MOUSE:KSYK

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Syk (synonyms: ptk72, Sykb)
Protein Name(s)	Tyrosine-protein kinase SYK Spleen tyrosine kinase
External Links
UniProt	P48025
EMBL	U25685 Z49877 U36776
CCDS	CCDS26517.1
PIR	I48781
RefSeq	NP_001185906.1 NP_035648.2 XP_006516958.1
UniGene	Mm.375031
PDB	2LCT 2MC1
PDBsum	2LCT 2MC1
ProteinModelPortal	P48025
SMR	P48025
BioGrid	203599
DIP	DIP-32621N
IntAct	P48025
MINT	MINT-1209968
PhosphoSite	P48025
MaxQB	P48025
PaxDb	P48025
PRIDE	P48025
Ensembl	ENSMUST00000055087 ENSMUST00000120135
GeneID	20963
KEGG	mmu:20963
UCSC	uc007qmz.1
CTD	6850
MGI	MGI:99515
eggNOG	COG0515
HOGENOM	HOG000113264
HOVERGEN	HBG001540
InParanoid	P48025
KO	K05855
OMA	KGYYQMK
OrthoDB	EOG7MWGWD
PhylomeDB	P48025
TreeFam	TF351629
BRENDA	2.7.10.2
Reactome	REACT_188185 REACT_188194 REACT_188202 REACT_188204 REACT_188530 REACT_196487 REACT_198374 REACT_210240 REACT_213364 REACT_220092 REACT_246176 REACT_261365
ChiTaRS	Syk
NextBio	299918
PRO	PR:P48025
Proteomes	UP000000589
Bgee	P48025
CleanEx	MM_SYK
ExpressionAtlas	P48025
Genevestigator	P48025
GO	GO:0019815 GO:0005737 GO:0005829 GO:0032009 GO:0005634 GO:0043234 GO:0042101 GO:0005524 GO:0004715 GO:0019901 GO:0004674 GO:0004713 GO:0004716 GO:0007257 GO:0000187 GO:0002250 GO:0001525 GO:0050853 GO:0043366 GO:0048514 GO:0007166 GO:0071226 GO:0042742 GO:0007167 GO:0007186 GO:0045087 GO:0007229 GO:0035556 GO:0002366 GO:0007159 GO:0019370 GO:0001945 GO:0002281 GO:0002283 GO:0030593 GO:0018105 GO:0018108 GO:0046638 GO:0046641 GO:0045579 GO:0045780 GO:0050850 GO:0033630 GO:0050715 GO:0045588 GO:0045425 GO:0045401 GO:0043306 GO:0050731 GO:0046777 GO:0006468 GO:0090237 GO:0070372 GO:0043313 GO:0050764 GO:0010543 GO:0090330 GO:0051090 GO:0032928 GO:0001820 GO:0002554 GO:0042991
Gene3D	1.10.930.10 3.30.505.10
InterPro	IPR011009 IPR023420 IPR000719 IPR017441 IPR001245 IPR000980 IPR008266 IPR020635 IPR012234
Pfam	PF07714 PF00017
PIRSF	PIRSF000604
PRINTS	PR00401 PR00109
SMART	SM00252 SM00219
SUPFAM	SSF55550 SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016310	phosphorylation	PMID:7513017^[1]	ECO:0000314			P		Figure 1-Lyn dependent phosphorylation increases autophosphorylation activity of Syk through BCR stimulation	complete CACAO 6530
	GO:1900180	regulation of protein localization to nucleus	PMID:23071339^[2]	ECO:0000314			P		Figure 3 shows Wild Type vs. Mutant IK (Ikaros)proteins. In contrast to wild-type IK, SYK-resistant IK protein M1-1 carrying A-mutations at both SYK phosphorylation sites showed no detectable nuclear localization when overexpressed in 293T cells	complete CACAO 7847
	GO:0002092	positive regulation of receptor internalization	PMID:23962979^[3]	ECO:0000315			P		Fig. 1.E and 1.D Internalization of TLR4 by LPS mediated endocytosis via CD14 amounts was increased in presence of Syk compared to mutant.	complete CACAO 8570
	GO:0032728	positive regulation of interferon-beta production	PMID:22078883^[4]	ECO:0000314			P		Figure 6 E graph 3 shows that when Syk ( Tyrosine kinase) is inhibited by Piceatannol there is a decrease in the production of IFN B in macrophages.	complete CACAO 9487
	GO:0032481	positive regulation of type I interferon production	PMID:22078883^[4]	ECO:0000315			P		Figure 6E shows inhibition of Syk results in decreased IFN-alpha production.	complete CACAO 9488
	GO:0002092	positive regulation of receptor internalization	PMID:22078883^[4]	ECO:0000315			P		Figure 6 E graph 1 shows that when piceatannol is used to inhibit syk, there is a decrease in the amount of TLR4 internalized showing that syk increases the amount of TLR4 internalization.	complete CACAO 9489
involved_in	GO:0038156	interleukin-3-mediated signaling pathway	PMID:19098920^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	PMID:19098920^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:29235464^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035325	Toll-like receptor binding	PMID:22496641^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9QUK6	F		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	PMID:22496641^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29351	F		Seeded From UniProt	complete
involved_in	GO:0071404	cellular response to low-density lipoprotein particle stimulus	PMID:23395392^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:23395392^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	PMID:23962979^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	PMID:22078883^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:22078883^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090330	regulation of platelet aggregation	PMID:9171347^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090237	regulation of arachidonic acid secretion	PMID:9171347^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071226	cellular response to molecule of fungal origin	PMID:15845454^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070372	regulation of ERK1 and ERK2 cascade	PMID:19797524^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050764	regulation of phagocytosis	PMID:19797524^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	PMID:12522250^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045780	positive regulation of bone resorption	PMID:17353363^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:15845454^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043313	regulation of neutrophil degranulation	PMID:19797524^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:19797524^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	PMID:11940607^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032928	regulation of superoxide anion generation	PMID:19797524^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032009	early phagosome	PMID:15845454^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43405	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:11672534^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14234	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:16456001^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010543	regulation of platelet activation	PMID:9171347^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:17086186^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:11940607^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007159	leukocyte cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43405	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1N9Y5	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:16456001^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002554	serotonin secretion by platelet	PMID:9171347^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002366	leukocyte activation involved in immune response	PMID:15845454^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002283	neutrophil activation involved in immune response	PMID:17086186^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002281	macrophage activation involved in immune response	PMID:17086186^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1N9Y5	P		Seeded From UniProt	complete
involved_in	GO:0001945	lymph vessel development	PMID:12522250^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090330	regulation of platelet aggregation	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479 UniProtKB:F1N9Y5	P		Seeded From UniProt	complete
involved_in	GO:0046641	positive regulation of alpha-beta T cell proliferation	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P		Seeded From UniProt	complete
involved_in	GO:0045579	positive regulation of B cell differentiation	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479 UniProtKB:P43405	P		Seeded From UniProt	complete
involved_in	GO:0043306	positive regulation of mast cell degranulation	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479 RGD:3796	P		Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P		Seeded From UniProt	complete
involved_in	GO:0002283	neutrophil activation involved in immune response	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P		Seeded From UniProt	complete
involved_in	GO:0002281	macrophage activation involved in immune response	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700479 UniProtKB:F1N9Y5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051090	regulation of DNA-binding transcription factor activity	PMID:23071339^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050853	B cell receptor signaling pathway	PMID:8626447^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050853	B cell receptor signaling pathway	PMID:7499277^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050850	positive regulation of calcium-mediated signaling	PMID:9000133^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050776	regulation of immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:9000133^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050715	positive regulation of cytokine secretion	PMID:19770268^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2157947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	PMID:9099676^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	PMID:8798454^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	PMID:8626447^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3796	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046641	positive regulation of alpha-beta T cell proliferation	PMID:9275205^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046638	positive regulation of alpha-beta T cell differentiation	PMID:9275205^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045588	positive regulation of gamma-delta T cell differentiation	PMID:8790395^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857421	P	occurs_in:(EMAPA:32874) regulates_o_results_in_acquisition_of_features_of:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045588	positive regulation of gamma-delta T cell differentiation	PMID:7477352^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	occurs_in:(EMAPA:18768) regulates_o_results_in_acquisition_of_features_of:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045579	positive regulation of B cell differentiation	PMID:7477353^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857421	P	occurs_in:(EMAPA:32760) regulates_o_results_in_acquisition_of_features_of:(CL:0000236)\|occurs_in(EMAPA:18767) regulates_o_results_in_acquisition_of_features_of:(CL:0000236)\|occurs_in(EMAPA:16138) regulates_o_results_in_acquisition_of_features_of:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045579	positive regulation of B cell differentiation	PMID:7477352^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	occurs_in:(EMAPA:16846) regulates_o_results_in_acquisition_of_features_of:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045579	positive regulation of B cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process	PMID:9000133^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045401	positive regulation of interleukin-3 biosynthetic process	PMID:9000133^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043366	beta selection	PMID:9275205^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043306	positive regulation of mast cell degranulation	PMID:9000133^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043306	positive regulation of mast cell degranulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3796	P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	PMID:27609517^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0042101	T cell receptor complex	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	PMID:27609517^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	PMID:9000133^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	PMID:8626447^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:22451653^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23071339^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3796	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030593	neutrophil chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3796	F		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	PMID:27609517^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8BGG7	F	occurs_in:(CL:0000233)	Seeded From UniProt	complete
part_of	GO:0019815	B cell receptor complex	PMID:8626447^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019370	leukotriene biosynthetic process	PMID:9000133^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:9099676^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:8798454^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:7499277^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:10872802^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	PMID:23071339^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016170	interleukin-15 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007257	activation of JUN kinase activity	PMID:9000133^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007167	enzyme linked receptor protein signaling pathway	PMID:7744830^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007166	cell surface receptor signaling pathway	PMID:9000133^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007166	cell surface receptor signaling pathway	PMID:9099676^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007159	leukocyte cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	PMID:23071339^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23071339^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23071339^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:8798454^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:8626447^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:9099676^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:8798454^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:7744830^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:7499277^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000236)	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:27609517^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:10872802^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3796	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:23071339^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3796	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001820	serotonin secretion	PMID:9000133^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	occurs_in:(CL:0000097)	Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43405	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	PMID:9000133^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384078	P	occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	PMID:8626447^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007159	leukocyte cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	F		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	P		Seeded From UniProt	complete
involved_in	GO:0045579	positive regulation of B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	P		Seeded From UniProt	complete
part_of	GO:0042101	T cell receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	C		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	P		Seeded From UniProt	complete
enables	GO:0016170	interleukin-15 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	F		Seeded From UniProt	complete
involved_in	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43405 ensembl:ENSP00000364898	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012234 InterPro:IPR023420	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR012234 InterPro:IPR017441	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012234	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR012234 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012234	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-9607032 Reactome:R-MMU-5621346 Reactome:R-MMU-5607754 Reactome:R-MMU-442289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	PMID:11676469^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0206	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kurosaki, T et al. (1994) Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J. Exp. Med. 179 1725-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Uckun, FM et al. (2012) Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros. Proc. Natl. Acad. Sci. U.S.A. 109 18072-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Lin, YC et al. (2013) The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3. Sci Signal 6 ra71 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Zanoni, I et al. (2011) CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell 147 868-80 PubMed GONUTS page
↑ ^5.0 ^5.1 Hida, S et al. (2009) Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat. Immunol. 10 214-22 PubMed GONUTS page
↑ Knoll, M et al. (2017) SYK kinase mediates brown fat differentiation and activation. Nat Commun 8 2115 PubMed GONUTS page
↑ ^7.0 ^7.1 Lu, R et al. (2012) CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PLoS Pathog. 8 e1002597 PubMed GONUTS page
↑ ^8.0 ^8.1 Heit, B et al. (2013) Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev. Cell 24 372-83 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Poole, A et al. (1997) The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J. 16 2333-41 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Rogers, NC et al. (2005) Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22 507-17 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Van Ziffle, JA & Lowell, CA (2009) Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood 114 4871-82 PubMed GONUTS page
↑ ^12.0 ^12.1 Abtahian, F et al. (2003) Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299 247-51 PubMed GONUTS page
↑ Zou, W et al. (2007) Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J. Cell Biol. 176 877-88 PubMed GONUTS page
↑ ^14.0 ^14.1 Obergfell, A et al. (2002) Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J. Cell Biol. 157 265-75 PubMed GONUTS page
↑ Vines, CM et al. (2001) Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15 507-19 PubMed GONUTS page
↑ ^16.0 ^16.1 Yu, M et al. (2006) Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. J. Immunol. 176 2421-9 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Mócsai, A et al. (2006) Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat. Immunol. 7 1326-33 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 ^18.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Richards, JD et al. (1996) Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. J. Biol. Chem. 271 6458-66 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Katagiri, T et al. (1995) Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J. Biol. Chem. 270 27987-90 PubMed GONUTS page
↑ ^21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 Costello, PS et al. (1996) Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene 13 2595-605 PubMed GONUTS page
↑ Tanne, A et al. (2009) A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J. Exp. Med. 206 2205-20 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Keshvara, LM et al. (1997) Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130. J. Biol. Chem. 272 10377-81 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Latour, S et al. (1996) Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. J. Biol. Chem. 271 22782-90 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Cheng, AM et al. (1997) The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 94 9797-801 PubMed GONUTS page
↑ Mallick-Wood, CA et al. (1996) Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 93 9704-9 PubMed GONUTS page
↑ ^27.0 ^27.1 Turner, M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378 298-302 PubMed GONUTS page
↑ Cheng, AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378 303-6 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 Reppschläger, K et al. (2016) TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J. Biol. Chem. 291 22427-22441 PubMed GONUTS page
↑ Ishida-Kitagawa, N et al. (2012) Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12). J. Biol. Chem. 287 17493-502 PubMed GONUTS page
↑ ^31.0 ^31.1 Iseki, M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem. Biophys. Res. Commun. 272 45-54 PubMed GONUTS page
↑ ^32.0 ^32.1 Sillman, AL & Monroe, JG (1995) Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes. J. Biol. Chem. 270 11806-11 PubMed GONUTS page
↑ Yanagi, S et al. (2001) Syk expression and novel function in a wide variety of tissues. Biochem. Biophys. Res. Commun. 288 495-8 PubMed GONUTS page

[PMID:7513017-1] Kurosaki, T et al. (1994) Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J. Exp. Med. 179 1725-9 PubMed GONUTS page

[PMID:23071339-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Uckun, FM et al. (2012) Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros. Proc. Natl. Acad. Sci. U.S.A. 109 18072-7 PubMed GONUTS page

[PMID:23962979-3] 3.0 ^3.1 Lin, YC et al. (2013) The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3. Sci Signal 6 ra71 PubMed GONUTS page

[PMID:22078883-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Zanoni, I et al. (2011) CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell 147 868-80 PubMed GONUTS page

[PMID:19098920-5] 5.0 ^5.1 Hida, S et al. (2009) Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat. Immunol. 10 214-22 PubMed GONUTS page

[PMID:29235464-6] Knoll, M et al. (2017) SYK kinase mediates brown fat differentiation and activation. Nat Commun 8 2115 PubMed GONUTS page

[PMID:22496641-7] 7.0 ^7.1 Lu, R et al. (2012) CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PLoS Pathog. 8 e1002597 PubMed GONUTS page

[PMID:23395392-8] 8.0 ^8.1 Heit, B et al. (2013) Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev. Cell 24 372-83 PubMed GONUTS page

[PMID:9171347-9] 9.0 ^9.1 ^9.2 ^9.3 Poole, A et al. (1997) The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J. 16 2333-41 PubMed GONUTS page

[PMID:15845454-10] 10.0 ^10.1 ^10.2 ^10.3 Rogers, NC et al. (2005) Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22 507-17 PubMed GONUTS page

[PMID:19797524-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Van Ziffle, JA & Lowell, CA (2009) Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood 114 4871-82 PubMed GONUTS page

[PMID:12522250-12] 12.0 ^12.1 Abtahian, F et al. (2003) Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299 247-51 PubMed GONUTS page

[PMID:17353363-13] Zou, W et al. (2007) Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J. Cell Biol. 176 877-88 PubMed GONUTS page

[PMID:11940607-14] 14.0 ^14.1 Obergfell, A et al. (2002) Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J. Cell Biol. 157 265-75 PubMed GONUTS page

[PMID:11672534-15] Vines, CM et al. (2001) Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15 507-19 PubMed GONUTS page

[PMID:16456001-16] 16.0 ^16.1 Yu, M et al. (2006) Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. J. Immunol. 176 2421-9 PubMed GONUTS page

[PMID:17086186-17] 17.0 ^17.1 ^17.2 Mócsai, A et al. (2006) Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat. Immunol. 7 1326-33 PubMed GONUTS page

[PMID:21873635-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 ^18.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8626447-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Richards, JD et al. (1996) Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. J. Biol. Chem. 271 6458-66 PubMed GONUTS page

[PMID:7499277-20] 20.0 ^20.1 ^20.2 Katagiri, T et al. (1995) Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J. Biol. Chem. 270 27987-90 PubMed GONUTS page

[PMID:9000133-21] 21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 Costello, PS et al. (1996) Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene 13 2595-605 PubMed GONUTS page

[PMID:19770268-22] Tanne, A et al. (2009) A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J. Exp. Med. 206 2205-20 PubMed GONUTS page

[PMID:9099676-23] 23.0 ^23.1 ^23.2 ^23.3 Keshvara, LM et al. (1997) Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130. J. Biol. Chem. 272 10377-81 PubMed GONUTS page

[PMID:8798454-24] 24.0 ^24.1 ^24.2 ^24.3 Latour, S et al. (1996) Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. J. Biol. Chem. 271 22782-90 PubMed GONUTS page

[PMID:9275205-25] 25.0 ^25.1 ^25.2 Cheng, AM et al. (1997) The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 94 9797-801 PubMed GONUTS page

[PMID:8790395-26] Mallick-Wood, CA et al. (1996) Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 93 9704-9 PubMed GONUTS page

[PMID:7477352-27] 27.0 ^27.1 Turner, M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378 298-302 PubMed GONUTS page

[PMID:7477353-28] Cheng, AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378 303-6 PubMed GONUTS page

[PMID:27609517-29] 29.0 ^29.1 ^29.2 ^29.3 Reppschläger, K et al. (2016) TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J. Biol. Chem. 291 22427-22441 PubMed GONUTS page

[PMID:22451653-30] Ishida-Kitagawa, N et al. (2012) Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12). J. Biol. Chem. 287 17493-502 PubMed GONUTS page

[PMID:10872802-31] 31.0 ^31.1 Iseki, M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem. Biophys. Res. Commun. 272 45-54 PubMed GONUTS page

[PMID:7744830-32] 32.0 ^32.1 Sillman, AL & Monroe, JG (1995) Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes. J. Biol. Chem. 270 11806-11 PubMed GONUTS page

[PMID:11676469-33] Yanagi, S et al. (2001) Syk expression and novel function in a wide variety of tissues. Biochem. Biophys. Res. Commun. 288 495-8 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

MOUSE:KSYK

Contents

Annotations

Notes

References

a

b

c

d

e

g

i

k

l

m

n

o

p

r

s

t

u

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools