PMID:16543460

Citation	Lien, WH, Klezovitch, O, Fernandez, TE, Delrow, J and Vasioukhin, V (2006) alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science 311:1609-12
Abstract	During development, cells monitor and adjust their rates of accumulation to produce organs of predetermined size. We show here that central nervous system-specific deletion of the essential adherens junction gene, alphaE-catenin, causes abnormal activation of the hedgehog pathway, resulting in shortening of the cell cycle, decreased apoptosis, and cortical hyperplasia. We propose that alphaE-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex.
Links	PubMed PMC2556178 Online version:10.1126/science.1121449
Keywords	Adherens Junctions/physiology; Adherens Junctions/ultrastructure; Animals; Apoptosis; Cell Adhesion; Cell Count; Cell Cycle; Cell Differentiation; Cell Polarity; Central Nervous System/embryology; Cerebral Cortex/cytology; Cerebral Cortex/embryology; Cerebral Cortex/pathology; Cerebral Cortex/physiology; Hedgehog Proteins; Hyperplasia; Mice; Mitosis; Models, Biological; Mutation; Neurons/cytology; Neurons/physiology; Neurons/ultrastructure; Oligonucleotide Array Sequence Analysis; Signal Transduction; Stem Cells/cytology; Stem Cells/ultrastructure; Trans-Activators/metabolism; Up-Regulation; alpha Catenin/genetics; alpha Catenin/physiology
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