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GO:0048639positive regulation of developmental growthPMID:24548465IMP: Inferred from Mutant Phenotype P
This annotation made on page: MOUSE:SMO
By: Drl5141 (group Team Protein Titans) on 2014-04-06 10:41:38 CDT.




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
ChallengeBiernate,
MichSt14A 26
2014-04-11 17:29:14 CDT

The GO term should be changed to GO:0040018, since the KO mutants of the Smoothened gene were unable to reach the sizes of their normal WT counterparts. The original GO term was wrong because the KO mutants had fully functional organs and were anatomically correct when compared to the WT sample. They could just not achieve the same weight as the WT did. And since the active gene is associated with the normal WT size, then the Smoothened gene must be involved in positively regulating growth of the organism.

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Suzialeksander2014-05-14 12:03:37 CDTYou need to be an instructor to view these notes.Updated by Instructor
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Suzialeksander2014-04-18 16:39:11 CDT

Biernate gets credit

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DanielRenfro2014-04-11 17:29:14 CDT

This annotation has been flagged because it has been edited since last assessment ||GO:0048639||positive regulation of developmental growth||PMID:24548465||IMP: Inferred from Mutant Phenotype||||P||Figure one shows that when the Smoothened part of the Hedgehog signaling receptor is knocked down, the over all growth and body weight of the organism decreases. This leads to the possibility that a SMO is involved in positively enhancing developmental growth.||complete

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Suzialeksander2014-04-10 14:58:25 CDTYou need to be an instructor to view these notes.Requires Changes
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