MOUSE:EGR1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Egr1 (synonyms: Egr-1, Krox-24)
Protein Name(s)	Early growth response protein 1 EGR-1 Nerve growth factor-induced protein A NGFI-A Transcription factor Zif268 Zinc finger protein Krox-24
External Links
UniProt	P08046
EMBL	M20157 M22326 M28845 M28844 M19643
CCDS	CCDS29136.1
PIR	JS0304
RefSeq	NP_031939.1
UniGene	Mm.181959
PDB	1A1F 1A1G 1A1H 1A1I 1A1J 1A1K 1A1L 1AAY 1F2I 1G2D 1G2F 1JK1 1JK2 1LLM 1P47 1ZAA
PDBsum	1A1F 1A1G 1A1H 1A1I 1A1J 1A1K 1A1L 1AAY 1F2I 1G2D 1G2F 1JK1 1JK2 1LLM 1P47 1ZAA
ProteinModelPortal	P08046
SMR	P08046
BioGrid	199404
PhosphoSite	P08046
MaxQB	P08046
PRIDE	P08046
Ensembl	ENSMUST00000064795 ENSMUST00000165033
GeneID	13653
KEGG	mmu:13653
UCSC	uc008elt.1
CTD	1958
MGI	MGI:95295
eggNOG	COG5048
HOGENOM	HOG000036856
HOVERGEN	HBG003909
InParanoid	P08046
KO	K09203
OMA	AFATQTG
OrthoDB	EOG7Z69C7
PhylomeDB	P08046
TreeFam	TF318980
ChiTaRS	Egr1
EvolutionaryTrace	P08046
NextBio	284384
PRO	PR:P08046
Proteomes	UP000000589
Bgee	P08046
CleanEx	MM_EGR1
ExpressionAtlas	P08046
Genevestigator	P08046
GO	GO:0005737 GO:0005634 GO:0003677 GO:0003690 GO:0046872 GO:0000982 GO:0001077 GO:0000979 GO:0000977 GO:0003700 GO:0044212 GO:0030509 GO:0071236 GO:0071320 GO:0035690 GO:0071372 GO:0071480 GO:0071371 GO:0071363 GO:0071504 GO:0071455 GO:0032869 GO:0071317 GO:0071260 GO:0071506 GO:0071310 GO:0071383 GO:0007623 GO:0072110 GO:0070498 GO:0007611 GO:0060291 GO:0043066 GO:0090090 GO:0000122 GO:0048709 GO:0072303 GO:0043525 GO:0045944 GO:0045893 GO:0048169 GO:0033233 GO:0061418 GO:0006355 GO:0001975 GO:0034465 GO:0042220 GO:0051602 GO:0045471 GO:0009749 GO:0032868 GO:0071873 GO:0031667 GO:0035914 GO:0030217
Gene3D	3.30.160.60
InterPro	IPR021839 IPR021849 IPR007087 IPR015880 IPR013087
Pfam	PF11914 PF11928
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0035176	social behavior	PMID:20921194^[1]	ECO:0000315			P		Figure 3 (I and J) shows significantly increased Egr-1 levels when an adult mouse is exposed to a juvenile mouse as opposed to a non-species specific control.	complete CACAO 9873
involved_in	GO:0032922	circadian regulation of gene expression	PMID:29138967^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:29138967^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060086	circadian temperature homeostasis	PMID:29138967^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:26471974^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:26471974^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18146	C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
involved_in	GO:0098759	cellular response to interleukin-8	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18146	P		Seeded From UniProt	complete
enables	GO:0044729	hemi-methylated DNA-binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
involved_in	GO:0050725	positive regulation of interleukin-1 beta biosynthetic process	PMID:11100120^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045080	positive regulation of chemokine biosynthetic process	PMID:11100120^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11100120^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11100120^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:11100120^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	PMID:11100120^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:15958557^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:15958557^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8703054^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000182	regulation of progesterone biosynthetic process	PMID:8703054^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044849	estrous cycle	PMID:8703054^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046886	positive regulation of hormone biosynthetic process	PMID:8703054^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8336701^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:14281)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:8336701^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:8336701^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:18281035^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	PMID:19057511^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20018936^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:18281035^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:20018936^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0072303	positive regulation of glomerular metanephric mesangial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08154	P		Seeded From UniProt	complete
involved_in	GO:0072110	glomerular mesangial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08154	P		Seeded From UniProt	complete
involved_in	GO:0071506	cellular response to mycophenolic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08154	P		Seeded From UniProt	complete
involved_in	GO:0071504	cellular response to heparin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08154	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12689920^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:7720589^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:12689920^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	PMID:12689920^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08154	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12689920^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08154	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12689920^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1354948 MGI:MGI:2153049 MGI:MGI:2153568 MGI:MGI:2181068 MGI:MGI:98968 PANTHER:PTN001145452 RGD:3738 UniProtKB:A0A1D8PNL1 UniProtKB:Q02446 UniProtKB:Q7RTV3 ZFIN:ZDB-GENE-021115-9	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0043364 FB:FBgn0261434 FB:FBgn0263239 MGI:MGI:1101353 MGI:MGI:1277166 MGI:MGI:1333856 MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1342772 MGI:MGI:1346318 MGI:MGI:1929988 MGI:MGI:1932575 MGI:MGI:2153568 MGI:MGI:95295 MGI:MGI:95296 MGI:MGI:98372 MGI:MGI:98968 PANTHER:PTN001145452 RGD:1306768 RGD:2544 RGD:3738 RGD:3741 RGD:3974 RGD:621445 RGD:621652 RGD:62389 UniProtKB:A0A0B4KHC8 UniProtKB:A0A0G2K5M1 UniProtKB:P18146 UniProtKB:P19544 UniProtKB:Q02086 UniProtKB:Q13351 UniProtKB:Q13886 UniProtKB:Q7RTV3 UniProtKB:Q8TDD2 UniProtKB:Q99612 UniProtKB:Q9UIH9 WB:WBGene00007772 WB:WBGene00012735	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001145452 UniProtKB:O14901 UniProtKB:Q9Y5W3 WB:WBGene00012735 ZFIN:ZDB-GENE-021115-9	F		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902949	positive regulation of tau-protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901216	positive regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098759	cellular response to interleukin-8	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072303	positive regulation of glomerular metanephric mesangial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072110	glomerular mesangial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071506	cellular response to mycophenolic acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071504	cellular response to heparin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071310	cellular response to organic substance	PMID:21357543^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070498	interleukin-1-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	PMID:18323529^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17202132^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384433	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
enables	GO:0044729	hemi-methylated DNA-binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:23277542^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035914	skeletal muscle cell differentiation	PMID:22147266^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033233	regulation of protein sumoylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:8769660^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030217	T cell differentiation	PMID:12165491^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384433	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007616	long-term memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12165491^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384433	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8668170^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18323529^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18323529^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002931	response to ischemia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	F		Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2544	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16033766^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	F		Seeded From UniProt	complete
involved_in	GO:0098759	cellular response to interleukin-8	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	P		Seeded From UniProt	complete
enables	GO:0044729	hemi-methylated DNA-binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	F		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	F		Seeded From UniProt	complete
involved_in	GO:0033233	regulation of protein sumoylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	P		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18146 ensembl:ENSP00000239938	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q546S1 ensembl:ENSP00000239938	C		Seeded From UniProt	complete
involved_in	GO:1902949	positive regulation of tau-protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0H2UHR3 ensembl:ENSRNOP00000026303	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0H2UHR3 ensembl:ENSRNOP00000026303	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wacker, DW et al. (2010) Expression of early growth response protein 1 in vasopressin neurones of the rat anterior olfactory nucleus following social odour exposure. J. Physiol. (Lond.) 588 4705-17 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Riedel, CS et al. (2018) Mice Lacking EGR1 Have Impaired Clock Gene (BMAL1) Oscillation, Locomotor Activity, and Body Temperature. J. Mol. Neurosci. 64 9-19 PubMed GONUTS page
↑ ^3.0 ^3.1 Tao, W et al. (2015) EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription. Sci Rep 5 15212 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Yan, SF et al. (2000) Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat. Med. 6 1355-61 PubMed GONUTS page
↑ ^5.0 ^5.1 Krones-Herzig, A et al. (2005) Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53. Cancer Res. 65 5133-43 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Lee, SL et al. (1996) Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science 273 1219-21 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Gashler, AL et al. (1993) A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1. Mol. Cell. Biol. 13 4556-71 PubMed GONUTS page
↑ ^8.0 ^8.1 Yoshida, T et al. (2008) Negative regulation of the Wnt signal by MM-1 through inhibiting expression of the wnt4 gene. Exp. Cell Res. 314 1217-28 PubMed GONUTS page
↑ Yu, J et al. (2009) PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 28 21-33 PubMed GONUTS page
↑ ^10.0 ^10.1 Wang, B et al. (2010) Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. Arterioscler. Thromb. Vasc. Biol. 30 536-45 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Hasan, RN et al. (2003) Differential regulation of early growth response gene-1 expression by insulin and glucose in vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 23 988-93 PubMed GONUTS page
↑ Ryan, G et al. (1995) Repression of Pax-2 by WT1 during normal kidney development. Development 121 867-75 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Gimferrer, I et al. (2011) Regulation of GATA-3 expression during CD4 lineage differentiation. J. Immunol. 186 3892-8 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Chang, JS et al. (2008) Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ. Res. 102 905-13 PubMed GONUTS page
↑ Li, T et al. (2007) Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J. Biol. Chem. 282 6619-28 PubMed GONUTS page
↑ Zhang, Q et al. (2013) Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc. Natl. Acad. Sci. U.S.A. 110 978-83 PubMed GONUTS page
↑ Rajan, S et al. (2012) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol. Genomics 44 183-97 PubMed GONUTS page
↑ Thesleff, I et al. (1996) Molecular mechanisms of cell and tissue interactions during early tooth development. Anat. Rec. 245 151-61 PubMed GONUTS page
↑ ^20.0 ^20.1 Bettini, M et al. (2002) Thymocyte development in early growth response gene 1-deficient mice. J. Immunol. 169 1713-20 PubMed GONUTS page
↑ Svaren, J et al. (1996) NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol. Cell. Biol. 16 3545-53 PubMed GONUTS page
↑ Reynolds, PR & Hoidal, JR (2005) Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development. J. Biol. Chem. 280 32548-54 PubMed GONUTS page

[PMID:20921194-1] Wacker, DW et al. (2010) Expression of early growth response protein 1 in vasopressin neurones of the rat anterior olfactory nucleus following social odour exposure. J. Physiol. (Lond.) 588 4705-17 PubMed GONUTS page

[PMID:29138967-2] 2.0 ^2.1 ^2.2 Riedel, CS et al. (2018) Mice Lacking EGR1 Have Impaired Clock Gene (BMAL1) Oscillation, Locomotor Activity, and Body Temperature. J. Mol. Neurosci. 64 9-19 PubMed GONUTS page

[PMID:26471974-3] 3.0 ^3.1 Tao, W et al. (2015) EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription. Sci Rep 5 15212 PubMed GONUTS page

[PMID:11100120-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Yan, SF et al. (2000) Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat. Med. 6 1355-61 PubMed GONUTS page

[PMID:15958557-5] 5.0 ^5.1 Krones-Herzig, A et al. (2005) Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53. Cancer Res. 65 5133-43 PubMed GONUTS page

[PMID:8703054-6] 6.0 ^6.1 ^6.2 ^6.3 Lee, SL et al. (1996) Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science 273 1219-21 PubMed GONUTS page

[PMID:8336701-7] 7.0 ^7.1 ^7.2 Gashler, AL et al. (1993) A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1. Mol. Cell. Biol. 13 4556-71 PubMed GONUTS page

[PMID:18281035-8] 8.0 ^8.1 Yoshida, T et al. (2008) Negative regulation of the Wnt signal by MM-1 through inhibiting expression of the wnt4 gene. Exp. Cell Res. 314 1217-28 PubMed GONUTS page

[PMID:19057511-9] Yu, J et al. (2009) PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 28 21-33 PubMed GONUTS page

[PMID:20018936-10] 10.0 ^10.1 Wang, B et al. (2010) Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. Arterioscler. Thromb. Vasc. Biol. 30 536-45 PubMed GONUTS page

[PMID:12689920-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Hasan, RN et al. (2003) Differential regulation of early growth response gene-1 expression by insulin and glucose in vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 23 988-93 PubMed GONUTS page

[PMID:7720589-12] Ryan, G et al. (1995) Repression of Pax-2 by WT1 during normal kidney development. Development 121 867-75 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21357543-14] Gimferrer, I et al. (2011) Regulation of GATA-3 expression during CD4 lineage differentiation. J. Immunol. 186 3892-8 PubMed GONUTS page

[PMID:18323529-15] 15.0 ^15.1 ^15.2 Chang, JS et al. (2008) Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ. Res. 102 905-13 PubMed GONUTS page

[PMID:17202132-16] Li, T et al. (2007) Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J. Biol. Chem. 282 6619-28 PubMed GONUTS page

[PMID:23277542-17] Zhang, Q et al. (2013) Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc. Natl. Acad. Sci. U.S.A. 110 978-83 PubMed GONUTS page

[PMID:22147266-18] Rajan, S et al. (2012) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol. Genomics 44 183-97 PubMed GONUTS page

[PMID:8769660-19] Thesleff, I et al. (1996) Molecular mechanisms of cell and tissue interactions during early tooth development. Anat. Rec. 245 151-61 PubMed GONUTS page

[PMID:12165491-20] 20.0 ^20.1 Bettini, M et al. (2002) Thymocyte development in early growth response gene 1-deficient mice. J. Immunol. 169 1713-20 PubMed GONUTS page

[PMID:8668170-21] Svaren, J et al. (1996) NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol. Cell. Biol. 16 3545-53 PubMed GONUTS page

[PMID:16033766-22] Reynolds, PR & Hoidal, JR (2005) Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development. J. Biol. Chem. 280 32548-54 PubMed GONUTS page

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MOUSE:EGR1

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