RAT:P85A

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Pik3r1
Protein Name(s)	Phosphatidylinositol 3-kinase regulatory subunit alpha PI3-kinase regulatory subunit alpha PI3K regulatory subunit alpha PtdIns-3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha PI3-kinase subunit p85-alpha PtdIns-3-kinase regulatory subunit p85-alpha
External Links
UniProt	Q63787
EMBL	D64045 D64048 U50412 D78486
RefSeq	NP_037137.1
UniGene	Rn.10599
PDB	1FU5 1FU6
PDBsum	1FU5 1FU6
ProteinModelPortal	Q63787
SMR	Q63787
BioGrid	247545
DIP	DIP-33696N
IntAct	Q63787
MINT	MINT-2880471
STRING	10116.ENSRNOP00000025687
iPTMnet	Q63787
PhosphoSite	Q63787
PaxDb	Q63787
PRIDE	Q63787
GeneID	25513
KEGG	rno:25513
UCSC	RGD:3329
CTD	5295
RGD	3329
eggNOG	KOG4637 ENOG410XP6R
HOGENOM	HOG000008438
HOVERGEN	HBG082100
InParanoid	Q63787
KO	K02649
PhylomeDB	Q63787
EvolutionaryTrace	Q63787
NextBio	606957
PRO	PR:Q63787
Proteomes	UP000002494
GO	GO:0005829 GO:0016020 GO:0043005 GO:0005634 GO:0005942 GO:0005943 GO:0005886 GO:0043234 GO:0016303 GO:0046935 GO:0051117 GO:0005516 GO:0043125 GO:0030331 GO:0005158 GO:0043560 GO:0005159 GO:0035014 GO:0051219 GO:0005161 GO:0008022 GO:0019904 GO:0019901 GO:0005102 GO:0030971 GO:0031625 GO:0007568 GO:0001678 GO:0071398 GO:0032869 GO:0006006 GO:0008286 GO:0048009 GO:0043066 GO:0045776 GO:0022408 GO:0010459 GO:0010656 GO:0045861 GO:0048662 GO:0046854 GO:0036092 GO:0030335 GO:1900103 GO:0010628 GO:2001275 GO:0045663 GO:0001934 GO:0033120 GO:0042993 GO:0045944 GO:0050821 GO:0015031 GO:0043551 GO:0043200 GO:0051591 GO:0071548 GO:0042493 GO:0034976 GO:0032355 GO:0045471 GO:0070542 GO:0009750 GO:0051384 GO:0070848 GO:0032868 GO:0010040 GO:0007584 GO:0032570 GO:0033574 GO:0001878
Gene3D	1.10.555.10 3.30.505.10
InterPro	IPR032498 IPR001720 IPR008936 IPR000198 IPR000980 IPR001452
PANTHER	PTHR10155
Pfam	PF16454 PF00620 PF00017
PRINTS	PR00401
SMART	SM00324 SM00252 SM00326
SUPFAM	SSF48350 SSF50044 SSF55550
PROSITE	PS50238 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0051965	positive regulation of synapse assembly	PMID:21414895^[1]	ECO:0000314			P	Figure 1B shows increase in synapse density after activation of PI3k by PTD4-PI3KAc.	complete CACAO 11259
involved_in	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P	Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P	Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26450	P	Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26450	P	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26450	P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26450	P	Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26450	P	Seeded From UniProt	complete
involved_in	GO:0048009	insulin-like growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O18683	P	Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26450	F	Seeded From UniProt	complete
enables	GO:0043125	ErbB-3 class receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	F	Seeded From UniProt	complete
enables	GO:0035014	phosphatidylinositol 3-kinase regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O18683	F	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P	Seeded From UniProt	complete
part_of	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O18683	C	Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	F	Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	F	Seeded From UniProt	complete
involved_in	GO:0071548	response to dexamethasone	PMID:20032058^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	PMID:17593346^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070848	response to growth factor	PMID:18421086^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	PMID:19369057^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	PMID:10875243^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	PMID:15187100^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:12882964^[8]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:628770	F	Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	PMID:17728397^[9]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2167	F	Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:19783773^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048009	insulin-like growth factor receptor signaling pathway	PMID:9440811^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	PMID:12882977^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045861	negative regulation of proteolysis	PMID:15161606^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	PMID:19015400^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	PMID:9440811^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:17622585^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:12891559^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:69316	F	Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:12891559^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2922	F	Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	PMID:12882977^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	PMID:19106217^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:17600839^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:20519555^[19]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	PMID:20032058^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:10973965^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:18922131^[21]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:16150536^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	PMID:18752305^[23]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:19462258^[24]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:18773943^[25]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1561386	F	Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	PMID:18292389^[26]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620028	F	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:15530849^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	PMID:16971528^[28]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2581	F	Seeded From UniProt	complete
involved_in	GO:0022408	negative regulation of cell-cell adhesion	PMID:15530849^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:10973965^[20]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621367	F	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:10973965^[20]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:619758	F	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:18854312^[29]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3443	F	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:15530849^[27]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2939	F	Seeded From UniProt	complete
contributes_to	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:20236230^[30]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:20519555^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010656	negative regulation of muscle cell apoptotic process	PMID:15089039^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20333648^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010459	negative regulation of heart rate	PMID:19015400^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010040	response to iron(II) ion	PMID:17600839^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009750	response to fructose	PMID:17976658^[33]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:15161606^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:12692262^[34]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	PMID:19880292^[35]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	PMID:19657097^[36]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:16123202^[37]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	PMID:9440811^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:20236230^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:12882977^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11826414^[38]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17918740^[39]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:17492691^[40]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2257	F	Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	PMID:18421086^[4]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3284 RGD:3285	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:14962484^[41]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3870	F	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:19723872^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001878	response to yeast	PMID:19958054^[43]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109277 PANTHER:PTN000806614 RGD:3329 RGD:621042	F	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020622 PANTHER:PTN000806614 UniProtKB:P23727	P	Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000016388 RGD:3329 UniProtKB:P23727	P	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109277 MGI:MGI:1098772 MGI:MGI:97583 PANTHER:PTN000016388 RGD:3329 UniProtKB:P23727 WB:WBGene00000001	P	Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109277 PANTHER:PTN000806614 RGD:3329 UniProtKB:P23727 WB:WBGene00000001	C	Seeded From UniProt	complete
involved_in	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016303	P	Seeded From UniProt	complete
involved_in	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016303	P	Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001720	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000198 InterPro:IPR008936	P	Seeded From UniProt	complete
enables	GO:0035014	phosphatidylinositol 3-kinase regulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001720	F	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:8621382^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:8621382^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-RNO-912619	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Cuesto, G et al. (2011) Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons. J. Neurosci. 31 2721-33 PubMed GONUTS page
↑ ^2.0 ^2.1 Wu, Y et al. (2010) REDD1 is a major target of testosterone action in preventing dexamethasone-induced muscle loss. Endocrinology 151 1050-9 PubMed GONUTS page
↑ Cazzolli, R et al. (2007) Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle. Diabetologia 50 1732-42 PubMed GONUTS page
↑ ^4.0 ^4.1 Biswas, SK et al. (2008) PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 49 3687-98 PubMed GONUTS page
↑ Kawashima, A et al. (2010) Effects of eicosapentaenoic acid on synaptic plasticity, fatty acid profile and phosphoinositide 3-kinase signaling in rat hippocampus and differentiated PC12 cells. J. Nutr. Biochem. 21 268-77 PubMed GONUTS page
↑ Nedachi, T et al. (2000) Tyrosine kinase and phosphatidylinositol 3-kinase activation are required for cyclic adenosine 3',5'-monophosphate-dependent potentiation of deoxyribonucleic acid synthesis induced by insulin-like growth factor-I in FRTL-5 cells. Endocrinology 141 2429-38 PubMed GONUTS page
↑ Andrade, MV et al. (2004) Dexamethasone suppresses antigen-induced activation of phosphatidylinositol 3-kinase and downstream responses in mast cells. J. Immunol. 172 7254-62 PubMed GONUTS page
↑ Bock, HH et al. (2003) Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. J. Biol. Chem. 278 38772-9 PubMed GONUTS page
↑ Liu, L et al. (2007) Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes. Am. J. Physiol., Cell Physiol. 293 C1489-97 PubMed GONUTS page
↑ Torella, D et al. (2009) Differential regulation of vascular smooth muscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85alphaPI3K. Am. J. Physiol. Heart Circ. Physiol. 297 H2015-25 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Kaliman, P et al. (1998) Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells. Mol. Endocrinol. 12 66-77 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Kaplan-Albuquerque, N et al. (2003) Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. J. Biol. Chem. 278 39830-8 PubMed GONUTS page
↑ ^13.0 ^13.1 Franch, HA et al. (2004) Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis. Am. J. Physiol. Renal Physiol. 287 F700-6 PubMed GONUTS page
↑ ^14.0 ^14.1 Zubcevic, J et al. (2009) Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat. Hypertension 53 97-103 PubMed GONUTS page
↑ He, L et al. (2007) Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health. Mol. Endocrinol. 21 2541-50 PubMed GONUTS page
↑ ^16.0 ^16.1 Khamzina, L et al. (2003) Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Gastroenterology 125 572-85 PubMed GONUTS page
↑ de Castro Barbosa, T et al. (2009) Potential role of growth hormone in impairment of insulin signaling in skeletal muscle, adipose tissue, and liver of rats chronically treated with arginine. Endocrinology 150 2080-6 PubMed GONUTS page
↑ ^18.0 ^18.1 Uranga, RM et al. (2007) Activation of phosphoinositide-3 kinase/Akt pathway by FeSO4 in rat cerebral cortex synaptic endings. J. Neurosci. Res. 85 2924-32 PubMed GONUTS page
↑ ^19.0 ^19.1 Haba, M et al. (2010) The modulation of vascular ATP-sensitive K+ channel function via the phosphatidylinositol 3-kinase-Akt pathway activated by phenylephrine. J. Pharmacol. Exp. Ther. 334 673-8 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Kong, M et al. (2000) Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes. J. Biol. Chem. 275 36035-42 PubMed GONUTS page
↑ Watson, ML et al. (2009) Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells. Biochem. J. 417 791-801 PubMed GONUTS page
↑ Benomar, Y et al. (2005) In vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus. Mol. Cell. Endocrinol. 242 59-66 PubMed GONUTS page
↑ Guerra-Araiza, C et al. (2009) Regulation of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling pathways by progesterone and its reduced metabolites in the rat brain. J. Neurosci. Res. 87 470-81 PubMed GONUTS page
↑ Moreno, M et al. (2010) Chronic 17beta-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging. Age (Dordr) 32 1-13 PubMed GONUTS page
↑ Wen, XR et al. (2008) Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury. Neuroscience 156 483-97 PubMed GONUTS page
↑ Cavet, ME et al. (2008) Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 28 886-91 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Ferrand, A et al. (2004) Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin. Exp. Cell Res. 301 128-38 PubMed GONUTS page
↑ Mannella, P & Brinton, RD (2006) Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action. J. Neurosci. 26 9439-47 PubMed GONUTS page
↑ Del Re, DP et al. (2008) Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J. Biol. Chem. 283 35622-9 PubMed GONUTS page
↑ ^30.0 ^30.1 Tups, A et al. (2010) Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. J. Neuroendocrinol. 22 534-42 PubMed GONUTS page
↑ Chae, HJ et al. (2004) Signal transduction of the protective effect of insulin like growth factor-1 on adriamycin-induced apoptosis in cardiac muscle cells. Arch. Pharm. Res. 27 324-33 PubMed GONUTS page
↑ Tung, WH et al. (2010) EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes. J. Cell. Physiol. 224 376-86 PubMed GONUTS page
↑ Liu, IM et al. (2007) Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats. Life Sci. 81 1479-88 PubMed GONUTS page
↑ Riggins, RB et al. (2003) Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cells. Mol. Cancer Res. 1 428-37 PubMed GONUTS page
↑ Feres, NH et al. (2010) Soybean diet alters the insulin-signaling pathway in the liver of rats recovering from early-life malnutrition. Nutrition 26 441-8 PubMed GONUTS page
↑ Page, KC et al. (2009) Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297 R1049-57 PubMed GONUTS page
↑ Majumdar, AP & Du, J (2006) Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging. Am. J. Physiol. Gastrointest. Liver Physiol. 290 G49-55 PubMed GONUTS page
↑ Kawanaka, H et al. (2002) Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI 3-kinase-Akt signaling pathway. Hepatology 35 393-402 PubMed GONUTS page
↑ Sephton, CF & Mousseau, DD (2008) Dephosphorylation of Akt in C6 cells grown in serum-free conditions corresponds with redistribution of p85/PI3K to the nucleus. J. Neurosci. Res. 86 675-82 PubMed GONUTS page
↑ Xu, J et al. (2007) Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation. Hippocampus 17 525-37 PubMed GONUTS page
↑ Li, C et al. (2004) Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Cardiovasc. Res. 61 538-47 PubMed GONUTS page
↑ Byun, JY et al. (2009) Oncogenic Ras signals through activation of both phosphoinositide 3-kinase and Rac1 to induce c-Jun NH2-terminal kinase-mediated, caspase-independent cell death. Mol. Cancer Res. 7 1534-42 PubMed GONUTS page
↑ Buts, JP & De Keyser, N (2010) Transduction pathways regulating the trophic effects of Saccharomyces boulardii in rat intestinal mucosa. Scand. J. Gastroenterol. 45 175-85 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 ^44.3 ^44.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^45.0 ^45.1 Inukai, K et al. (1996) A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. J. Biol. Chem. 271 5317-20 PubMed GONUTS page

[PMID:21414895-1] Cuesto, G et al. (2011) Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons. J. Neurosci. 31 2721-33 PubMed GONUTS page

[PMID:20032058-2] 2.0 ^2.1 Wu, Y et al. (2010) REDD1 is a major target of testosterone action in preventing dexamethasone-induced muscle loss. Endocrinology 151 1050-9 PubMed GONUTS page

[PMID:17593346-3] Cazzolli, R et al. (2007) Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle. Diabetologia 50 1732-42 PubMed GONUTS page

[PMID:18421086-4] 4.0 ^4.1 Biswas, SK et al. (2008) PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 49 3687-98 PubMed GONUTS page

[PMID:19369057-5] Kawashima, A et al. (2010) Effects of eicosapentaenoic acid on synaptic plasticity, fatty acid profile and phosphoinositide 3-kinase signaling in rat hippocampus and differentiated PC12 cells. J. Nutr. Biochem. 21 268-77 PubMed GONUTS page

[PMID:10875243-6] Nedachi, T et al. (2000) Tyrosine kinase and phosphatidylinositol 3-kinase activation are required for cyclic adenosine 3',5'-monophosphate-dependent potentiation of deoxyribonucleic acid synthesis induced by insulin-like growth factor-I in FRTL-5 cells. Endocrinology 141 2429-38 PubMed GONUTS page

[PMID:15187100-7] Andrade, MV et al. (2004) Dexamethasone suppresses antigen-induced activation of phosphatidylinositol 3-kinase and downstream responses in mast cells. J. Immunol. 172 7254-62 PubMed GONUTS page

[PMID:12882964-8] Bock, HH et al. (2003) Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. J. Biol. Chem. 278 38772-9 PubMed GONUTS page

[PMID:17728397-9] Liu, L et al. (2007) Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes. Am. J. Physiol., Cell Physiol. 293 C1489-97 PubMed GONUTS page

[PMID:19783773-10] Torella, D et al. (2009) Differential regulation of vascular smooth muscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85alphaPI3K. Am. J. Physiol. Heart Circ. Physiol. 297 H2015-25 PubMed GONUTS page

[PMID:9440811-11] 11.0 ^11.1 ^11.2 Kaliman, P et al. (1998) Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells. Mol. Endocrinol. 12 66-77 PubMed GONUTS page

[PMID:12882977-12] 12.0 ^12.1 ^12.2 Kaplan-Albuquerque, N et al. (2003) Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. J. Biol. Chem. 278 39830-8 PubMed GONUTS page

[PMID:15161606-13] 13.0 ^13.1 Franch, HA et al. (2004) Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis. Am. J. Physiol. Renal Physiol. 287 F700-6 PubMed GONUTS page

[PMID:19015400-14] 14.0 ^14.1 Zubcevic, J et al. (2009) Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat. Hypertension 53 97-103 PubMed GONUTS page

[PMID:17622585-15] He, L et al. (2007) Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health. Mol. Endocrinol. 21 2541-50 PubMed GONUTS page

[PMID:12891559-16] 16.0 ^16.1 Khamzina, L et al. (2003) Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Gastroenterology 125 572-85 PubMed GONUTS page

[PMID:19106217-17] Castro Barbosa, T et al. (2009) Potential role of growth hormone in impairment of insulin signaling in skeletal muscle, adipose tissue, and liver of rats chronically treated with arginine. Endocrinology 150 2080-6 PubMed GONUTS page

[PMID:17600839-18] 18.0 ^18.1 Uranga, RM et al. (2007) Activation of phosphoinositide-3 kinase/Akt pathway by FeSO4 in rat cerebral cortex synaptic endings. J. Neurosci. Res. 85 2924-32 PubMed GONUTS page

[PMID:20519555-19] 19.0 ^19.1 Haba, M et al. (2010) The modulation of vascular ATP-sensitive K+ channel function via the phosphatidylinositol 3-kinase-Akt pathway activated by phenylephrine. J. Pharmacol. Exp. Ther. 334 673-8 PubMed GONUTS page

[PMID:10973965-20] 20.0 ^20.1 ^20.2 Kong, M et al. (2000) Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes. J. Biol. Chem. 275 36035-42 PubMed GONUTS page

[PMID:18922131-21] Watson, ML et al. (2009) Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells. Biochem. J. 417 791-801 PubMed GONUTS page

[PMID:16150536-22] Benomar, Y et al. (2005) In vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus. Mol. Cell. Endocrinol. 242 59-66 PubMed GONUTS page

[PMID:18752305-23] Guerra-Araiza, C et al. (2009) Regulation of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling pathways by progesterone and its reduced metabolites in the rat brain. J. Neurosci. Res. 87 470-81 PubMed GONUTS page

[PMID:19462258-24] Moreno, M et al. (2010) Chronic 17beta-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging. Age (Dordr) 32 1-13 PubMed GONUTS page

[PMID:18773943-25] Wen, XR et al. (2008) Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury. Neuroscience 156 483-97 PubMed GONUTS page

[PMID:18292389-26] Cavet, ME et al. (2008) Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 28 886-91 PubMed GONUTS page

[PMID:15530849-27] 27.0 ^27.1 ^27.2 Ferrand, A et al. (2004) Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin. Exp. Cell Res. 301 128-38 PubMed GONUTS page

[PMID:16971528-28] Mannella, P & Brinton, RD (2006) Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action. J. Neurosci. 26 9439-47 PubMed GONUTS page

[PMID:18854312-29] Del Re, DP et al. (2008) Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J. Biol. Chem. 283 35622-9 PubMed GONUTS page

[PMID:20236230-30] 30.0 ^30.1 Tups, A et al. (2010) Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. J. Neuroendocrinol. 22 534-42 PubMed GONUTS page

[PMID:15089039-31] Chae, HJ et al. (2004) Signal transduction of the protective effect of insulin like growth factor-1 on adriamycin-induced apoptosis in cardiac muscle cells. Arch. Pharm. Res. 27 324-33 PubMed GONUTS page

[PMID:20333648-32] Tung, WH et al. (2010) EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes. J. Cell. Physiol. 224 376-86 PubMed GONUTS page

[PMID:17976658-33] Liu, IM et al. (2007) Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats. Life Sci. 81 1479-88 PubMed GONUTS page

[PMID:12692262-34] Riggins, RB et al. (2003) Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cells. Mol. Cancer Res. 1 428-37 PubMed GONUTS page

[PMID:19880292-35] Feres, NH et al. (2010) Soybean diet alters the insulin-signaling pathway in the liver of rats recovering from early-life malnutrition. Nutrition 26 441-8 PubMed GONUTS page

[PMID:19657097-36] Page, KC et al. (2009) Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297 R1049-57 PubMed GONUTS page

[PMID:16123202-37] Majumdar, AP & Du, J (2006) Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging. Am. J. Physiol. Gastrointest. Liver Physiol. 290 G49-55 PubMed GONUTS page

[PMID:11826414-38] Kawanaka, H et al. (2002) Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI 3-kinase-Akt signaling pathway. Hepatology 35 393-402 PubMed GONUTS page

[PMID:17918740-39] Sephton, CF & Mousseau, DD (2008) Dephosphorylation of Akt in C6 cells grown in serum-free conditions corresponds with redistribution of p85/PI3K to the nucleus. J. Neurosci. Res. 86 675-82 PubMed GONUTS page

[PMID:17492691-40] Xu, J et al. (2007) Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation. Hippocampus 17 525-37 PubMed GONUTS page

[PMID:14962484-41] Li, C et al. (2004) Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Cardiovasc. Res. 61 538-47 PubMed GONUTS page

[PMID:19723872-42] Byun, JY et al. (2009) Oncogenic Ras signals through activation of both phosphoinositide 3-kinase and Rac1 to induce c-Jun NH2-terminal kinase-mediated, caspase-independent cell death. Mol. Cancer Res. 7 1534-42 PubMed GONUTS page

[PMID:19958054-43] Buts, JP & De Keyser, N (2010) Transduction pathways regulating the trophic effects of Saccharomyces boulardii in rat intestinal mucosa. Scand. J. Gastroenterol. 45 175-85 PubMed GONUTS page

[PMID:21873635-44] 44.0 ^44.1 ^44.2 ^44.3 ^44.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8621382-45] 45.0 ^45.1 Inukai, K et al. (1996) A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. J. Biol. Chem. 271 5317-20 PubMed GONUTS page

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[17]

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[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

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