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PMID:18488910

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Citation

Lelevich, SV [Tissue-specific features of the pentose phosphate pathway in rats under acute alcoholic intoxication conditions]. Eksp Klin Farmakol 71:53-5

Abstract

The activity of pentose phosphate pathway (PPP) in the liver and skeletal muscles of rats has been studied after acute alcohol administration in a dose of 1, 2.5, and 5 g/kg body weight. Inhibition of the activity of the main PPP enzymes as well as a decrease in the liver pentose level in rats as a result of alcohol intoxication have been observed. In muscle tissues, alcohol leads to the activation of glucose-6-phosphate-dehydrogenase and the inhibition of the transketolase activity.

Links

PubMed

Keywords

Alcoholic Intoxication/enzymology; Animals; Blood Glucose/metabolism; Enzyme Activation; Glucosephosphate Dehydrogenase/metabolism; Insulin/blood; Liver/enzymology; Male; Muscle, Skeletal/enzymology; Organ Specificity; Pentose Phosphate Pathway; Rats

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:G6PD

involved_in

GO:0045471: response to ethanol

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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