MOUSE:PROX1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Prox1
Protein Name(s)	Prospero homeobox protein 1 Homeobox prospero-like protein PROX1 PROX-1
External Links
UniProt	P48437
EMBL	AF061576 AK052889 AK143179 BC051411
CCDS	CCDS35822.1
PIR	JE0269
RefSeq	NP_032963.1 XP_006497191.1
UniGene	Mm.132579 Mm.392678
ProteinModelPortal	P48437
SMR	P48437
BioGrid	202396
DIP	DIP-58960N
IntAct	P48437
MINT	MINT-4108644
PhosphoSite	P48437
MaxQB	P48437
PaxDb	P48437
PRIDE	P48437
Ensembl	ENSMUST00000010319 ENSMUST00000175916 ENSMUST00000177288
GeneID	19130
KEGG	mmu:19130
UCSC	uc007ebb.2
CTD	5629
MGI	MGI:97772
eggNOG	NOG323972
GeneTree	ENSGT00530000063507
HOGENOM	HOG000115708
HOVERGEN	HBG053693
InParanoid	P48437
OMA	FGNVQMP
OrthoDB	EOG7MSMNK
PhylomeDB	P48437
TreeFam	TF316638
NextBio	295746
PRO	PR:P48437
Proteomes	UP000000589
Bgee	P48437
CleanEx	MM_PROX1
Genevestigator	P48437
GO	GO:0005737 GO:0005634 GO:0001046 GO:0003705 GO:0043565 GO:0000981 GO:0003700 GO:0003714 GO:0090425 GO:0060414 GO:0055009 GO:0061114 GO:0001709 GO:0021707 GO:0007623 GO:0021542 GO:0060059 GO:0060214 GO:0045446 GO:0002194 GO:0070365 GO:0072574 GO:0048839 GO:0001822 GO:0070309 GO:0002089 GO:0030324 GO:0001945 GO:0001946 GO:0060836 GO:0070858 GO:0008285 GO:0043433 GO:0000122 GO:0045892 GO:0045071 GO:0097150 GO:0046619 GO:0045787 GO:1901978 GO:0008284 GO:0045737 GO:0010595 GO:0001938 GO:2000979 GO:0060421 GO:2000179 GO:0060298 GO:0045944 GO:0042752 GO:0010468 GO:0060849 GO:0031667 GO:0030240 GO:0006366 GO:0048845 GO:0055010 GO:0055005 GO:0060412
Gene3D	1.10.10.500
InterPro	IPR023082 IPR009057 IPR007738
PANTHER	PTHR12198
Pfam	PF05044
SUPFAM	SSF46689

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91018	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1P568	C		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23723244^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:23723244^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:23723244^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:23723244^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000979	positive regulation of forebrain neuron differentiation	PMID:20808958^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000179	positive regulation of neural precursor cell proliferation	PMID:20808958^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	PMID:20808958^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070365	hepatocyte differentiation	PMID:15232737^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070309	lens fiber cell morphogenesis	PMID:10080188^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060421	positive regulation of heart growth	PMID:19091769^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060414	aorta smooth muscle tissue morphogenesis	PMID:19091769^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	PMID:19091769^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060298	positive regulation of sarcomere organization	PMID:19091769^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060214	endocardium formation	PMID:19091769^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060059	embryonic retina morphogenesis in camera-type eye	PMID:12692551^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	PMID:19091769^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055009	atrial cardiac muscle tissue morphogenesis	PMID:19091769^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055005	ventricular cardiac myofibril assembly	PMID:19091769^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048845	venous blood vessel morphogenesis	PMID:19091769^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046619	optic placode formation involved in camera-type eye formation	PMID:11850194^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:10080188^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030240	skeletal muscle thin filament assembly	PMID:19091769^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021707	cerebellar granule cell differentiation	PMID:20808958^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021542	dentate gyrus development	PMID:20808958^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:10080188^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:12692551^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11850194^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11850194^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19091769^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19091769^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:19091769^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002089	lens morphogenesis in camera-type eye	PMID:10080188^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070309	lens fiber cell morphogenesis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97772 PANTHER:PTN000258078 UniProtKB:Q91018 UniProtKB:Q92786	P		Seeded From UniProt	complete
involved_in	GO:0060836	lymphatic endothelial cell differentiation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97772 PANTHER:PTN000258078 UniProtKB:Q92786	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004595 MGI:MGI:97772 PANTHER:PTN000258074	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004595 MGI:MGI:97772 PANTHER:PTN000258074 RGD:1306890 UniProtKB:Q91018 UniProtKB:Q92786	C		Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000258078 UniProtKB:Q91018 UniProtKB:Q92786	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004595 MGI:MGI:97772 PANTHER:PTN000258074 UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901978	positive regulation of cell cycle checkpoint	PMID:21040746^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090425	acinar cell differentiation	PMID:22178591^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3609548	P	regulates_o_results_in_development_of:(CL:0002064)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072574	hepatocyte proliferation	PMID:10888866^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386336	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070858	negative regulation of bile acid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061114	branching involved in pancreas morphogenesis	PMID:22178591^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3609548	P	results_in_morphogenesis_of:(EMAPA:17503)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060849	regulation of transcription involved in lymphatic endothelial cell fate commitment	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060836	lymphatic endothelial cell differentiation	PMID:19056883^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182767,MGI:MGI:3609548	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060836	lymphatic endothelial cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
enables	GO:0050693	LBD domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	F		Seeded From UniProt	complete
enables	GO:0050692	DBD domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	PMID:20186345^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386336	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16291864^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:35533) regulates_o_occurs_in:(CL:0002138) has_regulation_target:(MGI:MGI:95524)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045446	endothelial cell differentiation	PMID:11927535^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386336	P	occurs_in:(EMAPA:16240) results_in_acquisition_of_features_of:(CL:0000071)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045071	negative regulation of viral genome replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21040746^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042752	regulation of circadian rhythm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
enables	GO:0016922	nuclear receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:12692551^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386336	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21300049^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21040746^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19023449^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:17838)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306890	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002194	hepatocyte cell migration	PMID:10888866^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386336	P	occurs_in:(EMAPA:16846) results_in_movement_of:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001946	lymphangiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001945	lymph vessel development	PMID:16170315^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450311,MGI:MGI:3609548	P	results_in_development_of:(EMAPA:18248)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001709	cell fate determination	PMID:12692551^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386336	P	occurs_in:(EMAPA:17168) results_in_determination_of:(CL:0000745)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:16291864^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:35533) occurs_in:(CL:0002138) has_regulation_target:(MGI:MGI:95524)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21040746^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92786	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZU00 ensembl:ENSRNOP00000004905	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZU00 ensembl:ENSRNOP00000004905	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZU00 ensembl:ENSRNOP00000004905	C		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZU00 ensembl:ENSRNOP00000004905	P		Seeded From UniProt	complete
involved_in	GO:0070858	negative regulation of bile acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0070365	hepatocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0070309	lens fiber cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0060849	regulation of transcription involved in lymphatic endothelial cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0060836	lymphatic endothelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0060059	embryonic retina morphogenesis in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
enables	GO:0050693	LBD domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	F		Seeded From UniProt	complete
enables	GO:0050692	DBD domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
enables	GO:0016922	nuclear receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	F		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	F		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92786 ensembl:ENSP00000355925	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009057 InterPro:IPR023082 InterPro:IPR037131	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007738 InterPro:IPR039350	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Takeda, Y & Jetten, AM (2013) Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation. Nucleic Acids Res. 41 6992-7008 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lavado, A et al. (2010) Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol. 8 PubMed GONUTS page
↑ Dudas, J et al. (2004) The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium. Anat. Embryol. 208 359-66 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Wigle, JT et al. (1999) Prox1 function is crucial for mouse lens-fibre elongation. Nat. Genet. 21 318-22 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 Risebro, CA et al. (2009) Prox1 maintains muscle structure and growth in the developing heart. Development 136 495-505 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Dyer, MA et al. (2003) Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat. Genet. 34 53-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Duncan, MK et al. (2002) Prox1 is differentially localized during lens development. Mech. Dev. 112 195-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Baxter, SA et al. (2011) Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein. Biochim. Biophys. Acta 1813 201-12 PubMed GONUTS page
↑ ^10.0 ^10.1 Westmoreland, JJ et al. (2012) Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology 142 999-1009.e6 PubMed GONUTS page
↑ ^11.0 ^11.1 Sosa-Pineda, B et al. (2000) Hepatocyte migration during liver development requires Prox1. Nat. Genet. 25 254-5 PubMed GONUTS page
↑ Johnson, NC et al. (2008) Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev. 22 3282-91 PubMed GONUTS page
↑ Fritzsch, B et al. (2010) Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity. PLoS ONE 5 e9377 PubMed GONUTS page
↑ ^14.0 ^14.1 Shin, JW et al. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol. Biol. Cell 17 576-84 PubMed GONUTS page
↑ Wigle, JT et al. (2002) An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J. 21 1505-13 PubMed GONUTS page
↑ Tateya, T et al. (2011) Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. Dev. Biol. 352 329-40 PubMed GONUTS page
↑ Chen, X et al. (2008) PCNA interacts with Prox1 and represses its transcriptional activity. Mol. Vis. 14 2076-86 PubMed GONUTS page
↑ Harvey, NL et al. (2005) Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat. Genet. 37 1072-81 PubMed GONUTS page

[PMID:23723244-1] 1.0 ^1.1 ^1.2 ^1.3 Takeda, Y & Jetten, AM (2013) Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation. Nucleic Acids Res. 41 6992-7008 PubMed GONUTS page

[PMID:20808958-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lavado, A et al. (2010) Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol. 8 PubMed GONUTS page

[PMID:15232737-3] Dudas, J et al. (2004) The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium. Anat. Embryol. 208 359-66 PubMed GONUTS page

[PMID:10080188-4] 4.0 ^4.1 ^4.2 ^4.3 Wigle, JT et al. (1999) Prox1 function is crucial for mouse lens-fibre elongation. Nat. Genet. 21 318-22 PubMed GONUTS page

[PMID:19091769-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 Risebro, CA et al. (2009) Prox1 maintains muscle structure and growth in the developing heart. Development 136 495-505 PubMed GONUTS page

[PMID:12692551-6] 6.0 ^6.1 ^6.2 ^6.3 Dyer, MA et al. (2003) Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat. Genet. 34 53-8 PubMed GONUTS page

[PMID:11850194-7] 7.0 ^7.1 ^7.2 Duncan, MK et al. (2002) Prox1 is differentially localized during lens development. Mech. Dev. 112 195-8 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21040746-9] 9.0 ^9.1 ^9.2 ^9.3 Baxter, SA et al. (2011) Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein. Biochim. Biophys. Acta 1813 201-12 PubMed GONUTS page

[PMID:22178591-10] 10.0 ^10.1 Westmoreland, JJ et al. (2012) Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology 142 999-1009.e6 PubMed GONUTS page

[PMID:10888866-11] 11.0 ^11.1 Sosa-Pineda, B et al. (2000) Hepatocyte migration during liver development requires Prox1. Nat. Genet. 25 254-5 PubMed GONUTS page

[PMID:19056883-12] Johnson, NC et al. (2008) Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev. 22 3282-91 PubMed GONUTS page

[PMID:20186345-13] Fritzsch, B et al. (2010) Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity. PLoS ONE 5 e9377 PubMed GONUTS page

[PMID:16291864-14] 14.0 ^14.1 Shin, JW et al. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol. Biol. Cell 17 576-84 PubMed GONUTS page

[PMID:11927535-15] Wigle, JT et al. (2002) An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J. 21 1505-13 PubMed GONUTS page

[PMID:21300049-16] Tateya, T et al. (2011) Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. Dev. Biol. 352 329-40 PubMed GONUTS page

[PMID:19023449-17] Chen, X et al. (2008) PCNA interacts with Prox1 and represses its transcriptional activity. Mol. Vis. 14 2076-86 PubMed GONUTS page

[PMID:16170315-18] Harvey, NL et al. (2005) Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat. Genet. 37 1072-81 PubMed GONUTS page

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