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RAT:KPCD

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Prkcd (synonyms: Pkcd)
Protein Name(s) Protein kinase C delta type

nPKC-delta Protein kinase C delta type regulatory subunit Protein kinase C delta type catalytic subunit Sphingosine-dependent protein kinase-1 SDK1

External Links
UniProt P09215
EMBL M18330
AJ230617
AJ230618
AJ230619
AJ230620
AJ230621
AJ230622
AJ230623
AJ230624
AJ230625
AJ230626
AJ230627
AJ230628
AJ230629
AJ230630
AJ230631
AJ230632
AJ230633
AF219629
BC076505
PIR A28163
RefSeq NP_579841.1
UniGene Rn.98279
PDB 1BDY
PDBsum 1BDY
ProteinModelPortal P09215
SMR P09215
BioGrid 250924
IntAct P09215
MINT MINT-143019
ChEMBL CHEMBL3633
PhosphoSite P09215
PaxDb P09215
PRIDE P09215
GeneID 170538
KEGG rno:170538
UCSC RGD:67383
CTD 5580
RGD 67383
eggNOG COG0515
HOGENOM HOG000233022
HOVERGEN HBG108317
InParanoid P09215
KO K06068
PhylomeDB P09215
BRENDA 2.7.11.13
EvolutionaryTrace P09215
NextBio 621024
PMAP-CutDB P09215
Proteomes UP000002494
Genevestigator P09215
GO GO:0005737
GO:0005829
GO:0005783
GO:0016020
GO:0005739
GO:0005634
GO:0048471
GO:0005886
GO:0005524
GO:0004699
GO:0046872
GO:0019901
GO:0004697
GO:0070976
GO:0007568
GO:0006915
GO:0015810
GO:0007049
GO:0042149
GO:0032869
GO:0032963
GO:0042742
GO:0035556
GO:0030837
GO:0051490
GO:0034351
GO:0090331
GO:0043065
GO:0046326
GO:0043406
GO:0043410
GO:0032930
GO:0046777
GO:0006468
GO:0043200
GO:0042493
GO:0045471
GO:0009749
GO:0009408
GO:0042542
GO:0001666
GO:0009612
GO:0014070
GO:0010243
GO:0006979
Gene3D 2.60.40.150
InterPro IPR000961
IPR000008
IPR020454
IPR011009
IPR002219
IPR027436
IPR017892
IPR014376
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00130
PF00069
PF00433
PIRSF PIRSF000551
PIRSF501104
PRINTS PR00008
SMART SM00109
SM00239
SM00133
SM00220
SUPFAM SSF49562
SSF56112
PROSITE PS51285
PS00107
PS50011
PS00108
PS00479
PS50081

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0034599

cellular response to oxidative stress

PMID:21696630[1]

ECO:0000314

P

Figure 1 : A, B, C, D, & E.

complete
CACAO 3268

GO:0006915

apoptosis

PMID:21696630[1]

ECO:0000315

P

Figure 1: F "PKCδ knockdown by RNAi almost comple- tely blocked the cell death induced by H2O2 at 120 min of treatment, demonstrating the pro-apoptotic function performed by PKCδ in N27 cells" .

complete
CACAO 3269

involved_in

GO:1904385

cellular response to angiotensin

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q05655

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q05655

P

Seeded From UniProt

complete

involved_in

GO:0042325

regulation of phosphorylation

PMID:21696630[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:21696630[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0042325

regulation of phosphorylation

PMID:21696630[1]

ECO:0000314

P

Fig. 4D

complete
CACAO 3272

involved_in

GO:0034599

cellular response to oxidative stress

PMID:21696630[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070976

TIR domain binding

PMID:17161867[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P58753

F

Seeded From UniProt

complete

involved_in

GO:0090331

negative regulation of platelet aggregation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28867

P

Seeded From UniProt

complete

involved_in

GO:0051490

negative regulation of filopodium assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28867

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28867

P

Seeded From UniProt

complete

involved_in

GO:0034351

negative regulation of glial cell apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q05655

P

Seeded From UniProt

complete

involved_in

GO:0032930

positive regulation of superoxide anion generation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q05655

P

Seeded From UniProt

complete

involved_in

GO:0030837

negative regulation of actin filament polymerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28867

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q05655

C

Seeded From UniProt

complete

enables

GO:0004697

protein kinase C activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28867

F

Seeded From UniProt

complete

part_of

GO:0099524

postsynaptic cytosol

PMID:8263228[3]

ECO:0006003

electron microscopy evidence used in manual assertion

C

part_of:(UBERON:0001897)

Seeded From UniProt

complete

involved_in

GO:0070779

D-aspartate import across plasma membrane

PMID:17364745[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046777

protein autophosphorylation

PMID:10085132[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046326

positive regulation of glucose import

PMID:17098211[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

PMID:17728104[7]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043410

positive regulation of MAPK cascade

PMID:12790799[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043406

positive regulation of MAP kinase activity

PMID:16935468[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043200

response to amino acid

PMID:17210758[10]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:12663471[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042542

response to hydrogen peroxide

PMID:17397968[12]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042542

response to hydrogen peroxide

PMID:12226102[13]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:17123493[14]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042149

cellular response to glucose starvation

PMID:17728702[15]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:11562372[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032963

collagen metabolic process

PMID:17728702[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032869

cellular response to insulin stimulus

PMID:17046201[17]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:15337529[18]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:620795

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:9705215[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

PMID:11478406[20]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010243

response to organonitrogen compound

PMID:17563398[21]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009749

response to glucose

PMID:12960081[22]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009612

response to mechanical stimulus

PMID:17487266[23]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009408

response to heat

PMID:16990486[24]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

PMID:17008461[25]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

PMID:11576956[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:1915352[27]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:18945317[28]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:9950866[29]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:9705215[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18945317[28]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:17008461[25]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12663471[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12663471[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004699

calcium-independent protein kinase C activity

PMID:1915352[27]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:16936002[30]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[31]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003744
FB:FBgn0010379
MGI:MGI:97601
PANTHER:PTN000683254
PomBase:SPAC1B9.02c
PomBase:SPAC22E12.14c
PomBase:SPAPB18E9.02c
RGD:3395
RGD:3399
RGD:61925
RGD:620968
RGD:67383
SGD:S000000201
UniProtKB:O15530
UniProtKB:P31749
UniProtKB:Q15208
UniProtKB:Q9NRM7
UniProtKB:Q9Y2H1

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:21873635[31]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87986
PANTHER:PTN000683254
RGD:2081
RGD:3395
RGD:3399
RGD:3668
RGD:61925
SGD:S000001609
SGD:S000001861
SGD:S000002898
SGD:S000005460
UniProtKB:A0A1D5PUY5
UniProtKB:P31749
UniProtKB:P41743
UniProtKB:Q02156
UniProtKB:Q05513
UniProtKB:Q05655
WB:WBGene00000102
WB:WBGene00000103
WB:WBGene00004033
WB:WBGene00004034
WB:WBGene00004789
WB:WBGene00006599

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[31]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003091
FB:FBgn0003744
FB:FBgn0010379
FB:FBgn0260399
FB:FBgn0261854
MGI:MGI:104874
MGI:MGI:2182368
MGI:MGI:87986
MGI:MGI:894676
MGI:MGI:97595
MGI:MGI:97596
MGI:MGI:97599
MGI:MGI:97602
PANTHER:PTN000683254
PomBase:SPAC1B9.02c
PomBase:SPAC22E12.14c
PomBase:SPAC24B11.11c
PomBase:SPAC821.12
PomBase:SPAPB18E9.02c
PomBase:SPCC576.15c
RGD:2081
RGD:2082
RGD:3399
RGD:3668
RGD:620146
RGD:620968
RGD:62390
SGD:S000001248
SGD:S000001609
SGD:S000001861
SGD:S000002898
SGD:S000003324
SGD:S000005105
SGD:S000005460
SGD:S000006315
TAIR:locus:2088515
UniProtKB:O15530
UniProtKB:O95835
UniProtKB:P05771
UniProtKB:P17252
UniProtKB:P31749
UniProtKB:P31751
UniProtKB:P41743
UniProtKB:Q02156
UniProtKB:Q04759
UniProtKB:Q05513
UniProtKB:Q05655
UniProtKB:Q09013
UniProtKB:Q15208
UniProtKB:Q16512
UniProtKB:Q16513
UniProtKB:Q96GX5
UniProtKB:Q9NRM7
UniProtKB:Q9XF67
UniProtKB:Q9Y243
UniProtKB:Q9Y2H1
WB:WBGene00000102
WB:WBGene00000103
WB:WBGene00004034
WB:WBGene00004789
WB:WBGene00006599
dictyBase:DDB_G0268620

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000961
InterPro:IPR017892

F

Seeded From UniProt

complete

enables

GO:0004697

protein kinase C activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014376
InterPro:IPR027436

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR017441
InterPro:IPR017892

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR008271
InterPro:IPR014376
InterPro:IPR017892

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002219

P

Seeded From UniProt

complete

enables

GO:0004697

protein kinase C activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.13

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Asaithambi, A et al. (2011) Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Mol Neurodegener 6 43 PubMed GONUTS page
  2. ↑ Kubo-Murai, M et al. (2007) Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling. Mol. Immunol. 44 2257-64 PubMed GONUTS page
  3. ↑ Merchenthaler, I et al. (1993) Light and electron microscopic immunocytochemical localization of PKC delta immunoreactivity in the rat central nervous system. J. Comp. Neurol. 336 378-99 PubMed GONUTS page
  4. ↑ Bull, ND et al. (2007) Protein kinase C-mediated modulation of glutamate transporter activity in rat retina. Curr. Eye Res. 32 123-31 PubMed GONUTS page
  5. ↑ Stempka, L et al. (1999) Requirements of protein kinase cdelta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643. J. Biol. Chem. 274 8886-92 PubMed GONUTS page
  6. ↑ Alpert, E et al. (2007) Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner. Biochem. Pharmacol. 73 368-77 PubMed GONUTS page
  7. ↑ Zhang, Y et al. (2007) Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms. Cell. Signal. 19 2339-50 PubMed GONUTS page
  8. ↑ Wrede, CE et al. (2003) Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). J. Mol. Endocrinol. 30 271-86 PubMed GONUTS page
  9. ↑ Hsieh, HL et al. (2007) BK-induced COX-2 expression via PKC-delta-dependent activation of p42/p44 MAPK and NF-kappaB in astrocytes. Cell. Signal. 19 330-40 PubMed GONUTS page
  10. ↑ Gäreskog, M & Wentzel, P (2007) N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro. J. Endocrinol. 192 207-14 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 Eitel, K et al. (2003) Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Diabetes 52 991-7 PubMed GONUTS page
  12. ↑ Anantharam, V et al. (2007) Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease. Neurochem. Int. 50 834-47 PubMed GONUTS page
  13. ↑ Saito, S et al. (2002) Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. J. Biol. Chem. 277 44695-700 PubMed GONUTS page
  14. ↑ Papparella, I et al. (2007) Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat. Cardiovasc. Res. 73 432-8 PubMed GONUTS page
  15. ↑ 15.0 15.1 Baccora, MH et al. (2007) Effects of long-term elevated glucose on collagen formation by mesangial cells. Kidney Int. 72 1216-25 PubMed GONUTS page
  16. ↑ Mohammadi, K et al. (2001) Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. J. Biol. Chem. 276 42050-6 PubMed GONUTS page
  17. ↑ Horovitz-Fried, M et al. (2007) Activation of the nuclear transcription factor SP-1 by insulin rapidly increases the expression of protein kinase C delta in skeletal muscle. Cell. Signal. 19 556-62 PubMed GONUTS page
  18. ↑ Rosenzweig, T et al. (2004) Src tyrosine kinase regulates insulin-induced activation of protein kinase C (PKC) delta in skeletal muscle. Cell. Signal. 16 1299-308 PubMed GONUTS page
  19. ↑ 19.0 19.1 Mahadev, K & Vemuri, MC (1998) Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Arch. Biochem. Biophys. 356 249-57 PubMed GONUTS page
  20. ↑ Morabito, D et al. (2001) Obesity is associated with impaired ventricular protein kinase C-MAP kinase signaling and altered ANP mRNA expression in the heart of adult Zucker rats. J. Investig. Med. 49 310-8 PubMed GONUTS page
  21. ↑ Clavijo, C et al. (2007) Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent. Am. J. Physiol., Cell Physiol. 292 C2150-60 PubMed GONUTS page
  22. ↑ Steiler, TL et al. (2003) Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats. Endocrinology 144 5259-67 PubMed GONUTS page
  23. ↑ Bullard, TA et al. (2007) Altered PKC expression and phosphorylation in response to the nature, direction, and magnitude of mechanical stretch. Can. J. Physiol. Pharmacol. 85 243-50 PubMed GONUTS page
  24. ↑ Tan, J et al. (2007) Effects of burn injury on myocardial signaling and cytokine secretion: Possible role of PKC. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 R887-96 PubMed GONUTS page
  25. ↑ 25.0 25.1 Hunter, JC et al. (2007) Estrogen deficiency decreases ischemic tolerance in the aged rat heart: Roles of PKCdelta, PKCepsilon, Akt, and GSK3beta. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 R800-9 PubMed GONUTS page
  26. ↑ Ha, H et al. (2001) Activation of protein kinase c-delta and c-epsilon by oxidative stress in early diabetic rat kidney. Am. J. Kidney Dis. 38 S204-7 PubMed GONUTS page
  27. ↑ 27.0 27.1 Olivier, AR & Parker, PJ (1991) Expression and characterization of protein kinase C-delta. Eur. J. Biochem. 200 805-10 PubMed GONUTS page
  28. ↑ 28.0 28.1 Corsini, E et al. (2009) Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Br. J. Dermatol. 160 16-25 PubMed GONUTS page
  29. ↑ Albert, CJ & Ford, DA (1999) Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Am. J. Physiol. 276 H642-50 PubMed GONUTS page
  30. ↑ Kolár, F et al. (2007) Role of oxidative stress in PKC-delta upregulation and cardioprotection induced by chronic intermittent hypoxia. Am. J. Physiol. Heart Circ. Physiol. 292 H224-30 PubMed GONUTS page
  31. ↑ 31.0 31.1 31.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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