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PMID:20525224
| Citation |
Gris, P, Gauthier, J, Cheng, P, Gibson, DG, Gris, D, Laur, O, Pierson, J, Wentworth, S, Nackley, AG, Maixner, W and Diatchenko, L (2010) A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. Mol Pain 6:33 |
|---|---|
| Abstract |
Opioids are the most widely used analgesics for the treatment of clinical pain. They produce their therapeutic effects by binding to mu-opioid receptors (MORs), which are 7 transmembrane domain (7TM) G-protein-coupled receptors (GPCRs), and inhibiting cellular activity. However, the analgesic efficacy of opioids is compromised by side-effects such as analgesic tolerance, dependence and opioid-induced hyperalgesia (OIH). In contrast to opioid analgesia these side effects are associated with cellular excitation. Several hypotheses have been advanced to explain these phenomena, yet the molecular mechanisms underlying tolerance and OIH remain poorly understood. |
| Links |
PubMed PMC2894766 Online version:10.1186/1744-8069-6-33 |
| Keywords |
Alternative Splicing; Analgesics, Opioid/metabolism; Analgesics, Opioid/pharmacology; Animals; COS Cells; Calcium/metabolism; Cercopithecus aethiops; Cyclic AMP/metabolism; GTP-Binding Proteins/metabolism; Humans; Morphine/metabolism; Morphine/pharmacology; Nitric Oxide/metabolism; Protein Isoforms/antagonists & inhibitors; Protein Isoforms/genetics; Protein Isoforms/metabolism; Receptors, Opioid, mu/agonists; Receptors, Opioid, mu/antagonists & inhibitors; Receptors, Opioid, mu/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0043951: negative regulation of cAMP-mediated signaling |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045019: negative regulation of nitric oxide biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051481: negative regulation of cytosolic calcium ion concentration |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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