MOUSE:SMO

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Smo (synonyms: Smoh)
Protein Name(s)	Smoothened homolog SMO
External Links
UniProt	P56726
EMBL	AC069469
CCDS	CCDS19965.1
PIR	JC5539
RefSeq	NP_795970.3
UniGene	Mm.29279
ProteinModelPortal	P56726
SMR	P56726
BioGrid	235504
IntAct	P56726
BindingDB	P56726
ChEMBL	CHEMBL6080
GuidetoPHARMACOLOGY	239
PhosphoSite	P56726
PaxDb	P56726
PRIDE	P56726
Ensembl	ENSMUST00000001812
GeneID	319757
KEGG	mmu:319757
UCSC	uc009bef.2
CTD	6608
MGI	MGI:108075
eggNOG	NOG312505
HOGENOM	HOG000252964
HOVERGEN	HBG000352
InParanoid	P56726
KO	K06226
OMA	KNSNRYP
OrthoDB	EOG74J972
TreeFam	TF106460
Reactome	REACT_250061 REACT_269412
ChiTaRS	Smo
NextBio	395350
PRO	PR:P56726
Proteomes	UP000000589
Bgee	P56726
CleanEx	MM_SMO
ExpressionAtlas	P56726
Genevestigator	P56726
GO	GO:0005901 GO:0060170 GO:0005929 GO:0005737 GO:0070062 GO:0005794 GO:0016021 GO:0043025 GO:0005886 GO:0072372 GO:0008144 GO:0004930 GO:0030165 GO:0042813 GO:0017147 GO:0021984 GO:0009952 GO:0048143 GO:0060413 GO:0048846 GO:0060070 GO:0010002 GO:0048468 GO:0001708 GO:0071397 GO:0007417 GO:0021953 GO:0021696 GO:0021987 GO:0060830 GO:0060248 GO:0003140 GO:0007368 GO:0048589 GO:0048565 GO:0021904 GO:0009953 GO:0031076 GO:0048557 GO:0048702 GO:0048568 GO:0048703 GO:0060684 GO:0031017 GO:0021561 GO:0021508 GO:0048853 GO:0008406 GO:0031069 GO:0001947 GO:0003007 GO:0048873 GO:0001701 GO:0060644 GO:0072285 GO:0007494 GO:0035264 GO:0042693 GO:0051451 GO:0043066 GO:0043392 GO:0030857 GO:0010629 GO:0051799 GO:0000122 GO:0001755 GO:0048663 GO:0031102 GO:0042475 GO:0001503 GO:0001649 GO:0032474 GO:0061113 GO:0007389 GO:0090190 GO:0008284 GO:0050679 GO:0010628 GO:0007228 GO:0002053 GO:0002052 GO:0042307 GO:0045880 GO:0045944 GO:0034504 GO:0050821 GO:0010468 GO:2000826 GO:2000036 GO:0048752 GO:0048741 GO:0007224 GO:0021938 GO:0021910 GO:0061053 GO:0007283 GO:0021794 GO:0003323 GO:0001570 GO:0007371
Gene3D	1.10.2000.10
InterPro	IPR000539 IPR015526 IPR020067 IPR017981 IPR026544
PANTHER	PTHR11309 PTHR11309:SF35
Pfam	PF01534 PF01392
PRINTS	PR00489
SMART	SM00063
SUPFAM	SSF63501
PROSITE	PS50038 PS50261

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045892	negative regulation of transcription, DNA-templated	PMID:24548465^[1]	ECO:0000315			P		Figures 3 B, 4 C,D, and F show that hwne smoothened is knocked down hepatocytes show an increase in mRNA of Boc, Cdo, Ptch1, and Igfbp1 when compared to the WT control.	complete CACAO 9709
	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24548465^[1]	ECO:0000315			P		Figure 3 A,D,E,F,4 A,B,E, and F demonstrate that when smoothened is knocked down hepatocytes have a decrease in mRNA of Indian Hedgehog, Gli1,Gli3, and IGF-1.	complete CACAO 9712
	GO:0046622	positive regulation of organ growth	PMID:24548465^[1]	ECO:0000315			P		Table one shows that mutants of the smoothened receptor in the Hedge hog signalling pathway have smaller livers therefore it can positively regulate factors involved in growth.	complete CACAO 9947
	GO:0040018	positive regulation of multicellular organism growth	PMID:24548465^[1]	ECO:0000315			P		Figure one shows that when the Smoothened part of the Hedgehog signaling receptor is knocked down, the over all growth and body weight of the organism decreases. This leads to the possibility that a SMO is involved in positively enhancing developmental growth.	complete CACAO 9950
	GO:0051236	establishment of RNA localization	PMID:21209331^[2]	ECO:0000315			P		Fig S7B shows Mouse Smo (by comparison to the mutant phenotype) regulates the localisation of the expression of Shh , Nkx2.2, Nkx6.1 and ventralises Pax6	complete CACAO 2876
	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning	PMID:21209331^[2]	ECO:0000315			P		Fig S7B shows Mouse Smo (by comparison to the mutant phenotype)positively regulates the ventralisation of Pax6. Smo known to work within Smoothened signalling pathway	complete CACAO 2877
	GO:0005929	cilium	PMID:21209331^[2]	ECO:0000314			C		Fig 4A shows ciliary localisation in WT in absense of anatagonist	complete CACAO 2902
part_of	GO:0005929	cilium	PMID:21659505^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:25644602^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21209331^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning	PMID:21209331^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040018	positive regulation of multicellular organism growth	PMID:24548465^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046622	positive regulation of organ growth	PMID:24548465^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24548465^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:24548465^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000826	regulation of heart morphogenesis	PMID:11517919^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21209331^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071397	cellular response to cholesterol	PMID:21931618^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061053	somite development	PMID:11517919^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048853	forebrain morphogenesis	PMID:11517919^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning	PMID:21209331^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007494	midgut development	PMID:11517919^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007371	ventral midline determination	PMID:11517919^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007228	positive regulation of hh target transcription factor activity	PMID:11517919^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:11517919^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21931618^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003140	determination of left/right asymmetry in lateral mesoderm	PMID:11517919^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:11517919^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	PMID:16396903^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072285	mesenchymal to epithelial transition involved in metanephric renal vesicle formation	PMID:16396903^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060248	detection of cell density by contact stimulus involved in contact inhibition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99835	P		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	PMID:16396903^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:16396903^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:16396903^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:21177415^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:21177415^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99835	C		Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000885245 RGD:3726	P		Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108075 PANTHER:PTN000885245	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003444 PANTHER:PTN000885245 RGD:3726	C		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108075 PANTHER:PTN000885245 ZFIN:ZDB-GENE-980526-89	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003444 MGI:MGI:108075 PANTHER:PTN000885245 UniProtKB:Q99835	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003444 MGI:MGI:108075 PANTHER:PTN000885245 ZFIN:ZDB-GENE-980526-89	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0016797 MGI:MGI:108075 MGI:MGI:108460 MGI:MGI:108476 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1313278 PANTHER:PTN000139394 RGD:61916 RGD:628817 RGD:71012 UniProtKB:O00144 UniProtKB:O19116 UniProtKB:O60353 UniProtKB:O75084 UniProtKB:Q14332 UniProtKB:Q99835 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 WB:WBGene00003006 ZFIN:ZDB-GENE-990415-223	C		Seeded From UniProt	complete
enables	GO:0005113	patched binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000885245 UniProtKB:Q99835	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000179	positive regulation of neural precursor cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000036	regulation of stem cell population maintenance	PMID:17199044^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934268,MGI:MGI:2445832	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071679	commissural neuron axon guidance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070986	left/right axis specification	PMID:9636176^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137553	P	occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061113	pancreas morphogenesis	PMID:20185815^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2684317	P	has_participant:(EMAPA:17503)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060684	epithelial-mesenchymal cell signaling	PMID:19304890^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060644	mammary gland epithelial cell differentiation	PMID:17199044^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934268,MGI:MGI:2445832	P	occurs_in:(EMAPA:17759) results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060413	atrial septum morphogenesis	PMID:22898775^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102541	P	has_participant:(EMAPA:17011)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060248	detection of cell density by contact stimulus involved in contact inhibition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99835	P		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	PMID:22179047^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051799	negative regulation of hair follicle development	PMID:17199044^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934268,MGI:MGI:2445832	P	regulates_o_results_in_development_of:(EMAPA:18771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051451	myoblast migration	PMID:22987639^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1927138	P	occurs_in:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	PMID:19124651^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	PMID:19304890^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048873	homeostasis of number of cells within a tissue	PMID:23680462^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048846	axon extension involved in axon guidance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048741	skeletal muscle fiber development	PMID:22987639^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:3573783	P	results_in_development_of:(CL:0000189)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048589	developmental growth	PMID:16571630^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2446434	P	occurs_in:(EMAPA:16974)\|occurs_in:(EMAPA:17787)\|occurs_in:(EMAPA:19051)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048568	embryonic organ development	PMID:24302887^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2144467	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048565	digestive tract development	PMID:19619492^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176255	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048468	cell development	PMID:12403705^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2445832	P	occurs_in:(EMAPA:32897) occurs_in:(CL:0000059)\|occurs_in:(EMAPA:32888) occurs_in:(CL:0000059)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048143	astrocyte activation	PMID:23680462^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19304890^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256	P	has_regulation_target:(MGI:MGI:88313)\|has_regulation_target:(MGI:MGI:88314)\|has_regulation_target:(MGI:MGI:88177)\|has_regulation_target:(MGI:MGI:88180)\|has_regulation_target:(MGI:MGI:1347470)\|has_regulation_target:(MGI:MGI:1347479)\|has_regulation_target:(MGI:MGI:1099809)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15906375^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:96441)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045880	positive regulation of smoothened signaling pathway	PMID:16459297^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	C		Seeded From UniProt	complete
part_of	GO:0044294	dendritic growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043392	negative regulation of DNA binding	PMID:16396903^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99835	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:16571630^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2446434	P	regulates_o_occurs_in:(EMAPA:16472)\|regulates_o_occurs_in:(EMAPA:16480)\|regulates_o_occurs_in:(EMAPA:16974)\|regulates_o_occurs_in:(EMAPA:16918)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:17199044^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934268,MGI:MGI:2445832	P	has_participant:(EMAPA:35303)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:12403705^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2445832	P	has_participant:(EMAPA:32897)\|has_participant:(EMAPA:32888)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042307	positive regulation of protein import into nucleus	PMID:17043310^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729 MGI:MGI:98297	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:18590716^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1341070	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:18590716^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176255	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034504	protein localization to nucleus	PMID:19952108^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031069	hair follicle morphogenesis	PMID:17199044^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934268,MGI:MGI:2445832	P	has_participant:(EMAPA:18771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030857	negative regulation of epithelial cell differentiation	PMID:17199044^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934268,MGI:MGI:2445832	P	occurs_in:(EMAPA:17759) results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99835	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:23680462^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021953	central nervous system neuron differentiation	PMID:16571630^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2446434	P	occurs_in:(EMAPA:17108) results_in_acquisition_of_features_of:(CL:0000117)\|occurs_in(EMAPA:16976) results_in_acquisition_of_features_of:(CL:0000117)\|occurs_in(EMAPA:17093) results_in_acquisition_of_features_of:(CL:0000700)\|occurs_in(EMAPA:17093) results_in_acquisition_of_features_of:(CL:0000850)\|occurs_in(EMAPA:16975) results_in_acquisition_of_features_of:(CL:0000700)\|occurs_in(EMAPA:16975) results_in_acquisition_of_features_of:(CL:0000850)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	PMID:16571625^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2176256	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000120)\|occurs_in:(EMAPA:17787) occurs_in:(CL:0000120)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning	PMID:19286674^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176255	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:18590716^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176255	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021794	thalamus development	PMID:19357274^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:3576373	P	results_in_development_of:(EMAPA:16754)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021696	cerebellar cortex morphogenesis	PMID:16571625^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2176256	P	has_participant:(EMAPA:17787)\|has_participant:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021542	dentate gyrus development	PMID:18297065^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2179048	P	occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:23680462^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99835	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:18590716^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1341070	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:16571630^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2176256	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:15755804^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137553	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:22987639^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2450929	P	has_participant:(EMAPA:16177) has_participant:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:19124651^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:12403705^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2445832	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99835	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007417	central nervous system development	PMID:12435628^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	results_in_development_of:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:15107405^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256	P	occurs_in:(EMAPA:16382)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:15755804^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137553	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:12421714^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176255	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:17043310^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729 MGI:MGI:98297	P	occurs_in:(EMAPA:16674)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:20185815^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2684317	P	occurs_in:(EMAPA:32927)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:17199044^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934268,MGI:MGI:2445832	P	occurs_in:(EMAPA:32760) occurs_in:(CL:0000134)\|occurs_in:(EMAPA:32760) occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:16136078^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:15107405^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99835	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:28154160^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:22689656^[38]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19684112^[39]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19654211^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:18488998^[41]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:16229832^[42]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16075) part_of:(CL:0000064)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:16136078^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16075)	Seeded From UniProt	complete
colocalizes_with	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99835	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99835	C		Seeded From UniProt	complete
colocalizes_with	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99835	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18488998^[41]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3726	C		Seeded From UniProt	complete
enables	GO:0005113	patched binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99835	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003323	type B pancreatic cell development	PMID:20185815^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2684317	P	occurs_in:(EMAPA:18816)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003007	heart morphogenesis	PMID:16687132^[43]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101791	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:19304890^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	PMID:16543460^[44]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88274	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001755	neural crest cell migration	PMID:16687132^[43]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101791	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001708	cell fate specification	PMID:18590716^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176255	P	has_participant:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:17881493^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176255	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:14973297^[46]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:17881493^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176255	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:15294868^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176255	P	occurs_in:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001503	ossification	PMID:11748145^[48]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256,MGI:MGI:2176264	P	has_participant:(EMAPA:19142)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19304890^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176256	P	has_regulation_target:(MGI:MGI:88180)\|has_regulation_target:(MGI:MGI:97168)	Seeded From UniProt	complete
involved_in	GO:0072001	renal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99835 ensembl:ENSP00000249373	P		Seeded From UniProt	complete
involved_in	GO:0060248	detection of cell density by contact stimulus involved in contact inhibition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99835 ensembl:ENSP00000249373	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99835 ensembl:ENSP00000249373	C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99835 ensembl:ENSP00000249373	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99835 ensembl:ENSP00000249373	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99835 ensembl:ENSP00000249373	F		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99835 ensembl:ENSP00000249373	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99835 ensembl:ENSP00000249373	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99835 ensembl:ENSP00000249373	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99835 ensembl:ENSP00000249373	C		Seeded From UniProt	complete
enables	GO:0005113	patched binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99835 ensembl:ENSP00000249373	F		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539 InterPro:IPR017981	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026544	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	C		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	Reactome:R-MMU-5633169 Reactome:R-MMU-5632665 Reactome:R-MMU-5632663 Reactome:R-MMU-5632661 Reactome:R-MMU-5632658	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-MMU-5632657	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Matz-Soja, M et al. (2014) Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels. Cell Commun. Signal 12 11 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
↑ Evron, T et al. (2011) Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling. J. Biol. Chem. 286 27676-86 PubMed GONUTS page
↑ Chong, YC et al. (2015) Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5. Genes Dev. 29 262-76 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Zhang, XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106 781-92 PubMed GONUTS page
↑ ^6.0 ^6.1 Bidet, M et al. (2011) The hedgehog receptor patched is involved in cholesterol transport. PLoS ONE 6 e23834 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Hu, MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133 569-78 PubMed GONUTS page
↑ ^8.0 ^8.1 Roudaut, H et al. (2011) Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Mol. Pharmacol. 79 453-60 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gritli-Linde, A et al. (2007) Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev. Cell 12 99-112 PubMed GONUTS page
↑ Kasarskis, A et al. (1998) A phenotype-based screen for embryonic lethal mutations in the mouse. Proc. Natl. Acad. Sci. U.S.A. 95 7485-90 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Lau, J & Hebrok, M (2010) Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function. Diabetes 59 1211-21 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Lan, Y & Jiang, R (2009) Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development 136 1387-96 PubMed GONUTS page
↑ Xie, L et al. (2012) Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. Dev. Cell 23 280-91 PubMed GONUTS page
↑ Chih, B et al. (2012) A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat. Cell Biol. 14 61-72 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Hu, JK et al. (2012) Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev. 26 2088-102 PubMed GONUTS page
↑ ^17.0 ^17.1 Wall, DS et al. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J. Cell Biol. 184 101-12 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Komada, M et al. (2013) Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex. Neurosci. Lett. 547 87-91 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Blaess, S et al. (2006) Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133 1799-809 PubMed GONUTS page
↑ Cui, C et al. (2013) Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 11 e1001720 PubMed GONUTS page
↑ Spence, JR et al. (2009) Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev. Cell 17 62-74 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Gritli-Linde, A et al. (2002) Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 129 5323-37 PubMed GONUTS page
↑ Lipinski, RJ et al. (2005) Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development. Dev. Dyn. 233 829-36 PubMed GONUTS page
↑ Varjosalo, M et al. (2006) Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev. Cell 10 177-86 PubMed GONUTS page
↑ ^25.0 ^25.1 Kim, JW & Lemke, G (2006) Hedgehog-regulated localization of Vax2 controls eye development. Genes Dev. 20 2833-47 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 ^26.4 Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page
↑ Fernandez-L, A et al. (2009) YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev. 23 2729-41 PubMed GONUTS page
↑ ^28.0 ^28.1 Corrales, JD et al. (2006) The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 133 1811-21 PubMed GONUTS page
↑ Norman, RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum. Mol. Genet. 18 1740-54 PubMed GONUTS page
↑ Vue, TY et al. (2009) Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. J. Neurosci. 29 4484-97 PubMed GONUTS page
↑ Han, YG et al. (2008) Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat. Neurosci. 11 277-84 PubMed GONUTS page
↑ ^32.0 ^32.1 García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page
↑ Wijgerde, M et al. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 16 2849-64 PubMed GONUTS page
↑ ^34.0 ^34.1 Jeong, J et al. (2004) Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 18 937-51 PubMed GONUTS page
↑ Kawakami, T et al. (2002) Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development 129 5753-65 PubMed GONUTS page
↑ ^36.0 ^36.1 Corbit, KC et al. (2005) Vertebrate Smoothened functions at the primary cilium. Nature 437 1018-21 PubMed GONUTS page
↑ Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
↑ Liem, KF Jr et al. (2012) The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J. Cell Biol. 197 789-800 PubMed GONUTS page
↑ Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page
↑ Clement, CA et al. (2009) The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J. Cell. Sci. 122 3070-82 PubMed GONUTS page
↑ ^41.0 ^41.1 Ocbina, PJ & Anderson, KV (2008) Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts. Dev. Dyn. 237 2030-8 PubMed GONUTS page
↑ May, SR et al. (2005) Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev. Biol. 287 378-89 PubMed GONUTS page
↑ ^43.0 ^43.1 Lin, L et al. (2006) Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev. Biol. 295 756-63 PubMed GONUTS page
↑ Lien, WH et al. (2006) alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science 311 1609-12 PubMed GONUTS page
↑ ^45.0 ^45.1 Astorga, J & Carlsson, P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134 3753-61 PubMed GONUTS page
↑ Long, F et al. (2004) Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131 1309-18 PubMed GONUTS page
↑ Vokes, SA et al. (2004) Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development 131 4371-80 PubMed GONUTS page
↑ Long, F et al. (2001) Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128 5099-108 PubMed GONUTS page

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[PMID:19654211-40] Clement, CA et al. (2009) The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J. Cell. Sci. 122 3070-82 PubMed GONUTS page

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[PMID:16229832-42] May, SR et al. (2005) Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev. Biol. 287 378-89 PubMed GONUTS page

[PMID:16687132-43] 43.0 ^43.1 Lin, L et al. (2006) Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev. Biol. 295 756-63 PubMed GONUTS page

[PMID:16543460-44] Lien, WH et al. (2006) alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science 311 1609-12 PubMed GONUTS page

[PMID:17881493-45] 45.0 ^45.1 Astorga, J & Carlsson, P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134 3753-61 PubMed GONUTS page

[PMID:14973297-46] Long, F et al. (2004) Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131 1309-18 PubMed GONUTS page

[PMID:15294868-47] Vokes, SA et al. (2004) Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development 131 4371-80 PubMed GONUTS page

[PMID:11748145-48] Long, F et al. (2001) Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128 5099-108 PubMed GONUTS page

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