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PMID:18062843

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Citation

Huong, DT and Ide, T (2008) Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Br. J. Nutr. 100:79-87

Abstract

Effects of dietary alpha-lipoic acid on hepatic and serum lipid concentrations and the activity and mRNA levels of lipogenic enzymes were examined in rats. Rats were fed experimental diets containing varying amounts of lipoic acid (0, 1, 2.5, 5 g/kg) for 21 d. Lipoic acid profoundly decreased serum and liver concentrations of TAG, and also lowered serum concentrations of phospholipid and NEFA, and the concentration of cholesterol in the liver. A hypoglycaemic effect of this compound was also observed. Lipoic acid dose-dependently decreased the activity and mRNA levels of fatty acid synthase, ATP-citrate lyase, glucose 6-phosphate dehydrogenase, malic enzyme and pyruvate kinase in the liver despite that reductions were considerably attenuated in the NADPH-producing enzymes. This compound also dose-dependently lowered the mRNA levels of spot 14, adiponutrin, stearoyl-CoA desaturase 1, and Delta5- and Delta6-desaturases. In addition, lipoic acid dose-dependently lowered serum concentrations of insulin and leptin, but increased those of adiponectin. Lipoic acid appeared to reduce hepatic lipogenesis and hence decreases serum and liver lipid levels. Alterations in serum concentrations of insulin and (or) adiponectin may trigger this consequence.

Links

PubMed Online version:10.1017/S0007114507876227

Keywords

Adipokines/blood; Animals; Blood Glucose/metabolism; Diet; Dose-Response Relationship, Drug; Fatty Acids/biosynthesis; Gene Expression Regulation, Enzymologic/drug effects; Insulin/blood; Lipid Metabolism/drug effects; Lipogenesis/drug effects; Liver/enzymology; Liver/metabolism; Male; RNA, Messenger/genetics; Rats; Rats, Sprague-Dawley; Thioctic Acid/administration & dosage; Thioctic Acid/pharmacology; Triglycerides/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:KPYR

enables

GO:0004743: pyruvate kinase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:ACLY

involved_in

GO:0006101: citrate metabolic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ACLY

involved_in

GO:0006084: acetyl-CoA metabolic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ACLY

enables

GO:0003878: ATP citrate synthase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:G6PD

enables

GO:0004345: glucose-6-phosphate dehydrogenase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:FAS

enables

GO:0004312: fatty acid synthase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:FAS

involved_in

GO:0006084: acetyl-CoA metabolic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:MAOX

enables

GO:0004470: malic enzyme activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete


See also

References

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