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PMID:8812430
| Citation |
Chang, B, Hawes, NL, Smith, RS, Heckenlively, JR, Davisson, MT and Roderick, TH (1996) Chromosomal localization of a new mouse lens opacity gene (lop18) Genomics 36:171-3 |
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| Abstract |
Examination of mouse strains with a slit lamp and indirect ophthalmoscopy revealed that strain CBA/CaGnLe has a white cataract obvious at weaning age. It soon progresses to a large white nuclear cataract with mild cortical changes. Crosses with C57BL/6J showed that this is inherited as a single recessive fully penetrant gene, which we have designated lop18 (lens opacity 18). Linkage analysis using visible marker T (brachyury), histocompatibility marker H2, and microsatellite markers D17Mit21, D17Mit28, D17Mit38, and D17Mit46 shows that the lop18 gene is located, approximately 16 cM from the centromere on mouse Chromosome 17. It is a likely candidate mutation for the alpha-crystallin (Crya1) gene. |
| Links |
PubMed Online version:10.1006/geno.1996.0439 |
| Keywords |
Animals; Cataract/genetics; Cataract/pathology; Chromosome Mapping; Crosses, Genetic; Crystallins/genetics; Female; Genes, Recessive/genetics; H-2 Antigens/genetics; Lens, Crystalline/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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