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MOUSE:CRYAA

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Cryaa (synonyms: Crya1)
Protein Name(s) Alpha-crystallin A chain
External Links
UniProt P24622
EMBL V00730
V00730
J00375
J00375
J00376
CCDS CCDS37551.1
PIR A02893
B18860
RefSeq NP_038529.1
XP_006523637.1
UniGene Mm.1228
ProteinModelPortal P24622
SMR P24622
PhosphoSite P24622
MaxQB P24622
PaxDb P24622
PRIDE P24622
Ensembl ENSMUST00000019192
GeneID 12954
KEGG mmu:12954
UCSC uc008bvp.1
CTD 1409
MGI MGI:88515
eggNOG NOG278874
HOGENOM HOG000233954
HOVERGEN HBG054766
InParanoid P24622
KO K09541
OMA GPKVQSG
OrthoDB EOG7WHHBK
PhylomeDB P24622
TreeFam TF105049
ChiTaRS Cryaa
NextBio 282670
PRO PR:P24622
Proteomes UP000000589
Bgee P24622
CleanEx MM_CRYAA
ExpressionAtlas P24622
Genevestigator P24622
GO GO:0005737
GO:0005634
GO:0046872
GO:0005212
GO:0007015
GO:0006915
GO:0060561
GO:0043010
GO:0048596
GO:0002088
GO:0070309
GO:0002089
GO:0007017
GO:0007005
GO:0043066
GO:0043154
GO:0010629
GO:0030307
GO:0001934
GO:0006457
GO:0051260
GO:0042493
GO:0051384
GO:0042542
GO:0001666
GO:0010288
GO:0070141
GO:0007021
Gene3D 2.60.40.790
InterPro IPR002068
IPR001436
IPR012274
IPR003090
IPR008978
PANTHER PTHR11527:SF36
Pfam PF00525
PF00011
PIRSF PIRSF036514
PRINTS PR00299
SUPFAM SSF49764
PROSITE PS01031

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:2000378

negative regulation of reactive oxygen species metabolic process

PMID:22442691[1]

ECO:0000315

P

Figure 1E.

complete
CACAO 4018

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02489

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070309

lens fiber cell morphogenesis

PMID:18056999[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3777403

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070309

lens fiber cell morphogenesis

PMID:16799046[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665275

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070141

response to UV-A

PMID:9813033[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1858025

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060561

apoptotic process involved in morphogenesis

PMID:16439475[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88516

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051260

protein homooligomerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2413

P

Seeded From UniProt

complete

enables

GO:0051082

unfolded protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P02489

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048596

embryonic camera-type eye morphogenesis

PMID:18056999[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3777403

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16439475[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88516

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:18191123[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1858025

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043010

camera-type eye development

PMID:12546709[7]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1916503

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P02489

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2413

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042542

response to hydrogen peroxide

PMID:17438522[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1858025

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042542

response to hydrogen peroxide

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030307

positive regulation of cell growth

PMID:9813033[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1858025

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010629

negative regulation of gene expression

PMID:17893660[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1858025

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007021

tubulin complex assembly

PMID:16675842[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1858025

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007017

microtubule-based process

PMID:12584250[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1858025

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007015

actin filament organization

PMID:16799046[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665275

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007005

mitochondrion organization

PMID:16799046[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665275

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

PMID:18056999[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3777403

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006457

protein folding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2413

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P02489

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:A0A140G945

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:9813033[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12584250[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P02489

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2413

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P02489

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:A0A140G945

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P02489

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002089

lens morphogenesis in camera-type eye

PMID:8812430[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1858023

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002089

lens morphogenesis in camera-type eye

PMID:16799046[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665274
MGI:MGI:3665275

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002088

lens development in camera-type eye

PMID:16439475[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88516

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002088

lens development in camera-type eye

PMID:9023351[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1858025

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002088

lens development in camera-type eye

PMID:16439475[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1858025

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002088

lens development in camera-type eye

PMID:11687536[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2653028

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001934

positive regulation of protein phosphorylation

PMID:18056999[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3777403

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001666

response to hypoxia

PMID:18191123[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1858025

P

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24623
ensembl:ENSRNOP00000065714

P

Seeded From UniProt

complete

involved_in

GO:0051260

protein homooligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24623
ensembl:ENSRNOP00000065714

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24623
ensembl:ENSRNOP00000065714

F

Seeded From UniProt

complete

involved_in

GO:0042542

response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24623
ensembl:ENSRNOP00000065714

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24623
ensembl:ENSRNOP00000065714

P

Seeded From UniProt

complete

involved_in

GO:0010288

response to lead ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24623
ensembl:ENSRNOP00000065714

P

Seeded From UniProt

complete

involved_in

GO:0010259

multicellular organism aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24623
ensembl:ENSRNOP00000065714

P

Seeded From UniProt

complete

involved_in

GO:0006457

protein folding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24623
ensembl:ENSRNOP00000065714

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24623
ensembl:ENSRNOP00000065714

C

Seeded From UniProt

complete

involved_in

GO:0002088

lens development in camera-type eye

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24623
ensembl:ENSRNOP00000065714

P

Seeded From UniProt

complete

enables

GO:0005212

structural constituent of eye lens

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003090
InterPro:IPR012274

F

Seeded From UniProt

complete

enables

GO:0005212

structural constituent of eye lens

PMID:12546709[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0005212

structural constituent of eye lens

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0273

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Sreekumar, PG et al. (2012) Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. PLoS ONE 7 e33420 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Xi, JH et al. (2008) Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death. J. Biol. Chem. 283 5801-14 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Xia, CH et al. (2006) Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency. Invest. Ophthalmol. Vis. Sci. 47 3004-10 PubMed GONUTS page
  4. 4.0 4.1 4.2 Andley, UP et al. (1998) The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress. J. Biol. Chem. 273 31252-61 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Morozov, V & Wawrousek, EF (2006) Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice. Development 133 813-21 PubMed GONUTS page
  6. 6.0 6.1 Yaung, J et al. (2008) Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp. Eye Res. 86 355-65 PubMed GONUTS page
  7. 7.0 7.1 Boyle, DL et al. (2003) Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. BMC Ophthalmol 3 3 PubMed GONUTS page
  8. Yaung, J et al. (2007) alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol. Vis. 13 566-77 PubMed GONUTS page
  9. Bai, F et al. (2007) Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol. Vis. 13 1589-600 PubMed GONUTS page
  10. Xi, JH et al. (2006) Alpha-crystallin expression affects microtubule assembly and prevents their aggregation. FASEB J. 20 846-57 PubMed GONUTS page
  11. 11.0 11.1 Xi, JH et al. (2003) Reduced survival of lens epithelial cells in the alphaA-crystallin-knockout mouse. J. Cell. Sci. 116 1073-85 PubMed GONUTS page
  12. Chang, B et al. (1996) Chromosomal localization of a new mouse lens opacity gene (lop18) Genomics 36 171-3 PubMed GONUTS page
  13. Brady, JP et al. (1997) Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin. Proc. Natl. Acad. Sci. U.S.A. 94 884-9 PubMed GONUTS page
  14. Graw, J et al. (2001) Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene. Invest. Ophthalmol. Vis. Sci. 42 2909-15 PubMed GONUTS page