34 CST | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✗ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
