PMID:21696630

Citation	Asaithambi, A, Kanthasamy, A, Saminathan, H, Anantharam, V and Kanthasamy, AG (2011) Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Mol Neurodegener 6:43
Abstract	Oxidative stress is a key pathophysiological mechanism contributing to degenerative processes in many neurodegenerative diseases and therefore, unraveling molecular mechanisms underlying various stages of oxidative neuronal damage is critical to better understanding the diseases and developing new treatment modalities. We previously showed that protein kinase C delta (PKCδ) proteolytic activation during the late stages of oxidative stress is a key proapoptotic signaling mechanism that contributes to oxidative damage in Parkinson's disease (PD) models. The time course studies revealed that PKCδ activation precedes apoptotic cell death and that cells resisted early insults of oxidative damage, suggesting that some intrinsic compensatory response protects neurons from early oxidative insult. Therefore, the purpose of the present study was to characterize protective signaling pathways in dopaminergic neurons during early stages of oxidative stress.
Links	PubMed PMC3145571 Online version:10.1186/1750-1326-6-43
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:KPCD	involved_in	GO:0034599: cellular response to oxidative stress	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
RAT:KPCD	involved_in	GO:0006915: apoptotic process	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
RAT:KPCD	involved_in	GO:0042325: regulation of phosphorylation	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
RAT:KPCD		GO:0034599: cellular response to oxidative stress	ECO:0000314:		P		Figure 1 : A, B, C, D, & E.	complete CACAO 3268
RAT:KPCD		GO:0006915: apoptosis	ECO:0000315:		P		Figure 1: F "PKCδ knockdown by RNAi almost comple- tely blocked the cell death induced by H2O2 at 120 min of treatment, demonstrating the pro-apoptotic function performed by PKCδ in N27 cells" .	complete CACAO 3269
RAT:KPCD		GO:0042325: regulation of phosphorylation	ECO:0000314:		P		Fig. 4D	complete CACAO 3272
RAT:Q9ERV0	enables	GO:0016301: kinase activity	ECO:0000314: direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
RAT:Q9ERV0	involved_in	GO:0043066: negative regulation of apoptotic process	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
RAT:Q9ERV0		GO:0006979: response to oxidative stress	ECO:0000314:		P		Figure 2: C & D Figure 8: A	complete CACAO 3265
RAT:Q9ERV0		GO:0016301: kinase activity	ECO:0000314:		F		Figure 2: C & D.	complete CACAO 3266
RAT:Q9ERV0		GO:0006916: anti-apoptosis	ECO:0000315:		P		Figure 5: B, C, D & E. Figure 7: A, B, C & D.	complete CACAO 3267

References

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