HUMAN:IL4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IL4
Protein Name(s)	Interleukin-4 IL-4 B-cell stimulatory factor 1 BSF-1 Binetrakin Lymphocyte stimulatory factor 1 Pitrakinra
External Links
UniProt	P05112
EMBL	M13982 M23442 X81851 AF395008 BC066277 BC067514 BC070123 X06750
CCDS	CCDS4158.1 CCDS4159.1
PIR	A30546
RefSeq	NP_000580.1 NP_758858.1
UniGene	Hs.73917
PDB	1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7
PDBsum	1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7
ProteinModelPortal	P05112
SMR	P05112
BioGrid	109779
DIP	DIP-3222N
IntAct	P05112
MINT	MINT-90320
STRING	9606.ENSP00000231449
DMDM	124337
PaxDb	P05112
PRIDE	P05112
DNASU	3565
Ensembl	ENST00000231449 ENST00000350025
GeneID	3565
KEGG	hsa:3565
UCSC	uc003kxk.2
CTD	3565
GeneCards	GC05P132009
H-InvDB	HIX0164435
HGNC	HGNC:6014
MIM	147780 601367
neXtProt	NX_P05112
PharmGKB	PA197
eggNOG	NOG266404
GeneTree	ENSGT00390000013108
HOGENOM	HOG000254781
HOVERGEN	HBG000290
InParanoid	P05112
KO	K05430
OMA	KEKYSKC
OrthoDB	EOG7SJD75
PhylomeDB	P05112
TreeFam	TF336383
SignaLink	P05112
EvolutionaryTrace	P05112
GeneWiki	Interleukin_4
GenomeRNAi	3565
NextBio	13920
PRO	PR:P05112
Proteomes	UP000005640
Bgee	P05112
CleanEx	HS_IL4
ExpressionAtlas	P05112
Genevestigator	P05112
GO	GO:0009897 GO:0005615 GO:0008083 GO:0005136 GO:0031296 GO:0030183 GO:0006968 GO:0071288 GO:0006935 GO:0008203 GO:0045189 GO:0042832 GO:0097028 GO:0097192 GO:0007565 GO:0006955 GO:0002227 GO:0001774 GO:0002674 GO:0043066 GO:0002677 GO:2001237 GO:0043031 GO:0045019 GO:0045671 GO:2000320 GO:0045892 GO:0042104 GO:0030890 GO:0045080 GO:0002230 GO:2000424 GO:0032733 GO:0032736 GO:0048295 GO:0048304 GO:0045348 GO:0071677 GO:0051091 GO:0045582 GO:0042102 GO:0045944 GO:0045893 GO:0042523 GO:0050776 GO:0045191 GO:0042325 GO:0010155 GO:0034097 GO:0042493 GO:0045471 GO:0007584 GO:0014070 GO:0060041 GO:0002296 GO:0035745 GO:0045064 GO:0042092
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR002354 IPR001325 IPR018096
PANTHER	PTHR11456
Pfam	PF00727
PIRSF	PIRSF001941
PRINTS	PR00431
SMART	SM00190
SUPFAM	SSF47266
PROSITE	PS00838

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1900223	positive regulation of amyloid-beta clearance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P	regulates_o_occurs_in:(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1134) part_of:(GO:1905337)\|regulates_o_occurs_in(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1070) part_of:(GO:1905337)	Seeded From UniProt	complete
involved_in	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P	regulates_o_occurs_in:(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1134)\|regulates_o_occurs_in(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1070)	Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:12574355^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08575	P	has_regulation_target:(UniProtKB:P42226)	Seeded From UniProt	complete
involved_in	GO:0042976	activation of Janus kinase activity	PMID:12574355^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08575	P	has_regulation_target:(UniProtKB:P23458)\|has_regulation_target:(UniProtKB:P52333)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:12574355^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08575 UniProtKB:P29965 UniProtKB:P42226	P	regulates_expression_of:(ENSEMBL:ENSG00000111732) occurs_in:(CL:0000236) regulates_o_occurs_in:(CL:0000236)	Seeded From UniProt	complete
involved_in	GO:0150079	negative regulation of neuroinflammatory response	GO_REF:0000111	ECO:0000305	curator inference used in manual assertion	GO:0048260	P		Seeded From UniProt	complete
involved_in	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20096	P	regulates_o_occurs_in:(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1134)\|regulates_o_occurs_in(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1070)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20096	P	regulates_o_occurs_in:(CL:0000129) regulates_expression_of:(ENSEMBL:ENSG00000135218)\|regulates_o_occurs_in(CL:0000129) regulates_expression_of:(ENSEMBL:ENSG00000119912)	Seeded From UniProt	complete
involved_in	GO:1900223	positive regulation of amyloid-beta clearance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20096	P	regulates_o_occurs_in:(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1070) part_of:(GO:1905337)\|regulates_o_occurs_in(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1134) part_of:(GO:1905337)	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:24906148^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:18337562^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:16606666^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q7Z7D3)	Seeded From UniProt	complete
involved_in	GO:0043011	myeloid dendritic cell differentiation	PMID:16116184^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010633	negative regulation of epithelial cell migration	PMID:11698262^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	PMID:16034134^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903660	negative regulation of complement-dependent cytotoxicity	PMID:16034134^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097028	dendritic cell differentiation	PMID:21149635^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050776	regulation of immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
involved_in	GO:0048304	positive regulation of isotype switching to IgG isotypes	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
involved_in	GO:0048295	positive regulation of isotype switching to IgE isotypes	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19346497^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20554961^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18579517^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18579517^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045671	negative regulation of osteoclast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	PMID:20554961^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045348	positive regulation of MHC class II biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
	GO:0010633	negative regulation of epithelial cell migration	PMID:11698262^[6]	ECO:0000314			P		Figure 7 shows that Interleukin-4 (IL-4) inhibits the migration of the Calu-3 epithelial cells, but it does not directly prove the inhibition of wound healing.	complete CACAO 6412
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
involved_in	GO:0042325	regulation of phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
involved_in	GO:0035745	T-helper 2 cell cytokine production	PMID:20554961^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032736	positive regulation of interleukin-13 production	PMID:19346497^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	PMID:11971948^[12]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07750	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:11418631^[13]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
enables	GO:0005126	cytokine receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001325 InterPro:IPR018096	F		Seeded From UniProt	complete
enables	GO:0005136	interleukin-4 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002354	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001325 InterPro:IPR002354 InterPro:IPR018096	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001325 InterPro:IPR002354 InterPro:IPR018096	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002354	F		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:3016727^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:3016727^[14] PMID:11418631^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005136	interleukin-4 receptor binding	PMID:3016727^[14] PMID:11418631^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045191	regulation of isotype switching	PMID:11418631^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045189	connective tissue growth factor biosynthetic process	PMID:11967989^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042092	type 2 immune response	PMID:11676128^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:11418631^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6786124 Reactome:R-HSA-6786101 Reactome:R-HSA-6786096 Reactome:R-HSA-6786095 Reactome:R-HSA-6786092 Reactome:R-HSA-6786072 Reactome:R-HSA-6786070 Reactome:R-HSA-6786058 Reactome:R-HSA-6785821	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
involved_in	GO:0042113	B cell activation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0075	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Zhou, C et al. (2003) Human activation-induced cytidine deaminase is induced by IL-4 and negatively regulated by CD45: implication of CD45 as a Janus kinase phosphatase in antibody diversification. J. Immunol. 170 1887-93 PubMed GONUTS page
↑ Qiu, Y et al. (2014) Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157 1292-308 PubMed GONUTS page
↑ Murooka, TT et al. (2008) CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood 111 4892-901 PubMed GONUTS page
↑ Kryczek, I et al. (2006) B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med. 203 871-81 PubMed GONUTS page
↑ Dai, SY et al. (2005) Galectin-9 induces maturation of human monocyte-derived dendritic cells. J. Immunol. 175 2974-81 PubMed GONUTS page
↑ ^6.0 ^6.1 Ahdieh, M et al. (2001) Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma. Am. J. Physiol., Cell Physiol. 281 C2029-38 PubMed GONUTS page
↑ ^7.0 ^7.1 Grehan, JF et al. (2005) IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway. J. Immunol. 175 1903-10 PubMed GONUTS page
↑ Klimchenko, O et al. (2011) Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions. Blood 117 3065-75 PubMed GONUTS page
↑ ^9.0 ^9.1 Dai, J et al. (2009) IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells. Blood 113 5829-38 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Huber, JP et al. (2010) Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J. Immunol. 185 813-7 PubMed GONUTS page
↑ ^11.0 ^11.1 Hebenstreit, D et al. (2008) LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. J. Biol. Chem. 283 22490-7 PubMed GONUTS page
↑ King, VL et al. (2002) Interleukin-4 deficiency promotes gallstone formation. J. Lipid Res. 43 768-71 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Zhang, X et al. (2001) The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation. J. Immunol. 167 49-56 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Yokota, T et al. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc. Natl. Acad. Sci. U.S.A. 83 5894-8 PubMed GONUTS page
↑ Rishikof, DC et al. (2002) Interleukin-4 regulates connective tissue growth factor expression in human lung fibroblasts. J. Cell. Biochem. 85 496-504 PubMed GONUTS page
↑ Maeda, S & Yanagihara, Y (2001) [Inflammatory cytokines (IL-4, IL-5 and IL-13)]. Nippon Rinsho 59 1894-9 PubMed GONUTS page

[PMID:12574355-1] 1.0 ^1.1 ^1.2 Zhou, C et al. (2003) Human activation-induced cytidine deaminase is induced by IL-4 and negatively regulated by CD45: implication of CD45 as a Janus kinase phosphatase in antibody diversification. J. Immunol. 170 1887-93 PubMed GONUTS page

[PMID:24906148-2] Qiu, Y et al. (2014) Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157 1292-308 PubMed GONUTS page

[PMID:18337562-3] Murooka, TT et al. (2008) CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood 111 4892-901 PubMed GONUTS page

[PMID:16606666-4] Kryczek, I et al. (2006) B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med. 203 871-81 PubMed GONUTS page

[PMID:16116184-5] Dai, SY et al. (2005) Galectin-9 induces maturation of human monocyte-derived dendritic cells. J. Immunol. 175 2974-81 PubMed GONUTS page

[PMID:11698262-6] 6.0 ^6.1 Ahdieh, M et al. (2001) Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma. Am. J. Physiol., Cell Physiol. 281 C2029-38 PubMed GONUTS page

[PMID:16034134-7] 7.0 ^7.1 Grehan, JF et al. (2005) IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway. J. Immunol. 175 1903-10 PubMed GONUTS page

[PMID:21149635-8] Klimchenko, O et al. (2011) Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions. Blood 117 3065-75 PubMed GONUTS page

[PMID:19346497-9] 9.0 ^9.1 Dai, J et al. (2009) IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells. Blood 113 5829-38 PubMed GONUTS page

[PMID:20554961-10] 10.0 ^10.1 ^10.2 Huber, JP et al. (2010) Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J. Immunol. 185 813-7 PubMed GONUTS page

[PMID:18579517-11] 11.0 ^11.1 Hebenstreit, D et al. (2008) LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. J. Biol. Chem. 283 22490-7 PubMed GONUTS page

[PMID:11971948-12] King, VL et al. (2002) Interleukin-4 deficiency promotes gallstone formation. J. Lipid Res. 43 768-71 PubMed GONUTS page

[PMID:11418631-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Zhang, X et al. (2001) The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation. J. Immunol. 167 49-56 PubMed GONUTS page

[PMID:3016727-14] 14.0 ^14.1 ^14.2 Yokota, T et al. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc. Natl. Acad. Sci. U.S.A. 83 5894-8 PubMed GONUTS page

[PMID:11967989-15] Rishikof, DC et al. (2002) Interleukin-4 regulates connective tissue growth factor expression in human lung fibroblasts. J. Cell. Biochem. 85 496-504 PubMed GONUTS page

[PMID:11676128-16] Maeda, S & Yanagihara, Y (2001) [Inflammatory cytokines (IL-4, IL-5 and IL-13)]. Nippon Rinsho 59 1894-9 PubMed GONUTS page

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HUMAN:IL4

Contents

Annotations

Notes

References

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