RAT:CTNB1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Ctnnb1 (synonyms: Catnb)
Protein Name(s)	Catenin beta-1 Beta-catenin
External Links
UniProt	Q9WU82
EMBL	AF121265 AF397179
RefSeq	NP_445809.2 XP_008764913.1
UniGene	Rn.112601
ProteinModelPortal	Q9WU82
SMR	Q9WU82
BioGrid	249913
DIP	DIP-37053N
IntAct	Q9WU82
MINT	MINT-87458
STRING	10116.ENSRNOP00000026016
iPTMnet	Q9WU82
PhosphoSite	Q9WU82
PaxDb	Q9WU82
PRIDE	Q9WU82
GeneID	84353
KEGG	rno:84353
UCSC	RGD:70487
CTD	1499
RGD	70487
eggNOG	KOG4203 COG0035
HOGENOM	HOG000230958
HOVERGEN	HBG000919
InParanoid	Q9WU82
KO	K02105
OrthoDB	EOG7X9G6B
PhylomeDB	Q9WU82
TreeFam	TF317997
NextBio	616667
PRO	PR:Q9WU82
Proteomes	UP000002494
GO	GO:0030877 GO:0070369 GO:0016342 GO:0005938 GO:0030054 GO:0071944 GO:0005913 GO:0005911 GO:0005813 GO:0005737 GO:0005829 GO:0043198 GO:0016020 GO:0005634 GO:0048471 GO:0005886 GO:0043234 GO:0032993 GO:0000922 GO:0045202 GO:0005667 GO:0045294 GO:0045296 GO:0035255 GO:0050998 GO:0032403 GO:0019903 GO:0004871 GO:0003713 GO:0044212 GO:0034333 GO:0060070 GO:0044334 GO:0007155 GO:0044344 GO:0071363 GO:0071681 GO:1990314 GO:0071285 GO:0071260 GO:0061154 GO:0001889 GO:0007494 GO:0045445 GO:0008285 GO:0045976 GO:0033234 GO:0045892 GO:0042475 GO:0043065 GO:0010909 GO:0002052 GO:0045944 GO:0045893 GO:0051291 GO:0034394 GO:0090279 GO:0030997 GO:0070602 GO:2000008 GO:0048660 GO:0014823 GO:0046686 GO:0034097 GO:0032355 GO:0043627 GO:0009725 GO:0014070 GO:0014010 GO:0016337 GO:0061549 GO:0006351 GO:0016055
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR000225 IPR013284
Pfam	PF00514
PRINTS	PR01869
SMART	SM00185
SUPFAM	SSF48371
PROSITE	PS50176

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:16690606^[1]	ECO:0000314			C		Figure 3 shows localization of beta catenin in the nucleus	complete CACAO 11821
	GO:0005634	nucleus	PMID:20097766^[2]	ECO:0000314			C		Figure 4C shows localization of beta catenin in the nucleus	complete CACAO 11862
involved_in	GO:1990138	neuron projection extension	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:12610652^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:12610652^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12610652^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12610652^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608) exists_during:(GO:0071285)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23270756^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSRNOG00000012556) part_of:(GO:0071560) part_of:(GO:0001837)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16805831^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061549	sympathetic ganglion development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0045976	negative regulation of mitotic cell cycle, embryonic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
involved_in	GO:2000008	regulation of protein localization to cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0090279	regulation of calcium ion import	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0071681	cellular response to indole-3-methanol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0070602	regulation of centromeric sister chromatid cohesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
part_of	GO:0070369	beta-catenin-TCF7L2 complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
involved_in	GO:0061154	endothelial tube morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0048660	regulation of smooth muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0034333	adherens junction assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0033234	negative regulation of protein sumoylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0030997	regulation of centriole-centriole cohesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UI47	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16815997^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B6V8E6	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
involved_in	GO:0014010	Schwann cell proliferation	PMID:17941050^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:17708712^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007494	midgut development	PMID:17356920^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:8834786^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:12533412^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:17170212^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17170212^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	PMID:17236583^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990314	cellular response to insulin-like growth factor stimulus	PMID:20042609^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990314	cellular response to insulin-like growth factor stimulus	PMID:20042609^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:12533412^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071285	cellular response to lithium ion	PMID:12610652^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:20042609^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	PMID:8834786^[10]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1359485 RGD:69280	P		Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	PMID:15858215^[15]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3186	F		Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	PMID:15858215^[15]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3185	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:20042609^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	PMID:29224185^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	PMID:17136310^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045445	myoblast differentiation	PMID:17222478^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:12533412^[11]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:69280	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:9515794^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:12123611^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:12123611^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:15930126^[21]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620829 RGD:69280	F		Seeded From UniProt	complete
involved_in	GO:0044344	cellular response to fibroblast growth factor stimulus	PMID:12095987^[22]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:17170212^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	PMID:12123611^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0043005	neuron projection	PMID:16303851^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	PMID:10681393^[24]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:20007479^[25]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:17888912^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:12533412^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:22252247^[27]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	PMID:22252247^[27]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:25586361^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:18174280^[29]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[30]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000117 MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:21873635^[30]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 RGD:70487 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:21873635^[30]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979	F		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	PMID:21873635^[30]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:21873635^[30]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222	F		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:21873635^[30]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000117 MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979 ZFIN:ZDB-GENE-980526-362	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:21873635^[30]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 RGD:620412 RGD:70487 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21873635^[30]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013284	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013284	F		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:20299672^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9515794^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0448	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0009	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
	GO:0005634	nucleus	PMID:16690606^[1]	ECO:0000314			C		Figure 3 shows localization of beta catenin in the nucleus	complete CACAO 11758
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Li, TF et al. (2006) Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J. Biol. Chem. 281 21296-304 PubMed GONUTS page
↑ Zhang, M et al. (2010) Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. J. Biol. Chem. 285 8703-10 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 De Ferrari, GV et al. (2003) Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol. Psychiatry 8 195-208 PubMed GONUTS page
↑ Brønnum, H et al. (2013) Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells. Exp. Cell Res. 319 424-35 PubMed GONUTS page
↑ Caruso, A et al. (2006) Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. J. Neurochem. 98 364-71 PubMed GONUTS page
↑ Chen, HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 20 1933-45 PubMed GONUTS page
↑ Gess, B et al. (2008) Inhibition of N-cadherin and beta-catenin function reduces axon-induced Schwann cell proliferation. J. Neurosci. Res. 86 797-812 PubMed GONUTS page
↑ Wang, L et al. (2007) Thyroid hormone interacts with the Wnt/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes. J. Bone Miner. Res. 22 1988-95 PubMed GONUTS page
↑ Camac, KS et al. (2007) Activation of beta-catenin in the stem cell region of crypts during growth of the small intestine in infant rats. Dig. Dis. Sci. 52 1242-6 PubMed GONUTS page
↑ ^10.0 ^10.1 Hertig, CM et al. (1996) N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes. J. Cell. Sci. 109 ( Pt 1) 11-20 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Lee, NP et al. (2003) Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis? Biol. Reprod. 68 489-508 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Rider, V et al. (2006) Progesterone initiates Wnt-beta-catenin signaling but estradiol is required for nuclear activation and synchronous proliferation of rat uterine stromal cells. J. Endocrinol. 191 537-48 PubMed GONUTS page
↑ Wang, QM et al. (2006) [The role of beta-catenin in rat embryonic development and tumorigenesis]. Sichuan Da Xue Xue Bao Yi Xue Ban 37 872-5 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Sunters, A et al. (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. J. Biol. Chem. 285 8743-58 PubMed GONUTS page
↑ ^15.0 ^15.1 Lee, NP et al. (2005) Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study. Biol. Reprod. 73 458-71 PubMed GONUTS page
↑ Mao, Y et al. (2018) Tension force-induced bone formation in orthodontic tooth movement via modulation of the GSK-3β/β-catenin signaling pathway. J. Mol. Histol. 49 75-84 PubMed GONUTS page
↑ Thévenod, F et al. (2007) Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells. Biometals 20 807-20 PubMed GONUTS page
↑ Wróbel, E et al. (2007) M-cadherin and beta-catenin participate in differentiation of rat satellite cells. Eur. J. Cell Biol. 86 99-109 PubMed GONUTS page
↑ ^19.0 ^19.1 Dashwood, RH et al. (1998) High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. Cancer Res. 58 1127-9 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Murase, S et al. (2002) Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function. Neuron 35 91-105 PubMed GONUTS page
↑ Gorski, JA et al. (2005) Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Mol. Biol. Cell 16 3574-90 PubMed GONUTS page
↑ Hashimoto, M et al. (2002) Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection. J. Biol. Chem. 277 32985-91 PubMed GONUTS page
↑ Votin, V et al. (2005) Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin. J. Cell. Sci. 118 5699-708 PubMed GONUTS page
↑ Sorkin, BC et al. (2000) The cadherin-catenin complex is expressed alternately with the adenomatous polyposis coli protein during rat incisor amelogenesis. J. Histochem. Cytochem. 48 397-406 PubMed GONUTS page
↑ Li, YC et al. (2009) Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J. Neurosci. 29 15551-63 PubMed GONUTS page
↑ Kuwabara, M et al. (2007) Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of beta-catenin and cadherin. FEBS Lett. 581 4821-30 PubMed GONUTS page
↑ ^27.0 ^27.1 Bu, S et al. (2012) Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats. Eur. J. Appl. Physiol. 112 3295-304 PubMed GONUTS page
↑ Xi, XH et al. () Activation of Wnt/β-catenin/GSK3β signaling during the development of diabetic cardiomyopathy. Cardiovasc. Pathol. 24 179-86 PubMed GONUTS page
↑ Koduri, S et al. (2008) Mechanism of action of l-CDB-4022, a potential nonhormonal male contraceptive, in the seminiferous epithelium of the rat testis. Endocrinology 149 1850-60 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 ^30.6 ^30.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page

[PMID:16690606-1] 1.0 ^1.1 Li, TF et al. (2006) Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J. Biol. Chem. 281 21296-304 PubMed GONUTS page

[PMID:20097766-2] Zhang, M et al. (2010) Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. J. Biol. Chem. 285 8703-10 PubMed GONUTS page

[PMID:12610652-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 De Ferrari, GV et al. (2003) Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol. Psychiatry 8 195-208 PubMed GONUTS page

[PMID:23270756-4] Brønnum, H et al. (2013) Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells. Exp. Cell Res. 319 424-35 PubMed GONUTS page

[PMID:16805831-5] Caruso, A et al. (2006) Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. J. Neurochem. 98 364-71 PubMed GONUTS page

[PMID:16815997-6] Chen, HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 20 1933-45 PubMed GONUTS page

[PMID:17941050-7] Gess, B et al. (2008) Inhibition of N-cadherin and beta-catenin function reduces axon-induced Schwann cell proliferation. J. Neurosci. Res. 86 797-812 PubMed GONUTS page

[PMID:17708712-8] Wang, L et al. (2007) Thyroid hormone interacts with the Wnt/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes. J. Bone Miner. Res. 22 1988-95 PubMed GONUTS page

[PMID:17356920-9] Camac, KS et al. (2007) Activation of beta-catenin in the stem cell region of crypts during growth of the small intestine in infant rats. Dig. Dis. Sci. 52 1242-6 PubMed GONUTS page

[PMID:8834786-10] 10.0 ^10.1 Hertig, CM et al. (1996) N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes. J. Cell. Sci. 109 ( Pt 1) 11-20 PubMed GONUTS page

[PMID:12533412-11] 11.0 ^11.1 ^11.2 ^11.3 Lee, NP et al. (2003) Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis? Biol. Reprod. 68 489-508 PubMed GONUTS page

[PMID:17170212-12] 12.0 ^12.1 ^12.2 Rider, V et al. (2006) Progesterone initiates Wnt-beta-catenin signaling but estradiol is required for nuclear activation and synchronous proliferation of rat uterine stromal cells. J. Endocrinol. 191 537-48 PubMed GONUTS page

[PMID:17236583-13] Wang, QM et al. (2006) [The role of beta-catenin in rat embryonic development and tumorigenesis]. Sichuan Da Xue Xue Bao Yi Xue Ban 37 872-5 PubMed GONUTS page

[PMID:20042609-14] 14.0 ^14.1 ^14.2 ^14.3 Sunters, A et al. (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. J. Biol. Chem. 285 8743-58 PubMed GONUTS page

[PMID:15858215-15] 15.0 ^15.1 Lee, NP et al. (2005) Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study. Biol. Reprod. 73 458-71 PubMed GONUTS page

[PMID:29224185-16] Mao, Y et al. (2018) Tension force-induced bone formation in orthodontic tooth movement via modulation of the GSK-3β/β-catenin signaling pathway. J. Mol. Histol. 49 75-84 PubMed GONUTS page

[PMID:17136310-17] Thévenod, F et al. (2007) Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells. Biometals 20 807-20 PubMed GONUTS page

[PMID:17222478-18] Wróbel, E et al. (2007) M-cadherin and beta-catenin participate in differentiation of rat satellite cells. Eur. J. Cell Biol. 86 99-109 PubMed GONUTS page

[PMID:9515794-19] 19.0 ^19.1 Dashwood, RH et al. (1998) High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. Cancer Res. 58 1127-9 PubMed GONUTS page

[PMID:12123611-20] 20.0 ^20.1 ^20.2 Murase, S et al. (2002) Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function. Neuron 35 91-105 PubMed GONUTS page

[PMID:15930126-21] Gorski, JA et al. (2005) Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Mol. Biol. Cell 16 3574-90 PubMed GONUTS page

[PMID:12095987-22] Hashimoto, M et al. (2002) Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection. J. Biol. Chem. 277 32985-91 PubMed GONUTS page

[PMID:16303851-23] Votin, V et al. (2005) Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin. J. Cell. Sci. 118 5699-708 PubMed GONUTS page

[PMID:10681393-24] Sorkin, BC et al. (2000) The cadherin-catenin complex is expressed alternately with the adenomatous polyposis coli protein during rat incisor amelogenesis. J. Histochem. Cytochem. 48 397-406 PubMed GONUTS page

[PMID:20007479-25] Li, YC et al. (2009) Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J. Neurosci. 29 15551-63 PubMed GONUTS page

[PMID:17888912-26] Kuwabara, M et al. (2007) Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of beta-catenin and cadherin. FEBS Lett. 581 4821-30 PubMed GONUTS page

[PMID:22252247-27] 27.0 ^27.1 Bu, S et al. (2012) Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats. Eur. J. Appl. Physiol. 112 3295-304 PubMed GONUTS page

[PMID:25586361-28] Xi, XH et al. () Activation of Wnt/β-catenin/GSK3β signaling during the development of diabetic cardiomyopathy. Cardiovasc. Pathol. 24 179-86 PubMed GONUTS page

[PMID:18174280-29] Koduri, S et al. (2008) Mechanism of action of l-CDB-4022, a potential nonhormonal male contraceptive, in the seminiferous epithelium of the rat testis. Endocrinology 149 1850-60 PubMed GONUTS page

[PMID:21873635-30] 30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 ^30.6 ^30.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20299672-31] Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page

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RAT:CTNB1

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