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PMID:21049048
| Citation |
Gangolf, M, Czerniecki, J, Radermecker, M, Detry, O, Nisolle, M, Jouan, C, Martin, D, Chantraine, F, Lakaye, B, Wins, P, Grisar, T and Bettendorff, L (2010) Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells. PLoS ONE 5:e13616 |
|---|---|
| Abstract |
Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism. The less abundant thiamine monophosphate (ThMP), thiamine triphosphate (ThTP) and adenosine thiamine triphosphate (AThTP), present in many organisms, may have still unidentified physiological functions. Diseases linked to thiamine deficiency (polyneuritis, Wernicke-Korsakoff syndrome) remain frequent among alcohol abusers and other risk populations. This is the first comprehensive study on the distribution of thiamine derivatives in human biopsies, body fluids and cell lines. |
| Links |
PubMed PMC2963613 Online version:10.1371/journal.pone.0013616 |
| Keywords |
Animals; Biopsy; Body Fluids/metabolism; Cells, Cultured; Chromatography, High Pressure Liquid; Humans; Mice; Oxidation-Reduction; Phosphorylation; Rats; Reverse Transcriptase Polymerase Chain Reaction; Thiamine/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0050331: thiamin diphosphate kinase activity |
ECO:0000269: |
F |
Table 8 shows ThTp levels related to this protein. Also Figure 1 describes the kinase activity. |
complete | ||||
| GO:0006757: ADP phosphorylation |
ECO:0000269: |
P |
Table 8 shows AThDP levels related to this protein. Also Figure 1 illustrates how AThDP and ATP are created by ADP phosphorylation. |
complete | ||||
| GO:0019899: enzyme binding |
ECO:0000021: |
UniProtKB:Q9BU02
|
F |
Figure 2 and 3 both show ThTpase activity with the protein |
complete | |||
| GO:0050331: thiamin diphosphate kinase activity |
ECO:0000269: |
F |
Table 8 shows ThTp levels related to this protein. Also Figure 1 describes the kinase activity. |
complete | ||||
| GO:0006757: ADP phosphorylation |
ECO:0000269: |
P |
Table 8 shows AThDP levels related to this protein. Also Figure 1 illustrates how AThDP and ATP are created by ADP phosphorylation. |
complete | ||||
| GO:0019899: enzyme binding |
ECO:0000021: |
UniProtKB:Q8JZL3
|
F |
Figure 2 and 3 both show ThTpase activity with the protein |
complete | |||
| GO:0050331: thiamin diphosphate kinase activity |
ECO:0000269: |
F |
Table 8 shows ThTp levels related to this protein. Also Figure 1 describes the kinase activity. |
complete | ||||
| GO:0006757: ADP phosphorylation |
ECO:0000269: |
P |
Table 8 shows AThDP levels related to this protein. Also Figure 1 illustrates how AThDP and ATP are created by ADP phosphorylation. |
complete | ||||
| GO:0019899: enzyme binding |
ECO:0000021: |
UniProtKB:Q8JZL3
|
F |
Figure 2 and 3 both show ThTpase activity with the protein |
complete | |||
| GO:0050331: thiamin diphosphate kinase activity |
ECO:0000269: |
F |
Table 8 shows ThTp levels related to this protein. Also Figure 1 describes the kinase activity. |
complete | ||||
| GO:0006757: ADP phosphorylation |
ECO:0000269: |
P |
Table 8 shows AThDP levels related to this protein. Also Figure 1 illustrates how AThDP and ATP are created by ADP phosphorylation. |
complete | ||||
| GO:0031625: ubiquitin protein ligase binding |
ECO:0000021: |
UniProtKB:Q69250
|
F |
Figure 2 and 3 both show ThTpase activity with the protein |
complete | |||
| GO:0005515: protein binding |
ECO:0000021: |
UniProtKB:Q9D067
|
F |
Figure 2 and 3 both show ThTpase activity with the protein |
complete | |||
| GO:0005515: |
ECO:0000021: |
UniProtKB:P35372
|
Figure 2 and 3 both show ThTpase activity with the protein |
complete | ||||
See also
References
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