RAT:G6PD

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	G6pdx (synonyms: G6pd)
Protein Name(s)	Glucose-6-phosphate 1-dehydrogenase G6PD
External Links
UniProt	P05370
EMBL	X07467 BC081820 M26655 M26653 M26654
PIR	S01233
RefSeq	NP_058702.1
UniGene	Rn.11040
ProteinModelPortal	P05370
SMR	P05370
STRING	10116.ENSRNOP00000053157
PhosphoSite	P05370
World-2DPAGE	0004:P05370
PaxDb	P05370
PRIDE	P05370
Ensembl	ENSRNOT00000056317
GeneID	24377
KEGG	rno:24377
CTD	2539
RGD	2645
eggNOG	COG0364
GeneTree	ENSGT00530000063435
HOGENOM	HOG000046192
HOVERGEN	HBG000856
InParanoid	P05370
KO	K00036
OMA	HNLQTTK
OrthoDB	EOG7DRJ2T
PhylomeDB	P05370
TreeFam	TF300584
Reactome	REACT_226758
SABIO-RK	P05370
UniPathway	UPA00115
NextBio	603131
Proteomes	UP000002494
Genevestigator	P05370
GO	GO:0009898 GO:0005829 GO:0070062 GO:0043231 GO:0005634 GO:0030246 GO:0005536 GO:0004345 GO:0050661 GO:0034599 GO:0006695 GO:0001816 GO:0043249 GO:0051156 GO:0006749 GO:0006739 GO:0010734 GO:0019322 GO:0006098 GO:0009051 GO:0043523 GO:0045471 GO:0032094 GO:0014070 GO:0046390 GO:0021762
Gene3D	3.40.50.720
HAMAP	MF_00966
InterPro	IPR001282 IPR019796 IPR022675 IPR022674 IPR016040
PANTHER	PTHR23429
Pfam	PF02781 PF00479
PIRSF	PIRSF000110
PRINTS	PR00079
TIGRFAMs	TIGR00871
PROSITE	PS00069

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:21569266^[1]	ECO:0000314			F	Figure 4	complete CACAO 3558
	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:21930213^[2]	ECO:0000314			F	See Figure 1 of G6PD activity.	complete CACAO 5532
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:21930213^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:21569266^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006739	NADP metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11413	P	Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	PMID:24190878^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	PMID:23071515^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	PMID:24190878^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	PMID:16325866^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	PMID:17447164^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050661	NADP binding	PMID:16325866^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0050661	NADP binding	PMID:17447164^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:18488910^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043523	regulation of neuron apoptotic process	PMID:12414804^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:2843500^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032094	response to food	PMID:19076169^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	PMID:2843500^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:17250641^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010041	response to iron(III) ion	PMID:24599681^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009051	pentose-phosphate shunt, oxidative branch	PMID:9794092^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006098	pentose-phosphate shunt	PMID:2843500^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:1834654^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15942958^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005536	glucose binding	PMID:16325866^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005536	glucose binding	PMID:17447164^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:16325866^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:2843500^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:1834654^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:18062843^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:17447164^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:11735100^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	F	Seeded From UniProt	complete
involved_in	GO:0046390	ribose phosphate biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
involved_in	GO:0043249	erythrocyte maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	F	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
involved_in	GO:0019322	pentose biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
involved_in	GO:0010734	negative regulation of protein glutathionylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	C	Seeded From UniProt	complete
involved_in	GO:0009051	pentose-phosphate shunt, oxidative branch	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
involved_in	GO:0006749	glutathione metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
involved_in	GO:0006740	NADPH regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
involved_in	GO:0006739	NADP metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
involved_in	GO:0006098	pentose-phosphate shunt	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	C	Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	F	Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11413 ensembl:ENSP00000483686	F	Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019796 InterPro:IPR022674 InterPro:IPR022675	F	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001282 InterPro:IPR019796 InterPro:IPR022674 InterPro:IPR022675	P	Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022674 InterPro:IPR022675	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001282 InterPro:IPR019796 InterPro:IPR022674 InterPro:IPR022675	P	Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.49	F	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0313	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P	Seeded From UniProt	complete
involved_in	GO:0006098	pentose-phosphate shunt	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00115	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Alberdi, G et al. (2011) Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutr Metab (Lond) 8 29 PubMed GONUTS page
↑ ^2.0 ^2.1 Adem, S & Ciftci, M (2012) Purification of rat kidney glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase enzymes using 2',5'-ADP Sepharose 4B affinity in a single chromatography step. Protein Expr. Purif. 81 1-4 PubMed GONUTS page
↑ ^3.0 ^3.1 McCommis, KS et al. (2013) Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux. J Am Heart Assoc 2 e000355 PubMed GONUTS page
↑ Rawat, DK et al. (2012) Glucose-6-phosphate dehydrogenase and NADPH redox regulates cardiac myocyte L-type calcium channel activity and myocardial contractile function. PLoS ONE 7 e45365 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Díaz-Flores, M et al. (2006) Glucose-6-phosphate dehydrogenase activity and NADPH/NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat. Life Sci. 78 2601-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Tylicki, A et al. (2007) Effect of anabolic steroid nandrolone decanoate on the properties of certain enzymes in the heart, liver, and muscle of rats, and their effect on rats' cardiac electrophysiology. Horm. Metab. Res. 39 268-72 PubMed GONUTS page
↑ Lelevich, SV () [Tissue-specific features of the pentose phosphate pathway in rats under acute alcoholic intoxication conditions]. Eksp Klin Farmakol 71 53-5 PubMed GONUTS page
↑ García-Nogales, P et al. (2003) Peroxynitrite protects neurons against nitric oxide-mediated apoptosis. A key role for glucose-6-phosphate dehydrogenase activity in neuroprotection. J. Biol. Chem. 278 864-74 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Bublitz, C & Steavenson, S (1988) The pentose phosphate pathway in the endoplasmic reticulum. J. Biol. Chem. 263 12849-53 PubMed GONUTS page
↑ Marina Prendes, MG et al. (2009) Involvement of mitochondrial permeability transition, glutathione status, pentose phosphate pathway and oxidative damage in the protective effect of fasting on the ischaemic-reperfused rat heart. Clin. Exp. Pharmacol. Physiol. 36 637-42 PubMed GONUTS page
↑ Guz, G et al. (2007) Stobadine protects rat kidney against ischaemia/reperfusion injury. Clin. Exp. Pharmacol. Physiol. 34 210-6 PubMed GONUTS page
↑ Budak, H et al. (2014) Expression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in oxidative stress induced by long-term iron toxicity in rat liver. J. Biochem. Mol. Toxicol. 28 217-23 PubMed GONUTS page
↑ Zimmer, HG (1998) Significance of the 5-phosphoribosyl-1-pyrophosphate pool for cardiac purine and pyrimidine nucleotide synthesis: studies with ribose, adenine, inosine, and orotic acid in rats. Cardiovasc Drugs Ther 12 Suppl 2 179-87 PubMed GONUTS page
↑ ^14.0 ^14.1 Brand, IA & Heinickel, A (1991) Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). J. Biol. Chem. 266 20984-9 PubMed GONUTS page
↑ Shakib, K et al. (2005) Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Proteomics 5 2819-38 PubMed GONUTS page
↑ Huong, DT & Ide, T (2008) Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Br. J. Nutr. 100 79-87 PubMed GONUTS page
↑ Moura, MA et al. (2001) Effect of cold acclimation on brown adipose tissue fatty acid synthesis in rats adapted to a high-protein, carbohydrate-free diet. Metab. Clin. Exp. 50 1493-8 PubMed GONUTS page

[PMID:21569266-1] 1.0 ^1.1 Alberdi, G et al. (2011) Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutr Metab (Lond) 8 29 PubMed GONUTS page

[PMID:21930213-2] 2.0 ^2.1 Adem, S & Ciftci, M (2012) Purification of rat kidney glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase enzymes using 2',5'-ADP Sepharose 4B affinity in a single chromatography step. Protein Expr. Purif. 81 1-4 PubMed GONUTS page

[PMID:24190878-3] 3.0 ^3.1 McCommis, KS et al. (2013) Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux. J Am Heart Assoc 2 e000355 PubMed GONUTS page

[PMID:23071515-4] Rawat, DK et al. (2012) Glucose-6-phosphate dehydrogenase and NADPH redox regulates cardiac myocyte L-type calcium channel activity and myocardial contractile function. PLoS ONE 7 e45365 PubMed GONUTS page

[PMID:16325866-5] 5.0 ^5.1 ^5.2 ^5.3 Díaz-Flores, M et al. (2006) Glucose-6-phosphate dehydrogenase activity and NADPH/NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat. Life Sci. 78 2601-7 PubMed GONUTS page

[PMID:17447164-6] 6.0 ^6.1 ^6.2 ^6.3 Tylicki, A et al. (2007) Effect of anabolic steroid nandrolone decanoate on the properties of certain enzymes in the heart, liver, and muscle of rats, and their effect on rats' cardiac electrophysiology. Horm. Metab. Res. 39 268-72 PubMed GONUTS page

[PMID:18488910-7] Lelevich, SV () [Tissue-specific features of the pentose phosphate pathway in rats under acute alcoholic intoxication conditions]. Eksp Klin Farmakol 71 53-5 PubMed GONUTS page

[PMID:12414804-8] García-Nogales, P et al. (2003) Peroxynitrite protects neurons against nitric oxide-mediated apoptosis. A key role for glucose-6-phosphate dehydrogenase activity in neuroprotection. J. Biol. Chem. 278 864-74 PubMed GONUTS page

[PMID:2843500-9] 9.0 ^9.1 ^9.2 ^9.3 Bublitz, C & Steavenson, S (1988) The pentose phosphate pathway in the endoplasmic reticulum. J. Biol. Chem. 263 12849-53 PubMed GONUTS page

[PMID:19076169-10] Marina Prendes, MG et al. (2009) Involvement of mitochondrial permeability transition, glutathione status, pentose phosphate pathway and oxidative damage in the protective effect of fasting on the ischaemic-reperfused rat heart. Clin. Exp. Pharmacol. Physiol. 36 637-42 PubMed GONUTS page

[PMID:17250641-11] Guz, G et al. (2007) Stobadine protects rat kidney against ischaemia/reperfusion injury. Clin. Exp. Pharmacol. Physiol. 34 210-6 PubMed GONUTS page

[PMID:24599681-12] Budak, H et al. (2014) Expression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in oxidative stress induced by long-term iron toxicity in rat liver. J. Biochem. Mol. Toxicol. 28 217-23 PubMed GONUTS page

[PMID:9794092-13] Zimmer, HG (1998) Significance of the 5-phosphoribosyl-1-pyrophosphate pool for cardiac purine and pyrimidine nucleotide synthesis: studies with ribose, adenine, inosine, and orotic acid in rats. Cardiovasc Drugs Ther 12 Suppl 2 179-87 PubMed GONUTS page

[PMID:1834654-14] 14.0 ^14.1 Brand, IA & Heinickel, A (1991) Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). J. Biol. Chem. 266 20984-9 PubMed GONUTS page

[PMID:15942958-15] Shakib, K et al. (2005) Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Proteomics 5 2819-38 PubMed GONUTS page

[PMID:18062843-16] Huong, DT & Ide, T (2008) Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Br. J. Nutr. 100 79-87 PubMed GONUTS page

[PMID:11735100-17] Moura, MA et al. (2001) Effect of cold acclimation on brown adipose tissue fatty acid synthesis in rats adapted to a high-protein, carbohydrate-free diet. Metab. Clin. Exp. 50 1493-8 PubMed GONUTS page

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RAT:G6PD

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