MOUSE:GLI2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gli2 (ECO:0000312 with MGI:MGI:95728) (synonyms: Thp (ECO:0000250 with UniProtKB:P10070))
Protein Name(s)	Zinc finger protein GLI2 (ECO:0000305) Tax helper protein (ECO:0000250 with UniProtKB:P10070)
External Links
UniProt	Q0VGT2
EMBL	AC109271 AC122287 AC132589 BC085190
CCDS	CCDS35692.1
RefSeq	NP_001074594.1 XP_006529203.1
UniGene	Mm.273292
ProteinModelPortal	Q0VGT2
SMR	Q0VGT2
BioGrid	199943
DIP	DIP-60772N
IntAct	Q0VGT2
PhosphoSite	Q0VGT2
PRIDE	Q0VGT2
Ensembl	ENSMUST00000062483
GeneID	14633
KEGG	mmu:14633
UCSC	uc007cim.1
CTD	2736
MGI	MGI:95728
eggNOG	COG5048
GeneTree	ENSGT00760000118771
HOGENOM	HOG000290688
HOVERGEN	HBG005844
InParanoid	Q0VGT2
KO	K16798
OMA	MLYYYGQ
OrthoDB	EOG7X6KZ8
TreeFam	TF350216
Reactome	REACT_269412 REACT_270923
ChiTaRS	Gli2
NextBio	286486
PRO	PR:Q0VGT2
Proteomes	UP000000589
Bgee	Q0VGT2
ExpressionAtlas	Q0VGT2
Genevestigator	Q0VGT2
GO	GO:0097542 GO:0005929 GO:0005737 GO:0016020 GO:0031512 GO:0016607 GO:0005634 GO:0072372 GO:0003682 GO:0003677 GO:0043565 GO:0003700 GO:0044212 GO:0008270 GO:0048856 GO:0048646 GO:0007411 GO:0048754 GO:0030154 GO:0008283 GO:0071407 GO:0021696 GO:0002062 GO:0090103 GO:0048589 GO:0021904 GO:0009953 GO:0048566 GO:0042733 GO:0009913 GO:0021508 GO:0060322 GO:0007507 GO:0030902 GO:0007442 GO:0001701 GO:0001822 GO:0030324 GO:0030879 GO:0060603 GO:0002009 GO:0032331 GO:0000122 GO:0021915 GO:0048666 GO:0060032 GO:0042475 GO:0002076 GO:0001649 GO:0007389 GO:0021983 GO:0008284 GO:0045740 GO:0045666 GO:0045944 GO:0045893 GO:0060513 GO:0009954 GO:0008589 GO:0009612 GO:0001501 GO:0007224 GO:0060831 GO:0021938 GO:0021776 GO:0021775 GO:0021513 GO:0021522 GO:0021965 GO:0006351 GO:0035295 GO:0007418 GO:0021517
Gene3D	3.30.160.60
InterPro	IPR007087 IPR015880 IPR013087
Pfam	PF00096
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005930	axoneme	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Fig 4A shows ciliary localisation in WT	complete CACAO 2875
	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16254602^[2]	ECO:0000314			P		Gli2 increased transcription of Ptch1 in wild type cells (Figure 3B).	complete CACAO 10676
part_of	GO:0005929	cilium	PMID:25644602^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25808752^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:25808752^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:25808752^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61572	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16254602^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005930	axoneme	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:16880529^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16880529^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:16880529^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10070	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17035233^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11238441^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098586	cellular response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	P		Seeded From UniProt	complete
part_of	GO:0097542	ciliary tip	PMID:21653639^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090103	cochlea morphogenesis	PMID:17395647^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	has_participant:(EMAPA:17598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	PMID:19103752^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	PMID:20159594^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2442827	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	PMID:17395647^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060603	mammary gland duct morphogenesis	PMID:11783999^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060513	prostatic bud formation	PMID:16707121^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	results_in_formation_of:(EMAPA:19287)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060322	head development	PMID:19056373^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3834146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060032	notochord regression	PMID:10725236^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95727	P	has_participant:(EMAPA:16191)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048856	anatomical structure development	PMID:11485934^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	results_in_development_of:(EMAPA:18256)\|results_in_development_of:(EMAPA:18692)\|results_in_development_of:(EMAPA:16832)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048856	anatomical structure development	PMID:11485934^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	results_in_development_of:(EMAPA:18256)\|results_in_development_of:(EMAPA:18692)\|results_in_development_of:(EMAPA:16832)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048754	branching morphogenesis of an epithelial tube	PMID:9731531^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	has_participant:(EMAPA:16733)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048666	neuron development	PMID:16267219^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	occurs_in:(EMAPA:17577) results_in_development_of:(CL:0000741)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:9731531^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	results_in_formation_of:(EMAPA:16853)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048589	developmental growth	PMID:16571630^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2446434,MGI:MGI:3664541	P	occurs_in:(EMAPA:16974)\|occurs_in:(EMAPA:16916)\|occurs_in:(EMAPA:16974)\|occurs_in:(EMAPA:16916)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048566	embryonic digestive tract development	PMID:10693670^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16880529^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16950124^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97347)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16880529^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:88177)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16611981^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18590716^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17328886^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15614767^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045740	positive regulation of DNA replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:16950124^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97490	P	regulates_o_occurs_in:(EMAPA:16531) regulates_o_results_in_acquisition_of_features_of:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19124651^[26]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:104853)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:16611981^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:19056373^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:19056373^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3834146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:9655803^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	has_participant:(EMAPA:17942)\|has_participant:(EMAPA:17921)\|has_participant:(EMAPA:17918)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:9655803^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	has_participant:(EMAPA:17939)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035295	tube development	PMID:9731531^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	results_in_development_of:(EMAPA:16853)\|results_in_development_of:(EMAPA:16833)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032331	negative regulation of chondrocyte differentiation	PMID:17328886^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:18590716^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030902	hindbrain development	PMID:15496441^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030902	hindbrain development	PMID:8575294^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857164	P	results_in_development_of:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030902	hindbrain development	PMID:15496441^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:11783999^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	results_in_development_of:(EMAPA:35538)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:10725236^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95727	P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:9731531^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	results_in_development_of:(EMAPA:16733)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:9655799^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	occurs_in:(EMAPA:16532)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:9636069^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	occurs_in:(EMAPA:16165)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021983	pituitary gland development	PMID:10725236^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95727	P	results_in_development_of:(EMAPA:16898)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021965	spinal cord ventral commissure morphogenesis	PMID:10409510^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	PMID:16571625^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95727	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000120)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	PMID:16571625^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2446434,MGI:MGI:3664541	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000120)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021915	neural tube development	PMID:19056373^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3834146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:19286674^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:18590716^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:9247260^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021776	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	PMID:15215207^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	occurs_in:(EMAPA:16525) occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification	PMID:15215207^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	occurs_in:(EMAPA:16525) occurs_in:(CL:0000099)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021696	cerebellar cortex morphogenesis	PMID:16571625^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95727	P	has_participant:(EMAPA:17787)\|has_participant:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021696	cerebellar cortex morphogenesis	PMID:16571625^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2446434,MGI:MGI:3664541	P	has_participant:(EMAPA:17787)\|has_participant:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021522	spinal cord motor neuron differentiation	PMID:21552265^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	occurs_in:(EMAPA:16530) results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021517	ventral spinal cord development	PMID:11748151^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158472	P	results_in_development_of:(EMAPA:16531)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021513	spinal cord dorsal/ventral patterning	PMID:16364285^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99833	P	has_participant:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021513	spinal cord dorsal/ventral patterning	PMID:15215207^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	has_participant:(EMAPA:16525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021513	spinal cord dorsal/ventral patterning	PMID:16364285^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	has_participant:(EMAPA:16531)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021513	spinal cord dorsal/ventral patterning	PMID:11748151^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158472	P	has_participant:(EMAPA:16531)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021508	floor plate formation	PMID:9655799^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	results_in_formation_of:(EMAPA:16473)\|results_in_formation_of:(EMAPA:16481)\|results_in_formation_of:(EMAPA:16485)\|results_in_formation_of:(EMAPA:16489)\|results_in_formation_of:(EMAPA:16493)\|results_in_formation_of:(EMAPA:16497)\|results_in_formation_of:(EMAPA:16501)\|results_in_formation_of:(EMAPA:16505)\|results_in_formation_of:(EMAPA:16509)\|results_in_formation_of:(EMAPA:16509)\|results_in_formation_of:(EMAPA:16531)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021508	floor plate formation	PMID:9636069^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	results_in_formation_of:(EMAPA:16165)	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:19684112^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19286674^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009954	proximal/distal pattern formation	PMID:16342201^[41]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95727 MGI:MGI:95729	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:16342201^[41]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95727	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:22841643^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009913	epidermal cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008589	regulation of smoothened signaling pathway	PMID:19056373^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3834146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:16054035^[43]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:15496441^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:9731531^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:15496441^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:19056373^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	occurs_in:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:11172440^[44]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	results_in_development_of:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007442	hindgut morphogenesis	PMID:11485934^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	has_participant:(EMAPA:17896)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007442	hindgut morphogenesis	PMID:11485934^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	has_participant:(EMAPA:17896)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007418	ventral midline development	PMID:10725236^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95727	P	results_in_development_of:(EMAPA:16903)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007418	ventral midline development	PMID:10725236^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	results_in_development_of:(EMAPA:16531)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:10409510^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:14602680^[45]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	occurs_in:(EMAPA:16184)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:8575294^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857164	P	occurs_in:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:19124651^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95727	P	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:19124651^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:22689656^[46]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19684112^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19654211^[47]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)\|part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19286674^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:16254602^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16316410^[48]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1345643	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19684112^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19286674^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19684112^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19286674^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18590716^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16754)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16316410^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16254602^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16880529^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16396903^[49]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17373) has_participant:(MGI:MGI:97486)\|occurs_in(EMAPA:17373) has_participant:(MGI:MGI:1889585)\|occurs_in(EMAPA:17373) has_participant:(MGI:MGI:97357)\|occurs_in(EMAPA:17373) has_participant:(MGI:MGI:88313)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16880529^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:88177)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15614767^[25]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:1096383)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002076	osteoblast development	PMID:16880529^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002076	osteoblast development	PMID:16880529^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002062	chondrocyte differentiation	PMID:23333501^[50]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1915509	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002009	morphogenesis of an epithelium	PMID:16707121^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:11172440^[44]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P	results_in_development_of:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:19056373^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3834146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:22771375^[51]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1915509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:9006072^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16611981^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95727	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10070	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	P		Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	F		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	F		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10070 ensembl:ENSP00000390436	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-5610751 Reactome:R-NUL-5610715 Reactome:R-NUL-5610714 Reactome:R-NUL-5610711 Reactome:R-MMU-5610710	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-8986307	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Haycraft, CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 e53 PubMed GONUTS page
↑ Chong, YC et al. (2015) Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5. Genes Dev. 29 262-76 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Yoshida, M et al. (2015) The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification. Nat Commun 6 6653 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Zhao, M et al. (2006) The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol. Cell. Biol. 26 6197-208 PubMed GONUTS page
↑ He, J et al. (2006) Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. J. Biol. Chem. 281 35598-602 PubMed GONUTS page
↑ Koyabu, Y et al. (2001) Physical and functional interactions between Zic and Gli proteins. J. Biol. Chem. 276 6889-92 PubMed GONUTS page
↑ Friedland-Little, JM et al. (2011) A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. Hum. Mol. Genet. 20 3725-37 PubMed GONUTS page
↑ ^9.0 ^9.1 Bok, J et al. (2007) Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development 134 1713-22 PubMed GONUTS page
↑ Zhao, M et al. (2009) Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol. Cell. Biol. 29 1291-305 PubMed GONUTS page
↑ Ko, HW et al. (2010) Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev. Cell 18 237-47 PubMed GONUTS page
↑ ^12.0 ^12.1 Lewis, MT et al. (2001) The Gli2 transcription factor is required for normal mouse mammary gland development. Dev. Biol. 238 133-44 PubMed GONUTS page
↑ ^13.0 ^13.1 Doles, J et al. (2006) Functional compensation in Hedgehog signaling during mouse prostate development. Dev. Biol. 295 13-25 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Pan, Y et al. (2009) Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev. Biol. 326 177-89 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Park, HL et al. (2000) Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127 1593-605 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Mo, R et al. (2001) Anorectal malformations caused by defects in sonic hedgehog signaling. Am. J. Pathol. 159 765-74 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Motoyama, J et al. (1998) Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat. Genet. 20 54-7 PubMed GONUTS page
↑ Dillon, AK et al. (2005) Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cord. J. Neurosci. 25 10119-30 PubMed GONUTS page
↑ Blaess, S et al. (2006) Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133 1799-809 PubMed GONUTS page
↑ Kimmel, SG et al. (2000) New mouse models of congenital anorectal malformations. J. Pediatr. Surg. 35 227-30; discussion 230-1 PubMed GONUTS page
↑ ^21.0 ^21.1 Lei, Q et al. (2006) Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev. Cell 11 325-37 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Pan, Y et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 26 3365-77 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page
↑ ^24.0 ^24.1 Mau, E et al. (2007) PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev. Biol. 305 28-39 PubMed GONUTS page
↑ ^25.0 ^25.1 Saitsu, H et al. (2005) Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain. Dev. Dyn. 232 282-92 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Wall, DS et al. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J. Cell Biol. 184 101-12 PubMed GONUTS page
↑ ^27.0 ^27.1 Hardcastle, Z et al. (1998) The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 125 2803-11 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 Corrales, JD et al. (2004) Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development. Development 131 5581-90 PubMed GONUTS page
↑ ^29.0 ^29.1 Millen, KJ et al. (1995) A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum. Development 121 3935-45 PubMed GONUTS page
↑ ^30.0 ^30.1 Matise, MP et al. (1998) Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125 2759-70 PubMed GONUTS page
↑ ^31.0 ^31.1 Ding, Q et al. (1998) Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125 2533-43 PubMed GONUTS page
↑ ^32.0 ^32.1 Matise, MP et al. (1999) Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord. Development 126 3649-59 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 Corrales, JD et al. (2006) The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 133 1811-21 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 ^34.4 Norman, RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum. Mol. Genet. 18 1740-54 PubMed GONUTS page
↑ Hynes, M et al. (1997) Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19 15-26 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 Lei, Q et al. (2004) Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 131 3593-604 PubMed GONUTS page
↑ Ocbina, PJ et al. (2011) Complex interactions between genes controlling trafficking in primary cilia. Nat. Genet. 43 547-53 PubMed GONUTS page
↑ ^38.0 ^38.1 Bai, CB & Joyner, AL (2001) Gli1 can rescue the in vivo function of Gli2. Development 128 5161-72 PubMed GONUTS page
↑ ^39.0 ^39.1 Eggenschwiler, JT et al. (2006) Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins. Dev. Biol. 290 1-12 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 ^40.3 Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page
↑ ^41.0 ^41.1 Furimsky, M & Wallace, VA (2006) Complementary Gli activity mediates early patterning of the mouse visual system. Dev. Dyn. 235 594-605 PubMed GONUTS page
↑ Bowers, M et al. (2012) Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3. Dev. Biol. 370 110-24 PubMed GONUTS page
↑ Mill, P et al. (2005) Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev. Cell 9 293-303 PubMed GONUTS page
↑ ^44.0 ^44.1 Kim, PC et al. (2001) Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway. J. Pediatr. Surg. 36 381-4 PubMed GONUTS page
↑ Buttitta, L et al. (2003) Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130 6233-43 PubMed GONUTS page
↑ Liem, KF Jr et al. (2012) The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J. Cell Biol. 197 789-800 PubMed GONUTS page
↑ Clement, CA et al. (2009) The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J. Cell. Sci. 122 3070-82 PubMed GONUTS page
↑ ^48.0 ^48.1 Barnfield, PC et al. (2005) Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73 397-405 PubMed GONUTS page
↑ Hu, MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133 569-78 PubMed GONUTS page
↑ Wang, C et al. (2013) IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways. Exp. Cell Res. 319 623-32 PubMed GONUTS page
↑ Yang, S & Wang, C (2012) The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis. Bone 51 407-17 PubMed GONUTS page
↑ Mo, R et al. (1997) Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124 113-23 PubMed GONUTS page

[PMID:21209331-1] 1.0 ^1.1 ^1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page

[PMID:16254602-2] 2.0 ^2.1 ^2.2 ^2.3 Haycraft, CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 e53 PubMed GONUTS page

[PMID:25644602-3] Chong, YC et al. (2015) Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5. Genes Dev. 29 262-76 PubMed GONUTS page

[PMID:25808752-4] 4.0 ^4.1 ^4.2 Yoshida, M et al. (2015) The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification. Nat Commun 6 6653 PubMed GONUTS page

[PMID:16880529-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Zhao, M et al. (2006) The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol. Cell. Biol. 26 6197-208 PubMed GONUTS page

[PMID:17035233-6] He, J et al. (2006) Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. J. Biol. Chem. 281 35598-602 PubMed GONUTS page

[PMID:11238441-7] Koyabu, Y et al. (2001) Physical and functional interactions between Zic and Gli proteins. J. Biol. Chem. 276 6889-92 PubMed GONUTS page

[PMID:21653639-8] Friedland-Little, JM et al. (2011) A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. Hum. Mol. Genet. 20 3725-37 PubMed GONUTS page

[PMID:17395647-9] 9.0 ^9.1 Bok, J et al. (2007) Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development 134 1713-22 PubMed GONUTS page

[PMID:19103752-10] Zhao, M et al. (2009) Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol. Cell. Biol. 29 1291-305 PubMed GONUTS page

[PMID:20159594-11] Ko, HW et al. (2010) Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev. Cell 18 237-47 PubMed GONUTS page

[PMID:11783999-12] 12.0 ^12.1 Lewis, MT et al. (2001) The Gli2 transcription factor is required for normal mouse mammary gland development. Dev. Biol. 238 133-44 PubMed GONUTS page

[PMID:16707121-13] 13.0 ^13.1 Doles, J et al. (2006) Functional compensation in Hedgehog signaling during mouse prostate development. Dev. Biol. 295 13-25 PubMed GONUTS page

[PMID:19056373-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Pan, Y et al. (2009) Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev. Biol. 326 177-89 PubMed GONUTS page

[PMID:10725236-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Park, HL et al. (2000) Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127 1593-605 PubMed GONUTS page

[PMID:11485934-16] 16.0 ^16.1 ^16.2 ^16.3 Mo, R et al. (2001) Anorectal malformations caused by defects in sonic hedgehog signaling. Am. J. Pathol. 159 765-74 PubMed GONUTS page

[PMID:9731531-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Motoyama, J et al. (1998) Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat. Genet. 20 54-7 PubMed GONUTS page

[PMID:16267219-18] Dillon, AK et al. (2005) Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cord. J. Neurosci. 25 10119-30 PubMed GONUTS page

[PMID:16571630-19] Blaess, S et al. (2006) Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133 1799-809 PubMed GONUTS page

[PMID:10693670-20] Kimmel, SG et al. (2000) New mouse models of congenital anorectal malformations. J. Pediatr. Surg. 35 227-30; discussion 230-1 PubMed GONUTS page

[PMID:16950124-21] 21.0 ^21.1 Lei, Q et al. (2006) Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev. Cell 11 325-37 PubMed GONUTS page

[PMID:16611981-22] 22.0 ^22.1 ^22.2 Pan, Y et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 26 3365-77 PubMed GONUTS page

[PMID:18590716-23] 23.0 ^23.1 ^23.2 ^23.3 Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page

[PMID:17328886-24] 24.0 ^24.1 Mau, E et al. (2007) PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev. Biol. 305 28-39 PubMed GONUTS page

[PMID:15614767-25] 25.0 ^25.1 Saitsu, H et al. (2005) Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain. Dev. Dyn. 232 282-92 PubMed GONUTS page

[PMID:19124651-26] 26.0 ^26.1 ^26.2 Wall, DS et al. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J. Cell Biol. 184 101-12 PubMed GONUTS page

[PMID:9655803-27] 27.0 ^27.1 Hardcastle, Z et al. (1998) The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 125 2803-11 PubMed GONUTS page

[PMID:15496441-28] 28.0 ^28.1 ^28.2 ^28.3 Corrales, JD et al. (2004) Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development. Development 131 5581-90 PubMed GONUTS page

[PMID:8575294-29] 29.0 ^29.1 Millen, KJ et al. (1995) A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum. Development 121 3935-45 PubMed GONUTS page

[PMID:9655799-30] 30.0 ^30.1 Matise, MP et al. (1998) Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125 2759-70 PubMed GONUTS page

[PMID:9636069-31] 31.0 ^31.1 Ding, Q et al. (1998) Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125 2533-43 PubMed GONUTS page

[PMID:10409510-32] 32.0 ^32.1 Matise, MP et al. (1999) Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord. Development 126 3649-59 PubMed GONUTS page

[PMID:16571625-33] 33.0 ^33.1 ^33.2 ^33.3 Corrales, JD et al. (2006) The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 133 1811-21 PubMed GONUTS page

[PMID:19286674-34] 34.0 ^34.1 ^34.2 ^34.3 ^34.4 Norman, RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum. Mol. Genet. 18 1740-54 PubMed GONUTS page

[PMID:9247260-35] Hynes, M et al. (1997) Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19 15-26 PubMed GONUTS page

[PMID:15215207-36] 36.0 ^36.1 ^36.2 Lei, Q et al. (2004) Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 131 3593-604 PubMed GONUTS page

[PMID:21552265-37] Ocbina, PJ et al. (2011) Complex interactions between genes controlling trafficking in primary cilia. Nat. Genet. 43 547-53 PubMed GONUTS page

[PMID:11748151-38] 38.0 ^38.1 Bai, CB & Joyner, AL (2001) Gli1 can rescue the in vivo function of Gli2. Development 128 5161-72 PubMed GONUTS page

[PMID:16364285-39] 39.0 ^39.1 Eggenschwiler, JT et al. (2006) Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins. Dev. Biol. 290 1-12 PubMed GONUTS page

[PMID:19684112-40] 40.0 ^40.1 ^40.2 ^40.3 Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page

[PMID:16342201-41] 41.0 ^41.1 Furimsky, M & Wallace, VA (2006) Complementary Gli activity mediates early patterning of the mouse visual system. Dev. Dyn. 235 594-605 PubMed GONUTS page

[PMID:22841643-42] Bowers, M et al. (2012) Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3. Dev. Biol. 370 110-24 PubMed GONUTS page

[PMID:16054035-43] Mill, P et al. (2005) Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev. Cell 9 293-303 PubMed GONUTS page

[PMID:11172440-44] 44.0 ^44.1 Kim, PC et al. (2001) Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway. J. Pediatr. Surg. 36 381-4 PubMed GONUTS page

[PMID:14602680-45] Buttitta, L et al. (2003) Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130 6233-43 PubMed GONUTS page

[PMID:22689656-46] Liem, KF Jr et al. (2012) The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J. Cell Biol. 197 789-800 PubMed GONUTS page

[PMID:19654211-47] Clement, CA et al. (2009) The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J. Cell. Sci. 122 3070-82 PubMed GONUTS page

[PMID:16316410-48] 48.0 ^48.1 Barnfield, PC et al. (2005) Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73 397-405 PubMed GONUTS page

[PMID:16396903-49] Hu, MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133 569-78 PubMed GONUTS page

[PMID:23333501-50] Wang, C et al. (2013) IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways. Exp. Cell Res. 319 623-32 PubMed GONUTS page

[PMID:22771375-51] Yang, S & Wang, C (2012) The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis. Bone 51 407-17 PubMed GONUTS page

[PMID:9006072-52] Mo, R et al. (1997) Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124 113-23 PubMed GONUTS page

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MOUSE:GLI2

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