MOUSE:MLH1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mlh1
Protein Name(s)	DNA mismatch repair protein Mlh1 MutL protein homolog 1
External Links
UniProt	Q9JK91
EMBL	AF250844 AK168849 U60872 U59881 U59882 U59883 U59884
CCDS	CCDS40784.1
RefSeq	NP_081086.2
UniGene	Mm.486383
ProteinModelPortal	Q9JK91
SMR	Q9JK91
STRING	10090.ENSMUSP00000035079
PhosphoSite	Q9JK91
MaxQB	Q9JK91
PaxDb	Q9JK91
PRIDE	Q9JK91
Ensembl	ENSMUST00000035079
GeneID	17350
KEGG	mmu:17350
UCSC	uc009rvp.2
CTD	4292
MGI	MGI:101938
eggNOG	COG0323
GeneTree	ENSGT00550000074923
HOGENOM	HOG000176000
HOVERGEN	HBG006374
InParanoid	Q9JK91
KO	K08734
OMA	MVRTDCR
OrthoDB	EOG7MSMNH
TreeFam	TF300493
Reactome	REACT_198629 REACT_240368 REACT_246095 REACT_27235
NextBio	291948
PRO	PR:Q9JK91
Proteomes	UP000000589
Bgee	Q9JK91
CleanEx	MM_MLH1
ExpressionAtlas	Q9JK91
Genevestigator	Q9JK91
GO	GO:0005712 GO:0005694 GO:0000793 GO:0000794 GO:0001673 GO:0016020 GO:0032389 GO:0005654 GO:0000795 GO:0005524 GO:0016887 GO:0032137 GO:0003697 GO:0043566 GO:0006200 GO:0006974 GO:0006281 GO:0006303 GO:0008630 GO:0045190 GO:0007140 GO:0007060 GO:0045132 GO:0043060 GO:0007126 GO:0051257 GO:0006298 GO:0045950 GO:0000289 GO:0048477 GO:0007131 GO:0000712 GO:0016446 GO:0016447 GO:0002204 GO:0007283 GO:0007129
Gene3D	3.30.230.10 3.30.565.10
InterPro	IPR013507 IPR014762 IPR002099 IPR011186 IPR003594 IPR020568 IPR014721
PANTHER	PTHR10073:SF12
Pfam	PF01119
SMART	SM00387
SUPFAM	SSF54211 SSF55874
TIGRFAMs	TIGR00585
PROSITE	PS00058

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0048298	positive regulation of isotype switching to IgA isotypes	PMID:10430621^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002106) occurs_in:(CL:0000236)	Seeded From UniProt	complete
involved_in	GO:0048304	positive regulation of isotype switching to IgG isotypes	PMID:10430621^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002106) occurs_in:(CL:0000236)	Seeded From UniProt	complete
part_of	GO:0032389	MutLalpha complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101938 PANTHER:PTN000008164 SGD:S000004777	C		Seeded From UniProt	complete
part_of	GO:0032300	mismatch repair complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11281 MGI:MGI:1353455 PANTHER:PTN000008161	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11281 PANTHER:PTN000008161 SGD:S000004777 SGD:S000005026 UniProtKB:Q8IIJ0	F		Seeded From UniProt	complete
involved_in	GO:0016446	somatic hypermutation of immunoglobulin genes	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101938 PANTHER:PTN000008172	P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11281 MGI:MGI:101938 MGI:MGI:104288 MGI:MGI:1202302 MGI:MGI:1353455 PANTHER:PTN000008161 PomBase:SPAC19G12.02c SGD:S000004025 SGD:S000004777 SGD:S000005026 SGD:S000006085 TAIR:locus:2133274 UniProtKB:P40692 UniProtKB:P54278	P		Seeded From UniProt	complete
part_of	GO:0005712	chiasma	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101938 PANTHER:PTN000008164	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051321	meiotic cell cycle	PMID:12091911^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051257	meiotic spindle midzone assembly	PMID:10385520^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048477	oogenesis	PMID:8674118^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045950	negative regulation of mitotic recombination	PMID:15480418^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045190	isotype switching	PMID:12743174^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045143	homologous chromosome segregation	PMID:25533956^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000023)\|occurs_in:(CL:0000017)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045141	meiotic telomere clustering	PMID:17010969^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045132	meiotic chromosome segregation	PMID:12217320^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043060	meiotic metaphase I plate congression	PMID:10385520^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
contributes_to	GO:0032407	MutSalpha complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40692	F		Seeded From UniProt	complete
part_of	GO:0032389	MutLalpha complex	PMID:22164254^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000023)	Seeded From UniProt	complete
part_of	GO:0032389	MutLalpha complex	PMID:16713580^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0032137	guanine/thymine mispair binding	PMID:16713580^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00497	F		Seeded From UniProt	complete
enables	GO:0032137	guanine/thymine mispair binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00497	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40692	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016447	somatic recombination of immunoglobulin gene segments	PMID:11828012^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P	occurs_in:(EMAPA:18767) occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016446	somatic hypermutation of immunoglobulin genes	PMID:10429667^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016446	somatic hypermutation of immunoglobulin genes	PMID:10092760^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016321	female meiosis chromosome segregation	PMID:25533956^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	PMID:23012479^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:14562041^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:8674118^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:12217320^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007140	male meiotic nuclear division	PMID:15467367^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P	occurs_in:(CL:0000017)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007131	reciprocal meiotic recombination	PMID:8673133^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007131	reciprocal meiotic recombination	PMID:16307920^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007131	reciprocal meiotic recombination	PMID:10385520^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007129	synapsis	PMID:8674118^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858054	P	occurs_in:(CL:0000017)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007060	male meiosis chromosome segregation	PMID:8673133^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007060	male meiosis chromosome segregation	PMID:25533956^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:9560238^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96977	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:10657972^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96977	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:16204034^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:14562041^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:15084308^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:9560238^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930998	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:9500552^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:8674118^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:16728433^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:16204034^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:11313994^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:10851078^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:10657972^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930998	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:10429667^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:10359802^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:10096563^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:10747038^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:23603115^[32]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:11555625^[33]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00497	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006281	DNA repair	PMID:15480418^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006281	DNA repair	PMID:13679151^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930998	P		Seeded From UniProt	complete
part_of	GO:0005715	late recombination nodule	PMID:27760146^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005712	chiasma	PMID:21743440^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0005712	chiasma	PMID:17696610^[37]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0005712	chiasma	PMID:17291760^[38]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000656)	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:11934988^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40692	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40692	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620937	C		Seeded From UniProt	complete
contributes_to	GO:0003697	single-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40692	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:14716311^[40]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40692	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002204	somatic recombination of immunoglobulin genes involved in immune response	PMID:12743174^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101816	P		Seeded From UniProt	complete
part_of	GO:0001673	male germ cell nucleus	PMID:17696610^[37]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000795	synaptonemal complex	PMID:16260499^[41]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17972) part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000795	synaptonemal complex	PMID:15467367^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000795	synaptonemal complex	PMID:16968740^[42]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97679	C		Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:24891606^[43]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:23555294^[44]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:18316482^[45]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	PMID:8673133^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	C		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	PMID:12913077^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	PMID:12091911^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000712	resolution of meiotic recombination intermediates	PMID:12217320^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000712	resolution of meiotic recombination intermediates	PMID:10385520^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	PMID:11337385^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857946	P		Seeded From UniProt	complete
enables	GO:0032407	MutSalpha complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40692 ensembl:ENSP00000231790	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40692 ensembl:ENSP00000231790	F		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40692 ensembl:ENSP00000231790	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40692 ensembl:ENSP00000231790	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40692 ensembl:ENSP00000231790	C		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40692 ensembl:ENSP00000231790	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40692 ensembl:ENSP00000231790	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002099 InterPro:IPR013507	F		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002099 InterPro:IPR011186 InterPro:IPR013507 InterPro:IPR038973	P		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038973	F		Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002099 InterPro:IPR013507	F		Seeded From UniProt	complete
part_of	GO:0032300	mismatch repair complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011186 InterPro:IPR038973	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-912487	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051321	meiotic cell cycle	PMID:10809667^[48]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Schrader, CE et al. (1999) Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J. Exp. Med. 190 323-30 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Lipkin, SM et al. (2002) Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat. Genet. 31 385-90 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Woods, LM et al. (1999) Chromosomal influence on meiotic spindle assembly: abnormal meiosis I in female Mlh1 mutant mice. J. Cell Biol. 145 1395-406 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Edelmann, W et al. (1996) Meiotic pachytene arrest in MLH1-deficient mice. Cell 85 1125-34 PubMed GONUTS page
↑ ^6.0 ^6.1 Shao, C et al. (2004) Mlh1 mediates tissue-specific regulation of mitotic recombination. Oncogene 23 9017-24 PubMed GONUTS page
↑ ^7.0 ^7.1 Schrader, CE et al. (2003) Mlh1 can function in antibody class switch recombination independently of Msh2. J. Exp. Med. 197 1377-83 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Kim, J et al. (2015) Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Nature 517 466-71 PubMed GONUTS page
↑ Liebe, B et al. (2006) Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Exp. Cell Res. 312 3768-81 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Eaker, S et al. (2002) Meiotic prophase abnormalities and metaphase cell death in MLH1-deficient mouse spermatocytes: insights into regulation of spermatogenic progress. Dev. Biol. 249 85-95 PubMed GONUTS page
↑ Kouznetsova, A et al. (2011) Meiosis in mice without a synaptonemal complex. PLoS ONE 6 e28255 PubMed GONUTS page
↑ ^12.0 ^12.1 Yoshioka, K et al. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 22 501-10 PubMed GONUTS page
↑ Schrader, CE et al. (2002) Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. J. Exp. Med. 195 367-73 PubMed GONUTS page
↑ ^14.0 ^14.1 Kim, N et al. (1999) Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications. J. Exp. Med. 190 21-30 PubMed GONUTS page
↑ Phung, QH et al. (1999) Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein. J. Immunol. 162 3121-4 PubMed GONUTS page
↑ Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page
↑ ^17.0 ^17.1 Sansom, OJ et al. (2003) MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene 22 7130-6 PubMed GONUTS page
↑ ^18.0 ^18.1 Kolas, NK & Cohen, PE (2004) Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination. Cytogenet. Genome Res. 107 216-31 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Baker, SM et al. (1996) Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat. Genet. 13 336-42 PubMed GONUTS page
↑ Guillon, H et al. (2005) Crossover and noncrossover pathways in mouse meiosis. Mol. Cell 20 563-73 PubMed GONUTS page
↑ ^21.0 ^21.1 Kawate, H et al. (1998) Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes. Proc. Natl. Acad. Sci. U.S.A. 95 5116-20 PubMed GONUTS page
↑ ^22.0 ^22.1 Kawate, H et al. (2000) A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice. Carcinogenesis 21 301-5 PubMed GONUTS page
↑ ^23.0 ^23.1 Chen, PC et al. (2005) Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Cancer Res. 65 8662-70 PubMed GONUTS page
↑ Bannister, LA et al. (2004) Modulation of error-prone double-strand break repair in mammalian chromosomes by DNA mismatch repair protein Mlh1. DNA Repair (Amst.) 3 465-74 PubMed GONUTS page
↑ Prolla, TA et al. (1998) Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat. Genet. 18 276-9 PubMed GONUTS page
↑ Hegan, DC et al. (2006) Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Carcinogenesis 27 2402-8 PubMed GONUTS page
↑ Baross-Francis, A et al. (2001) Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells. Oncogene 20 619-25 PubMed GONUTS page
↑ Shoemaker, AR et al. (2000) Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice. Oncogene 19 2774-9 PubMed GONUTS page
↑ Yao, X et al. (1999) Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 96 6850-5 PubMed GONUTS page
↑ Edelmann, W et al. (1999) Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice. Cancer Res. 59 1301-7 PubMed GONUTS page
↑ Oda, S et al. (2000) Efficient repair of A/C mismatches in mouse cells deficient in long-patch mismatch repair. EMBO J. 19 1711-8 PubMed GONUTS page
↑ Ghodgaonkar, MM et al. (2013) Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol. Cell 50 323-32 PubMed GONUTS page
↑ Ellison, AR et al. (2001) Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae. Hum. Mol. Genet. 10 1889-900 PubMed GONUTS page
↑ Takagi, Y et al. (2003) Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. DNA Repair (Amst.) 2 1135-46 PubMed GONUTS page
↑ Finsterbusch, F et al. (2016) Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein. PLoS Genet. 12 e1006393 PubMed GONUTS page
↑ Herrán, Y et al. (2011) The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility. EMBO J. 30 3091-105 PubMed GONUTS page
↑ ^37.0 ^37.1 Li, XC et al. (2007) Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS Genet. 3 e130 PubMed GONUTS page
↑ Cherry, SM et al. (2007) The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr. Biol. 17 373-8 PubMed GONUTS page
↑ Celeste, A et al. (2002) Genomic instability in mice lacking histone H2AX. Science 296 922-7 PubMed GONUTS page
↑ Bardwell, PD et al. (2004) Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nat. Immunol. 5 224-9 PubMed GONUTS page
↑ Kolas, NK et al. (2005) Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. J. Cell Biol. 171 447-58 PubMed GONUTS page
↑ Hamer, G et al. (2006) Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex. J. Cell. Sci. 119 4025-32 PubMed GONUTS page
↑ Holloway, JK et al. (2014) Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. J. Cell Biol. 205 633-41 PubMed GONUTS page
↑ Guiraldelli, MF et al. (2013) Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. PLoS Genet. 9 e1003383 PubMed GONUTS page
↑ Yang, F et al. (2008) Meiotic failure in male mice lacking an X-linked factor. Genes Dev. 22 682-91 PubMed GONUTS page
↑ Wong, JC et al. (2003) Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum. Mol. Genet. 12 2063-76 PubMed GONUTS page
↑ Blake, C et al. (2001) Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers. Am. J. Pathol. 158 1867-70 PubMed GONUTS page
↑ Kneitz, B et al. (2000) MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev. 14 1085-97 PubMed GONUTS page

[PMID:10430621-1] 1.0 ^1.1 Schrader, CE et al. (1999) Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J. Exp. Med. 190 323-30 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12091911-3] 3.0 ^3.1 Lipkin, SM et al. (2002) Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat. Genet. 31 385-90 PubMed GONUTS page

[PMID:10385520-4] 4.0 ^4.1 ^4.2 ^4.3 Woods, LM et al. (1999) Chromosomal influence on meiotic spindle assembly: abnormal meiosis I in female Mlh1 mutant mice. J. Cell Biol. 145 1395-406 PubMed GONUTS page

[PMID:8674118-5] 5.0 ^5.1 ^5.2 ^5.3 Edelmann, W et al. (1996) Meiotic pachytene arrest in MLH1-deficient mice. Cell 85 1125-34 PubMed GONUTS page

[PMID:15480418-6] 6.0 ^6.1 Shao, C et al. (2004) Mlh1 mediates tissue-specific regulation of mitotic recombination. Oncogene 23 9017-24 PubMed GONUTS page

[PMID:12743174-7] 7.0 ^7.1 Schrader, CE et al. (2003) Mlh1 can function in antibody class switch recombination independently of Msh2. J. Exp. Med. 197 1377-83 PubMed GONUTS page

[PMID:25533956-8] 8.0 ^8.1 ^8.2 Kim, J et al. (2015) Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Nature 517 466-71 PubMed GONUTS page

[PMID:17010969-9] Liebe, B et al. (2006) Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Exp. Cell Res. 312 3768-81 PubMed GONUTS page

[PMID:12217320-10] 10.0 ^10.1 ^10.2 Eaker, S et al. (2002) Meiotic prophase abnormalities and metaphase cell death in MLH1-deficient mouse spermatocytes: insights into regulation of spermatogenic progress. Dev. Biol. 249 85-95 PubMed GONUTS page

[PMID:22164254-11] Kouznetsova, A et al. (2011) Meiosis in mice without a synaptonemal complex. PLoS ONE 6 e28255 PubMed GONUTS page

[PMID:16713580-12] 12.0 ^12.1 Yoshioka, K et al. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 22 501-10 PubMed GONUTS page

[PMID:11828012-13] Schrader, CE et al. (2002) Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. J. Exp. Med. 195 367-73 PubMed GONUTS page

[PMID:10429667-14] 14.0 ^14.1 Kim, N et al. (1999) Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications. J. Exp. Med. 190 21-30 PubMed GONUTS page

[PMID:10092760-15] Phung, QH et al. (1999) Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein. J. Immunol. 162 3121-4 PubMed GONUTS page

[PMID:23012479-16] Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page

[PMID:14562041-17] 17.0 ^17.1 Sansom, OJ et al. (2003) MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene 22 7130-6 PubMed GONUTS page

[PMID:15467367-18] 18.0 ^18.1 Kolas, NK & Cohen, PE (2004) Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination. Cytogenet. Genome Res. 107 216-31 PubMed GONUTS page

[PMID:8673133-19] 19.0 ^19.1 ^19.2 Baker, SM et al. (1996) Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat. Genet. 13 336-42 PubMed GONUTS page

[PMID:16307920-20] Guillon, H et al. (2005) Crossover and noncrossover pathways in mouse meiosis. Mol. Cell 20 563-73 PubMed GONUTS page

[PMID:9560238-21] 21.0 ^21.1 Kawate, H et al. (1998) Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes. Proc. Natl. Acad. Sci. U.S.A. 95 5116-20 PubMed GONUTS page

[PMID:10657972-22] 22.0 ^22.1 Kawate, H et al. (2000) A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice. Carcinogenesis 21 301-5 PubMed GONUTS page

[PMID:16204034-23] 23.0 ^23.1 Chen, PC et al. (2005) Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Cancer Res. 65 8662-70 PubMed GONUTS page

[PMID:15084308-24] Bannister, LA et al. (2004) Modulation of error-prone double-strand break repair in mammalian chromosomes by DNA mismatch repair protein Mlh1. DNA Repair (Amst.) 3 465-74 PubMed GONUTS page

[PMID:9500552-25] Prolla, TA et al. (1998) Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat. Genet. 18 276-9 PubMed GONUTS page

[PMID:16728433-26] Hegan, DC et al. (2006) Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Carcinogenesis 27 2402-8 PubMed GONUTS page

[PMID:11313994-27] Baross-Francis, A et al. (2001) Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells. Oncogene 20 619-25 PubMed GONUTS page

[PMID:10851078-28] Shoemaker, AR et al. (2000) Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice. Oncogene 19 2774-9 PubMed GONUTS page

[PMID:10359802-29] Yao, X et al. (1999) Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 96 6850-5 PubMed GONUTS page

[PMID:10096563-30] Edelmann, W et al. (1999) Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice. Cancer Res. 59 1301-7 PubMed GONUTS page

[PMID:10747038-31] Oda, S et al. (2000) Efficient repair of A/C mismatches in mouse cells deficient in long-patch mismatch repair. EMBO J. 19 1711-8 PubMed GONUTS page

[PMID:23603115-32] Ghodgaonkar, MM et al. (2013) Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol. Cell 50 323-32 PubMed GONUTS page

[PMID:11555625-33] Ellison, AR et al. (2001) Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae. Hum. Mol. Genet. 10 1889-900 PubMed GONUTS page

[PMID:13679151-34] Takagi, Y et al. (2003) Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. DNA Repair (Amst.) 2 1135-46 PubMed GONUTS page

[PMID:27760146-35] Finsterbusch, F et al. (2016) Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein. PLoS Genet. 12 e1006393 PubMed GONUTS page

[PMID:21743440-36] Herrán, Y et al. (2011) The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility. EMBO J. 30 3091-105 PubMed GONUTS page

[PMID:17696610-37] 37.0 ^37.1 Li, XC et al. (2007) Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS Genet. 3 e130 PubMed GONUTS page

[PMID:17291760-38] Cherry, SM et al. (2007) The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr. Biol. 17 373-8 PubMed GONUTS page

[PMID:11934988-39] Celeste, A et al. (2002) Genomic instability in mice lacking histone H2AX. Science 296 922-7 PubMed GONUTS page

[PMID:14716311-40] Bardwell, PD et al. (2004) Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nat. Immunol. 5 224-9 PubMed GONUTS page

[PMID:16260499-41] Kolas, NK et al. (2005) Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. J. Cell Biol. 171 447-58 PubMed GONUTS page

[PMID:16968740-42] Hamer, G et al. (2006) Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex. J. Cell. Sci. 119 4025-32 PubMed GONUTS page

[PMID:24891606-43] Holloway, JK et al. (2014) Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. J. Cell Biol. 205 633-41 PubMed GONUTS page

[PMID:23555294-44] Guiraldelli, MF et al. (2013) Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. PLoS Genet. 9 e1003383 PubMed GONUTS page

[PMID:18316482-45] Yang, F et al. (2008) Meiotic failure in male mice lacking an X-linked factor. Genes Dev. 22 682-91 PubMed GONUTS page

[PMID:12913077-46] Wong, JC et al. (2003) Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum. Mol. Genet. 12 2063-76 PubMed GONUTS page

[PMID:11337385-47] Blake, C et al. (2001) Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers. Am. J. Pathol. 158 1867-70 PubMed GONUTS page

[PMID:10809667-48] Kneitz, B et al. (2000) MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev. 14 1085-97 PubMed GONUTS page

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[17]

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[28]

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[34]

[35]

[36]

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