PMID:8566034

Citation	Kong, YY, Kishihara, K, Sumichika, H, Nakamura, T, Kaneko, M and Nomoto, K (1995) Differential requirements of CD45 for lymphocyte development and function. Eur. J. Immunol. 25:3431-6
Abstract	CD45 exon 6-deficient mice show a profound block of thymocyte development at a transitional differentiation step from immature CD4+ CD8+ to mature single-positive cells. Only a few T lymphocytes are observed in the periphery of such animals, but B cell development is not affected. We investigated whether mature B lymphocytes in CD45 exon 6-deficient mice have normal functions in the absence of CD45 expression and show here that CD45-defective B lymphocytes from CD45 exon 6-deficient mice have intact B lymphocyte functions, including T-dependent and T-independent antigen-specific antibody production and class switching in vivo if normal CD4+ T lymphocytes were adoptively transferred into the mutant mice. From these results, we conclude that CD45 expression on B lymphocytes is not essential for B cell responses following antigen stimulation in vivo. However, CD4+ T helper function was severely diminished in CD45 exon 6-deficient mice, suggesting that the requirements of CD45 molecules in antigen-specific response and development are different between T and B lymphocytes.
Links	PubMed Online version:10.1002/eji.1830251234
Keywords	Animals; Antibody-Producing Cells/cytology; Antigens, CD45/genetics; Antigens, CD45/physiology; B-Lymphocytes/classification; B-Lymphocytes/cytology; B-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/transplantation; Cell Differentiation/genetics; Cell Differentiation/immunology; Cell Division/drug effects; Cell Division/immunology; Epitopes; Immunophenotyping; Immunotherapy, Adoptive; Lymphocyte Activation/drug effects; Mice; Mice, Inbred C57BL; Mice, Knockout
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