MOUSE:IL4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Il4 (synonyms: Il-4)
Protein Name(s)	Interleukin-4 IL-4 B-cell IgG differentiation factor B-cell growth factor 1 B-cell stimulatory factor 1 BSF-1 IGG1 induction factor Lymphocyte stimulatory factor 1
External Links
UniProt	P07750
EMBL	X03532 X05064 X05252 X05253 M13238 M25892 BC027514
CCDS	CCDS24682.1
PIR	A25870
RefSeq	NP_067258.1
UniGene	Mm.276360
ProteinModelPortal	P07750
SMR	P07750
IntAct	P07750
PRIDE	P07750
Ensembl	ENSMUST00000000889
GeneID	16189
KEGG	mmu:16189
UCSC	uc007iwq.2
CTD	3565
MGI	MGI:96556
eggNOG	NOG266404
GeneTree	ENSGT00390000013108
HOGENOM	HOG000254781
HOVERGEN	HBG000290
InParanoid	P07750
KO	K05430
OrthoDB	EOG7SJD75
PhylomeDB	P07750
TreeFam	TF336383
NextBio	289093
PRO	PR:P07750
Proteomes	UP000000589
Bgee	P07750
CleanEx	MM_IL4
ExpressionAtlas	P07750
Genevestigator	P07750
GO	GO:0009897 GO:0005615 GO:0005125 GO:0042113 GO:0031296 GO:0071288 GO:0008203 GO:0042832 GO:0097028 GO:0097192 GO:0007565 GO:0002227 GO:0001774 GO:0002674 GO:0002677 GO:2001237 GO:0043031 GO:0045019 GO:0045671 GO:0050868 GO:2000320 GO:0045892 GO:0042104 GO:0050871 GO:0030890 GO:0045080 GO:0002230 GO:2000424 GO:0002639 GO:0032733 GO:0032736 GO:0048295 GO:0048304 GO:0043306 GO:0045348 GO:0071677 GO:0050731 GO:0001934 GO:0051091 GO:0045582 GO:0042102 GO:0045944 GO:0045893 GO:0042523 GO:0050776 GO:0010155 GO:0034097 GO:0042493 GO:0045471 GO:0007584 GO:0014070 GO:0060041 GO:0002296 GO:0035745 GO:0045064
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR002354 IPR001325 IPR018096
PANTHER	PTHR11456
Pfam	PF00727
PIRSF	PIRSF001941
PRINTS	PR00431
SMART	SM00190
SUPFAM	SSF47266
PROSITE	PS00838

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0070351	negative regulation of fat cell differentiation	PMID:24347527^[1]	ECO:0000314			P		Figure 2, panels C and D show that treatment with IL-4 in the stage of fat cell development where replication occurs is sufficient to inhibit adipogenesis.	complete CACAO 10416
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:26416964^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:24906148^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048260	positive regulation of receptor-mediated endocytosis	PMID:18941241^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1139)\|regulates_o_occurs_in(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1107)	Seeded From UniProt	complete
involved_in	GO:1900223	positive regulation of amyloid-beta clearance	PMID:18941241^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1139) part_of:(GO:1905337)\|regulates_o_occurs_in(CL:0000129) has_regulation_target:(ComplexPortal:CPX-1107) part_of:(GO:1905337)	Seeded From UniProt	complete
involved_in	GO:0070351	negative regulation of white fat cell proliferation	PMID:24347527^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:7749983^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15187136^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:7749983^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045080	positive regulation of chemokine biosynthetic process	PMID:9013979^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002227	innate immune response in mucosa	PMID:9973465^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20696860^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	PMID:11971948^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:10429671^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000810)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000424	positive regulation of eosinophil chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000320	negative regulation of T-helper 17 cell differentiation	PMID:18792410^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903660	negative regulation of complement-dependent cytotoxicity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901741	positive regulation of myoblast fusion	PMID:12757709^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857194	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901741	positive regulation of myoblast fusion	PMID:12757709^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900223	positive regulation of amyloid-beta clearance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:12115603^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097028	dendritic cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071677	positive regulation of mononuclear cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050871	positive regulation of B cell activation	PMID:8566034^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050868	negative regulation of T cell activation	PMID:18997793^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050776	regulation of immune response	PMID:12882831^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:8022486^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048304	positive regulation of isotype switching to IgG isotypes	PMID:14988498^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048304	positive regulation of isotype switching to IgG isotypes	PMID:12882831^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048295	positive regulation of isotype switching to IgE isotypes	PMID:14988498^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9110977^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103034	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8200916^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:32760) regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18997793^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:95663)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16493007^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000788) has_regulation_target:(MGI:MGI:102969)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:1588041^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000236)\|regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045671	negative regulation of osteoclast differentiation	PMID:17442941^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045671	negative regulation of osteoclast differentiation	PMID:12941478^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045348	positive regulation of MHC class II biosynthetic process	PMID:11027433^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045348	positive regulation of MHC class II biosynthetic process	PMID:10549626^[27]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045064	T-helper 2 cell differentiation	PMID:20706986^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045019	negative regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043306	positive regulation of mast cell degranulation	PMID:15944273^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96541	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043306	positive regulation of mast cell degranulation	PMID:15944273^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857195	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043031	negative regulation of macrophage activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043011	myeloid dendritic cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042976	activation of Janus kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042832	defense response to protozoan	PMID:7927664^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:10485657^[31]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042113	B cell activation	PMID:9798653^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042113	B cell activation	PMID:16129705^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042110	T cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042104	positive regulation of activated T cell proliferation	PMID:9841920^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042104	positive regulation of activated T cell proliferation	PMID:10485657^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	PMID:18997793^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	PMID:1588041^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035745	T-helper 2 cell cytokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032736	positive regulation of interleukin-13 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031296	B cell costimulation	PMID:18762567^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030890	positive regulation of B cell proliferation	PMID:14607964^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030890	positive regulation of B cell proliferation	PMID:10979977^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010633	negative regulation of epithelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010155	regulation of proton transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21613615^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21217760^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:20956546^[40]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:20399120^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:19666510^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21460847^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19139201^[44]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35770)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17277142^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17082577^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16769892^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16275384^[48]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35770)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15087456^[49]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11894098^[50]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11057672^[51]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:9841920^[34]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000084)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:1588041^[23]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000084)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:11027433^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:10979977^[37]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000236)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:10549626^[27]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000236)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:10485657^[31]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002677	negative regulation of chronic inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002674	negative regulation of acute inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002639	positive regulation of immunoglobulin production	PMID:15944273^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96541	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002639	positive regulation of immunoglobulin production	PMID:15944273^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857195	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002296	T-helper 1 cell lineage commitment	PMID:20706986^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103034	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002230	positive regulation of defense response to virus by host	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:12115603^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001774	microglial cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2898	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
enables	GO:0005126	cytokine receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001325 InterPro:IPR018096	F		Seeded From UniProt	complete
enables	GO:0005136	interleukin-4 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002354	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001325 InterPro:IPR002354 InterPro:IPR018096	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001325 InterPro:IPR002354 InterPro:IPR018096	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002354	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
involved_in	GO:0042113	B cell activation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0075	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Tsao, CH et al. (2014) Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis. J. Lipid Res. 55 385-97 PubMed GONUTS page
↑ Terawaki, S et al. (2015) RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4. J. Cell Biol. 210 1133-52 PubMed GONUTS page
↑ Qiu, Y et al. (2014) Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157 1292-308 PubMed GONUTS page
↑ ^4.0 ^4.1 Shimizu, E et al. (2008) IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. J. Immunol. 181 6503-13 PubMed GONUTS page
↑ ^5.0 ^5.1 Stüber, E et al. (1995) Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 2 507-21 PubMed GONUTS page
↑ Pauleau, AL et al. (2004) Enhancer-mediated control of macrophage-specific arginase I expression. J. Immunol. 172 7565-73 PubMed GONUTS page
↑ Rumsaeng, V et al. (1997) Lymphotactin gene expression in mast cells following Fc(epsilon) receptor I aggregation: modulation by TGF-beta, IL-4, dexamethasone, and cyclosporin A. J. Immunol. 158 1353-60 PubMed GONUTS page
↑ Lillard, JW Jr et al. (1999) Lymphotactin acts as an innate mucosal adjuvant. J. Immunol. 162 1959-65 PubMed GONUTS page
↑ Cook, KD & Miller, J (2010) TCR-dependent translational control of GATA-3 enhances Th2 differentiation. J. Immunol. 185 3209-16 PubMed GONUTS page
↑ King, VL et al. (2002) Interleukin-4 deficiency promotes gallstone formation. J. Lipid Res. 43 768-71 PubMed GONUTS page
↑ Kishimoto, H & Sprent, J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190 65-73 PubMed GONUTS page
↑ van Hamburg, JP et al. (2008) Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur. J. Immunol. 38 2573-86 PubMed GONUTS page
↑ ^13.0 ^13.1 Horsley, V et al. (2003) IL-4 acts as a myoblast recruitment factor during mammalian muscle growth. Cell 113 483-94 PubMed GONUTS page
↑ ^14.0 ^14.1 Ayllón, V et al. (2002) The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Eur. J. Immunol. 32 1847-55 PubMed GONUTS page
↑ Kong, YY et al. (1995) Differential requirements of CD45 for lymphocyte development and function. Eur. J. Immunol. 25 3431-6 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Dardalhon, V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat. Immunol. 9 1347-55 PubMed GONUTS page
↑ ^17.0 ^17.1 Gerth, AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int. Immunol. 15 937-44 PubMed GONUTS page
↑ Witthuhn, BA et al. (1994) Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370 153-7 PubMed GONUTS page
↑ ^19.0 ^19.1 Castigli, E et al. (2004) Impaired IgA class switching in APRIL-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 101 3903-8 PubMed GONUTS page
↑ Dent, AL et al. (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276 589-92 PubMed GONUTS page
↑ Lacey, DL et al. (1994) Interleukin 4 increases type 5 acid phosphatase mRNA expression in murine bone marrow macrophages. J. Cell. Biochem. 54 365-71 PubMed GONUTS page
↑ Schenten, D et al. (2006) M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood 107 4849-56 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Casey, LS et al. (1992) IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes. J. Immunol. 148 3418-26 PubMed GONUTS page
↑ Kim, K et al. (2007) Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor. J. Immunol. 178 5588-94 PubMed GONUTS page
↑ Kitaura, H et al. (2003) Interleukin-4 directly inhibits tumor necrosis factor-alpha-mediated osteoclast formation in mouse bone marrow macrophages. Immunol. Lett. 88 193-8 PubMed GONUTS page
↑ ^26.0 ^26.1 Walter, W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br. J. Cancer 83 1192-201 PubMed GONUTS page
↑ ^27.0 ^27.1 Takeuchi, O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 443-51 PubMed GONUTS page
↑ ^28.0 ^28.1 Wang, L et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur. J. Immunol. 40 2385-90 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 Fish, SC et al. (2005) IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13. J. Immunol. 174 7716-24 PubMed GONUTS page
↑ Gessner, A et al. (1994) Recombinant soluble interleukin-4 (IL-4) receptor acts as an antagonist of IL-4 in murine cutaneous Leishmaniasis. Infect. Immun. 62 4112-7 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Moriggl, R et al. (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11 225-30 PubMed GONUTS page
↑ Chu, CC & Paul, WE (1998) Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol. Immunol. 35 487-502 PubMed GONUTS page
↑ Xing, Y et al. (2005) Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. J. Exp. Med. 202 707-19 PubMed GONUTS page
↑ ^34.0 ^34.1 Imada, K et al. (1998) Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J. Exp. Med. 188 2067-74 PubMed GONUTS page
↑ de Yébenes, VG et al. (2008) miR-181b negatively regulates activation-induced cytidine deaminase in B cells. J. Exp. Med. 205 2199-206 PubMed GONUTS page
↑ Aldrich, MB et al. (2003) Impaired germinal center maturation in adenosine deaminase deficiency. J. Immunol. 171 5562-70 PubMed GONUTS page
↑ ^37.0 ^37.1 Sexl, V et al. (2000) Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood 96 2277-83 PubMed GONUTS page
↑ Stellato, C et al. (2011) Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J. Immunol. 187 441-9 PubMed GONUTS page
↑ Li, Z et al. (2011) ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat. Immunol. 12 178-85 PubMed GONUTS page
↑ Onodera, A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J. Exp. Med. 207 2493-506 PubMed GONUTS page
↑ Yagi, R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 32 507-17 PubMed GONUTS page
↑ Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page
↑ Motomura, Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12 450-9 PubMed GONUTS page
↑ Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page
↑ Hervas-Stubbs, S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J. Immunol. 178 2361-9 PubMed GONUTS page
↑ Kim, PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J. Immunol. 177 6650-9 PubMed GONUTS page
↑ Chae, WJ et al. (2006) The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc. Natl. Acad. Sci. U.S.A. 103 9631-6 PubMed GONUTS page
↑ Lin, W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116 1106-15 PubMed GONUTS page
↑ Yamashita, M et al. (2004) Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279 26983-90 PubMed GONUTS page
↑ Kobayashi, K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416 194-9 PubMed GONUTS page
↑ Chen, Q et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407 916-20 PubMed GONUTS page

[PMID:24347527-1] 1.0 ^1.1 Tsao, CH et al. (2014) Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis. J. Lipid Res. 55 385-97 PubMed GONUTS page

[PMID:26416964-2] Terawaki, S et al. (2015) RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4. J. Cell Biol. 210 1133-52 PubMed GONUTS page

[PMID:24906148-3] Qiu, Y et al. (2014) Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157 1292-308 PubMed GONUTS page

[PMID:18941241-4] 4.0 ^4.1 Shimizu, E et al. (2008) IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. J. Immunol. 181 6503-13 PubMed GONUTS page

[PMID:7749983-5] 5.0 ^5.1 Stüber, E et al. (1995) Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 2 507-21 PubMed GONUTS page

[PMID:15187136-6] Pauleau, AL et al. (2004) Enhancer-mediated control of macrophage-specific arginase I expression. J. Immunol. 172 7565-73 PubMed GONUTS page

[PMID:9013979-7] Rumsaeng, V et al. (1997) Lymphotactin gene expression in mast cells following Fc(epsilon) receptor I aggregation: modulation by TGF-beta, IL-4, dexamethasone, and cyclosporin A. J. Immunol. 158 1353-60 PubMed GONUTS page

[PMID:9973465-8] Lillard, JW Jr et al. (1999) Lymphotactin acts as an innate mucosal adjuvant. J. Immunol. 162 1959-65 PubMed GONUTS page

[PMID:20696860-9] Cook, KD & Miller, J (2010) TCR-dependent translational control of GATA-3 enhances Th2 differentiation. J. Immunol. 185 3209-16 PubMed GONUTS page

[PMID:11971948-10] King, VL et al. (2002) Interleukin-4 deficiency promotes gallstone formation. J. Lipid Res. 43 768-71 PubMed GONUTS page

[PMID:10429671-11] Kishimoto, H & Sprent, J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190 65-73 PubMed GONUTS page

[PMID:18792410-12] van Hamburg, JP et al. (2008) Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur. J. Immunol. 38 2573-86 PubMed GONUTS page

[PMID:12757709-13] 13.0 ^13.1 Horsley, V et al. (2003) IL-4 acts as a myoblast recruitment factor during mammalian muscle growth. Cell 113 483-94 PubMed GONUTS page

[PMID:12115603-14] 14.0 ^14.1 Ayllón, V et al. (2002) The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Eur. J. Immunol. 32 1847-55 PubMed GONUTS page

[PMID:8566034-15] Kong, YY et al. (1995) Differential requirements of CD45 for lymphocyte development and function. Eur. J. Immunol. 25 3431-6 PubMed GONUTS page

[PMID:18997793-16] 16.0 ^16.1 ^16.2 Dardalhon, V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat. Immunol. 9 1347-55 PubMed GONUTS page

[PMID:12882831-17] 17.0 ^17.1 Gerth, AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int. Immunol. 15 937-44 PubMed GONUTS page

[PMID:8022486-18] Witthuhn, BA et al. (1994) Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370 153-7 PubMed GONUTS page

[PMID:14988498-19] 19.0 ^19.1 Castigli, E et al. (2004) Impaired IgA class switching in APRIL-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 101 3903-8 PubMed GONUTS page

[PMID:9110977-20] Dent, AL et al. (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276 589-92 PubMed GONUTS page

[PMID:8200916-21] Lacey, DL et al. (1994) Interleukin 4 increases type 5 acid phosphatase mRNA expression in murine bone marrow macrophages. J. Cell. Biochem. 54 365-71 PubMed GONUTS page

[PMID:16493007-22] Schenten, D et al. (2006) M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood 107 4849-56 PubMed GONUTS page

[PMID:1588041-23] 23.0 ^23.1 ^23.2 Casey, LS et al. (1992) IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes. J. Immunol. 148 3418-26 PubMed GONUTS page

[PMID:17442941-24] Kim, K et al. (2007) Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor. J. Immunol. 178 5588-94 PubMed GONUTS page

[PMID:12941478-25] Kitaura, H et al. (2003) Interleukin-4 directly inhibits tumor necrosis factor-alpha-mediated osteoclast formation in mouse bone marrow macrophages. Immunol. Lett. 88 193-8 PubMed GONUTS page

[PMID:11027433-26] 26.0 ^26.1 Walter, W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br. J. Cancer 83 1192-201 PubMed GONUTS page

[PMID:10549626-27] 27.0 ^27.1 Takeuchi, O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 443-51 PubMed GONUTS page

[PMID:20706986-28] 28.0 ^28.1 Wang, L et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur. J. Immunol. 40 2385-90 PubMed GONUTS page

[PMID:15944273-29] 29.0 ^29.1 ^29.2 ^29.3 Fish, SC et al. (2005) IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13. J. Immunol. 174 7716-24 PubMed GONUTS page

[PMID:7927664-30] Gessner, A et al. (1994) Recombinant soluble interleukin-4 (IL-4) receptor acts as an antagonist of IL-4 in murine cutaneous Leishmaniasis. Infect. Immun. 62 4112-7 PubMed GONUTS page

[PMID:10485657-31] 31.0 ^31.1 ^31.2 Moriggl, R et al. (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11 225-30 PubMed GONUTS page

[PMID:9798653-32] Chu, CC & Paul, WE (1998) Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol. Immunol. 35 487-502 PubMed GONUTS page

[PMID:16129705-33] Xing, Y et al. (2005) Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. J. Exp. Med. 202 707-19 PubMed GONUTS page

[PMID:9841920-34] 34.0 ^34.1 Imada, K et al. (1998) Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J. Exp. Med. 188 2067-74 PubMed GONUTS page

[PMID:18762567-35] Yébenes, VG et al. (2008) miR-181b negatively regulates activation-induced cytidine deaminase in B cells. J. Exp. Med. 205 2199-206 PubMed GONUTS page

[PMID:14607964-36] Aldrich, MB et al. (2003) Impaired germinal center maturation in adenosine deaminase deficiency. J. Immunol. 171 5562-70 PubMed GONUTS page

[PMID:10979977-37] 37.0 ^37.1 Sexl, V et al. (2000) Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood 96 2277-83 PubMed GONUTS page

[PMID:21613615-38] Stellato, C et al. (2011) Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J. Immunol. 187 441-9 PubMed GONUTS page

[PMID:21217760-39] Li, Z et al. (2011) ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat. Immunol. 12 178-85 PubMed GONUTS page

[PMID:20956546-40] Onodera, A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J. Exp. Med. 207 2493-506 PubMed GONUTS page

[PMID:20399120-41] Yagi, R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 32 507-17 PubMed GONUTS page

[PMID:19666510-42] Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page

[PMID:21460847-43] Motomura, Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12 450-9 PubMed GONUTS page

[PMID:19139201-44] Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page

[PMID:17277142-45] Hervas-Stubbs, S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J. Immunol. 178 2361-9 PubMed GONUTS page

[PMID:17082577-46] Kim, PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J. Immunol. 177 6650-9 PubMed GONUTS page

[PMID:16769892-47] Chae, WJ et al. (2006) The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc. Natl. Acad. Sci. U.S.A. 103 9631-6 PubMed GONUTS page

[PMID:16275384-48] Lin, W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116 1106-15 PubMed GONUTS page

[PMID:15087456-49] Yamashita, M et al. (2004) Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279 26983-90 PubMed GONUTS page

[PMID:11894098-50] Kobayashi, K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416 194-9 PubMed GONUTS page

[PMID:11057672-51] Chen, Q et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407 916-20 PubMed GONUTS page

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