MOUSE:GRIA1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gria1 (synonyms: Glur1)
Protein Name(s)	Glutamate receptor 1 GluR-1 AMPA-selective glutamate receptor 1 GluR-A GluR-K1 Glutamate receptor ionotropic, AMPA 1 GluA1
External Links
UniProt	P23818
EMBL	X57497
CCDS	CCDS48800.1
PIR	S12874
RefSeq	NP_001106796.1
UniGene	Mm.4920
ProteinModelPortal	P23818
SMR	P23818
BioGrid	200058
DIP	DIP-31970N
IntAct	P23818
MINT	MINT-1897734
BindingDB	P23818
ChEMBL	CHEMBL2096617
GuidetoPHARMACOLOGY	444
PhosphoSite	P23818
MaxQB	P23818
PaxDb	P23818
PRIDE	P23818
Ensembl	ENSMUST00000036315
GeneID	14799
KEGG	mmu:14799
UCSC	uc007izs.3
CTD	2890
MGI	MGI:95808
eggNOG	NOG316680
GeneTree	ENSGT00760000118920
HOGENOM	HOG000234372
HOVERGEN	HBG051839
InParanoid	P23818
KO	K05197
OMA	NMGFMDI
OrthoDB	EOG7C2R0J
TreeFam	TF315232
Reactome	REACT_252788 REACT_253367 REACT_258217
ChiTaRS	Gria1
NextBio	286953
PRO	PR:P23818
Proteomes	UP000000589
Bgee	P23818
CleanEx	MM_GRIA1
ExpressionAtlas	P23818
Genevestigator	P23818
GO	GO:0032281 GO:0044308 GO:0030054 GO:0009986 GO:0030425 GO:0032590 GO:0043197 GO:0005783 GO:0005789 GO:0008328 GO:0016020 GO:0043005 GO:0044309 GO:0043025 GO:0005886 GO:0014069 GO:0045211 GO:0045202 GO:0008021 GO:0004971 GO:0005234 GO:0034220 GO:0035235 GO:0060292 GO:0007616 GO:0031623 GO:0007268 GO:0035249
InterPro	IPR001828 IPR019594 IPR001508 IPR001320 IPR028082
Pfam	PF01094 PF00060 PF10613
PRINTS	PR00177
SMART	SM00918 SM00079
SUPFAM	SSF53822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0009986	cell surface	PMID:17229826^[1]	ECO:0000315			C		Cell surface protein biotinylation and Western blotting was used. Figure 3 A-C, cells treated with Reelin showed increase levels of surface GluR1 compared to control.	complete CACAO 2392
	GO:0032590	dendrite membrane	PMID:21795692^[2]	ECO:0000315			C		Mutant Shank3 mice, Figure 6E and F, showed decrease in cluster at plasma membrane of dendrite.	complete CACAO 3099
	GO:0019717	synaptosome	PMID:21558424^[3]	ECO:0000315			C		Figure 6B and D, A decrease of receptor subunit in synaptosome membrane fraction. There was a decrease in GluA1 subunit in mutant Shank3 mice compared to control. Similar results was seen in figure 6E, confirmed by quantitative analyses.	complete CACAO 3128
part_of	GO:0014069	postsynaptic density	PMID:15601948^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:21144999^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0005377)	Seeded From UniProt	complete
part_of	GO:0036477	somatodendritic compartment	PMID:18341993^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:14555717^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0043197) part_of:(CL:0000540) part_of:(UBERON:0014554)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:14555717^[7]	ECO:0000305	curator inference used in manual assertion	GO:0098839	C	part_of:(GO:0060076) part_of:(CL:1001571) part_of:(UBERON:0003881)	Seeded From UniProt	complete
enables	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	PMID:24983627^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(GO:0060076) occurs_in:(UBERON:0001851)	Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	PMID:11431570^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0060076) occurs_in:(CL:0002608) occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:11431570^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(GO:0060076) occurs_in:(CL:1001571) occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	PMID:21795692^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17229826^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:15207857^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044309	neuron spine	PMID:16606358^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:16606358^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21558424^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	PMID:21795692^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17229826^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0008328	ionotropic glutamate receptor complex	PMID:15207857^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16606358^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21172611^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:12628184^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21172611^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21172611^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:12628184^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:12628184^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004971	AMPA glutamate receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42261	F		Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:11431570^[9]	ECO:0006063	over expression analysis evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:11431570^[9]	ECO:0006003	electron microscopy evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:14555717^[7]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:11431570^[9]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:14555717^[7]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:11431570^[9]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95808 PANTHER:PTN000438139	F		Seeded From UniProt	complete
part_of	GO:0032281	AMPA glutamate receptor complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95808 MGI:MGI:95809 MGI:MGI:95810 MGI:MGI:95811 PANTHER:PTN000438080 RGD:61862 RGD:61863 RGD:621531 RGD:70958	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0052704 MGI:MGI:95808 MGI:MGI:95813 MGI:MGI:95816 PANTHER:PTN000437926 RGD:621531 TAIR:locus:2207165 UniProtKB:Q12879 UniProtKB:Q13224 UniProtKB:Q16478 WB:WBGene00001612	C		Seeded From UniProt	complete
enables	GO:0004971	AMPA glutamate receptor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000438080 RGD:61862 RGD:61863 RGD:621531 RGD:70958 UniProtKB:P42261 UniProtKB:P42263 UniProtKB:P48058	F		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:25429150^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060292	long-term synaptic depression	PMID:24259587^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99401	P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42261	C		Seeded From UniProt	complete
enables	GO:0051018	protein kinase A binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045838	positive regulation of membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:24259587^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:15681343^[17]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19490	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0044309	neuron spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0044308	axonal spine	PMID:23303939^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:24259587^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0032591	dendritic spine membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42261	C		Seeded From UniProt	complete
part_of	GO:0032281	AMPA glutamate receptor complex	PMID:22632720^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032281	AMPA glutamate receptor complex	PMID:15883194^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0032281	AMPA glutamate receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0032279	asymmetric synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
enables	GO:0031698	beta-2 adrenergic receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
enables	GO:0031681	G-protein beta-subunit binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031623	receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	P		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
enables	GO:0031489	myosin V binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
enables	GO:0031267	small GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:23303939^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
enables	GO:0019865	immunoglobulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019228	neuronal action potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:17093100^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:23395379^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009636	response to toxic substance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	P		Seeded From UniProt	complete
enables	GO:0008179	adenylate cyclase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:20418887^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17549)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007616	long-term memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:19657020^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201678	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:16814779^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17787)	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	C		Seeded From UniProt	complete
enables	GO:0004971	AMPA glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42261	F		Seeded From UniProt	complete
enables	GO:0004971	AMPA glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001919	regulation of receptor recycling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005216	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004971	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004970	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004971	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004970	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004971	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004971	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004971	P		Seeded From UniProt	complete
involved_in	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099583	P		Seeded From UniProt	complete
involved_in	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099583	P		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42261 ensembl:ENSP00000428994	C		Seeded From UniProt	complete
part_of	GO:0032591	dendritic spine membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42261 ensembl:ENSP00000428994	C		Seeded From UniProt	complete
enables	GO:0004971	AMPA glutamate receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42261 ensembl:ENSP00000428994	F		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR019594	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR001508 InterPro:IPR019594	C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
part_of	GO:0055038	recycling endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0231	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Qiu, S & Weeber, EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J. Neurophysiol. 97 2312-21 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page
↑ ^3.0 ^3.1 Wang, X et al. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum. Mol. Genet. 20 3093-108 PubMed GONUTS page
↑ Roumier, A et al. (2004) Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J. Neurosci. 24 11421-8 PubMed GONUTS page
↑ Dani, A et al. (2010) Superresolution imaging of chemical synapses in the brain. Neuron 68 843-56 PubMed GONUTS page
↑ Matsuda, S et al. (2008) Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Neuron 57 730-45 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Jensen, V et al. (2003) A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A. J. Physiol. (Lond.) 553 843-56 PubMed GONUTS page
↑ Kim, S & Ziff, EB (2014) Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol. 12 e1001900 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Mack, V et al. (2001) Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice. Science 292 2501-4 PubMed GONUTS page
↑ ^10.0 ^10.1 Uemura, T et al. (2004) Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol. Cell. Neurosci. 26 330-41 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Uchino, S et al. (2006) Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J. Neurochem. 97 1203-14 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Kato, AS et al. (2010) Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron 68 1082-96 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Lee, HK et al. (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112 631-43 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Williams, LE & Featherstone, DE (2014) Regulation of hippocampal synaptic strength by glial xCT. J. Neurosci. 34 16093-102 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Kamikubo, Y et al. (2013) Functional cooperation of metabotropic adenosine and glutamate receptors regulates postsynaptic plasticity in the cerebellum. J. Neurosci. 33 18661-71 PubMed GONUTS page
↑ Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page
↑ ^18.0 ^18.1 Deane, EC et al. (2013) Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation. J. Neurosci. 33 595-610 PubMed GONUTS page
↑ Schwenk, J et al. (2012) High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron 74 621-33 PubMed GONUTS page
↑ Fukata, Y et al. (2005) Molecular constituents of neuronal AMPA receptors. J. Cell Biol. 169 399-404 PubMed GONUTS page
↑ Lai, C et al. (2006) Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. J. Neurosci. 26 11798-806 PubMed GONUTS page
↑ Jurado, S et al. (2013) LTP requires a unique postsynaptic SNARE fusion machinery. Neuron 77 542-58 PubMed GONUTS page
↑ Shmelkov, SV et al. (2010) Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat. Med. 16 598-602, 1p following 602 PubMed GONUTS page
↑ Hildebrand, ME et al. (2009) Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J. Neurosci. 29 9668-82 PubMed GONUTS page
↑ Miyazaki, T et al. (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 580 4057-64 PubMed GONUTS page

[PMID:17229826-1] 1.0 ^1.1 ^1.2 Qiu, S & Weeber, EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J. Neurophysiol. 97 2312-21 PubMed GONUTS page

[PMID:21795692-2] 2.0 ^2.1 ^2.2 Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page

[PMID:21558424-3] 3.0 ^3.1 Wang, X et al. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum. Mol. Genet. 20 3093-108 PubMed GONUTS page

[PMID:15601948-4] Roumier, A et al. (2004) Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J. Neurosci. 24 11421-8 PubMed GONUTS page

[PMID:21144999-5] Dani, A et al. (2010) Superresolution imaging of chemical synapses in the brain. Neuron 68 843-56 PubMed GONUTS page

[PMID:18341993-6] Matsuda, S et al. (2008) Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Neuron 57 730-45 PubMed GONUTS page

[PMID:14555717-7] 7.0 ^7.1 ^7.2 ^7.3 Jensen, V et al. (2003) A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A. J. Physiol. (Lond.) 553 843-56 PubMed GONUTS page

[PMID:24983627-8] Kim, S & Ziff, EB (2014) Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol. 12 e1001900 PubMed GONUTS page

[PMID:11431570-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Mack, V et al. (2001) Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice. Science 292 2501-4 PubMed GONUTS page

[PMID:15207857-10] 10.0 ^10.1 Uemura, T et al. (2004) Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol. Cell. Neurosci. 26 330-41 PubMed GONUTS page

[PMID:16606358-11] 11.0 ^11.1 ^11.2 Uchino, S et al. (2006) Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J. Neurochem. 97 1203-14 PubMed GONUTS page

[PMID:21172611-12] 12.0 ^12.1 ^12.2 Kato, AS et al. (2010) Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron 68 1082-96 PubMed GONUTS page

[PMID:12628184-13] 13.0 ^13.1 ^13.2 Lee, HK et al. (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112 631-43 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25429150-15] Williams, LE & Featherstone, DE (2014) Regulation of hippocampal synaptic strength by glial xCT. J. Neurosci. 34 16093-102 PubMed GONUTS page

[PMID:24259587-16] 16.0 ^16.1 ^16.2 Kamikubo, Y et al. (2013) Functional cooperation of metabotropic adenosine and glutamate receptors regulates postsynaptic plasticity in the cerebellum. J. Neurosci. 33 18661-71 PubMed GONUTS page

[PMID:15681343-17] Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page

[PMID:23303939-18] 18.0 ^18.1 Deane, EC et al. (2013) Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation. J. Neurosci. 33 595-610 PubMed GONUTS page

[PMID:22632720-19] Schwenk, J et al. (2012) High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron 74 621-33 PubMed GONUTS page

[PMID:15883194-20] Fukata, Y et al. (2005) Molecular constituents of neuronal AMPA receptors. J. Cell Biol. 169 399-404 PubMed GONUTS page

[PMID:17093100-21] Lai, C et al. (2006) Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. J. Neurosci. 26 11798-806 PubMed GONUTS page

[PMID:23395379-22] Jurado, S et al. (2013) LTP requires a unique postsynaptic SNARE fusion machinery. Neuron 77 542-58 PubMed GONUTS page

[PMID:20418887-23] Shmelkov, SV et al. (2010) Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat. Med. 16 598-602, 1p following 602 PubMed GONUTS page

[PMID:19657020-24] Hildebrand, ME et al. (2009) Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J. Neurosci. 29 9668-82 PubMed GONUTS page

[PMID:16814779-25] Miyazaki, T et al. (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 580 4057-64 PubMed GONUTS page

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MOUSE:GRIA1

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