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PMID:16170315
| Citation |
Harvey, NL, Srinivasan, RS, Dillard, ME, Johnson, NC, Witte, MH, Boyd, K, Sleeman, MW and Oliver, G (2005) Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat. Genet. 37:1072-81 |
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| Abstract |
Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease. |
| Links |
PubMed Online version:10.1038/ng1642 |
| Keywords |
Alleles; Animals; Disease Models, Animal; Gene Deletion; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Insulin/blood; Leptin/blood; Lipid Metabolism/genetics; Lipids/analysis; Liver/metabolism; Lymph/metabolism; Lymphatic Abnormalities/complications; Lymphatic Abnormalities/genetics; Lymphatic Vessels/abnormalities; Lymphatic Vessels/physiopathology; Mice; Mice, Knockout; Obesity/complications; Obesity/genetics; Tumor Suppressor Proteins |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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