MOUSE:IRF1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Irf1
Protein Name(s)	Interferon regulatory factor 1 IRF-1
External Links
UniProt	P15314
EMBL	M21065 BC003821
CCDS	CCDS24686.1
PIR	A31595
RefSeq	NP_001152868.1 NP_032416.1
UniGene	Mm.105218
PDB	1IF1
PDBsum	1IF1
ProteinModelPortal	P15314
SMR	P15314
BioGrid	200784
IntAct	P15314
PhosphoSite	P15314
MaxQB	P15314
PRIDE	P15314
Ensembl	ENSMUST00000019043 ENSMUST00000108920
GeneID	16362
KEGG	mmu:16362
UCSC	uc007iww.2
CTD	3659
MGI	MGI:96590
eggNOG	NOG42582
HOGENOM	HOG000037937
HOVERGEN	HBG003455
InParanoid	P15314
KO	K09444
OMA	CKEEPEV
OrthoDB	EOG72ZCFD
PhylomeDB	P15314
TreeFam	TF328512
Reactome	REACT_198521 REACT_198649 REACT_198660
EvolutionaryTrace	P15314
NextBio	289466
PRO	PR:P15314
Proteomes	UP000000589
Bgee	P15314
CleanEx	MM_IRF1
ExpressionAtlas	P15314
Genevestigator	P15314
GO	GO:0005737 GO:0000790 GO:0005634 GO:0003677 GO:0000978 GO:0043565 GO:0003700 GO:0006915 GO:0043374 GO:0007050 GO:0035458 GO:0071260 GO:0051607 GO:0060333 GO:0045590 GO:0045629 GO:0045892 GO:0032728 GO:0045084 GO:0032825 GO:0045627 GO:0045944 GO:0045893 GO:0032481 GO:0002819 GO:2000564 GO:0010468 GO:0045088 GO:0034124 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR017431 IPR019817 IPR001346 IPR011991
Pfam	PF00605
PIRSF	PIRSF038196
PRINTS	PR00267
SMART	SM00348
PROSITE	PS00601 PS51507

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation	PMID:21909274^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	PMID:21909274^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:20451243^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20308629^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18641303^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045590	negative regulation of regulatory T cell differentiation	PMID:18641303^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway	PMID:17018642^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:17018642^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17018642^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17018642^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096873 MGI:MGI:1859179 MGI:MGI:96395 MGI:MGI:96590 PANTHER:PTN000942746 RGD:2920 UniProtKB:O14896 UniProtKB:P10914 UniProtKB:P14316 UniProtKB:Q02556 UniProtKB:Q13568 UniProtKB:Q14653 UniProtKB:Q15306 UniProtKB:Q92985 ZFIN:ZDB-GENE-041114-13 ZFIN:ZDB-GENE-070912-330	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096873 MGI:MGI:1350924 MGI:MGI:1859179 MGI:MGI:1859212 MGI:MGI:96395 MGI:MGI:96590 PANTHER:PTN000942747 UniProtKB:P10914 UniProtKB:P14316 UniProtKB:Q02556 UniProtKB:Q92985 ZFIN:ZDB-GENE-040718-367 ZFIN:ZDB-GENE-070912-330	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859212 PANTHER:PTN000942746 UniProtKB:P10914 UniProtKB:P14316 UniProtKB:Q02556 UniProtKB:Q14653 UniProtKB:Q15306 UniProtKB:Q92985 ZFIN:ZDB-GENE-070912-330	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2920	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2920	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071347	cellular response to interleukin-1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2920	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060416	response to growth hormone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2920	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17159910^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000312) has_regulation_target:(MGI:MGI:1355313)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2920	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14568984^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045084	positive regulation of interleukin-12 biosynthetic process	PMID:14568984^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857205	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045084	positive regulation of interleukin-12 biosynthetic process	PMID:14568984^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:17159910^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:1355313)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2920	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043374	CD8-positive, alpha-beta T cell differentiation	PMID:11359801^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857205	P	occurs_in:(EMAPA:18768)\|occurs_in:(EMAPA:18767)\|occurs_in:(EMAPA:16332)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2920	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035458	cellular response to interferon-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032728	positive regulation of interferon-beta production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2920	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:11359801^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857205	P	occurs_in:(CL:0000625) has_regulation_target:(MGI:MGI:88138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007249	I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2920	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10914	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14568984^[8]	ECO:0000305	curator inference used in manual assertion	GO:0003700	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2920	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17159910^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:1355313)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14568984^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14568984^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10914	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10914	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10914	C		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	P		Seeded From UniProt	complete
involved_in	GO:0035458	cellular response to interferon-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10914 ensembl:ENSP00000245414	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017431 InterPro:IPR019817 InterPro:IPR031215	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017431 InterPro:IPR019817 InterPro:IPR031215	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031215	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031215	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001346	F		Seeded From UniProt	complete
involved_in	GO:0050776	regulation of immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031215	P		Seeded From UniProt	complete
involved_in	GO:0045629	negative regulation of T-helper 2 cell differentiation	PMID:11244049^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045627	positive regulation of T-helper 1 cell differentiation	PMID:11244049^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045088	regulation of innate immune response	PMID:21909274^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032825	positive regulation of natural killer cell differentiation	PMID:11244049^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002819	regulation of adaptive immune response	PMID:21909274^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Brien, JD et al. (2011) Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection. PLoS Pathog. 7 e1002230 PubMed GONUTS page
↑ Dixit, E et al. (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141 668-81 PubMed GONUTS page
↑ Stirnweiss, A et al. (2010) IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. J. Immunol. 184 5179-85 PubMed GONUTS page
↑ ^4.0 ^4.1 Fragale, A et al. (2008) IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression. J. Immunol. 181 1673-82 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Negishi, H et al. (2006) Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc. Natl. Acad. Sci. U.S.A. 103 15136-41 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Byun, SJ et al. (2007) IFN-gamma upregulates expression of the mouse complement C1rA gene in keratinocytes via IFN-regulatory factor-1. J. Invest. Dermatol. 127 1187-96 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Liu, J et al. (2003) Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J. Exp. Med. 198 1265-76 PubMed GONUTS page
↑ ^9.0 ^9.1 Ohteki, T et al. (2001) Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice. J. Immunol. 166 6509-13 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Taniguchi, T et al. (2001) IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19 623-55 PubMed GONUTS page

[PMID:21909274-1] 1.0 ^1.1 ^1.2 ^1.3 Brien, JD et al. (2011) Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection. PLoS Pathog. 7 e1002230 PubMed GONUTS page

[PMID:20451243-2] Dixit, E et al. (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141 668-81 PubMed GONUTS page

[PMID:20308629-3] Stirnweiss, A et al. (2010) IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. J. Immunol. 184 5179-85 PubMed GONUTS page

[PMID:18641303-4] 4.0 ^4.1 Fragale, A et al. (2008) IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression. J. Immunol. 181 1673-82 PubMed GONUTS page

[PMID:17018642-5] 5.0 ^5.1 ^5.2 ^5.3 Negishi, H et al. (2006) Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc. Natl. Acad. Sci. U.S.A. 103 15136-41 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17159910-7] 7.0 ^7.1 ^7.2 Byun, SJ et al. (2007) IFN-gamma upregulates expression of the mouse complement C1rA gene in keratinocytes via IFN-regulatory factor-1. J. Invest. Dermatol. 127 1187-96 PubMed GONUTS page

[PMID:14568984-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Liu, J et al. (2003) Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J. Exp. Med. 198 1265-76 PubMed GONUTS page

[PMID:11359801-9] 9.0 ^9.1 Ohteki, T et al. (2001) Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice. J. Immunol. 166 6509-13 PubMed GONUTS page

[PMID:11244049-10] 10.0 ^10.1 ^10.2 Taniguchi, T et al. (2001) IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19 623-55 PubMed GONUTS page

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MOUSE:IRF1

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