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MOUSE:CSKP
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Cask | |
| Protein Name(s) | Peripheral plasma membrane protein CASK
Calcium/calmodulin-dependent serine protein kinase | |
| External Links | ||
| UniProt | O70589 | |
| EMBL | Y17138 Y17137 AL671117 AL672204 BX005215 AL671117 AL672204 BX005215 AL671117 AL672204 AL672204 AL671117 BX005215 AL672204 BX005215 AL671117 AL672204 AL671117 BX005215 AL672204 AL671117 BX005215 AL672204 AL671117 AK136523 | |
| CCDS | CCDS40878.1 CCDS72343.1 | |
| RefSeq | NP_001271432.1 NP_001271433.1 NP_001271434.1 NP_033936.2 | |
| UniGene | Mm.327591 Mm.474948 | |
| PDB | 1Y74 | |
| PDBsum | 1Y74 | |
| ProteinModelPortal | O70589 | |
| SMR | O70589 | |
| BioGrid | 198491 | |
| IntAct | O70589 | |
| MINT | MINT-4092125 | |
| PhosphoSite | O70589 | |
| MaxQB | O70589 | |
| PaxDb | O70589 | |
| PRIDE | O70589 | |
| DNASU | 12361 | |
| Ensembl | ENSMUST00000033321 ENSMUST00000115436 ENSMUST00000115438 | |
| GeneID | 12361 | |
| KEGG | mmu:12361 | |
| UCSC | uc009srp.1 uc009srq.1 uc012hez.1 | |
| CTD | 8573 | |
| MGI | MGI:1309489 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00760000118866 | |
| HOGENOM | HOG000233034 | |
| HOVERGEN | HBG001858 | |
| InParanoid | O70589 | |
| KO | K06103 | |
| OMA | RCINRET | |
| OrthoDB | EOG79CXZ5 | |
| PhylomeDB | O70589 | |
| TreeFam | TF314263 | |
| BRENDA | 2.7.11.1 | |
| Reactome | REACT_196644 REACT_257032 | |
| ChiTaRS | Cask | |
| EvolutionaryTrace | O70589 | |
| NextBio | 281028 | |
| PRO | PR:O70589 | |
| Proteomes | UP000000589 | |
| Bgee | O70589 | |
| ExpressionAtlas | O70589 | |
| Genevestigator | O70589 | |
| GO | GO:0005604 GO:0016323 GO:0005911 GO:0005737 GO:0005829 GO:0016020 GO:0005652 GO:0016363 GO:0005730 GO:0005634 GO:0045202 GO:0005524 GO:0042043 GO:0004674 GO:0070509 GO:0001953 GO:0090288 GO:0010839 GO:0061045 GO:0090280 GO:0045944 | |
| Gene3D | 2.30.42.10 3.40.50.300 | |
| InterPro | IPR008145 IPR008144 IPR020590 IPR011009 IPR004172 IPR014775 IPR027417 IPR001478 IPR000719 IPR002290 IPR011511 IPR001452 | |
| Pfam | PF00625 PF02828 PF00595 PF00069 PF07653 | |
| SMART | SM00072 SM00569 SM00228 SM00220 SM00326 | |
| SUPFAM | SSF50044 SSF50156 SSF52540 SSF56112 | |
| PROSITE | PS00856 PS50052 PS51022 PS50106 PS50011 PS50002 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 1A,B, E immunofluorescence used in new born mice, CASK is located in nucleus and colocalized with nucleoskeletal protein lamin A in nuclei of cells of the basal layer of the epidermis. |
complete | |||||
| GO:0005604 |
basement membrane |
ECO:0000314 |
C |
Figure 1C immunofluorescence used in adult mice, Cask localizes to cell borders of cells of the basal layer of the epidermis. Dashed line indicate basement membrane zone. |
complete | |||||
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Figure 1E found CASK in new born mice primary keratinocytes in cytoplasm, which was confirmed in western blot in cytosolic protein fraction, figure 1F. |
complete | |||||
| GO:0005911 |
cell-cell junction |
ECO:0000314 |
C |
Figure 1E found CASK in new born primary mouse keratinocytes at intercellular junction of cells. |
complete | |||||
|
part_of |
GO:0031982 |
vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:1001571) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0005604 |
basement membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0001225 |
knockout evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098685 |
Schaffer collateral - CA1 synapse |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098685 |
Schaffer collateral - CA1 synapse |
ECO:0001225 |
knockout evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098846 |
podocyte foot |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0097440 |
apical dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0097060 |
synaptic membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090288 |
negative regulation of cellular response to growth factor stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090280 |
positive regulation of calcium ion import |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0072659 |
protein localization to plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0070509 |
calcium ion import |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000540) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0061045 |
negative regulation of wound healing |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0060170 |
ciliary membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:107404 |
P |
has_regulation_target:(MGI:MGI:95821) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0045202 |
synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16894) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202 |
synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0042734 |
presynaptic membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042043 |
neurexin family protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_in:(EMAPA:16894) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042043 |
neurexin family protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032024 |
positive regulation of insulin secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016363 |
nuclear matrix |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010839 |
negative regulation of keratinocyte proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005652 |
nuclear lamina |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:62004 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0005604 |
basement membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001953 |
negative regulation of cell-matrix adhesion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090288 |
negative regulation of cellular response to growth factor stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O14936 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061045 |
negative regulation of wound healing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O14936 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016363 |
nuclear matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O14936 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010839 |
negative regulation of keratinocyte proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O14936 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O14936 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O14936 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O14936 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005652 |
nuclear lamina |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O14936 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O14936 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001953 |
negative regulation of cell-matrix adhesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O14936 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Ojeh, N et al. (2008) The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. J. Cell. Sci. 121 2705-17 PubMed GONUTS page
- ↑ Fairless, R et al. (2008) Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences. J. Neurosci. 28 12969-81 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Atasoy, D et al. (2007) Deletion of CASK in mice is lethal and impairs synaptic function. Proc. Natl. Acad. Sci. U.S.A. 104 2525-30 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Samuels, BA et al. (2007) Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 56 823-37 PubMed GONUTS page
- ↑ Wang, TF et al. (2004) Identification of Tbr-1/CASK complex target genes in neurons. J. Neurochem. 91 1483-92 PubMed GONUTS page
- ↑ Olsen, O et al. (2005) Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J. Cell Biol. 170 1127-34 PubMed GONUTS page
- ↑ Bamji, SX et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40 719-31 PubMed GONUTS page
- ↑ 8.0 8.1 Biederer, T et al. (2002) SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297 1525-31 PubMed GONUTS page
- ↑ Naim, E et al. (2005) Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney. Kidney Int. 68 955-65 PubMed GONUTS page
- ↑ Karnak, D et al. (2002) Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97. J. Biol. Chem. 277 46730-5 PubMed GONUTS page
c
g
m
n
- GO:0061045 ! negative regulation of wound healing
- GO:0010839 ! negative regulation of keratinocyte proliferation
- GO:0001953 ! negative regulation of cell-matrix adhesion
- GO:0090288 ! negative regulation of cellular response to growth factor stimulus
- GO:0042043 ! neurexin family protein binding
- GO:0043025 ! neuronal cell body
- GO:0005652 ! nuclear lamina
- GO:0016363 ! nuclear matrix
- GO:0005730 ! nucleolus
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
p
- GO:0030165 ! PDZ domain binding
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0098846 ! podocyte foot
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0090280 ! positive regulation of calcium ion import
- GO:0032024 ! positive regulation of insulin secretion
- GO:0061003 ! positive regulation of dendritic spine morphogenesis
- GO:0014069 ! postsynaptic density
- GO:0042734 ! presynaptic membrane
- GO:0032991 ! protein-containing complex
- GO:0044877 ! protein-containing complex binding
- GO:0004672 ! protein kinase activity
- GO:0072659 ! protein localization to plasma membrane
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
r
s
