GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:9636069

From GONUTS
Jump to: navigation, search
Citation

Ding, Q, Motoyama, J, Gasca, S, Mo, R, Sasaki, H, Rossant, J and Hui, CC (1998) Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125:2533-43

Abstract

Floor plate cells at the midline of the neural tube are specified by high-level activity of Sonic hedgehog (Shh) secreted by notochord, whereas motor neurons are thought to be specified by a lower level activity of Shh secreted in turn by floor plate cells. In Drosophila, the Gli zinc finger protein Cubitus interruptus functions as a transcription factor activating Hedgehog-responsive genes. We report that the expression of known Shh-responsive genes such as Ptc and Gli1 is downregulated in mutant mice lacking Gli2 function. Gli2 mutants fail to develop a floor plate yet still develop motor neurons, which occupy the ventral midline of the neural tube. Our results imply that Gli2 is required to mediate high level but not low level Shh activity and show that the development of motor neurons can occur in the absence of floor plate induction.

Links

PubMed

Keywords

Animals; Cell Differentiation/genetics; DNA-Binding Proteins/analysis; DNA-Binding Proteins/metabolism; Down-Regulation/physiology; Embryo, Mammalian/cytology; Eye Proteins; Gene Expression Regulation, Developmental/genetics; Hedgehog Proteins; Hepatocyte Nuclear Factor 3-beta; Homeodomain Proteins; Kruppel-Like Transcription Factors; Membrane Proteins/metabolism; Mice; Mice, Knockout; Motor Neurons/physiology; Mutation/genetics; Nerve Tissue Proteins; Neural Crest/growth & development; Notochord/growth & development; Nuclear Proteins/metabolism; Oncogene Proteins/analysis; Paired Box Transcription Factors; Proteins/metabolism; Proteins/physiology; Receptors, Cell Surface; Repressor Proteins; Signal Transduction/physiology; Trans-Activators; Transcription Factors/analysis; Xenopus Proteins

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

See Help:References for how to manage references in GONUTS.