HUMAN:OPRM

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	OPRM1 (synonyms: MOR1)
Protein Name(s)	Mu-type opioid receptor M-OR-1 MOR-1 Mu opiate receptor Mu opioid receptor MOP hMOP
External Links
UniProt	P35372
EMBL	L25119 U12569 L29301 AY036622 AY036623 AY195733 AY225404 AY309001 AY309005 AY309006 AY309007 AY309008 AY309009 EU340241 EU340242 EU340243 AY364230 AY364890 HQ699462 EU360599 EU362990 AK313901 AY521028 AY587764 FJ041292 FJ041293 FJ041294 AL132774 AL136444 AL445220 CH471051 BC074927 AY292290 AY292291 AF153500
CCDS	CCDS43517.1 CCDS43518.1 CCDS47503.1 CCDS47504.1 CCDS47505.1 CCDS47506.1 CCDS47507.1 CCDS47508.1 CCDS55068.1 CCDS55069.1 CCDS55070.1 CCDS55071.1
PIR	I56553 S65693
RefSeq	NP_000905.3 NP_001008503.2 NP_001008504.2 NP_001008505.2 NP_001138751.1 NP_001138752.1 NP_001138753.1 NP_001138754.1 NP_001138755.1 NP_001138756.1 NP_001138757.1 NP_001138758.1 NP_001138759.1 NP_001272452.1 NP_001272453.1 NP_001272455.1 NP_001272456.1 NP_001272457.1 XP_006715559.1
UniGene	Hs.2353
DisProt	DP00272
ProteinModelPortal	P35372
SMR	P35372
BioGrid	111033
IntAct	P35372
MINT	MINT-100121
BindingDB	P35372
ChEMBL	CHEMBL233
DrugBank	DB00802 DB06274 DB00321 DB00913 DB00921 DB00611 DB00318 DB00514 DB00647 DB01209 DB01081 DB01466 DB00813 DB01452 DB00956 DB00327 DB01221 DB06738 DB00504 DB01227 DB00854 DB00836 DB00333 DB01433 DB06800 DB00295 DB00844 DB01183 DB00704 DB00904 DB00497 DB01192 DB00652 DB00454 DB00899 DB00708 DB06204 DB00193
GuidetoPHARMACOLOGY	319
PhosphoSite	P35372
DMDM	2851402
PaxDb	P35372
PRIDE	P35372
Ensembl	ENST00000229768 ENST00000330432 ENST00000337049 ENST00000414028 ENST00000419506 ENST00000428397 ENST00000434900 ENST00000435918 ENST00000452687 ENST00000518759 ENST00000519083 ENST00000520708 ENST00000522236 ENST00000522555 ENST00000522739 ENST00000524150 ENST00000524163
GeneID	4988
KEGG	hsa:4988
UCSC	uc003qpn.2 uc003qpo.1 uc003qpq.1 uc003qpr.2 uc003qpt.1 uc003qpu.2 uc011efb.2 uc011efc.1 uc011eff.1 uc011efg.1 uc011efh.1 uc011efi.2
CTD	4988
GeneCards	GC06P154391
HGNC	HGNC:8156
HPA	HPA014509
MIM	600018
neXtProt	NX_P35372
PharmGKB	PA31945
eggNOG	NOG279457
GeneTree	ENSGT00760000118797
HOGENOM	HOG000230486
HOVERGEN	HBG106919
InParanoid	P35372
KO	K04215
OMA	CTDPFTH
PhylomeDB	P35372
TreeFam	TF315737
Reactome	REACT_14819 REACT_15295 REACT_15457 REACT_19231
GeneWiki	%CE%9C-opioid_receptor
GenomeRNAi	4988
NextBio	19206
PRO	PR:P35372
Proteomes	UP000005640
Bgee	P35372
CleanEx	HS_OPRM1
ExpressionAtlas	P35372
Genevestigator	P35372
GO	GO:0032839 GO:0032590 GO:0005783 GO:0005925 GO:0005794 GO:0005887 GO:0045121 GO:0043204 GO:0005886 GO:0042383 GO:0004979 GO:0001965 GO:0004930 GO:0038047 GO:0005245 GO:0002438 GO:0007191 GO:0031635 GO:0048149 GO:0033554 GO:0007187 GO:0007626 GO:0007194 GO:0043951 GO:0008285 GO:0051481 GO:0045019 GO:0061358 GO:0007218 GO:0007200 GO:0032100 GO:0043950 GO:0007204 GO:0070374 GO:0050769 GO:0045429 GO:0060079 GO:2000310 GO:0051930 GO:0042220 GO:0032094 GO:0070848 GO:0032496 GO:0007600 GO:0019233 GO:0042060
InterPro	IPR000276 IPR017452 IPR000105 IPR001418
Pfam	PF00001
PRINTS	PR00237 PR00537 PR00384
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0050331	thiamin diphosphate kinase activity	PMID:21049048^[1]	ECO:0000269			F	Table 8 shows ThTp levels related to this protein. Also Figure 1 describes the kinase activity.	complete
	GO:0006757	ADP phosphorylation	PMID:21049048^[1]	ECO:0000269			P	Table 8 shows AThDP levels related to this protein. Also Figure 1 illustrates how AThDP and ATP are created by ADP phosphorylation.	complete
	GO:0019899	enzyme binding	PMID:21049048^[1]	ECO:0000021		UniProtKB:Q9BU02	F	Figure 2 and 3 both show ThTpase activity with the protein	complete
involved_in	GO:0038003	opioid receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97266	P	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97266	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97266	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97266	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97266	C	Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33535	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33535	P	Seeded From UniProt	complete
involved_in	GO:0061358	negative regulation of Wnt protein secretion	PMID:20214800^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42866	P	Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	PMID:21039637^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0038047	morphine receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33535	F	Seeded From UniProt	complete
involved_in	GO:0080135	regulation of cellular response to stress	PMID:21039637^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42866	P	Seeded From UniProt	complete
involved_in	GO:0007600	sensory perception	PMID:9689128^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33535	P	Seeded From UniProt	complete
involved_in	GO:0007197	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33535	P	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33535	F	Seeded From UniProt	complete
enables	GO:0004979	beta-endorphin receptor activity	PMID:9689128^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33535	F	Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	PMID:20214800^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042277	peptide binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200938 ZFIN:ZDB-GENE-030729-1	F	Seeded From UniProt	complete
enables	GO:0038047	morphine receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002796119 RGD:3234	F	Seeded From UniProt	complete
involved_in	GO:0038003	opioid receptor signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000659929 RGD:3234	P	Seeded From UniProt	complete
enables	GO:0031681	G-protein beta-subunit binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002796119 RGD:3234	F	Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97441 PANTHER:PTN000659929	P	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036789 FB:FBgn0036790 FB:FBgn0266429 MGI:MGI:97438 MGI:MGI:98327 MGI:MGI:98328 PANTHER:PTN000659780	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0266429 MGI:MGI:97439 PANTHER:PTN001200938 UniProtKB:P41145 UniProtKB:P41146 ZFIN:ZDB-GENE-990415-199	C	Seeded From UniProt	complete
enables	GO:0004979	beta-endorphin receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002796119 UniProtKB:P35372	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1330275 PANTHER:PTN001200938 RGD:3234 UniProtKB:P41146 UniProtKB:Q9Y5Y4	F	Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002796119 UniProtKB:P35372	F	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005245	P	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005245	P	Seeded From UniProt	complete
involved_in	GO:0071315	cellular response to morphine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0038047	P	Seeded From UniProt	complete
involved_in	GO:0071315	cellular response to morphine	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0038047	P	Seeded From UniProt	complete
involved_in	GO:0071315	cellular response to morphine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0038047	P	Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
part_of	GO:0097444	spine apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
involved_in	GO:0070848	response to growth factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
involved_in	GO:0044849	estrous cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
enables	GO:0038047	morphine receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	F	Seeded From UniProt	complete
involved_in	GO:0038003	opioid receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0032094	response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
enables	GO:0031681	G-protein beta-subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	F	Seeded From UniProt	complete
involved_in	GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
enables	GO:0031005	filamin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	F	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	F	Seeded From UniProt	complete
involved_in	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0007197	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	C	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	F	Seeded From UniProt	complete
involved_in	GO:0002438	acute inflammatory response to antigenic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33535 ensembl:ENSRNOP00000068988	P	Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	P	Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	C	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	P	Seeded From UniProt	complete
involved_in	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	P	Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	P	Seeded From UniProt	complete
enables	GO:0004985	opioid receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
enables	GO:0004979	beta-endorphin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000105	F	Seeded From UniProt	complete
enables	GO:0004985	opioid receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001418	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000105 InterPro:IPR000276 InterPro:IPR001418	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000105 InterPro:IPR000276 InterPro:IPR001418 InterPro:IPR017452	C	Seeded From UniProt	complete
involved_in	GO:0051481	negative regulation of cytosolic calcium ion concentration	PMID:20525224^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045019	negative regulation of nitric oxide biosynthetic process	PMID:20525224^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043951	negative regulation of cAMP-mediated signaling	PMID:20525224^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0051481	C	Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:20214800^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043950	positive regulation of cAMP-mediated signaling	PMID:20214800^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:20214800^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0007204	C	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:2159143^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:7905839^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:7905839^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9242668^[9] Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-6793958 Reactome:R-HSA-380073 Reactome:R-HSA-374298 Reactome:R-HSA-167429 Reactome:R-HSA-167427 Reactome:R-HSA-167419 Reactome:R-HSA-167408 Reactome:R-HSA-112271 Reactome:R-HSA-112042	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:9242668^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:9242668^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Gangolf, M et al. (2010) Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells. PLoS ONE 5 e13616 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Jin, J et al. (2010) Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence. BMC Neurosci 11 33 PubMed GONUTS page
↑ ^3.0 ^3.1 Ray, LA (2011) Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes. Alcohol. Clin. Exp. Res. 35 166-74 PubMed GONUTS page
↑ ^4.0 ^4.1 Bond, C et al. (1998) Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc. Natl. Acad. Sci. U.S.A. 95 9608-13 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Gris, P et al. (2010) A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. Mol Pain 6 33 PubMed GONUTS page
↑ Maneckjee, R & Minna, JD (1990) Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc. Natl. Acad. Sci. U.S.A. 87 3294-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Wang, JB et al. (1994) Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett. 338 217-22 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Massotte, D et al. (1997) Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells. J. Biol. Chem. 272 19987-92 PubMed GONUTS page

[PMID:21049048-1] 1.0 ^1.1 ^1.2 Gangolf, M et al. (2010) Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells. PLoS ONE 5 e13616 PubMed GONUTS page

[PMID:20214800-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Jin, J et al. (2010) Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence. BMC Neurosci 11 33 PubMed GONUTS page

[PMID:21039637-3] 3.0 ^3.1 Ray, LA (2011) Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes. Alcohol. Clin. Exp. Res. 35 166-74 PubMed GONUTS page

[PMID:9689128-4] 4.0 ^4.1 Bond, C et al. (1998) Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc. Natl. Acad. Sci. U.S.A. 95 9608-13 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20525224-6] 6.0 ^6.1 ^6.2 Gris, P et al. (2010) A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. Mol Pain 6 33 PubMed GONUTS page

[PMID:2159143-7] Maneckjee, R & Minna, JD (1990) Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc. Natl. Acad. Sci. U.S.A. 87 3294-8 PubMed GONUTS page

[PMID:7905839-8] 8.0 ^8.1 Wang, JB et al. (1994) Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett. 338 217-22 PubMed GONUTS page

[PMID:9242668-9] 9.0 ^9.1 ^9.2 Massotte, D et al. (1997) Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells. J. Biol. Chem. 272 19987-92 PubMed GONUTS page

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