MOUSE:GRB2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Grb2
Protein Name(s)	Growth factor receptor-bound protein 2 Adapter protein GRB2 SH2/SH3 adapter GRB2
External Links
UniProt	Q60631
EMBL	U07617 D85748 BC052377 BC085254
CCDS	CCDS25645.1
PIR	A54688
RefSeq	NP_032189.1
UniGene	Mm.439649 Mm.490413
PDB	1GBQ 1GBR 2GBQ 3GBQ 4GBQ
PDBsum	1GBQ 1GBR 2GBQ 3GBQ 4GBQ
ProteinModelPortal	Q60631
SMR	Q60631
BioGrid	200046
DIP	DIP-259N
IntAct	Q60631
MINT	MINT-84889
BindingDB	Q60631
ChEMBL	CHEMBL4830
PhosphoSite	Q60631
MaxQB	Q60631
PaxDb	Q60631
PRIDE	Q60631
Ensembl	ENSMUST00000021090 ENSMUST00000106497 ENSMUST00000106499
GeneID	14784
KEGG	mmu:14784
UCSC	uc007mij.1
CTD	2885
MGI	MGI:95805
eggNOG	NOG298780
GeneTree	ENSGT00550000074482
HOGENOM	HOG000251625
HOVERGEN	HBG005404
InParanoid	Q60631
KO	K04364
OMA	RFQDSVQ
OrthoDB	EOG75F4F6
PhylomeDB	Q60631
TreeFam	TF354288
Reactome	REACT_188185 REACT_188194 REACT_188202 REACT_188528 REACT_188530 REACT_188574 REACT_188578 REACT_188580 REACT_196455 REACT_196460 REACT_196588 REACT_198350 REACT_198374 REACT_198525 REACT_198526 REACT_198634 REACT_199123 REACT_203917 REACT_206286 REACT_210793 REACT_211860 REACT_213364 REACT_215348 REACT_215628 REACT_220092 REACT_223974 REACT_223993 REACT_225477 REACT_225836 REACT_226341 REACT_227425 REACT_230639 REACT_234357 REACT_237796 REACT_239466 REACT_239722 REACT_240139 REACT_241824 REACT_244029 REACT_245103 REACT_260286 REACT_261451 REACT_94437
ChiTaRS	Grb2
EvolutionaryTrace	Q60631
NextBio	286907
PRO	PR:Q60631
Proteomes	UP000000589
Bgee	Q60631
CleanEx	MM_GRB2
ExpressionAtlas	Q60631
Genevestigator	Q60631
GO	GO:0005911 GO:0008180 GO:0005737 GO:0005829 GO:0005768 GO:0070062 GO:0005794 GO:0070436 GO:0016020 GO:0005634 GO:0005886 GO:0012506 GO:0046875 GO:0044822 GO:0019904 GO:0019903 GO:0017124 GO:0005070 GO:0007568 GO:0048646 GO:0060670 GO:0030154 GO:0071479 GO:0008286 GO:0030838 GO:2000379 GO:0009967 GO:0051291 GO:0007265 GO:0031623 GO:0043408 GO:0042770
Gene3D	3.30.505.10
InterPro	IPR030219 IPR000980 IPR001452
PANTHER	PTHR22820:SF27
Pfam	PF00017 PF00018
PRINTS	PR00401 PR00452
SMART	SM00252 SM00326
SUPFAM	SSF50044 SSF55550
PROSITE	PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0046875	ephrin receptor binding	PMID:12925710^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8CBF3	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:20398064^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:E9Q612	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P62993	F		Seeded From UniProt	complete
part_of	GO:0008180	COP9 signalosome	PMID:22561606^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P62993	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P62993	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000379	positive regulation of reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071479	cellular response to ionizing radiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	P		Seeded From UniProt	complete
part_of	GO:0070436	Grb2-EGFR complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060670	branching involved in labyrinthine layer morphogenesis	PMID:11369229^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2677457	P	has_participant:(EMAPA:16042)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619758	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619758	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:11369229^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2677457	P	results_in_formation_of:(EMAPA:16272)	Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619758	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043408	regulation of MAPK cascade	PMID:15569713^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1930016	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042770	signal transduction in response to DNA damage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619758	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031623	receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030838	positive regulation of actin filament polymerization	PMID:17923684^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1891396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:16908534^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16051) results_in_acquisition_of_features_of:(CL:0000223)	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:8438166^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q06649	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619758	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619758	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15983387^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	PMID:12147689^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008286	insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	P		Seeded From UniProt	complete
part_of	GO:0008180	COP9 signalosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007568	aging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619758	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:23793062^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17923684^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15736129^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039) part_of:(CL:0000007)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	C		Seeded From UniProt	complete
enables	GO:0005168	neurotrophin TRKA receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	F		Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	F		Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619758	F		Seeded From UniProt	complete
enables	GO:0005070	SH3/SH2 adaptor activity	PMID:7689150^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P62993	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619758	F		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005070	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0LPF3 ensembl:ENSP00000376345	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0LPF3 ensembl:ENSP00000376345	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0LPF3 ensembl:ENSP00000376345	C		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62994 ensembl:ENSRNOP00000005347	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62994 ensembl:ENSRNOP00000005347	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62994 ensembl:ENSRNOP00000005347	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62994 ensembl:ENSRNOP00000005347	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62994 ensembl:ENSRNOP00000005347	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62994 ensembl:ENSRNOP00000005347	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62994 ensembl:ENSRNOP00000005347	P		Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62994 ensembl:ENSRNOP00000005347	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62994 ensembl:ENSRNOP00000005347	F		Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	P		Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	P		Seeded From UniProt	complete
part_of	GO:0070436	Grb2-EGFR complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F		Seeded From UniProt	complete
involved_in	GO:0042770	signal transduction in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	P		Seeded From UniProt	complete
part_of	GO:0008180	COP9 signalosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C		Seeded From UniProt	complete
enables	GO:0005168	neurotrophin TRKA receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F		Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030219	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-9036961 Reactome:R-MMU-914067 Reactome:R-MMU-9029162 Reactome:R-MMU-9029152 Reactome:R-MMU-9029146 Reactome:R-MMU-9007137 Reactome:R-MMU-9007126 Reactome:R-MMU-8983356 Reactome:R-MMU-2730869 Reactome:R-MMU-2730846	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007265	Ras protein signal transduction	PMID:1322798^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Vindis, C et al. (2003) EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J. Cell Biol. 162 661-71 PubMed GONUTS page
↑ Murata, Y et al. (2010) Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn. Genes Cells 15 513-24 PubMed GONUTS page
↑ Wang, D et al. (2012) Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat. Immunol. 13 560-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Saxton, TM et al. (2001) Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis. Curr. Biol. 11 662-70 PubMed GONUTS page
↑ Schuetz, G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J. Cell Biol. 167 945-52 PubMed GONUTS page
↑ ^6.0 ^6.1 Garg, P et al. (2007) Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol. Cell. Biol. 27 8698-712 PubMed GONUTS page
↑ Hamazaki, T et al. (2006) The Grb2/Mek pathway represses Nanog in murine embryonic stem cells. Mol. Cell. Biol. 26 7539-49 PubMed GONUTS page
↑ Ren, R et al. (1993) Identification of a ten-amino acid proline-rich SH3 binding site. Science 259 1157-61 PubMed GONUTS page
↑ Ishii, H et al. (2005) Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc. Natl. Acad. Sci. U.S.A. 102 9655-60 PubMed GONUTS page
↑ Benesch, S et al. (2002) Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2. J. Biol. Chem. 277 37771-6 PubMed GONUTS page
↑ Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page
↑ Xie, Y et al. (2005) Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells. Mol. Reprod. Dev. 71 1-11 PubMed GONUTS page
↑ Suen, KL et al. (1993) Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. Mol. Cell. Biol. 13 5500-12 PubMed GONUTS page
↑ Lowenstein, EJ et al. (1992) The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70 431-42 PubMed GONUTS page

[PMID:12925710-1] Vindis, C et al. (2003) EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J. Cell Biol. 162 661-71 PubMed GONUTS page

[PMID:20398064-2] Murata, Y et al. (2010) Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn. Genes Cells 15 513-24 PubMed GONUTS page

[PMID:22561606-3] Wang, D et al. (2012) Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat. Immunol. 13 560-8 PubMed GONUTS page

[PMID:11369229-4] 4.0 ^4.1 Saxton, TM et al. (2001) Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis. Curr. Biol. 11 662-70 PubMed GONUTS page

[PMID:15569713-5] Schuetz, G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J. Cell Biol. 167 945-52 PubMed GONUTS page

[PMID:17923684-6] 6.0 ^6.1 Garg, P et al. (2007) Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol. Cell. Biol. 27 8698-712 PubMed GONUTS page

[PMID:16908534-7] Hamazaki, T et al. (2006) The Grb2/Mek pathway represses Nanog in murine embryonic stem cells. Mol. Cell. Biol. 26 7539-49 PubMed GONUTS page

[PMID:8438166-8] Ren, R et al. (1993) Identification of a ten-amino acid proline-rich SH3 binding site. Science 259 1157-61 PubMed GONUTS page

[PMID:15983387-9] Ishii, H et al. (2005) Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc. Natl. Acad. Sci. U.S.A. 102 9655-60 PubMed GONUTS page

[PMID:12147689-10] Benesch, S et al. (2002) Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2. J. Biol. Chem. 277 37771-6 PubMed GONUTS page

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MOUSE:GRB2

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