GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | PMID:30845261 | ECO:0007046 IDA: Inferred from Direct Assay | Biological Process | Figure 3A is a scanning electron micrograph that shows brain cell exposure to the CNF1 protein promoted cell spreading and flattening, which increased monolayer confluence. This expansion of the monolayer can be seen through the comparison of cells treated with CNF1 to the TNF-alpha controls. | complete | ||
| This annotation made on page: ECOLX:A0A1W5T566 By: SLudwig (group Team Red A 2019) on 2019-04-10 10:46:34 CDT. | ||||||||
You must be logged in to challenge this annotation.
| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment | ||||||||||||||||||||||
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| Challenge | GFurletti, Team Green A 2019 | 2019-04-15 23:49:11 CDT | I do not think the notes are descriptive enough. What is the role of the mutant recombinant toxin CNF1 C866S and what is that showing? | 1 | ||||||||||||||||||||||
| Challenge | KAtanasoff, Team Blue A 2019 | 2019-04-15 10:23:58 CDT | I'm not sure if your GO term is appropriate, since the figure doesn't demonstrate that the brain endothelial cells are specifically adhering to the substrate (i.e. the CNF1 protein) and that that's causing the cell spreading. If there was a less specific GO term for causing cell spreading, that might be better to use. | 2 | ||||||||||||||||||||||
| Public Assessment | Ivanerill | 2019-04-21 04:31:43 CDT | No notes given. | Acceptable ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original | ||||||||||||||||||||||
| Public Assessment | DanielRenfro | 2019-04-20 17:41:48 CDT | This annotation has been flagged because it has been edited since last assessment
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| Public Assessment | DanielRenfro | 2019-04-20 17:39:36 CDT | This annotation has been flagged because it has been edited since last assessment
| Flagged | ||||||||||||||||||||||
| Public Assessment | DanielRenfro | 2019-04-20 17:38:11 CDT | This annotation has been flagged because it has been edited since last assessment
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| Public Assessment | Ivanerill | 2019-04-18 09:56:26 CDT | Read your challenges and address them. I am also not convinced of the GO term. What in Fig. 3 shows positive regulation? | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✗ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
