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PMID:14555717

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Citation

Jensen, V, Kaiser, KM, Borchardt, T, Adelmann, G, Rozov, A, Burnashev, N, Brix, C, Frotscher, M, Andersen, P, Hvalby, Ø, Sakmann, B, Seeburg, PH and Sprengel, R (2003) A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A. J. Physiol. (Lond.) 553:843-56

Abstract

In adult mice, long-term potentiation (LTP) of synaptic transmission at CA3-to-CA1 synapses induced by tetanic stimulation requires L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors containing GluR-A subunits. Here, we report a GluR-A-independent form of LTP, which is comparable in size to LTP in wild-type mice at postnatal day 14 (P14) but diminishes between P14 and P42 in brain slices of GluR-A-deficient mice. The GluR-A-independent form of LTP is sensitive to D(-)-2-amino-5-phosphonopentanoic acid (D-AP5), but lacks short-term potentiation (STP) and can also be observed in the pairing induction protocol. As judged by unaltered paired-pulse facilitation, this LTP form is postsynaptically expressed despite depleted extrasynaptic AMPA receptor pools with reduced levels of GluR-B, which accumulates in somata and synapses of CA1 pyramidal neurons in GluR-A-deficient mice. Our results show that in the developing hippocampus synaptic plasticity can be expressed by AMPA receptors lacking the GluR-A subunit.

Links

PubMed PMC2343614 Online version:10.1113/jphysiol.2003.053637

Keywords

Animals; Base Sequence; Crosses, Genetic; DNA Primers; Excitatory Postsynaptic Potentials/physiology; Hippocampus/physiology; In Vitro Techniques; Long-Term Potentiation/physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Immunoelectron; Protein Subunits/genetics; Pyramidal Cells/physiology; Receptors, AMPA/deficiency; Receptors, AMPA/genetics; Receptors, AMPA/physiology; Reference Values; Synaptic Transmission

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:GRIA1

located_in

GO:0099061: integral component of postsynaptic density membrane

ECO:0000305: curator inference used in manual assertion

GO:0098839

C

  • part_of:(GO:0060076)
  • part_of:(CL:1001571)
  • part_of:(UBERON:0003881)

Seeded From UniProt

complete

MOUSE:GRIA1

located_in

GO:0098839: postsynaptic density membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(GO:0043197)
  • part_of:(CL:0000540)
  • part_of:(UBERON:0014554)

Seeded From UniProt

complete

MOUSE:GRIA1

located_in

GO:0099061: integral component of postsynaptic density membrane

ECO:0006003: electron microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:GRIA1

located_in

GO:0098978: glutamatergic synapse

ECO:0006003: electron microscopy evidence used in manual assertion

C

  • part_of:(UBERON:0002421)

Seeded From UniProt

complete

MOUSE:GRIA2

located_in

GO:0099061: integral component of postsynaptic density membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(GO:0043197)
  • part_of:(CL:1001571)
  • part_of:(UBERON:0003881)

Seeded From UniProt

complete

MOUSE:GRIA2

located_in

GO:0098839: postsynaptic density membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(GO:0043197)
  • part_of:(CL:1001571)
  • part_of:(UBERON:0003881)

Seeded From UniProt

complete

MOUSE:GRIA2

located_in

GO:0099061: integral component of postsynaptic density membrane

ECO:0006003: electron microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:GRIA2

located_in

GO:0098978: glutamatergic synapse

ECO:0006003: electron microscopy evidence used in manual assertion

C

  • part_of:(UBERON:0002421)

Seeded From UniProt

complete

MOUSE:GRIA1

part_of

GO:0099061: integral component of postsynaptic density membrane

ECO:0000305: curator inference used in manual assertion

GO:0098839

C

  • part_of:(GO:0060076)
  • part_of:(CL:1001571)
  • part_of:(UBERON:0003881)

Seeded From UniProt

complete

MOUSE:GRIA1

part_of

GO:0098839: postsynaptic density membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(GO:0043197)
  • part_of:(CL:0000540)
  • part_of:(UBERON:0014554)

Seeded From UniProt

complete

MOUSE:GRIA1

part_of

GO:0098978: glutamatergic synapse

ECO:0006003: electron microscopy evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

MOUSE:GRIA1

part_of

GO:0099061: integral component of postsynaptic density membrane

ECO:0006003: electron microscopy evidence used in manual assertion

C

  • part_of:(GO:0098978)
  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0002421)

Seeded From UniProt

complete

Notes

See also

References

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