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MOUSE:MDM1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Mdm1 (synonyms: Mdm-1) | |
| Protein Name(s) | Nuclear protein MDM1
Mdm4 transformed 3T3 cell double minute 1 protein Mouse double minute 1 | |
| External Links | ||
| UniProt | Q9D067 | |
| EMBL | M20823 M20824 AK004789 AK011769 | |
| CCDS | CCDS36069.1 | |
| PIR | A31794 B31794 | |
| RefSeq | NP_001156376.1 NP_001156377.1 NP_034915.2 NP_683724.2 | |
| UniGene | Mm.101191 Mm.442618 | |
| ProteinModelPortal | Q9D067 | |
| PhosphoSite | Q9D067 | |
| MaxQB | Q9D067 | |
| PRIDE | Q9D067 | |
| Ensembl | ENSMUST00000020437 | |
| GeneID | 17245 | |
| KEGG | mmu:17245 | |
| UCSC | uc007hds.2 uc007hdt.2 | |
| CTD | 56890 | |
| MGI | MGI:96951 | |
| eggNOG | NOG72701 | |
| GeneTree | ENSGT00390000004106 | |
| HOVERGEN | HBG108124 | |
| InParanoid | Q9D067 | |
| KO | K17886 | |
| PhylomeDB | Q9D067 | |
| NextBio | 291700 | |
| PRO | PR:Q9D067 | |
| Proteomes | UP000000589 | |
| Bgee | Q9D067 | |
| CleanEx | MM_MDM1 | |
| ExpressionAtlas | Q9D067 | |
| Genevestigator | Q9D067 | |
| GO | GO:0005634 GO:0060041 | |
| InterPro | IPR029136 | |
| Pfam | PF15501 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0050331 |
thiamin diphosphate kinase activity |
ECO:0000269 |
F |
Table 8 shows ThTp levels related to this protein. Also Figure 1 describes the kinase activity. |
complete | |||||
| GO:0006757 |
ADP phosphorylation |
ECO:0000269 |
P |
Table 8 shows AThDP levels related to this protein. Also Figure 1 illustrates how AThDP and ATP are created by ADP phosphorylation. |
complete | |||||
| GO:0019899 |
enzyme binding |
ECO:0000021 |
|
F |
Figure 2 and 3 both show ThTpase activity with the protein |
complete | ||||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046600 |
negative regulation of centriole replication |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005814 |
centriole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060041 |
retina development in camera-type eye |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96951 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0097730 |
non-motile cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060041 |
retina development in camera-type eye |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2664154 |
P |
results_in_development_of:(EMAPA:17168) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0046600 |
negative regulation of centriole replication |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005814 |
centriole |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046600 |
negative regulation of centriole replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005874 |
microtubule |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005814 |
centriole |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0106083 |
nuclear membrane protein complex |
ECO:0000177 |
genomic context evidence |
C |
Figure 3. Mdm1 mutation in arrd2. (A) Linkage cross-data: 73 inter-cross progeny from the (arrd2/C57BL/6J)F1 (arrd2/C57BL/6J)F1 was phenotyped for histological phenotype and genotyped for the indicated microsatellite markers. Black boxes represent haplotypes for arrd2-derived alleles and white boxes represent haplotypes for C57BL/6J-derived alleles. |
complete | ||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Gangolf, M et al. (2010) Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells. PLoS ONE 5 e13616 PubMed GONUTS page
- ↑ Van de Mark, D et al. (2015) MDM1 is a microtubule-binding protein that negatively regulates centriole duplication. Mol. Biol. Cell 26 3788-802 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 Hoh, RA et al. (2012) Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease. PLoS ONE 7 e52166 PubMed GONUTS page
- ↑ Won, J et al. (2011) Mouse model resources for vision research. J Ophthalmol 2011 391384 PubMed GONUTS page
- ↑ Chang, B et al. (2008) Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene. Hum. Mol. Genet. 17 3929-41 PubMed GONUTS page
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