GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:0006974 | cellular response to DNA damage stimulus | PMID:27611590 | IMP: Inferred from Mutant Phenotype | P | ||||
| This annotation made on page: SCHPO:PIF1 By: EClary (group Team Squirtle) on 2016-09-13 20:15:56 CDT. | ||||||||
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| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | CSears, Team Pik-Achoo! | 2016-09-25 17:19:07 CDT | GO:0097046 replication fork progression beyond termination site (Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks). Supplementary figure 2 shows that many G-quadruplex motifs show increased DNA damage associated with replication fork slowing. Figures 3b and 3c show that, in cells deficient in Pfh1, there is a higher occurrence of DNA damage at G-quadruplex motifs than in wild-type cells. Evidence code:IMP | 0 |
| Challenge | PGiovanelli, Team Onix | 2016-09-20 20:38:15 CDT | Figure 3 does not exactly show that Pfh1 is exactly a cellular response to DNA damage. These figures do not show, for example, that Pfh1 production increases when DNA damage occurs. They do show, however, that Pfh1 absence results in DNA damage. I would use the following Go term instead: GO:0045740 positive regulation of DNA replication Because Pfh1 is a helicase that unwinds DNA duplexes, thus promoting progression of the replication fork. | 1 |
| Private Assessment | Suzialeksander | 2016-11-30 14:41:09 CST | You need to be an instructor to view these notes. | Unacceptable |
| Private Assessment | Suzialeksander | 2016-09-26 14:37:50 CDT | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✗ Go term ✔ Evidence ✔ With/From ✔ Unique/Original |
