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Wacker, DW, Tobin, VA, Noack, J, Bishop, VR, Duszkiewicz, AJ, Engelmann, M, Meddle, SL and Ludwig, M (2010) Expression of early growth response protein 1 in vasopressin neurones of the rat anterior olfactory nucleus following social odour exposure. J. Physiol. (Lond.) 588:4705-17
The anterior olfactory nucleus (AON), a component of the main olfactory system, is a cortical region that processes olfactory information and acts as a relay between the main olfactory bulbs and higher brain regions such as the piriform cortex. Utilizing a transgenic rat in which an enhanced green fluorescent protein reporter gene is expressed in vasopressin neurones (eGFP-vasopressin), we have discovered a population of vasopressin neurones in the AON. These vasopressin neurones co-express vasopressin V1 receptors. They also co-express GABA and calbinin-D28k indicating that they are neurochemically different from the newly described vasopressin neurons in the main olfactory bulb. We utilized the immediate early gene product, early growth response protein 1 (Egr-1), to examine the functional role of these vasopressin neurons in processing social and non-social odours in the AON. Exposure of adult rats to a conspecific juvenile or a heterospecific predator odour leads to increases in Egr-1 expression in the AON in a subregion specific manner. However, only exposure to a juvenile increases Egr-1 expression in AON vasopressin neurons. These data suggest that vasopressin neurones in the AON may be selectively involved in the coding of social odour information.
Animals; Behavior, Animal; Cats; Early Growth Response Protein 1/genetics; Early Growth Response Protein 1/metabolism; Female; Foxes; Gene Expression Regulation/physiology; Green Fluorescent Proteins; Male; Neurons/metabolism; Odors; Olfactory Pathways/cytology; Olfactory Pathways/physiology; Rats; Rats, Sprague-Dawley; Vasopressins/metabolism
|Gene product||Qualifier||GO Term||Evidence Code||with/from||Aspect||Extension||Notes||Status|
|GO:0035176: social behavior||
Figure 3 (I and J) shows significantly increased Egr-1 levels when an adult mouse is exposed to a juvenile mouse as opposed to a non-species specific control.
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