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PMID:16105026
| Citation |
Naim, E, Bernstein, A, Bertram, JF and Caruana, G (2005) Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney. Kidney Int. 68:955-65 |
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| Abstract |
During development of the permanent mammalian kidney (metanephros) several key epithelial events occur such as ureteric branching morphogenesis and nephrogenesis. One of the first stages of nephrogenesis involves the conversion of mesenchymal cells to epithelial cells, and thus the metanephros provides an excellent model to study epithelial polarization. The aim of this study was to investigate the role of the epithelial polarity gene, discs large 1 (dlg1), during development of the mouse kidney. |
| Links |
PubMed Online version:10.1111/j.1523-1755.2005.00489.x |
| Keywords |
Animals; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Cell Polarity/physiology; Epithelial Cells/cytology; Epithelial Cells/physiology; Female; Gene Expression Regulation, Developmental; Guanylate Kinase; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mutagenesis; Nephrons/abnormalities; Nephrons/cytology; Nephrons/physiology; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Organ Culture Techniques; Pregnancy; Protein Structure, Tertiary; Ureter/abnormalities; Ureter/cytology; Ureter/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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