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PMID:20808958

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Citation

Lavado, A, Lagutin, OV, Chow, LM, Baker, SJ and Oliver, G (2010) Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol. 8

Abstract

The dentate gyrus has an important role in learning and memory, and adult neurogenesis in the subgranular zone of the dentate gyrus may play a role in the acquisition of new memories. The homeobox gene Prox1 is expressed in the dentate gyrus during embryonic development and adult neurogenesis. Here we show that Prox1 is necessary for the maturation of granule cells in the dentate gyrus during development and for the maintenance of intermediate progenitors during adult neurogenesis. We also demonstrate that Prox1-expressing intermediate progenitors are required for adult neural stem cell self-maintenance in the subgranular zone; thus, we have identified a previously unknown non-cell autonomous regulatory feedback mechanism that controls adult neurogenesis in this region of the mammalian brain. Finally, we show that the ectopic expression of Prox1 induces premature differentiation of neural stem cells.

Links

PubMed PMC2923090 Online version:10.1371/journal.pbio.1000460

Keywords

Adult Stem Cells/cytology; Animals; Brain/embryology; Cell Differentiation; Dentate Gyrus/cytology; Dentate Gyrus/embryology; Dentate Gyrus/metabolism; Female; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Homeodomain Proteins/pharmacology; Mice; Neural Stem Cells/cytology; Neurogenesis/drug effects; Neurons/cytology; Neurons/metabolism; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism; Tumor Suppressor Proteins/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:PROX1

involved_in

GO:0021542: dentate gyrus development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:PROX1

involved_in

GO:0021707: cerebellar granule cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:PROX1

involved_in

GO:0097150: neuronal stem cell population maintenance

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:PROX1

involved_in

GO:2000179: positive regulation of neural precursor cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:PROX1

involved_in

GO:2000979: positive regulation of forebrain neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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