MOUSE:PGH2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ptgs2 (synonyms: Cox-2, Cox2, Pghs-b, Tis10)
Protein Name(s)	Prostaglandin G/H synthase 2 Cyclooxygenase-2 COX-2 Glucocorticoid-regulated inflammatory cyclooxygenase Gripghs Macrophage activation-associated marker protein P71/73 PES-2 PHS II Prostaglandin H2 synthase 2 PGH synthase 2 PGHS-2 Prostaglandin-endoperoxide synthase 2 TIS10 protein
External Links
UniProt	Q05769
EMBL	M64291 M94967 M82866 M82862 M82863 M82864 M82865 M88242 AK049923 AK144956 AK166221 AK172161 CH466520
CCDS	CCDS15353.1
PIR	A49010
RefSeq	NP_035328.2
UniGene	Mm.292547
PDB	1CVU 1CX2 1DCX 1DD0 1DDX 1PXX 3HS5 3HS6 3HS7 3KRK 3LN0 3LN1 3MDL 3MQE 3NT1 3NTB 3NTG 3OLT 3OLU 3PGH 3Q7D 3QH0 3QMO 3RR3 3TZI 4COX 4E1G 4FM5 4M10 4M11 4OTY 5COX 6COX
PDBsum	1CVU 1CX2 1DCX 1DD0 1DDX 1PXX 3HS5 3HS6 3HS7 3KRK 3LN0 3LN1 3MDL 3MQE 3NT1 3NTB 3NTG 3OLT 3OLU 3PGH 3Q7D 3QH0 3QMO 3RR3 3TZI 4COX 4E1G 4FM5 4M10 4M11 4OTY 5COX 6COX
ProteinModelPortal	Q05769
SMR	Q05769
BioGrid	202463
DIP	DIP-31082N
IntAct	Q05769
BindingDB	Q05769
ChEMBL	CHEMBL4321
PeroxiBase	3360
PhosphoSite	Q05769
UniCarbKB	Q05769
MaxQB	Q05769
PaxDb	Q05769
PRIDE	Q05769
Ensembl	ENSMUST00000035065
GeneID	19225
KEGG	mmu:19225
UCSC	uc007cxv.1
CTD	5743
MGI	MGI:97798
eggNOG	NOG39991
GeneTree	ENSGT00390000010743
HOGENOM	HOG000013149
HOVERGEN	HBG000366
InParanoid	Q05769
KO	K11987
OMA	ICNNVKG
OrthoDB	EOG7RFTHC
PhylomeDB	Q05769
TreeFam	TF329675
Reactome	REACT_188623 REACT_196559 REACT_211619
UniPathway	UPA00662
EvolutionaryTrace	Q05769
NextBio	296012
PRO	PR:Q05769
Proteomes	UP000000589
Bgee	Q05769
CleanEx	MM_PTGS2
Genevestigator	Q05769
GO	GO:0005901 GO:0005737 GO:0005789 GO:0043005 GO:0043234 GO:0020037 GO:0008289 GO:0046872 GO:0016702 GO:0004601 GO:0004666 GO:0042803 GO:0001525 GO:0030282 GO:0050873 GO:0071318 GO:0071456 GO:0071260 GO:0034644 GO:0019371 GO:0046697 GO:0007566 GO:0042633 GO:0006954 GO:0030216 GO:0007612 GO:0035633 GO:0007613 GO:0051926 GO:0045786 GO:0008285 GO:0045986 GO:0032227 GO:0030728 GO:0043065 GO:0090336 GO:0090050 GO:0031622 GO:0090271 GO:0042346 GO:0045429 GO:0090362 GO:0048661 GO:0045987 GO:0031915 GO:0051968 GO:0071636 GO:0045907 GO:0010575 GO:0001516 GO:0008217 GO:0042127 GO:0042493 GO:0032355 GO:0070542 GO:0009750 GO:0051384 GO:0032496 GO:0010226 GO:0010042 GO:0006979 GO:0034612 GO:0033280 GO:0019233
Gene3D	1.10.640.10
InterPro	IPR029576 IPR000742 IPR010255 IPR019791
PANTHER	PTHR11903:SF8
Pfam	PF03098
PRINTS	PR00457
SMART	SM00181
SUPFAM	SSF48113
PROSITE	PS50026 PS50292

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0150077	regulation of neuroinflammatory response	PMID:29662056^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	PMID:21716255^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:21716255^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031394	positive regulation of prostaglandin biosynthetic process	PMID:21716255^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:21716255^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21716255^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071471	cellular response to non-ionic osmotic stress	PMID:21716255^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21716255^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090336	positive regulation of brown fat cell differentiation	PMID:20448152^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050873	brown fat cell differentiation	PMID:20448152^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031622	positive regulation of fever generation	PMID:19940926^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:12925531^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q05769	F		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	PMID:12067981^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:12925531^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019371	cyclooxygenase pathway	PMID:12925531^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	PMID:12925531^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	PMID:12925531^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097756	negative regulation of blood vessel diameter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090362	positive regulation of platelet-derived growth factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090271	positive regulation of fibroblast growth factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071636	positive regulation of transforming growth factor beta production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071498	cellular response to fluid shear stress	PMID:24841674^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051926	negative regulation of calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046697	decidualization	PMID:10385625^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857239	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046697	decidualization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045986	negative regulation of smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045786	negative regulation of cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:12355421^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17168)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:12355421^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35354	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:8945508^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:11809702^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039 MGI:MGI:894293	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:11245490^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:10987272^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:10783317^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035633	maintenance of permeability of blood-brain barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034097	response to cytokine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032227	negative regulation of synaptic transmission, dopaminergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031915	positive regulation of synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031622	positive regulation of fever generation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030728	ovulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030282	bone mineralization	PMID:18519738^[15]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35355	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35354	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019371	cyclooxygenase pathway	PMID:1419907^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019371	cyclooxygenase pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35354	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
enables	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010575	positive regulation of vascular endothelial growth factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008217	regulation of blood pressure	PMID:12093889^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158457	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007566	embryo implantation	PMID:10385625^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857239	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007566	embryo implantation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
colocalizes_with	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35354	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12021206^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18681) part_of:(CL:0000362)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35354	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	C		Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	PMID:1419907^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35354	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620349	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P		Seeded From UniProt	complete
involved_in	GO:1990776	response to angiotensin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0097756	negative regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0090362	positive regulation of platelet-derived growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0090271	positive regulation of fibroblast growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0071636	positive regulation of transforming growth factor beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0071318	cellular response to ATP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0071284	cellular response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0051926	negative regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0045986	negative regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0042633	hair cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0035633	maintenance of permeability of blood-brain barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0034612	response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0033280	response to vitamin D	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	C		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0032227	negative regulation of synaptic transmission, dopaminergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0031915	positive regulation of synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0031622	positive regulation of fever generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0030728	ovulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0030282	bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
enables	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0010243	response to organonitrogen compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0010226	response to lithium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0010042	response to manganese ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0009750	response to fructose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35354 ensembl:ENSP00000356438	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35354 ensembl:ENSP00000356438	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35354 ensembl:ENSP00000356438	F		Seeded From UniProt	complete
involved_in	GO:0019371	cyclooxygenase pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35354 ensembl:ENSP00000356438	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35354 ensembl:ENSP00000356438	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35354 ensembl:ENSP00000356438	C		Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35354 ensembl:ENSP00000356438	F		Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029576	P		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	F		Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029576	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029576	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	P		Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029576	P		Seeded From UniProt	complete
involved_in	GO:0019371	cyclooxygenase pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029576	P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255 InterPro:IPR029576	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	P		Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.99.1	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492	C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0643 UniPathway:UPA00662	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0051213	dioxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0223	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0006693	prostaglandin metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0644	P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0575	F		Seeded From UniProt	complete
part_of	GO:0031090	organelle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0165	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lee, JY et al. (2018) Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Nat Commun 9 1479 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Küper, C et al. (2011) Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells. Kidney Int. 80 938-945 PubMed GONUTS page
↑ ^3.0 ^3.1 Vegiopoulos, A et al. (2010) Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328 1158-61 PubMed GONUTS page
↑ Hanada, R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462 505-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Rowlinson, SW et al. (2003) A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J. Biol. Chem. 278 45763-9 PubMed GONUTS page
↑ Tiano, HF et al. (2002) Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res. 62 3395-401 PubMed GONUTS page
↑ Hum, JM et al. (2014) Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression. PLoS ONE 9 e97942 PubMed GONUTS page
↑ ^8.0 ^8.1 Lim, H et al. (1999) Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev. 13 1561-74 PubMed GONUTS page
↑ ^9.0 ^9.1 Ju, WK & Neufeld, AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J. Comp. Neurol. 452 392-9 PubMed GONUTS page
↑ Oshima, M et al. (1996) Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87 803-9 PubMed GONUTS page
↑ Seno, H et al. (2002) Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res. 62 506-11 PubMed GONUTS page
↑ Oshima, M et al. (2001) Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Cancer Res. 61 1733-40 PubMed GONUTS page
↑ Chulada, PC et al. (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 60 4705-8 PubMed GONUTS page
↑ Sasai, H et al. (2000) Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. Carcinogenesis 21 953-8 PubMed GONUTS page
↑ Panupinthu, N et al. (2008) P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. J. Cell Biol. 181 859-71 PubMed GONUTS page
↑ ^16.0 ^16.1 Ryseck, RP et al. (1992) Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity. Cell Growth Differ. 3 443-50 PubMed GONUTS page
↑ Qi, Z et al. (2002) Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. J. Clin. Invest. 110 61-9 PubMed GONUTS page
↑ Lazarus, M et al. (2002) Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs. Endocrinology 143 2410-9 PubMed GONUTS page

[PMID:29662056-1] Lee, JY et al. (2018) Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Nat Commun 9 1479 PubMed GONUTS page

[PMID:21716255-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Küper, C et al. (2011) Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells. Kidney Int. 80 938-945 PubMed GONUTS page

[PMID:20448152-3] 3.0 ^3.1 Vegiopoulos, A et al. (2010) Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328 1158-61 PubMed GONUTS page

[PMID:19940926-4] Hanada, R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462 505-9 PubMed GONUTS page

[PMID:12925531-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Rowlinson, SW et al. (2003) A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J. Biol. Chem. 278 45763-9 PubMed GONUTS page

[PMID:12067981-6] Tiano, HF et al. (2002) Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res. 62 3395-401 PubMed GONUTS page

[PMID:24841674-7] Hum, JM et al. (2014) Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression. PLoS ONE 9 e97942 PubMed GONUTS page

[PMID:10385625-8] 8.0 ^8.1 Lim, H et al. (1999) Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev. 13 1561-74 PubMed GONUTS page

[PMID:12355421-9] 9.0 ^9.1 Ju, WK & Neufeld, AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J. Comp. Neurol. 452 392-9 PubMed GONUTS page

[PMID:8945508-10] Oshima, M et al. (1996) Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87 803-9 PubMed GONUTS page

[PMID:11809702-11] Seno, H et al. (2002) Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res. 62 506-11 PubMed GONUTS page

[PMID:11245490-12] Oshima, M et al. (2001) Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Cancer Res. 61 1733-40 PubMed GONUTS page

[PMID:10987272-13] Chulada, PC et al. (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 60 4705-8 PubMed GONUTS page

[PMID:10783317-14] Sasai, H et al. (2000) Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. Carcinogenesis 21 953-8 PubMed GONUTS page

[PMID:18519738-15] Panupinthu, N et al. (2008) P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. J. Cell Biol. 181 859-71 PubMed GONUTS page

[PMID:1419907-16] 16.0 ^16.1 Ryseck, RP et al. (1992) Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity. Cell Growth Differ. 3 443-50 PubMed GONUTS page

[PMID:12093889-17] Qi, Z et al. (2002) Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. J. Clin. Invest. 110 61-9 PubMed GONUTS page

[PMID:12021206-18] Lazarus, M et al. (2002) Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs. Endocrinology 143 2410-9 PubMed GONUTS page

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