MOUSE:P63

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tp63 (synonyms: P63, P73l, Tp73l, Trp63)
Protein Name(s)	Tumor protein 63 p63 Transformation-related protein 63 TP63 Tumor protein p73-like p73L
External Links
UniProt	O88898
EMBL	AF075434 AF075435 AF075436 AF075437 AF075438 AF075439 AB010152 AF533892 AF533892 AF533892 AF533892 AF533892 AF533892 AK048623
CCDS	CCDS28085.1 CCDS49808.1 CCDS49809.1 CCDS49810.1
RefSeq	NP_001120731.1 NP_001120732.1 NP_001120733.1 NP_001120734.1 NP_001120736.1 NP_001120737.1 NP_035771.1
UniGene	Mm.20894
ProteinModelPortal	O88898
SMR	O88898
BioGrid	204325
IntAct	O88898
MINT	MINT-4585054
STRING	10090.ENSMUSP00000110965
iPTMnet	O88898
PhosphoSitePlus	O88898
PaxDb	O88898
PRIDE	O88898
Ensembl	ENSMUST00000040231 ENSMUST00000065523 ENSMUST00000115308 ENSMUST00000115310
GeneID	22061
KEGG	mmu:22061
UCSC	uc007yuo.2 uc007yup.2 uc007yuq.2 uc007yut.2 uc007yuu.2 uc007yuv.2
CTD	22061
MGI	MGI:1330810
eggNOG	ENOG410IGE4 ENOG410XV9W
GeneTree	ENSGT00390000015092
HOVERGEN	HBG005201
InParanoid	O88898
KO	K10149
OMA	VPSSHCT
OrthoDB	EOG091G0XY5
PhylomeDB	O88898
TreeFam	TF106101
Reactome	[www.reactome.org/content/detail/R-MMU-6804759 R-MMU-6804759]
PRO	PR:O88898
Proteomes	UP000000589
Bgee	ENSMUSG00000022510
CleanEx	MM_TRP63
ExpressionAtlas	O88898
Genevisible	O88898
GO	GO:0000785 GO:0005737 GO:0005829 GO:0030425 GO:0005794 GO:0000790 GO:0005654 GO:0005634 GO:0005791 GO:0005667 GO:0003682 GO:0003684 GO:0003677 GO:0003690 GO:0042802 GO:0046872 GO:0002039 GO:0043565 GO:0000989 GO:0044212 GO:0001077 GO:0050699 GO:0048646 GO:0009887 GO:0006915 GO:0007569 GO:0030154 GO:0006974 GO:0034644 GO:0006338 GO:0060197 GO:0006978 GO:0007499 GO:0030326 GO:0010481 GO:0008544 GO:0002064 GO:0030855 GO:0001736 GO:0061436 GO:0048807 GO:0001942 GO:0031069 GO:0042771 GO:0030216 GO:0043616 GO:0031571 GO:0001738 GO:0010259 GO:0007275 GO:0043066 GO:2000773 GO:0045617 GO:2000381 GO:0000122 GO:0045892 GO:0051402 GO:0007219 GO:0042475 GO:0007389 GO:0030859 GO:2001235 GO:1902808 GO:2000271 GO:0010838 GO:0002053 GO:0045747 GO:0045669 GO:0045944 GO:0045893 GO:0036342 GO:0030850 GO:0060513 GO:0051289 GO:0009954 GO:0043281 GO:0010482 GO:0043523 GO:0001302 GO:0010332 GO:0010165 GO:0001501 GO:0043589 GO:0048745 GO:0007283 GO:0060529 GO:0048485 GO:0060157
CDD	cd08367
Gene3D	1.10.150.50 2.60.40.720 4.10.170.10
InterPro	IPR008967 IPR012346 IPR011615 IPR010991 IPR002117 IPR001660 IPR013761 IPR032645
PANTHER	PTHR11447 PTHR11447:SF24
Pfam	PF00870 PF07710 PF07647
PRINTS	PR00386
SMART	SM00454
SUPFAM	SSF47719 SSF47769 SSF49417
PROSITE	PS00348

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:22035303^[1]	ECO:0000314			C		Organism: Mouse Protein: P63 (Fig. 3I, arrow), in striking contrast to that of p63, which is restricted within the nuclei (Fig. 3K, arrow). These results imply that Xpod functions in the cytoplasm (I) and (K) are high magnification views of (H) and (J), respectively. Localization of antibody is shown in green. Nuclei of the cell were stained with TOPRO3 nucleic acid stain (magenta). Overlapping area of green and magenta is shown in white.	complete CACAO 12335
involved_in	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	PMID:25655704^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904674	positive regulation of somatic stem cell population maintenance	PMID:25655704^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061436	establishment of skin barrier	PMID:24075906^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010482	regulation of epidermal cell division	PMID:24075906^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:9774969^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000773	negative regulation of cellular senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000381	negative regulation of mesoderm development	PMID:21127502^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000271	positive regulation of fibroblast apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904888	cranial skeletal system development	PMID:25503409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5882555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904888	cranial skeletal system development	PMID:25503409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5882553	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902808	positive regulation of cell cycle G1/S phase transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098773	skin epidermis development	PMID:25503409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5882555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098773	skin epidermis development	PMID:25503409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5882553	P		Seeded From UniProt	complete
enables	GO:0097371	MDM2/MDM4 family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	PMID:15371309^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060513	prostatic bud formation	PMID:11106548^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	results_in_formation_of:(EMAPA:19287)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060197	cloacal septation	PMID:12368184^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	has_participant:(EMAPA:17896)\|has_participant:(EMAPA:18986)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:16337913^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P	occurs_in:(EMAPA:17157) occurs_in:(CL:0000107)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051289	protein homotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	P		Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048807	female genitalia morphogenesis	PMID:12368184^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	has_participant:(EMAPA:30819)\|has_participant:(EMAPA:18986)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:17878916^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861713	P	results_in_formation_of:(EMAPA:18692)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048485	sympathetic nervous system development	PMID:16337913^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18326838^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3795257	P	regulates_o_occurs_in:(EMAPA:32744) has_regulation_target:(MGI:MGI:101926)\|has_regulation_target:(MGI:MGI:101926) has_regulation_target:(MGI:MGI:94901) has_regulation_target:(MGI:MGI:94902) has_regulation_target:(MGI:MGI:101927) has_regulation_target:(MGI:MGI:1929938) regulates_o_occurs_in:(EMAPA:16779)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18256694^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000312) has_regulation_target:(MGI:MGI:1918588)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15982302^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861713	P	regulates_o_occurs_in:(EMAPA:17528) has_regulation_target:(MGI:MGI:104627)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9774969^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23906066^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21930775^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21285247^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045747	positive regulation of Notch signaling pathway	PMID:22274697^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5140823	P	regulates_o_occurs_in:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045617	negative regulation of keratinocyte differentiation	PMID:22274697^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5140823	P	occurs_in:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043589	skin morphogenesis	PMID:17041603^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3693324	P	has_participant:(EMAPA:17525)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:18256694^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000312) has_input:(MGI:MGI:1918588)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18159078^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620863	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:17122775^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	occurs_in:(EMAPA:17962) occurs_in:(CL:0000023)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:16524929^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P	has_participant:(EMAPA:17917)\|has_participant:(EMAPA:17938)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:16410075^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	has_participant:(EMAPA:17921)\|has_participant:(EMAPA:17918)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036342	post-anal tail morphogenesis	PMID:12368184^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	has_participant:(EMAPA:16748)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035116	embryonic hindlimb morphogenesis	PMID:25503409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5882555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035116	embryonic hindlimb morphogenesis	PMID:25503409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5882553	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035115	embryonic forelimb morphogenesis	PMID:25503409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5882555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035115	embryonic forelimb morphogenesis	PMID:25503409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5882553	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620863	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031069	hair follicle morphogenesis	PMID:16524929^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P	has_participant:(EMAPA:18771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030859	polarized epithelial cell differentiation	PMID:15189821^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	occurs_in:(EMAPA:35321) results_in_acquisition_of_features_of:(CL:0000067)\|occurs_in(EMAPA:16855) results_in_acquisition_of_features_of:(CL:0000067)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030855	epithelial cell differentiation	PMID:17878916^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861713	P	occurs_in:(EMAPA:18692) results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030855	epithelial cell differentiation	PMID:12368184^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	occurs_in:(EMAPA:30991) results_in_acquisition_of_features_of:(CL:0000066)\|occurs_in(EMAPA:36631) results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030850	prostate gland development	PMID:11106548^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	results_in_development_of:(EMAPA:19287)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620863	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:18326838^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101926 MGI:MGI:101927	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:10227293^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P	has_participant:(EMAPA:16778)\|has_participant:(EMAPA:16892)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030216	keratinocyte differentiation	PMID:14729569^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:15371309^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P	occurs_in:(EMAPA:19287) results_in_acquisition_of_features_of:(CL:0000646)	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620863	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010838	positive regulation of keratinocyte proliferation	PMID:24075906^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1916323	P	acts_on_population_of:(CL:0002187) occurs_in:(EMAPA:17525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010481	epidermal cell division	PMID:21127502^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	occurs_in:(EMAPA:17931)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010259	multicellular organism aging	PMID:16107615^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385473	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009954	proximal/distal pattern formation	PMID:10227293^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009913	epidermal cell differentiation	PMID:25503409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5882555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:10227294^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:22274697^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5140823	P	results_in_development_of:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:10227293^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P	results_in_development_of:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:25503409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5882553	P	acts_on_population_of:(CL:1000428)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007569	cell aging	PMID:16107615^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385473	P	occurs_in:(EMAPA:17528) occurs_in:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007499	ectoderm and mesoderm interaction	PMID:10227294^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007499	ectoderm and mesoderm interaction	PMID:10227293^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P	has_participant:(EMAPA:16405)\|has_participant:(EMAPA:17529)\|has_participant:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:10227294^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006338	chromatin remodeling	PMID:21930775^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934580	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620863	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23608756^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17751)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21285247^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18296)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18326838^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32744)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18159078^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17522155^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18862) part_of:(CL:0000646)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17383628^[31]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16737) part_of:(CL:0000075)\|part_of:(EMAPA:16737) part_of:(CL:0000075)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16466397^[32]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17162) part_of:(CL:0000646)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16080917^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17162) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15585950^[34]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17972) part_of:(CL:0000216)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15361520^[35]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17525) part_of:(CL:0000362)\|part_of:(EMAPA:17525) part_of:(CL:0000362)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14729569^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12368184^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:28747) part_of:(CL:0000066)\|part_of:(EMAPA:35896) part_of:(CL:0000066)\|part_of:(EMAPA:35897) part_of:(CL:0000066)\|part_of:(EMAPA:28089) part_of:(CL:0000066)\|part_of:(EMAPA:29929) part_of:(CL:0000075)\|part_of:(EMAPA:30991) part_of:(CL:0000076)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11522642^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17881) part_of:(CL:0000646)\|part_of:(EMAPA:16835) part_of:(CL:0000646)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11106548^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32290) part_of:(CL:0000646)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11106548^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620863	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620863	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620863	F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:17122775^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17962) occurs_in:(CL:0000023)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16524929^[22]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:103302)\|has_participant:(MGI:MGI:97363)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16363065^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002064	epithelial cell development	PMID:21127502^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	occurs_in:(EMAPA:17162)	Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001942	hair follicle development	PMID:25503409^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5882553	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001942	hair follicle development	PMID:16410075^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	results_in_development_of:(EMAPA:17529)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001738	morphogenesis of a polarized epithelium	PMID:15189821^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	has_participant:(EMAPA:35321)\|has_participant:(EMAPA:16855)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001736	establishment of planar polarity	PMID:14729569^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:10227294^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001302	replicative cell aging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620863	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:21930775^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H3D4	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23906066^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21335238^[38]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88898	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	P		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	F		Seeded From UniProt	complete
involved_in	GO:0001302	replicative cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	P		Seeded From UniProt	complete
involved_in	GO:2000271	positive regulation of fibroblast apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	P		Seeded From UniProt	complete
enables	GO:0097371	MDM2/MDM4 family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	F		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	P		Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H3D4 ensembl:ENSP00000264731	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0S2Z4N5 ensembl:ENSP00000264731	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0S2Z4N5 ensembl:ENSP00000264731	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0S2Z4N5 ensembl:ENSP00000264731	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346 InterPro:IPR032645	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346 InterPro:IPR032645 InterPro:IPR037611	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR032645	P		Seeded From UniProt	complete
involved_in	GO:0032502	developmental process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032645	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011615	F		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010991 InterPro:IPR036674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:16601749^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	results_in_development_of:(EMAPA:17528)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16601749^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21335238^[38]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88898-1	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18326838^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:101926)\|has_regulation_target:(MGI:MGI:101927)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17093266^[40]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17528) regulates_o_occurs_in:(CL:0000312) has_regulation_target:(MGI:MGI:99484)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16601749^[39]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:96688)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12789272^[41]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045617	negative regulation of keratinocyte differentiation	PMID:16618808^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97363	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043616	keratinocyte proliferation	PMID:16601749^[39]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:32779) acts_on_population_of:(CL:0000312)\|occurs_in(EMAPA:32779) acts_on_population_of:(CL:0000646)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:18326838^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:101926)\|has_direct_input:(MGI:MGI:101927)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:16618808^[42]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000312) has_input:(MGI:MGI:104853)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:16601749^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934269	P	results_in_development_of:(EMAPA:17528)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16601749^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16601749^[39]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:96688)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002064	epithelial cell development	PMID:16601749^[39]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:32787) results_in_development_of:(CL:0000312)\|occurs_in(EMAPA:32786) results_in_development_of:(CL:0000312)\|results_in_development_of:(CL:0000312) occurs_in:(EMAPA:35314)\|results_in_development_of(CL:0000312) occurs_in:(EMAPA:32785)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16618808^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97363	P	occurs_in:(CL:0000312) has_regulation_target:(MGI:MGI:104853)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16618808^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000312) has_regulation_target:(MGI:MGI:104853)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:25503409^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	PR:Q9H3D4-2	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22575646^[43]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88898-2	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21335238^[38]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88898-2	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:25503409^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	PR:Q9H3D4-3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:25503409^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	PR:Q9H3D4-5	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21335238^[38]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88898-5	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007275	multicellular organism development	PMID:14555234^[44]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:14555234^[44]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yoshii, S et al. (2011) The analysis of the expression of a novel gene, Xenopus polka dots, which was expressed in the embryonic and larval epidermis during early development. Zool. Sci. 28 809-16 PubMed GONUTS page
↑ ^2.0 ^2.1 Lindley, LE et al. (2015) The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage. Development 142 893-904 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Lee, S et al. (2013) Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells. Dev. Biol. 383 201-13 PubMed GONUTS page
↑ ^4.0 ^4.1 Yang, A et al. (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2 305-16 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Shalom-Feuerstein, R et al. (2011) ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ. 18 887-96 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 Suzuki, D et al. (2015) The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells. Development 142 282-90 PubMed GONUTS page
↑ ^7.0 ^7.1 Kurita, T et al. (2004) Role of p63 and basal cells in the prostate. Development 131 4955-64 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Signoretti, S et al. (2000) p63 is a prostate basal cell marker and is required for prostate development. Am. J. Pathol. 157 1769-75 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Ince, TA et al. (2002) p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract. Am. J. Pathol. 161 1111-7 PubMed GONUTS page
↑ ^10.0 ^10.1 Jacobs, WB et al. (2005) p63 is an essential proapoptotic protein during neural development. Neuron 48 743-56 PubMed GONUTS page
↑ ^11.0 ^11.1 Suzuki, K et al. (2008) Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4. Eur. J. Hum. Genet. 16 36-44 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Lo Iacono, N et al. (2008) Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects. Development 135 1377-88 PubMed GONUTS page
↑ ^13.0 ^13.1 Antonini, D et al. (2008) Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63. J. Invest. Dermatol. 128 1676-85 PubMed GONUTS page
↑ Osada, M et al. (2005) p63-specific activation of the BPAG-1e promoter. J. Invest. Dermatol. 125 52-60 PubMed GONUTS page
↑ ^15.0 ^15.1 Günschmann, C et al. (2013) Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev. Cell 26 176-87 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Fessing, MY et al. (2011) p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J. Cell Biol. 194 825-39 PubMed GONUTS page
↑ ^17.0 ^17.1 Jheon, AH et al. (2011) PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J. Cell. Sci. 124 745-54 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Romano, RA et al. (2012) ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development 139 772-82 PubMed GONUTS page
↑ Richardson, RJ et al. (2006) Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat. Genet. 38 1329-34 PubMed GONUTS page
↑ ^20.0 ^20.1 Livera, G et al. (2008) p63 null mutation protects mouse oocytes from radio-induced apoptosis. Reproduction 135 3-12 PubMed GONUTS page
↑ ^21.0 ^21.1 Suh, EK et al. (2006) p63 protects the female germ line during meiotic arrest. Nature 444 624-8 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Laurikkala, J et al. (2006) p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development 133 1553-63 PubMed GONUTS page
↑ ^23.0 ^23.1 Rufini, A et al. (2006) p63 protein is essential for the embryonic development of vibrissae and teeth. Biochem. Biophys. Res. Commun. 340 737-41 PubMed GONUTS page
↑ ^24.0 ^24.1 Daniely, Y et al. (2004) Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am. J. Physiol., Cell Physiol. 287 C171-81 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Mills, AA et al. (1999) p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398 708-13 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Koster, MI et al. (2004) p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 18 126-31 PubMed GONUTS page
↑ ^27.0 ^27.1 Keyes, WM et al. (2005) p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev. 19 1986-99 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 Yang, A et al. (1999) p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398 714-8 PubMed GONUTS page
↑ Simons, AL et al. (2013) The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation. Lab. Invest. 93 711-9 PubMed GONUTS page
↑ Que, J et al. (2007) Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development 134 2521-31 PubMed GONUTS page
↑ Danielian, PS et al. (2007) E2f4 is required for normal development of the airway epithelium. Dev. Biol. 305 564-76 PubMed GONUTS page
↑ Birger, Y et al. (2006) A role for chromosomal protein HMGN1 in corneal maturation. Differentiation 74 19-29 PubMed GONUTS page
↑ Ramaesh, T et al. (2005) Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/- mouse model of aniridia. Exp. Eye Res. 81 224-35 PubMed GONUTS page
↑ Nakamuta, N & Kobayashi, S (2004) Expression of p63 in the mouse primordial germ cells. J. Vet. Med. Sci. 66 1365-70 PubMed GONUTS page
↑ Kurata, S et al. (2004) p51/p63 Controls subunit alpha3 of the major epidermis integrin anchoring the stem cells to the niche. J. Biol. Chem. 279 50069-77 PubMed GONUTS page
↑ Suliman, Y et al. (2001) p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice. Cancer Res. 61 6467-73 PubMed GONUTS page
↑ Kulesz-Martin, M et al. (2005) Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. J. Investig. Dermatol. Symp. Proc. 10 142-52 PubMed GONUTS page
↑ ^38.0 ^38.1 ^38.2 ^38.3 Deutsch, GB et al. (2011) DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer. Cell 144 566-76 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 ^39.3 ^39.4 ^39.5 ^39.6 ^39.7 Candi, E et al. (2006) Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Cell Death Differ. 13 1037-47 PubMed GONUTS page
↑ Candi, E et al. (2006) p63 is upstream of IKK alpha in epidermal development. J. Cell. Sci. 119 4617-22 PubMed GONUTS page
↑ King, KE et al. (2003) deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes. Oncogene 22 3635-44 PubMed GONUTS page
↑ ^42.0 ^42.1 ^42.2 ^42.3 Nguyen, BC et al. (2006) Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev. 20 1028-42 PubMed GONUTS page
↑ Chae, YS et al. (2012) Cell density-dependent acetylation of ΔNp63α is associated with p53-dependent cell cycle arrest. FEBS Lett. 586 1128-34 PubMed GONUTS page
↑ ^44.0 ^44.1 Maisse, C et al. (2003) p73 and p63 protein stability: the way to regulate function? Biochem. Pharmacol. 66 1555-61 PubMed GONUTS page

[PMID:22035303-1] Yoshii, S et al. (2011) The analysis of the expression of a novel gene, Xenopus polka dots, which was expressed in the embryonic and larval epidermis during early development. Zool. Sci. 28 809-16 PubMed GONUTS page

[PMID:25655704-2] 2.0 ^2.1 Lindley, LE et al. (2015) The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage. Development 142 893-904 PubMed GONUTS page

[PMID:24075906-3] 3.0 ^3.1 ^3.2 Lee, S et al. (2013) Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells. Dev. Biol. 383 201-13 PubMed GONUTS page

[PMID:9774969-4] 4.0 ^4.1 Yang, A et al. (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2 305-16 PubMed GONUTS page

[PMID:21127502-5] 5.0 ^5.1 ^5.2 Shalom-Feuerstein, R et al. (2011) ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ. 18 887-96 PubMed GONUTS page

[PMID:25503409-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 Suzuki, D et al. (2015) The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells. Development 142 282-90 PubMed GONUTS page

[PMID:15371309-7] 7.0 ^7.1 Kurita, T et al. (2004) Role of p63 and basal cells in the prostate. Development 131 4955-64 PubMed GONUTS page

[PMID:11106548-8] 8.0 ^8.1 ^8.2 ^8.3 Signoretti, S et al. (2000) p63 is a prostate basal cell marker and is required for prostate development. Am. J. Pathol. 157 1769-75 PubMed GONUTS page

[PMID:12368184-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Ince, TA et al. (2002) p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract. Am. J. Pathol. 161 1111-7 PubMed GONUTS page

[PMID:16337913-10] 10.0 ^10.1 Jacobs, WB et al. (2005) p63 is an essential proapoptotic protein during neural development. Neuron 48 743-56 PubMed GONUTS page

[PMID:17878916-11] 11.0 ^11.1 Suzuki, K et al. (2008) Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4. Eur. J. Hum. Genet. 16 36-44 PubMed GONUTS page

[PMID:18326838-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Lo Iacono, N et al. (2008) Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects. Development 135 1377-88 PubMed GONUTS page

[PMID:18256694-13] 13.0 ^13.1 Antonini, D et al. (2008) Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63. J. Invest. Dermatol. 128 1676-85 PubMed GONUTS page

[PMID:15982302-14] Osada, M et al. (2005) p63-specific activation of the BPAG-1e promoter. J. Invest. Dermatol. 125 52-60 PubMed GONUTS page

[PMID:23906066-15] 15.0 ^15.1 Günschmann, C et al. (2013) Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev. Cell 26 176-87 PubMed GONUTS page

[PMID:21930775-16] 16.0 ^16.1 ^16.2 Fessing, MY et al. (2011) p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J. Cell Biol. 194 825-39 PubMed GONUTS page

[PMID:21285247-17] 17.0 ^17.1 Jheon, AH et al. (2011) PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J. Cell. Sci. 124 745-54 PubMed GONUTS page

[PMID:22274697-18] 18.0 ^18.1 ^18.2 Romano, RA et al. (2012) ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development 139 772-82 PubMed GONUTS page

[PMID:17041603-19] Richardson, RJ et al. (2006) Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat. Genet. 38 1329-34 PubMed GONUTS page

[PMID:18159078-20] 20.0 ^20.1 Livera, G et al. (2008) p63 null mutation protects mouse oocytes from radio-induced apoptosis. Reproduction 135 3-12 PubMed GONUTS page

[PMID:17122775-21] 21.0 ^21.1 Suh, EK et al. (2006) p63 protects the female germ line during meiotic arrest. Nature 444 624-8 PubMed GONUTS page

[PMID:16524929-22] 22.0 ^22.1 ^22.2 Laurikkala, J et al. (2006) p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development 133 1553-63 PubMed GONUTS page

[PMID:16410075-23] 23.0 ^23.1 Rufini, A et al. (2006) p63 protein is essential for the embryonic development of vibrissae and teeth. Biochem. Biophys. Res. Commun. 340 737-41 PubMed GONUTS page

[PMID:15189821-24] 24.0 ^24.1 Daniely, Y et al. (2004) Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am. J. Physiol., Cell Physiol. 287 C171-81 PubMed GONUTS page

[PMID:10227293-25] 25.0 ^25.1 ^25.2 ^25.3 Mills, AA et al. (1999) p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398 708-13 PubMed GONUTS page

[PMID:14729569-26] 26.0 ^26.1 ^26.2 Koster, MI et al. (2004) p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 18 126-31 PubMed GONUTS page

[PMID:16107615-27] 27.0 ^27.1 Keyes, WM et al. (2005) p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev. 19 1986-99 PubMed GONUTS page

[PMID:10227294-28] 28.0 ^28.1 ^28.2 ^28.3 Yang, A et al. (1999) p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398 714-8 PubMed GONUTS page

[PMID:23608756-29] Simons, AL et al. (2013) The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation. Lab. Invest. 93 711-9 PubMed GONUTS page

[PMID:17522155-30] Que, J et al. (2007) Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development 134 2521-31 PubMed GONUTS page

[PMID:17383628-31] Danielian, PS et al. (2007) E2f4 is required for normal development of the airway epithelium. Dev. Biol. 305 564-76 PubMed GONUTS page

[PMID:16466397-32] Birger, Y et al. (2006) A role for chromosomal protein HMGN1 in corneal maturation. Differentiation 74 19-29 PubMed GONUTS page

[PMID:16080917-33] Ramaesh, T et al. (2005) Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/- mouse model of aniridia. Exp. Eye Res. 81 224-35 PubMed GONUTS page

[PMID:15585950-34] Nakamuta, N & Kobayashi, S (2004) Expression of p63 in the mouse primordial germ cells. J. Vet. Med. Sci. 66 1365-70 PubMed GONUTS page

[PMID:15361520-35] Kurata, S et al. (2004) p51/p63 Controls subunit alpha3 of the major epidermis integrin anchoring the stem cells to the niche. J. Biol. Chem. 279 50069-77 PubMed GONUTS page

[PMID:11522642-36] Suliman, Y et al. (2001) p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice. Cancer Res. 61 6467-73 PubMed GONUTS page

[PMID:16363065-37] Kulesz-Martin, M et al. (2005) Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. J. Investig. Dermatol. Symp. Proc. 10 142-52 PubMed GONUTS page

[PMID:21335238-38] 38.0 ^38.1 ^38.2 ^38.3 Deutsch, GB et al. (2011) DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer. Cell 144 566-76 PubMed GONUTS page

[PMID:16601749-39] 39.0 ^39.1 ^39.2 ^39.3 ^39.4 ^39.5 ^39.6 ^39.7 Candi, E et al. (2006) Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Cell Death Differ. 13 1037-47 PubMed GONUTS page

[PMID:17093266-40] Candi, E et al. (2006) p63 is upstream of IKK alpha in epidermal development. J. Cell. Sci. 119 4617-22 PubMed GONUTS page

[PMID:12789272-41] King, KE et al. (2003) deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes. Oncogene 22 3635-44 PubMed GONUTS page

[PMID:16618808-42] 42.0 ^42.1 ^42.2 ^42.3 Nguyen, BC et al. (2006) Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev. 20 1028-42 PubMed GONUTS page

[PMID:22575646-43] Chae, YS et al. (2012) Cell density-dependent acetylation of ΔNp63α is associated with p53-dependent cell cycle arrest. FEBS Lett. 586 1128-34 PubMed GONUTS page

[PMID:14555234-44] 44.0 ^44.1 Maisse, C et al. (2003) p73 and p63 protein stability: the way to regulate function? Biochem. Pharmacol. 66 1555-61 PubMed GONUTS page

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