GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:12355421

From GONUTS
Jump to: navigation, search
Citation

Ju, WK and Neufeld, AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J. Comp. Neurol. 452:392-9

Abstract

Prostaglandins, synthesized by cyclooxygenase (COX), regulate diverse neurophysiological actions such as regulation of autonomic responses, transmission of pain, generation of fever, control of sleep-wake cycle, synaptic signaling, and cross-talk between neurons and glia in the central nervous system. Although prostaglandins have been widely studied in the anterior segment tissues of the eye, relatively little is known about prostaglandins in the neural retina. By using immunohistochemistry, we have compared the cellular expression and localization of COX-1 and COX-2 in the normal mouse, rat, and human retina. In the normal mouse retina, COX-1 immunoreactivity is present in the outer segments of photoreceptor cells, horizontal cells, microglia, retinal ganglion cells, and displaced amacrine cells. In the normal rat retina, COX-1 immunoreactivity is present in microglia, retinal ganglion cells, and displaced amacrine cells. In the normal human retina, COX-1 immunoreactivity is present in microglia, astrocytes, retinal ganglion cells, and displaced amacrine cells. In the normal mouse and rat retina, COX-2 immunoreactivity is present in processes of the outer plexiform layer and in certain amacrine cells and retinal ganglion cells. In the normal human retina, COX-2 immunoreactivity is only present in processes of the outer plexiform layer. These results suggest that prostaglandins, synthesized by COX-1 or COX-2, may contribute to normal physiological and homeostatic functions in the retina.

Links

PubMed Online version:10.1002/cne.10400

Keywords

Amacrine Cells/enzymology; Animals; Astrocytes/enzymology; Cyclooxygenase 1; Cyclooxygenase 2; Humans; Immunoblotting; Immunohistochemistry; Isoenzymes/analysis; Male; Membrane Proteins; Mice; Mice, Inbred BALB C/metabolism; Microglia/enzymology; Middle Aged; Photoreceptor Cells, Vertebrate/enzymology; Prostaglandin-Endoperoxide Synthases/analysis; Rats; Rats, Wistar/metabolism; Retina/cytology; Retina/enzymology; Retinal Ganglion Cells/enzymology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:GFAP

located_in

GO:0005737: cytoplasm

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P14136

C

Seeded From UniProt

complete

HUMAN:GFAP

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:PGH1

located_in

GO:0005737: cytoplasm

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P23219

C

Seeded From UniProt

complete

MOUSE:PGH1

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000287)
  • part_of:(EMAPA:17168)|part_of:(CL:0000745)
  • part_of:(EMAPA:17168)|part_of:(CL:0000129)
  • part_of:(EMAPA:17168)|part_of:(CL:0000127)
  • part_of:(EMAPA:17168)|part_of:(CL:0000740)
  • part_of:(EMAPA:17168)|part_of:(CL:0000561)
  • part_of:(EMAPA:17168)

Seeded From UniProt

complete

MOUSE:PGH1

located_in

GO:0001750: photoreceptor outer segment

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000287)
  • part_of:(EMAPA:17168)

Seeded From UniProt

complete

HUMAN:PGH1

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:PGH2

located_in

GO:0043005: neuron projection

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:ACTA

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:ACTA

located_in

GO:0005737: cytoplasm

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P62736

C

Seeded From UniProt

complete

MOUSE:PGH2

located_in

GO:0043005: neuron projection

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P35354

C

Seeded From UniProt

complete

MOUSE:PGH2

located_in

GO:0043005: neuron projection

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17168)

Seeded From UniProt

complete

MOUSE:GFAP

part_of

GO:0005737: cytoplasm

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P14136

C

Seeded From UniProt

complete

MOUSE:PGH2

part_of

GO:0043005: neuron projection

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(EMAPA:17168)

Seeded From UniProt

complete

MOUSE:PGH2

part_of

GO:0043005: neuron projection

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P35354

C

Seeded From UniProt

complete

HUMAN:GFAP

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:PGH1

part_of

GO:0001750: photoreceptor outer segment

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17168)
  • part_of:(CL:0000287)

Seeded From UniProt

complete

MOUSE:PGH1

part_of

GO:0005737: cytoplasm

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P23219

C

Seeded From UniProt

complete

MOUSE:PGH1

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17168)
  • part_of:(CL:0000287)|part_of:(EMAPA:17168)
  • part_of:(CL:0000745)|part_of:(EMAPA:17168)
  • part_of:(CL:0000129)|part_of:(EMAPA:17168)
  • part_of:(CL:0000127)|part_of:(EMAPA:17168)
  • part_of:(CL:0000740)|part_of:(EMAPA:17168)
  • part_of:(CL:0000561)

Seeded From UniProt

complete

HUMAN:PGH2

part_of

GO:0043005: neuron projection

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.