GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:10979977
| Citation |
Sexl, V, Piekorz, R, Moriggl, R, Rohrer, J, Brown, MP, Bunting, KD, Rothammer, K, Roussel, MF and Ihle, JN (2000) Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood 96:2277-83 |
|---|---|
| Abstract |
The cytokines interleukin 7 (IL-7) and interleukin 4 (IL-4) regulate lymphoid differentiation and function and activate the transcription factor Stat5. Using mice deficient for the 2 highly related transcription factors, Stat5a and Stat5b (Stat5a/b(-/-)), we investigated the role of Stat5 for B-cell differentiation, expansion, and function. Peripheral blood B cells of Stat5-deficient mice are significantly reduced, but no proliferation defects in response to various mitogenic stimuli are found. Also, IgM and IgG1 antibody production and immunoglobulin class switching are not affected. Pre- and pro-B cells of Stat5-deficient animals were found to have reduced responses to IL-7. Pro- and pre-B cells are the target cells of the abl oncogene and numerous studies have suggested that Stat5a/b is essential for transformation by derivatives of the Abelson (abl) gene. To assess the role of Stat5a/b in transformation, we have evaluated the ability of various abl derivatives to transform cells from Stat5a/b-deficient mice in vitro or in vivo. We demonstrate that the absence of Stat5a/b is not essential for the induction of lymphoid or myeloid tumors in vivo or on the ability to transform bone marrow cells in vitro. |
| Links | |
| Keywords |
Animals; B-Lymphocytes/pathology; B-Lymphocytes/physiology; Cell Differentiation/drug effects; Cell Differentiation/genetics; Cell Transformation, Neoplastic/genetics; DNA-Binding Proteins/genetics; Fusion Proteins, bcr-abl/genetics; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, abl; Interleukin-7/genetics; Interleukin-7/pharmacology; Mice; Milk Proteins; STAT5 Transcription Factor; Trans-Activators/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
