MOUSE:VEGFA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Vegfa (synonyms: Vegf)
Protein Name(s)	Vascular endothelial growth factor A VEGF-A Vascular permeability factor VPF
External Links
UniProt	Q00731
EMBL	S37052 S38083 S38100 M95200 U50279 AY263146 AC127690 BC061468 AY707864 AY750956 AY750957 U41383
CCDS	CCDS28818.2 CCDS70817.1
PIR	A44881 B44881
RefSeq	NP_001020421.2 NP_001020428.2 NP_001103736.1 NP_001103737.1 NP_001103738.1 NP_001273985.1 NP_001273986.1 NP_001273987.1 NP_001303970.1 NP_033531.3
UniGene	Mm.282184
ProteinModelPortal	Q00731
SMR	Q00731
BioGrid	204512
ComplexPortal	CPX-3160
DIP	DIP-31909N
IntAct	Q00731
STRING	10090.ENSMUSP00000115883
PhosphoSitePlus	Q00731
MaxQB	Q00731
PaxDb	Q00731
PRIDE	Q00731
Ensembl	ENSMUST00000024747 ENSMUST00000214739
GeneID	22339
KEGG	mmu:22339
UCSC	uc008crn.4 uc008cro.4 uc008crp.4 uc008crr.3
CTD	7422
MGI	MGI:103178
eggNOG	ENOG410IGCM ENOG410ZWYU
GeneTree	ENSGT00940000157284
HOGENOM	HOG000230896
HOVERGEN	HBG000105
InParanoid	Q00731
KO	K05448
OrthoDB	1364454at2759
PhylomeDB	Q00731
Reactome	R-MMU-114608 R-MMU-194313 R-MMU-195399 R-MMU-4420097 R-MMU-5218921
ChiTaRS	Vegfa
PRO	PR:Q00731
Proteomes	UP000000589
Bgee	ENSMUSG00000023951
ExpressionAtlas	Q00731
Genevisible	Q00731
GO	GO:0005604 GO:0009986 GO:0005737 GO:0005576 GO:0005615 GO:0005634 GO:0005886 GO:0030141 GO:0031982 GO:0042056 GO:0005125 GO:0050840 GO:0001968 GO:0008083 GO:0019838 GO:0008201 GO:0042802 GO:0038191 GO:0005161 GO:0046982 GO:0042803 GO:0048018 GO:0005102 GO:0043183 GO:0043184 GO:0005172 GO:0032147 GO:0001525 GO:0060978 GO:0048844 GO:0002575 GO:0001568 GO:0002043 GO:0048514 GO:0001974 GO:0060346 GO:0061430 GO:0001569 GO:0048754 GO:0048593 GO:0048739 GO:0060948 GO:0060326 GO:0048469 GO:0016477 GO:0002042 GO:0008283 GO:0071456 GO:0035924 GO:0097533 GO:0071679 GO:0060982 GO:0003169 GO:0071542 GO:0035767 GO:0043542 GO:0030855 GO:0042462 GO:0003007 GO:0048873 GO:0001701 GO:0050930 GO:0001822 GO:0007595 GO:0048286 GO:0030324 GO:0060426 GO:0036303 GO:0001946 GO:0030225 GO:0060749 GO:0007498 GO:0030224 GO:0097475 GO:0048255 GO:0043066 GO:0045779 GO:0022408 GO:0043154 GO:0010719 GO:2001237 GO:0045599 GO:0010629 GO:0043524 GO:1901215 GO:0043069 GO:0000122 GO:0007399 GO:0048666 GO:0003151 GO:0001541 GO:0050918 GO:0045766 GO:0048842 GO:0043536 GO:1903589 GO:0090190 GO:0045785 GO:0051781 GO:0030335 GO:0090050 GO:0008284 GO:0038091 GO:0051272 GO:0120162 GO:0032793 GO:2000573 GO:0038033 GO:0010595 GO:0001938 GO:0050679 GO:0070374 GO:0051894 GO:0010628 GO:1901727 GO:1901492 GO:0043406 GO:0060754 GO:0002053 GO:0002052 GO:0045669 GO:1900745 GO:0033138 GO:1900086 GO:0050731 GO:0042327 GO:0050927 GO:0031954 GO:0031334 GO:0051897 GO:0090037 GO:1903572 GO:1902966 GO:0001934 GO:0002092 GO:1902336 GO:0009967 GO:0048661 GO:1903672 GO:0045944 GO:0061419 GO:0030949 GO:0043117 GO:0031077 GO:0060319 GO:0008360 GO:0045601 GO:0040008 GO:1901532 GO:0010749 GO:0090259 GO:0006357 GO:0001666 GO:0061304 GO:0002040 GO:0043129 GO:0042088 GO:0035148 GO:0048010 GO:0038084 GO:0001944 GO:0038190
CDD	cd00135
Gene3D	2.10.160.10 2.10.90.10
InterPro	IPR029034 IPR023581 IPR000072 IPR027928 IPR036841
Pfam	PF00341 PF14554
SMART	SM00141
SUPFAM	SSF57501 SSF57593
PROSITE	PS00249 PS50278

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:26683794^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24006456^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0010719	negative regulation of epithelial to mesenchymal transition	PMID:23863481^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0004145)	Seeded From UniProt	complete
involved_in	GO:0097475	motor neuron migration	PMID:26503042^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:24401374^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P97333	P		Seeded From UniProt	complete
involved_in	GO:0061304	retinal blood vessel morphogenesis	PMID:23093773^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	PMID:22426001^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:22426001^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090259	regulation of retinal ganglion cell axon guidance	PMID:21658587^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	PMID:21658587^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000740) occurs_in:(UBERON:0000959)	Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	PMID:21658587^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000740)	Seeded From UniProt	complete
involved_in	GO:0048842	positive regulation of axon extension involved in axon guidance	PMID:21658587^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000740) occurs_in:(UBERON:0000959)	Seeded From UniProt	complete
involved_in	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:1903572	positive regulation of protein kinase D signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	PMID:16291795^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0090037	positive regulation of protein kinase C signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0051272	positive regulation of cellular component movement	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0050927	positive regulation of positive chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0043183	vascular endothelial growth factor receptor 1 binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
involved_in	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0035767	endothelial cell chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0035148	tube formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0032793	positive regulation of CREB transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0031334	positive regulation of protein complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0030225	macrophage differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0030224	monocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	C		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	C		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0005172	vascular endothelial growth factor receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0060754	positive regulation of mast cell chemotaxis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767	P		Seeded From UniProt	complete
involved_in	GO:0050930	induction of positive chemotaxis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767	P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:108037 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619991 RGD:620695 UniProtKB:P15692 UniProtKB:P49767 ZFIN:ZDB-GENE-990415-273	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619850 RGD:619991 UniProtKB:P15692	P		Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246424 RGD:619991 UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0043183	vascular endothelial growth factor receptor 1 binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN002635039 UniProtKB:P15692 UniProtKB:P49765	F		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619991 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767	F		Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 UniProtKB:P15692 ZFIN:ZDB-GENE-040303-4	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:108037 PANTHER:PTN000246442 RGD:619991 UniProtKB:P15691 UniProtKB:P15692 UniProtKB:P49763	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:105095 MGI:MGI:108037 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619850 RGD:619991 UniProtKB:P15691 UniProtKB:P15692 UniProtKB:P49765	C		Seeded From UniProt	complete
enables	GO:0005172	vascular endothelial growth factor receptor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:108037 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619800 RGD:619991 RGD:620695 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767 ZFIN:ZDB-GENE-040303-4	F		Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619850 ZFIN:ZDB-GENE-030131-4605 ZFIN:ZDB-GENE-040303-4	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619850 UniProtKB:P15691 UniProtKB:P15692 UniProtKB:P49765	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 RGD:619850 RGD:619991 RGD:620695 UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619799 RGD:619800 RGD:619991 UniProtKB:P15692 ZFIN:ZDB-GENE-070810-6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903572	positive regulation of protein kinase D signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902966	positive regulation of protein localization to early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901727	positive regulation of histone deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901532	regulation of hematopoietic progenitor cell differentiation	PMID:18772315^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901492	positive regulation of lymphangiogenesis	PMID:20133819^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17161)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097533	cellular stress response to acid chemical	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090037	positive regulation of protein kinase C signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071542	dopaminergic neuron differentiation	PMID:17215402^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106918	P	results_in_acquisition_of_features_of:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	PMID:10575000^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15691 UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061430	bone trabecula morphogenesis	PMID:22886301^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931048	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060978	angiogenesis involved in coronary vascular morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060754	positive regulation of mast cell chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060749	mammary gland alveolus development	PMID:17625068^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926815,MGI:MGI:1931048	P	results_in_development_of:(EMAPA:36566)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060426	lung vasculature development	PMID:11169844^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060346	bone trabecula formation	PMID:22886301^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931048	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060326	cell chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060319	primitive erythrocyte differentiation	PMID:14729577^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2383985	P	occurs_in:(EMAPA:16085)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051272	positive regulation of cellular component movement	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050930	induction of positive chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050927	positive regulation of positive chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050918	positive chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:18772315^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_input:(MGI:MGI:96683)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	PMID:15927453^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048873	homeostasis of number of cells within a tissue	PMID:22886301^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931048	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048844	artery morphogenesis	PMID:10229225^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048739	cardiac muscle fiber development	PMID:10229225^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048593	camera-type eye morphogenesis	PMID:16251428^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931048,MGI:MGI:2387296	P	has_participant:(EMAPA:19077)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048514	blood vessel morphogenesis	PMID:15919073^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98294	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048514	blood vessel morphogenesis	PMID:16027358^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:18768)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048514	blood vessel morphogenesis	PMID:15919073^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048469	cell maturation	PMID:12053176^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P	occurs_in:(CL:0000322) results_in_maturation_of:(EMAPA:32682)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048286	lung alveolus development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048255	mRNA stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:8702615^[25]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045785	positive regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045779	negative regulation of bone resorption	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	PMID:20133819^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:22886301^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931048	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045601	regulation of endothelial cell differentiation	PMID:18772315^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045599	negative regulation of fat cell differentiation	PMID:22886301^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931048	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043542	endothelial cell migration	PMID:24403062^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	F		Seeded From UniProt	complete
enables	GO:0043183	vascular endothelial growth factor receptor 1 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043129	surfactant homeostasis	PMID:12053176^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043117	positive regulation of vascular permeability	PMID:24403062^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043117	positive regulation of vascular permeability	PMID:10617467^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043117	positive regulation of vascular permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043117	positive regulation of vascular permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043069	negative regulation of programmed cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:15073147^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931048	P	regulates_o_occurs_in:(EMAPA:19143) regulates_o_occurs_in:(CL:0000138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042462	eye photoreceptor cell development	PMID:16251428^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931048,MGI:MGI:2387296	P	occurs_in:(EMAPA:17168) results_in_development_of:(CL:0000210)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042327	positive regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042088	T-helper 1 type immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040008	regulation of growth	PMID:10229225^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P		Seeded From UniProt	complete
enables	GO:0038191	neuropilin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038190	VEGF-activated neuropilin signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038084	vascular endothelial growth factor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035767	endothelial cell chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035148	tube formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032793	positive regulation of CREB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032147	activation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031954	positive regulation of protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031334	positive regulation of protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031077	post-embryonic camera-type eye development	PMID:10229225^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030855	epithelial cell differentiation	PMID:16251428^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931048,MGI:MGI:2387296	P	occurs_in:(EMAPA:17172) results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:15927453^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:12053176^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030225	macrophage differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030224	monocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022408	negative regulation of cell-cell adhesion	PMID:24367707^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87859 MGI:MGI:87860	P	regulates_o_occurs_in:(EMAPA:35176)	Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:15601856^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95558 MGI:MGI:96683	P	occurs_in:(EMAPA:16039) results_in_movement_of:(CL:0000007)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:15601856^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16039) results_in_movement_of:(CL:0000007)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010749	regulation of nitric oxide mediated signal transduction	PMID:16150726^[31]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:22886301^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009967	positive regulation of signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008360	regulation of cell shape	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:17475663^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:14722611^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386592 MGI:MGI:2386595	P	acts_on_population_of:(CL:0000138)	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007595	lactation	PMID:17625068^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926815,MGI:MGI:1931048	P	has_participant:(EMAPA:36566)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007498	mesoderm development	PMID:12890722^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2383985	P	results_in_development_of:(EMAPA:16087)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007399	nervous system development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22886301^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002092)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12975317^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22886301^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002092)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:25184477^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22009797^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18772315^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18753609^[38]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)\|part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18559975^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17475663^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12053176^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16728)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	C		Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	C		Seeded From UniProt	complete
enables	GO:0005172	vascular endothelial growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003007	heart morphogenesis	PMID:10229225^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002575	basophil chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002092	positive regulation of receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	PMID:17215402^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106918	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002042	cell migration involved in sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001974	blood vessel remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001946	lymphangiogenesis	PMID:19233265^[40]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102469 MGI:MGI:107163	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001944	vasculature development	PMID:10229225^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	PMID:12714610^[41]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:10229225^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:10229225^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:16251428^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931048,MGI:MGI:2387296	P	occurs_in:(EMAPA:17828)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:15927453^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17655)\|occurs_in:(EMAPA:17663)\|occurs_in:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001541	ovarian follicle development	PMID:17050862^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(EMAPA:30755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:16778080^[43]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1202890	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:17625068^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926815,MGI:MGI:1931048	P	has_participant:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:15073147^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931048	P	has_participant:(EMAPA:18512)\|has_participant:(EMAPA:18513)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:14722611^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386592 MGI:MGI:2386595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:12890722^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2383985	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:14998491^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:12975317^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:10617467^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619991	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000072	F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027928 InterPro:IPR036841	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000072	C		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:21828096^[45]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000165)	Seeded From UniProt	complete
involved_in	GO:1902336	positive regulation of retinal ganglion cell axon guidance	PMID:21658587^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090259	regulation of retinal ganglion cell axon guidance	PMID:21658587^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000740) occurs_in:(UBERON:0000959)	Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	PMID:21658587^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000740) occurs_in:(UBERON:0000959)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21828096^[45]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000165) happens_during:(GO:0038084)	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21828096^[45]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000165) happens_during:(GO:0038084)	Seeded From UniProt	complete
involved_in	GO:0048842	positive regulation of axon extension involved in axon guidance	PMID:21658587^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000740) occurs_in:(UBERON:0000959)	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	PMID:21828096^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000165)	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:21828096^[45]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000165)	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:21658587^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000740)	Seeded From UniProt	complete
involved_in	GO:0038190	VEGF-activated neuropilin signaling pathway	PMID:21658587^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000740) causally_upstream_of:(GO:1902336)	Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	PMID:21828096^[45]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000165)	Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:24401374^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060426	lung vasculature development	PMID:11066091^[46]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
enables	GO:0050840	extracellular matrix binding	PMID:17626017^[47]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048754	branching morphogenesis of an epithelial tube	PMID:16375885^[48]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:32860)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:1592003^[49]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:10705382^[50]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35918	F	occurs_in:(EMAPA:35269)\|occurs_in:(EMAPA:35689)	Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:17626017^[47]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043183	vascular endothelial growth factor receptor 1 binding	PMID:17626017^[47]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:16375885^[48]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:32860)	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:8614412^[51]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:32927)	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:17626017^[47]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:8614412^[51]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32927)	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:17626017^[47]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:16375885^[48]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	PMID:1592003^[49]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001569	branching involved in blood vessel morphogenesis	PMID:17428830^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931047	P	occurs_in:(EMAPA:16916)\|occurs_in:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:17626017^[47]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0090259	regulation of retinal ganglion cell axon guidance	PMID:21658587^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0071679	commissural neuron axon guidance	PMID:21658587^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060982	coronary artery morphogenesis	PMID:18093989^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060948	cardiac vascular smooth muscle cell development	PMID:18093989^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0048842	positive regulation of axon extension involved in axon guidance	PMID:21658587^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036303	lymph vessel morphogenesis	PMID:18093989^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003169	coronary vein morphogenesis	PMID:18093989^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	PMID:18093989^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:1592003^[49]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:1592003^[49]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:8614412^[51]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32927)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	PMID:1592003^[49]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:17626017^[47]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:9446618^[54]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:9446618^[54]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	PMID:9446618^[54]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mahdaviani, K et al. (2016) Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes. Metab. Clin. Exp. 65 26-35 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ Bai, Y et al. (2013) Bmp signaling represses Vegfa to promote outflow tract cushion development. Development 140 3395-402 PubMed GONUTS page
↑ He, W et al. (2015) CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature 526 710-4 PubMed GONUTS page
↑ ^5.0 ^5.1 Fantin, A et al. (2014) Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development 141 556-62 PubMed GONUTS page
↑ Kurihara, T et al. (2012) Targeted deletion of Vegfa in adult mice induces vision loss. J. Clin. Invest. 122 4213-7 PubMed GONUTS page
↑ ^7.0 ^7.1 Benedito, R et al. (2012) Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature 484 110-4 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 Erskine, L et al. (2011) VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron 70 951-65 PubMed GONUTS page
↑ Gao, X et al. (2005) Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development 132 5437-49 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Purpura, KA et al. (2008) Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner. Stem Cells 26 2832-42 PubMed GONUTS page
↑ ^12.0 ^12.1 Heishi, T et al. (2010) Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis. Am. J. Pathol. 176 1950-8 PubMed GONUTS page
↑ ^13.0 ^13.1 Milosevic, J et al. (2007) Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. J. Neurosci. 27 412-21 PubMed GONUTS page
↑ Yonekura, H et al. (1999) Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J. Biol. Chem. 274 35172-8 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 Liu, Y et al. (2012) Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J. Clin. Invest. 122 3101-13 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Rossiter, H et al. (2007) Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function. FASEB J. 21 3994-4004 PubMed GONUTS page
↑ Ng, YS et al. (2001) Differential expression of VEGF isoforms in mouse during development and in the adult. Dev. Dyn. 220 112-21 PubMed GONUTS page
↑ Martin, R et al. (2004) SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis. Development 131 693-702 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Zhao, L et al. (2005) Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature. Mech. Dev. 122 877-86 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 Carmeliet, P et al. (1999) Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat. Med. 5 495-502 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Marneros, AG et al. (2005) Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am. J. Pathol. 167 1451-9 PubMed GONUTS page
↑ ^22.0 ^22.1 Rolny, C et al. (2005) Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling. Exp. Cell Res. 308 381-93 PubMed GONUTS page
↑ Müller, SM et al. (2005) Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture. Proc. Natl. Acad. Sci. U.S.A. 102 10587-92 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Compernolle, V et al. (2002) Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat. Med. 8 702-10 PubMed GONUTS page
↑ Olofsson, B et al. (1996) Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. J. Biol. Chem. 271 19310-7 PubMed GONUTS page
↑ ^26.0 ^26.1 Zimmerman, MW et al. (2014) Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. J. Biol. Chem. 289 5904-13 PubMed GONUTS page
↑ ^27.0 ^27.1 Thurston, G et al. (1999) Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286 2511-4 PubMed GONUTS page
↑ ^28.0 ^28.1 Zelzer, E et al. (2004) VEGFA is necessary for chondrocyte survival during bone development. Development 131 2161-71 PubMed GONUTS page
↑ Chislock, EM & Pendergast, AM (2013) Abl family kinases regulate endothelial barrier function in vitro and in mice. PLoS ONE 8 e85231 PubMed GONUTS page
↑ ^30.0 ^30.1 Hiratsuka, S et al. (2005) Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos. Mol. Cell. Biol. 25 355-63 PubMed GONUTS page
↑ Isenberg, JS et al. (2005) Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 102 13141-6 PubMed GONUTS page
↑ ^32.0 ^32.1 Amura, CR et al. (2007) VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice. Am. J. Physiol., Cell Physiol. 293 C419-28 PubMed GONUTS page
↑ ^33.0 ^33.1 Maes, C et al. (2004) Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J. Clin. Invest. 113 188-99 PubMed GONUTS page
↑ ^34.0 ^34.1 Duan, LJ et al. (2003) Gastrulation and angiogenesis, not endothelial specification, is sensitive to partial deficiency in vascular endothelial growth factor-a in mice. Biol. Reprod. 69 1852-8 PubMed GONUTS page
↑ ^35.0 ^35.1 Zheng, H et al. (2003) The transcription factor Net regulates the angiogenic switch. Genes Dev. 17 2283-97 PubMed GONUTS page
↑ Suenaga, K et al. (2014) Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation. PLoS ONE 9 e104728 PubMed GONUTS page
↑ Shan, B et al. (2012) RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Endocr. Relat. Cancer 19 13-27 PubMed GONUTS page
↑ Wu, JA et al. (2008) Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy. Biol. Reprod. 79 1054-61 PubMed GONUTS page
↑ Novitskiy, SV et al. (2008) Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112 1822-31 PubMed GONUTS page
↑ Kulkarni, RM et al. () NFATc1 regulates lymphatic endothelial development. Mech. Dev. 126 350-65 PubMed GONUTS page
↑ Oshima, Y et al. (2003) Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes. Invest. Ophthalmol. Vis. Sci. 44 1814-23 PubMed GONUTS page
↑ Roberts, AE et al. (2007) Neutralization of endogenous vascular endothelial growth factor depletes primordial follicles in the mouse ovary. Biol. Reprod. 76 218-23 PubMed GONUTS page
↑ Lavine, KJ et al. (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev. 20 1651-66 PubMed GONUTS page
↑ Marchiò, S et al. (2004) Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell 5 151-62 PubMed GONUTS page
↑ ^45.0 ^45.1 ^45.2 ^45.3 ^45.4 ^45.5 Cariboni, A et al. (2011) VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development 138 3723-33 PubMed GONUTS page
↑ Healy, AM et al. (2000) VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung. Dev. Dyn. 219 341-52 PubMed GONUTS page
↑ ^47.0 ^47.1 ^47.2 ^47.3 ^47.4 ^47.5 ^47.6 Krilleke, D et al. (2007) Molecular mapping and functional characterization of the VEGF164 heparin-binding domain. J. Biol. Chem. 282 28045-56 PubMed GONUTS page
↑ ^48.0 ^48.1 ^48.2 Del Moral, PM et al. (2006) VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev. Biol. 290 177-88 PubMed GONUTS page
↑ ^49.0 ^49.1 ^49.2 ^49.3 ^49.4 Breier, G et al. (1992) Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114 521-32 PubMed GONUTS page
↑ Halder, JB et al. (2000) Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation. Genesis 26 213-24 PubMed GONUTS page
↑ ^51.0 ^51.1 ^51.2 Christofori, G et al. (1995) Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol. Endocrinol. 9 1760-70 PubMed GONUTS page
↑ Vieira, JM et al. (2007) Selective requirements for NRP1 ligands during neurovascular patterning. Development 134 1833-43 PubMed GONUTS page
↑ ^53.0 ^53.1 ^53.2 ^53.3 ^53.4 van den Akker, NM et al. (2008) Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling. Cardiovasc. Res. 78 366-75 PubMed GONUTS page
↑ ^54.0 ^54.1 ^54.2 Sugihara, T et al. (1998) A novel alternatively spliced form of murine vascular endothelial growth factor, VEGF 115. J. Biol. Chem. 273 3033-8 PubMed GONUTS page

[PMID:26683794-1] Mahdaviani, K et al. (2016) Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes. Metab. Clin. Exp. 65 26-35 PubMed GONUTS page

[PMID:24006456-2] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:23863481-3] Bai, Y et al. (2013) Bmp signaling represses Vegfa to promote outflow tract cushion development. Development 140 3395-402 PubMed GONUTS page

[PMID:26503042-4] He, W et al. (2015) CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature 526 710-4 PubMed GONUTS page

[PMID:24401374-5] 5.0 ^5.1 Fantin, A et al. (2014) Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development 141 556-62 PubMed GONUTS page

[PMID:23093773-6] Kurihara, T et al. (2012) Targeted deletion of Vegfa in adult mice induces vision loss. J. Clin. Invest. 122 4213-7 PubMed GONUTS page

[PMID:22426001-7] 7.0 ^7.1 Benedito, R et al. (2012) Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature 484 110-4 PubMed GONUTS page

[PMID:21658587-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 Erskine, L et al. (2011) VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron 70 951-65 PubMed GONUTS page

[PMID:16291795-9] Gao, X et al. (2005) Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development 132 5437-49 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18772315-11] 11.0 ^11.1 ^11.2 ^11.3 Purpura, KA et al. (2008) Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner. Stem Cells 26 2832-42 PubMed GONUTS page

[PMID:20133819-12] 12.0 ^12.1 Heishi, T et al. (2010) Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis. Am. J. Pathol. 176 1950-8 PubMed GONUTS page

[PMID:17215402-13] 13.0 ^13.1 Milosevic, J et al. (2007) Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. J. Neurosci. 27 412-21 PubMed GONUTS page

[PMID:10575000-14] Yonekura, H et al. (1999) Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J. Biol. Chem. 274 35172-8 PubMed GONUTS page

[PMID:22886301-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 Liu, Y et al. (2012) Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J. Clin. Invest. 122 3101-13 PubMed GONUTS page

[PMID:17625068-16] 16.0 ^16.1 ^16.2 Rossiter, H et al. (2007) Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function. FASEB J. 21 3994-4004 PubMed GONUTS page

[PMID:11169844-17] Ng, YS et al. (2001) Differential expression of VEGF isoforms in mouse during development and in the adult. Dev. Dyn. 220 112-21 PubMed GONUTS page

[PMID:14729577-18] Martin, R et al. (2004) SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis. Development 131 693-702 PubMed GONUTS page

[PMID:15927453-19] 19.0 ^19.1 ^19.2 Zhao, L et al. (2005) Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature. Mech. Dev. 122 877-86 PubMed GONUTS page

[PMID:10229225-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 Carmeliet, P et al. (1999) Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat. Med. 5 495-502 PubMed GONUTS page

[PMID:16251428-21] 21.0 ^21.1 ^21.2 ^21.3 Marneros, AG et al. (2005) Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am. J. Pathol. 167 1451-9 PubMed GONUTS page

[PMID:15919073-22] 22.0 ^22.1 Rolny, C et al. (2005) Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling. Exp. Cell Res. 308 381-93 PubMed GONUTS page

[PMID:16027358-23] Müller, SM et al. (2005) Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture. Proc. Natl. Acad. Sci. U.S.A. 102 10587-92 PubMed GONUTS page

[PMID:12053176-24] 24.0 ^24.1 ^24.2 ^24.3 Compernolle, V et al. (2002) Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat. Med. 8 702-10 PubMed GONUTS page

[PMID:8702615-25] Olofsson, B et al. (1996) Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. J. Biol. Chem. 271 19310-7 PubMed GONUTS page

[PMID:24403062-26] 26.0 ^26.1 Zimmerman, MW et al. (2014) Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. J. Biol. Chem. 289 5904-13 PubMed GONUTS page

[PMID:10617467-27] 27.0 ^27.1 Thurston, G et al. (1999) Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286 2511-4 PubMed GONUTS page

[PMID:15073147-28] 28.0 ^28.1 Zelzer, E et al. (2004) VEGFA is necessary for chondrocyte survival during bone development. Development 131 2161-71 PubMed GONUTS page

[PMID:24367707-29] Chislock, EM & Pendergast, AM (2013) Abl family kinases regulate endothelial barrier function in vitro and in mice. PLoS ONE 8 e85231 PubMed GONUTS page

[PMID:15601856-30] 30.0 ^30.1 Hiratsuka, S et al. (2005) Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos. Mol. Cell. Biol. 25 355-63 PubMed GONUTS page

[PMID:16150726-31] Isenberg, JS et al. (2005) Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 102 13141-6 PubMed GONUTS page

[PMID:17475663-32] 32.0 ^32.1 Amura, CR et al. (2007) VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice. Am. J. Physiol., Cell Physiol. 293 C419-28 PubMed GONUTS page

[PMID:14722611-33] 33.0 ^33.1 Maes, C et al. (2004) Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J. Clin. Invest. 113 188-99 PubMed GONUTS page

[PMID:12890722-34] 34.0 ^34.1 Duan, LJ et al. (2003) Gastrulation and angiogenesis, not endothelial specification, is sensitive to partial deficiency in vascular endothelial growth factor-a in mice. Biol. Reprod. 69 1852-8 PubMed GONUTS page

[PMID:12975317-35] 35.0 ^35.1 Zheng, H et al. (2003) The transcription factor Net regulates the angiogenic switch. Genes Dev. 17 2283-97 PubMed GONUTS page

[PMID:25184477-36] Suenaga, K et al. (2014) Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation. PLoS ONE 9 e104728 PubMed GONUTS page

[PMID:22009797-37] Shan, B et al. (2012) RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Endocr. Relat. Cancer 19 13-27 PubMed GONUTS page

[PMID:18753609-38] Wu, JA et al. (2008) Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy. Biol. Reprod. 79 1054-61 PubMed GONUTS page

[PMID:18559975-39] Novitskiy, SV et al. (2008) Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112 1822-31 PubMed GONUTS page

[PMID:19233265-40] Kulkarni, RM et al. () NFATc1 regulates lymphatic endothelial development. Mech. Dev. 126 350-65 PubMed GONUTS page

[PMID:12714610-41] Oshima, Y et al. (2003) Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes. Invest. Ophthalmol. Vis. Sci. 44 1814-23 PubMed GONUTS page

[PMID:17050862-42] Roberts, AE et al. (2007) Neutralization of endogenous vascular endothelial growth factor depletes primordial follicles in the mouse ovary. Biol. Reprod. 76 218-23 PubMed GONUTS page

[PMID:16778080-43] Lavine, KJ et al. (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev. 20 1651-66 PubMed GONUTS page

[PMID:14998491-44] Marchiò, S et al. (2004) Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell 5 151-62 PubMed GONUTS page

[PMID:21828096-45] 45.0 ^45.1 ^45.2 ^45.3 ^45.4 ^45.5 Cariboni, A et al. (2011) VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development 138 3723-33 PubMed GONUTS page

[PMID:11066091-46] Healy, AM et al. (2000) VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung. Dev. Dyn. 219 341-52 PubMed GONUTS page

[PMID:17626017-47] 47.0 ^47.1 ^47.2 ^47.3 ^47.4 ^47.5 ^47.6 Krilleke, D et al. (2007) Molecular mapping and functional characterization of the VEGF164 heparin-binding domain. J. Biol. Chem. 282 28045-56 PubMed GONUTS page

[PMID:16375885-48] 48.0 ^48.1 ^48.2 Del Moral, PM et al. (2006) VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev. Biol. 290 177-88 PubMed GONUTS page

[PMID:1592003-49] 49.0 ^49.1 ^49.2 ^49.3 ^49.4 Breier, G et al. (1992) Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114 521-32 PubMed GONUTS page

[PMID:10705382-50] Halder, JB et al. (2000) Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation. Genesis 26 213-24 PubMed GONUTS page

[PMID:8614412-51] 51.0 ^51.1 ^51.2 Christofori, G et al. (1995) Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol. Endocrinol. 9 1760-70 PubMed GONUTS page

[PMID:17428830-52] Vieira, JM et al. (2007) Selective requirements for NRP1 ligands during neurovascular patterning. Development 134 1833-43 PubMed GONUTS page

[PMID:18093989-53] 53.0 ^53.1 ^53.2 ^53.3 ^53.4 van den Akker, NM et al. (2008) Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling. Cardiovasc. Res. 78 366-75 PubMed GONUTS page

[PMID:9446618-54] 54.0 ^54.1 ^54.2 Sugihara, T et al. (1998) A novel alternatively spliced form of murine vascular endothelial growth factor, VEGF 115. J. Biol. Chem. 273 3033-8 PubMed GONUTS page

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