MOUSE:CRYAA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cryaa (synonyms: Crya1)
Protein Name(s)	Alpha-crystallin A chain
External Links
UniProt	P24622
EMBL	V00730 V00730 J00375 J00375 J00376
CCDS	CCDS37551.1
PIR	A02893 B18860
RefSeq	NP_038529.1 XP_006523637.1
UniGene	Mm.1228
ProteinModelPortal	P24622
SMR	P24622
PhosphoSite	P24622
MaxQB	P24622
PaxDb	P24622
PRIDE	P24622
Ensembl	ENSMUST00000019192
GeneID	12954
KEGG	mmu:12954
UCSC	uc008bvp.1
CTD	1409
MGI	MGI:88515
eggNOG	NOG278874
HOGENOM	HOG000233954
HOVERGEN	HBG054766
InParanoid	P24622
KO	K09541
OMA	GPKVQSG
OrthoDB	EOG7WHHBK
PhylomeDB	P24622
TreeFam	TF105049
ChiTaRS	Cryaa
NextBio	282670
PRO	PR:P24622
Proteomes	UP000000589
Bgee	P24622
CleanEx	MM_CRYAA
ExpressionAtlas	P24622
Genevestigator	P24622
GO	GO:0005737 GO:0005634 GO:0046872 GO:0005212 GO:0007015 GO:0006915 GO:0060561 GO:0043010 GO:0048596 GO:0002088 GO:0070309 GO:0002089 GO:0007017 GO:0007005 GO:0043066 GO:0043154 GO:0010629 GO:0030307 GO:0001934 GO:0006457 GO:0051260 GO:0042493 GO:0051384 GO:0042542 GO:0001666 GO:0010288 GO:0070141 GO:0007021
Gene3D	2.60.40.790
InterPro	IPR002068 IPR001436 IPR012274 IPR003090 IPR008978
PANTHER	PTHR11527:SF36
Pfam	PF00525 PF00011
PIRSF	PIRSF036514
PRINTS	PR00299
SUPFAM	SSF49764
PROSITE	PS01031

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:2000378	negative regulation of reactive oxygen species metabolic process	PMID:22442691^[1]	ECO:0000315			P	Figure 1E.	complete CACAO 4018
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02489	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070309	lens fiber cell morphogenesis	PMID:18056999^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3777403	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070309	lens fiber cell morphogenesis	PMID:16799046^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3665275	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070141	response to UV-A	PMID:9813033^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858025	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060561	apoptotic process involved in morphogenesis	PMID:16439475^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88516	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2413	P	Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02489	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048596	embryonic camera-type eye morphogenesis	PMID:18056999^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3777403	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:16439475^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88516	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:18191123^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858025	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:12546709^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1916503	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02489	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2413	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042542	response to hydrogen peroxide	PMID:17438522^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858025	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042542	response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2413	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030307	positive regulation of cell growth	PMID:9813033^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858025	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:17893660^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858025	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007021	tubulin complex assembly	PMID:16675842^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858025	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007017	microtubule-based process	PMID:12584250^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858025	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007015	actin filament organization	PMID:16799046^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3665275	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	PMID:16799046^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3665275	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:18056999^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3777403	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006457	protein folding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2413	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02489	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:A0A140G945	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9813033^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12584250^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02489	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2413	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02489	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:A0A140G945	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02489	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002089	lens morphogenesis in camera-type eye	PMID:8812430^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858023	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002089	lens morphogenesis in camera-type eye	PMID:16799046^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3665274 MGI:MGI:3665275	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002088	lens development in camera-type eye	PMID:16439475^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88516	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002088	lens development in camera-type eye	PMID:9023351^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858025	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002088	lens development in camera-type eye	PMID:16439475^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858025	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002088	lens development in camera-type eye	PMID:11687536^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2653028	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:18056999^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3777403	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:18191123^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858025	P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24623 ensembl:ENSRNOP00000065714	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24623 ensembl:ENSRNOP00000065714	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24623 ensembl:ENSRNOP00000065714	F	Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24623 ensembl:ENSRNOP00000065714	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24623 ensembl:ENSRNOP00000065714	P	Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24623 ensembl:ENSRNOP00000065714	P	Seeded From UniProt	complete
involved_in	GO:0010259	multicellular organism aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24623 ensembl:ENSRNOP00000065714	P	Seeded From UniProt	complete
involved_in	GO:0006457	protein folding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24623 ensembl:ENSRNOP00000065714	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24623 ensembl:ENSRNOP00000065714	C	Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24623 ensembl:ENSRNOP00000065714	P	Seeded From UniProt	complete
enables	GO:0005212	structural constituent of eye lens	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003090 InterPro:IPR012274	F	Seeded From UniProt	complete
enables	GO:0005212	structural constituent of eye lens	PMID:12546709^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0005212	structural constituent of eye lens	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0273	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sreekumar, PG et al. (2012) Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. PLoS ONE 7 e33420 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Xi, JH et al. (2008) Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death. J. Biol. Chem. 283 5801-14 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Xia, CH et al. (2006) Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency. Invest. Ophthalmol. Vis. Sci. 47 3004-10 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Andley, UP et al. (1998) The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress. J. Biol. Chem. 273 31252-61 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Morozov, V & Wawrousek, EF (2006) Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice. Development 133 813-21 PubMed GONUTS page
↑ ^6.0 ^6.1 Yaung, J et al. (2008) Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp. Eye Res. 86 355-65 PubMed GONUTS page
↑ ^7.0 ^7.1 Boyle, DL et al. (2003) Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. BMC Ophthalmol 3 3 PubMed GONUTS page
↑ Yaung, J et al. (2007) alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol. Vis. 13 566-77 PubMed GONUTS page
↑ Bai, F et al. (2007) Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol. Vis. 13 1589-600 PubMed GONUTS page
↑ Xi, JH et al. (2006) Alpha-crystallin expression affects microtubule assembly and prevents their aggregation. FASEB J. 20 846-57 PubMed GONUTS page
↑ ^11.0 ^11.1 Xi, JH et al. (2003) Reduced survival of lens epithelial cells in the alphaA-crystallin-knockout mouse. J. Cell. Sci. 116 1073-85 PubMed GONUTS page
↑ Chang, B et al. (1996) Chromosomal localization of a new mouse lens opacity gene (lop18) Genomics 36 171-3 PubMed GONUTS page
↑ Brady, JP et al. (1997) Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin. Proc. Natl. Acad. Sci. U.S.A. 94 884-9 PubMed GONUTS page
↑ Graw, J et al. (2001) Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene. Invest. Ophthalmol. Vis. Sci. 42 2909-15 PubMed GONUTS page

[PMID:22442691-1] Sreekumar, PG et al. (2012) Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. PLoS ONE 7 e33420 PubMed GONUTS page

[PMID:18056999-2] 2.0 ^2.1 ^2.2 ^2.3 Xi, JH et al. (2008) Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death. J. Biol. Chem. 283 5801-14 PubMed GONUTS page

[PMID:16799046-3] 3.0 ^3.1 ^3.2 ^3.3 Xia, CH et al. (2006) Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency. Invest. Ophthalmol. Vis. Sci. 47 3004-10 PubMed GONUTS page

[PMID:9813033-4] 4.0 ^4.1 ^4.2 Andley, UP et al. (1998) The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress. J. Biol. Chem. 273 31252-61 PubMed GONUTS page

[PMID:16439475-5] 5.0 ^5.1 ^5.2 ^5.3 Morozov, V & Wawrousek, EF (2006) Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice. Development 133 813-21 PubMed GONUTS page

[PMID:18191123-6] 6.0 ^6.1 Yaung, J et al. (2008) Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp. Eye Res. 86 355-65 PubMed GONUTS page

[PMID:12546709-7] 7.0 ^7.1 Boyle, DL et al. (2003) Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. BMC Ophthalmol 3 3 PubMed GONUTS page

[PMID:17438522-8] Yaung, J et al. (2007) alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol. Vis. 13 566-77 PubMed GONUTS page

[PMID:17893660-9] Bai, F et al. (2007) Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol. Vis. 13 1589-600 PubMed GONUTS page

[PMID:16675842-10] Xi, JH et al. (2006) Alpha-crystallin expression affects microtubule assembly and prevents their aggregation. FASEB J. 20 846-57 PubMed GONUTS page

[PMID:12584250-11] 11.0 ^11.1 Xi, JH et al. (2003) Reduced survival of lens epithelial cells in the alphaA-crystallin-knockout mouse. J. Cell. Sci. 116 1073-85 PubMed GONUTS page

[PMID:8812430-12] Chang, B et al. (1996) Chromosomal localization of a new mouse lens opacity gene (lop18) Genomics 36 171-3 PubMed GONUTS page

[PMID:9023351-13] Brady, JP et al. (1997) Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin. Proc. Natl. Acad. Sci. U.S.A. 94 884-9 PubMed GONUTS page

[PMID:11687536-14] Graw, J et al. (2001) Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene. Invest. Ophthalmol. Vis. Sci. 42 2909-15 PubMed GONUTS page

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MOUSE:CRYAA

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