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PMID:9841920

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Citation

Imada, K, Bloom, ET, Nakajima, H, Horvath-Arcidiacono, JA, Udy, GB, Davey, HW and Leonard, WJ (1998) Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J. Exp. Med. 188:2067-74

Abstract

We have analyzed the immune system in Stat5-deficient mice. Although Stat5a-/- splenocytes have a partial defect in anti-CD3-induced proliferation that can be overcome by high dose interleukin (IL)-2, we now demonstrate that defective proliferation in Stat5b-/- splenocytes cannot be corrected by this treatment. Interestingly, this finding may be at least partially explained by diminished expression of the IL-2 receptor beta chain (IL-2Rbeta), which is a component of the receptors for both IL-2 and IL-15, although other defects may also exist. Similar to the defect in proliferation in activated splenocytes, freshly isolated splenocytes from Stat5b-/- mice exhibited greatly diminished proliferation in response to IL-2 and IL-15. This results from both a decrease in the number and responsiveness of natural killer (NK) cells. Corresponding to the diminished proliferation, basal as well as IL-2- and IL-15-mediated boosting of NK cytolytic activity was also greatly diminished. These data indicate an essential nonredundant role for Stat5b for potent NK cell-mediated proliferation and cytolytic activity.

Links

PubMed PMC2212377

Keywords

Animals; Cell Division/immunology; Cytotoxicity, Immunologic; DNA-Binding Proteins/genetics; DNA-Binding Proteins/immunology; Gene Expression Regulation/immunology; Interleukin-15/immunology; Interleukin-2/immunology; Killer Cells, Natural/immunology; Lymphocyte Activation/immunology; Mice; Mice, Knockout; Milk Proteins; STAT5 Transcription Factor; Trans-Activators/genetics; Trans-Activators/immunology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:IL4

enables

GO:0005125: cytokine activity

ECO:0000314: direct assay evidence used in manual assertion

F

  • occurs_in:(CL:0000084)

Seeded From UniProt

complete

MOUSE:IL2RB

located_in

GO:0009897: external side of plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000623)

Seeded From UniProt

complete

MOUSE:STA5A

acts_upstream_of_or_within

GO:0032825: positive regulation of natural killer cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857249

P

  • regulates_o_results_in_acquisition_of_features_of:(CL:0000623)

Seeded From UniProt

complete

MOUSE:STA5A

acts_upstream_of_or_within

GO:0045954: positive regulation of natural killer cell mediated cytotoxicity

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857249

P

  • regulates_o_occurs_in:(CL:0000623)

Seeded From UniProt

complete

MOUSE:STA5B

acts_upstream_of_or_within

GO:0032825: positive regulation of natural killer cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2181592

P

  • regulates_o_results_in_acquisition_of_features_of:(CL:0000623)

Seeded From UniProt

complete

MOUSE:STA5B

acts_upstream_of_or_within

GO:0032819: positive regulation of natural killer cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2181592

P

Seeded From UniProt

complete

MOUSE:STA5B

acts_upstream_of_or_within

GO:0045954: positive regulation of natural killer cell mediated cytotoxicity

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2181592

P

  • regulates_o_occurs_in:(CL:0000623)

Seeded From UniProt

complete

MOUSE:STA5B

acts_upstream_of_or_within

GO:0042104: positive regulation of activated T cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2181592

P

Seeded From UniProt

complete

MOUSE:STA5B

acts_upstream_of_or_within

GO:0070672: response to interleukin-15

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2181592

P

Seeded From UniProt

complete

MOUSE:STA5B

acts_upstream_of_or_within

GO:0070670: response to interleukin-4

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2181592

P

Seeded From UniProt

complete

MOUSE:STA5B

acts_upstream_of_or_within

GO:0070669: response to interleukin-2

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2181592

P

Seeded From UniProt

complete

MOUSE:IL4

acts_upstream_of_or_within

GO:0042104: positive regulation of activated T cell proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:IL4

enables

GO:0005125: cytokine activity

ECO:0000314: direct assay evidence used in manual assertion

F

occurs_in:(CL:0000084)

Seeded From UniProt

complete


See also

References

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