SCHPO:PIF1

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	pfh1 (synonyms: pif1, rph1)
Protein Name(s)	ATP-dependent DNA helicase pfh1 DNA repair and recombination helicase pfh1 PIF1 helicase homolog RRM3/PIF1 homolog 1
External Links
UniProt	Q9UUA2
EMBL	AF074944 CU329671
PIR	T40739 T47241
RefSeq	NP_596488.1
ProteinModelPortal	Q9UUA2
BioGrid	277727
STRING	4896.SPBC887.14c.1
iPTMnet	Q9UUA2
PaxDb	Q9UUA2
PRIDE	Q9UUA2
EnsemblFungi	SPBC887.14c.1
GeneID	2541213
KEGG	spo:SPBC887.14c
EuPathDB	FungiDB:SPBC887.14c
PomBase	SPBC887.14c
HOGENOM	HOG000132960
InParanoid	Q9UUA2
KO	K15255
OMA	QRETWNI
PhylomeDB	Q9UUA2
BRENDA	3.6.4.12
PRO	PR:Q9UUA2
Proteomes	UP000002485
GO	GO:0005739 GO:0000790 GO:1902377 GO:0043601 GO:0005724 GO:0005730 GO:0005634 GO:0005657 GO:0035861 GO:0005524 GO:0043141 GO:0033682 GO:0061995 GO:0016887 GO:1990814 GO:0070336 GO:0051880 GO:0003723 GO:1990518 GO:0017116 GO:0032508 GO:0006310 GO:0006260 GO:1902983 GO:0044806 GO:0043504 GO:1905467 GO:1903469 GO:0031297 GO:0000723
HAMAP	MF_03176
InterPro	IPR003593 IPR003840 IPR010285 IPR027417
Pfam	PF02689 PF05970
SMART	SM00382
SUPFAM	SSF52540

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033128	negative regulation of histone phosphorylation	PMID:27611590^[1]	ECO:0000315			P		Figure 3, parts B-F, show that in the absence of pfh-1 protein there was more phosphorylated histone protein indicating increased DNA damage.	complete CACAO 12101
	GO:0006974	cellular response to DNA damage stimulus	PMID:27611590^[1]	ECO:0000315			P		Figure 3, parts B-F, show that in the absence of pfh-1 protein there was more phosphorylated histone protein indicating increased DNA damage.	complete CACAO 12102
	GO:0031297	replication fork processing	PMID:27611590^[1]	ECO:0000315			P		In figure 2, they used Cdc 20 occupancy as a way to denote pausing within the replication fork. They found that in cells where Pfh1 was absent, Cdc 20 occupancy was increased.	complete CACAO 12121
	GO:0031297	replication fork processing	PMID:22426535^[2]	ECO:0000315			P		Fig. 2 B-D states how Pfh1 promotes replication fork progression at a tRNA gene, with it performing a sweepase function in promoting replication fork passage. A child term was created for this regarding progress and tRNA genes. The organism is S. pombe.	complete CACAO 12234
part_of	GO:0035861	site of double-strand break	PMID:23628481^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0033682	ATP-dependent 5'-3' DNA/RNA helicase activity	PMID:30053106^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	PMID:12058079^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031297	replication fork processing	PMID:27611590^[1]	ECO:0000269	experimental evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017116	single-stranded DNA-dependent ATP-dependent DNA helicase activity	PMID:15302919^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:15302919^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000004526	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:16823372^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18725402^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:18725402^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005724	nuclear telomeric heterochromatin	PMID:27185885^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0000003)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16823372^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18725402^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12409464^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000050	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR003593	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:30053106^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:27611590^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0001637)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:27611590^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0001272)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:27611590^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0000339)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:27611590^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0000205)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:25471935^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0001637)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:25471935^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0000003)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22426534^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0002021)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22426534^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0001914)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22426534^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(PomBase:SPCC622.09)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22426534^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(PomBase:SPCC622.08c)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22426534^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(PomBase:SPBC32H8.12c)	Seeded From UniProt	complete
part_of	GO:0000262	mitochondrial chromosome	GO_REF:0000111	ECO:0000305	curator inference used in manual assertion	GO:0003677 GO:0005739	C		Seeded From UniProt	complete
enables	GO:1990814	DNA/DNA annealing activity	PMID:30053106^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1990518	single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity	PMID:15302919^[6]	ECO:0000305	curator inference used in manual assertion	GO:0017116 GO:0043141	F		Seeded From UniProt	complete
involved_in	GO:1905467	positive regulation of G-quadruplex DNA unwinding	PMID:25471935^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903469	removal of RNA primer involved in mitotic DNA replication	PMID:15302919^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC16D10.04c	P		Seeded From UniProt	complete
involved_in	GO:1903469	removal of RNA primer involved in mitotic DNA replication	PMID:12409464^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPAC8F11.07c	P		Seeded From UniProt	complete
involved_in	GO:1902983	DNA strand elongation involved in mitotic DNA replication	PMID:22426534^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(SO:0002021)	Seeded From UniProt	complete
involved_in	GO:1902983	DNA strand elongation involved in mitotic DNA replication	PMID:22426534^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(SO:0001914)	Seeded From UniProt	complete
involved_in	GO:1902983	DNA strand elongation involved in mitotic DNA replication	PMID:22426534^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(SO:0001272)	Seeded From UniProt	complete
part_of	GO:1902377	nuclear rDNA heterochromatin	PMID:27185885^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0000003)	Seeded From UniProt	complete
enables	GO:0070336	flap-structured DNA binding	PMID:30053106^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0061995	ATP-dependent protein-DNA complex displacement activity	PMID:30053106^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051880	G-quadruplex DNA binding	PMID:30053106^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051880	G-quadruplex DNA binding	PMID:27185885^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001637)	Seeded From UniProt	complete
enables	GO:0051880	G-quadruplex DNA binding	PMID:27185885^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000624)	Seeded From UniProt	complete
involved_in	GO:0044806	G-quadruplex DNA unwinding	PMID:26041456^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044806	G-quadruplex DNA unwinding	PMID:30053106^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044806	G-quadruplex DNA unwinding	PMID:27185885^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043601	nuclear replisome	PMID:27611590^[1]	ECO:0000269	experimental evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043504	mitochondrial DNA repair	PMID:18725402^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043141	ATP-dependent 5'-3' DNA helicase activity	PMID:27185885^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043141	ATP-dependent 5'-3' DNA helicase activity	PMID:15302919^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043141	ATP-dependent 5'-3' DNA helicase activity	PMID:12409464^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043141	ATP-dependent 5'-3' DNA helicase activity	PMID:12058079^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:18420)	Seeded From UniProt	complete
enables	GO:0043141	ATP-dependent 5'-3' DNA helicase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001149889 PomBase:SPBC887.14c UniProtKB:Q9H611	F		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001149889 PomBase:SPBC887.14c	P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001149889 SGD:S000001073	P		Seeded From UniProt	complete
part_of	GO:0005657	replication fork	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001149889 SGD:S000001073 SGD:S000004526	C		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010285	P		Seeded From UniProt	complete
enables	GO:0003678	DNA helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010285	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003840	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003840	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010285	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112749	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112749	P		Seeded From UniProt	complete
enables	GO:0043141	ATP-dependent 5'-3' DNA helicase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112749	F		Seeded From UniProt	complete
involved_in	GO:0000002	mitochondrial genome maintenance	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112749	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112749	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112749	C		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112749	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 McDonald, KR et al. (2016) Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity. PLoS Genet. 12 e1006238 PubMed GONUTS page
↑ Steinacher, R et al. (2012) The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability. Genes Dev. 26 594-602 PubMed GONUTS page
↑ Yu, Y et al. (2013) A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks. DNA Repair (Amst.) 12 433-43 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Mohammad, JB et al. (2018) The Pif1 signature motif of Pfh1 is necessary for both protein displacement and helicase unwinding activities, but is dispensable for strand-annealing activity. Nucleic Acids Res. PubMed GONUTS page
↑ ^5.0 ^5.1 Zhou, JQ et al. (2002) Schizosaccharomyces pombe pfh1+ encodes an essential 5' to 3' DNA helicase that is a member of the PIF1 subfamily of DNA helicases. Mol. Biol. Cell 13 2180-91 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Ryu, GH et al. (2004) Genetic and biochemical analyses of Pfh1 DNA helicase function in fission yeast. Nucleic Acids Res. 32 4205-16 PubMed GONUTS page
↑ ^7.0 ^7.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Pinter, SF et al. (2008) The Schizosaccharomyces pombe Pfh1p DNA helicase is essential for the maintenance of nuclear and mitochondrial DNA. Mol. Cell. Biol. 28 6594-608 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Wallgren, M et al. (2016) G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structures in vitro and are unwound by the Pfh1 DNA helicase. Nucleic Acids Res. 44 6213-31 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Tanaka, H et al. (2002) The fission yeast pfh1(+) gene encodes an essential 5' to 3' DNA helicase required for the completion of S-phase. Nucleic Acids Res. 30 4728-39 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Sabouri, N et al. (2014) The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage. BMC Biol. 12 101 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Sabouri, N et al. (2012) DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase. Genes Dev. 26 581-93 PubMed GONUTS page
↑ Audry, J et al. (2015) RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends. EMBO J. 34 1942-58 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27611590-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 McDonald, KR et al. (2016) Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity. PLoS Genet. 12 e1006238 PubMed GONUTS page

[PMID:22426535-2] Steinacher, R et al. (2012) The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability. Genes Dev. 26 594-602 PubMed GONUTS page

[PMID:23628481-3] Yu, Y et al. (2013) A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks. DNA Repair (Amst.) 12 433-43 PubMed GONUTS page

[PMID:30053106-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Mohammad, JB et al. (2018) The Pif1 signature motif of Pfh1 is necessary for both protein displacement and helicase unwinding activities, but is dispensable for strand-annealing activity. Nucleic Acids Res. PubMed GONUTS page

[PMID:12058079-5] 5.0 ^5.1 Zhou, JQ et al. (2002) Schizosaccharomyces pombe pfh1+ encodes an essential 5' to 3' DNA helicase that is a member of the PIF1 subfamily of DNA helicases. Mol. Biol. Cell 13 2180-91 PubMed GONUTS page

[PMID:15302919-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Ryu, GH et al. (2004) Genetic and biochemical analyses of Pfh1 DNA helicase function in fission yeast. Nucleic Acids Res. 32 4205-16 PubMed GONUTS page

[PMID:16823372-7] 7.0 ^7.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:18725402-8] 8.0 ^8.1 ^8.2 ^8.3 Pinter, SF et al. (2008) The Schizosaccharomyces pombe Pfh1p DNA helicase is essential for the maintenance of nuclear and mitochondrial DNA. Mol. Cell. Biol. 28 6594-608 PubMed GONUTS page

[PMID:27185885-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Wallgren, M et al. (2016) G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structures in vitro and are unwound by the Pfh1 DNA helicase. Nucleic Acids Res. 44 6213-31 PubMed GONUTS page

[PMID:12409464-10] 10.0 ^10.1 ^10.2 Tanaka, H et al. (2002) The fission yeast pfh1(+) gene encodes an essential 5' to 3' DNA helicase required for the completion of S-phase. Nucleic Acids Res. 30 4728-39 PubMed GONUTS page

[PMID:25471935-11] 11.0 ^11.1 ^11.2 Sabouri, N et al. (2014) The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage. BMC Biol. 12 101 PubMed GONUTS page

[PMID:22426534-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Sabouri, N et al. (2012) DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase. Genes Dev. 26 581-93 PubMed GONUTS page

[PMID:26041456-13] Audry, J et al. (2015) RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends. EMBO J. 34 1942-58 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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SCHPO:PIF1

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