MOUSE:CD4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cd4
Protein Name(s)	T-cell surface glycoprotein CD4 T-cell differentiation antigen L3T4 T-cell surface antigen T4/Leu-3
External Links
UniProt	P06332
EMBL	M36850 M13816 X04836 M36851 M17080 M17078 M17079 AC002397 BC039137
CCDS	CCDS20535.1
PIR	A02110
RefSeq	NP_038516.1
UniGene	Mm.2209
ProteinModelPortal	P06332
SMR	P06332
BioGrid	198599
IntAct	P06332
MINT	MINT-5024918
PhosphoSite	P06332
MaxQB	P06332
PRIDE	P06332
Ensembl	ENSMUST00000024044
GeneID	12504
KEGG	mmu:12504
UCSC	uc009dsi.1
CTD	920
MGI	MGI:88335
eggNOG	NOG47205
HOGENOM	HOG000008696
HOVERGEN	HBG005281
InParanoid	P06332
KO	K06454
OMA	PEAGMWQ
OrthoDB	EOG7HXCQS
PhylomeDB	P06332
TreeFam	TF335974
Reactome	REACT_215414 REACT_216080 REACT_225145 REACT_225768 REACT_260145 REACT_263643
NextBio	281462
PRO	PR:P06332
Proteomes	UP000000589
Bgee	P06332
CleanEx	MM_CD4
ExpressionAtlas	P06332
Genevestigator	P06332
GO	GO:0009986 GO:0005788 GO:0005789 GO:0009897 GO:0016021 GO:0045121 GO:0005886 GO:0015026 GO:0008270 GO:0007155 GO:0007166 GO:0001816 GO:0050829 GO:0006955 GO:0006948 GO:0032507 GO:0050850 GO:0050731 GO:0045860 GO:0050870 GO:0045234 GO:0030217 GO:0045058
Gene3D	2.60.40.10
InterPro	IPR000973 IPR015274 IPR007110 IPR013783 IPR008424 IPR003599 IPR003596 IPR013151 IPR021963
Pfam	PF05790 PF09191 PF00047 PF12104
PRINTS	PR00692
SMART	SM00409 SM00406
PROSITE	PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002294	CD4-positive, alpha-beta T cell differentiation involved in immune response	PMID:23100516^[1]	ECO:0000314			P		Figure 2 shows TCR and CD5 levels for the two different CD4+ T cell lines.	complete CACAO 5468
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:2784195^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035397	helper T cell enhancement of adaptive immune response	PMID:1832488^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:3262426^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045058	T cell selection	PMID:9551897^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	PMID:1533274^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 RGD:2306 UniProtKB:P01730	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 UniProtKB:P01730	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88335 PANTHER:PTN002605579 UniProtKB:P01730	C		Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 UniProtKB:P01730	F		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 RGD:2306	P		Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 UniProtKB:P01730	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88335 PANTHER:PTN002605579 RGD:2306 UniProtKB:P01730	C		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	F		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2306	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051924	regulation of calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050870	positive regulation of T cell activation	PMID:12421911^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050863	regulation of T cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050850	positive regulation of calcium-mediated signaling	PMID:9208839^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050829	defense response to Gram-negative bacterium	PMID:14688352^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857281	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:9208839^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046598	positive regulation of viral entry into host cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045657	positive regulation of monocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:15128768^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045058	T cell selection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	F		Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042110	T cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2306	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2306	P		Seeded From UniProt	complete
enables	GO:0042012	interleukin-16 receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	F		Seeded From UniProt	complete
enables	GO:0042011	interleukin-16 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035723	interleukin-15-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033674	positive regulation of kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032507	maintenance of protein location in cell	PMID:15128768^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030217	T cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2306	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	F		Seeded From UniProt	complete
enables	GO:0019865	immunoglobulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2306	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010524	positive regulation of calcium ion transport into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2306	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:8612131^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:9208839^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:9133426^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:8788039^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18768) part_of:(CL:0000084)\|part_of:(EMAPA:18767) part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:8769481^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:8755570^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:8524870^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:7688139^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:7630421^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18768) part_of:(CL:0000084)\|part_of:(EMAPA:18767) part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:7589135^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:7477353^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18767) part_of:(CL:0000084)\|part_of:(EMAPA:18768) part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:7477352^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18768) part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:22072979^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21508411^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21460847^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:20709950^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000738)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:20706986^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:20399120^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:19934022^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:19838199^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:19723499^[31]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:19349303^[32]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000775)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:19008373^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:18836449^[34]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000893)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:18776904^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:18641307^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000798)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:17357106^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:17082577^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16973387^[39]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000624)\|part_of:(CL:0000625)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16455951^[40]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16287714^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:15843532^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:15795238^[43]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:15728238^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:15368291^[45]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:15322158^[46]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18768) part_of:(CL:0000625)\|part_of:(EMAPA:18768) part_of:(CL:0000624)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:14609575^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:12421911^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:10943842^[48]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16332) part_of:(CL:0000081)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:10704459^[49]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:10072077^[50]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:17213291^[51]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2306	C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007166	cell surface receptor signaling pathway	PMID:9208839^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006948	induction by virus of host cell-cell fusion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14517216^[52]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2306	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:16223484^[53]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	PMID:16223484^[53]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2306	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01730	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001816	cytokine production	PMID:7930593^[54]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1891436	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001816	cytokine production	PMID:7930593^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857281	P		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F		Seeded From UniProt	complete
involved_in	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0050863	regulation of T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0046598	positive regulation of viral entry into host cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0045657	positive regulation of monocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	C		Seeded From UniProt	complete
involved_in	GO:0045058	T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F		Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F		Seeded From UniProt	complete
enables	GO:0042012	interleukin-16 receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F		Seeded From UniProt	complete
enables	GO:0042011	interleukin-16 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F		Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0033674	positive regulation of kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0032507	maintenance of protein location in cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0030225	macrophage differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F		Seeded From UniProt	complete
involved_in	GO:0006948	induction by virus of host cell-cell fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	C		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000973	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008424	P		Seeded From UniProt	complete
enables	GO:0015026	coreceptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000973	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000973	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008424	C		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Graw, F et al. (2012) Dynamics of CD4(+) T cell responses against Listeria monocytogenes. J. Immunol. 189 5250-6 PubMed GONUTS page
↑ Veillette, A et al. (1989) Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature 338 257-9 PubMed GONUTS page
↑ Rahemtulla, A et al. (1991) Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353 180-4 PubMed GONUTS page
↑ Veillette, A et al. (1988) The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 55 301-8 PubMed GONUTS page
↑ Frank, GD & Parnes, JR (1998) The level of CD4 surface protein influences T cell selection in the thymus. J. Immunol. 160 634-42 PubMed GONUTS page
↑ Seong, RH et al. (1992) Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356 718-20 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 Workman, CJ et al. (2002) Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J. Immunol. 169 5392-5 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Wiest, DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity 6 663-71 PubMed GONUTS page
↑ Bry, L & Brenner, MB (2004) Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J. Immunol. 172 433-41 PubMed GONUTS page
↑ ^11.0 ^11.1 Balamuth, F et al. (2004) CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J. Immunol. 172 5887-92 PubMed GONUTS page
↑ Sant'Angelo, DB et al. (1996) The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4 367-76 PubMed GONUTS page
↑ Mendiratta, SK et al. (1997) CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6 469-77 PubMed GONUTS page
↑ Li, T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ. 7 107-14 PubMed GONUTS page
↑ Hazenbos, WL et al. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity 5 181-8 PubMed GONUTS page
↑ Bouvier, G et al. (1996) Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc. Natl. Acad. Sci. U.S.A. 93 7877-81 PubMed GONUTS page
↑ Chu, K et al. (1995) A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc. Natl. Acad. Sci. U.S.A. 92 11894-8 PubMed GONUTS page
↑ Shahinian, A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261 609-12 PubMed GONUTS page
↑ Negishi, I et al. (1995) Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376 435-8 PubMed GONUTS page
↑ Simpson, SJ et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur. J. Immunol. 25 2618-25 PubMed GONUTS page
↑ Cheng, AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378 303-6 PubMed GONUTS page
↑ Turner, M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378 298-302 PubMed GONUTS page
↑ Nowell, CS et al. (2011) Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet. 7 e1002348 PubMed GONUTS page
↑ Hu, MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood 117 6120-31 PubMed GONUTS page
↑ Motomura, Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12 450-9 PubMed GONUTS page
↑ Gartlan, KH et al. (2010) A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. J. Immunol. 185 3158-66 PubMed GONUTS page
↑ Wang, L et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur. J. Immunol. 40 2385-90 PubMed GONUTS page
↑ Yagi, R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 32 507-17 PubMed GONUTS page
↑ Hosoya, T et al. (2009) GATA-3 is required for early T lineage progenitor development. J. Exp. Med. 206 2987-3000 PubMed GONUTS page
↑ Du, C et al. (2009) MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 10 1252-9 PubMed GONUTS page
↑ Terauchi, M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab. 10 229-40 PubMed GONUTS page
↑ Stone, EL et al. (2009) Glycosyltransferase function in core 2-type protein O glycosylation. Mol. Cell. Biol. 29 3770-82 PubMed GONUTS page
↑ Abe, J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am. J. Pathol. 173 1682-92 PubMed GONUTS page
↑ Shiow, LR et al. (2008) The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat. Immunol. 9 1307-15 PubMed GONUTS page
↑ Wang, L et al. (2008) Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat. Immunol. 9 1122-30 PubMed GONUTS page
↑ Kisielow, J et al. (2008) SCART scavenger receptors identify a novel subset of adult gammadelta T cells. J. Immunol. 181 1710-6 PubMed GONUTS page
↑ Ling, KW et al. (2007) GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Eur. J. Immunol. 37 1043-52 PubMed GONUTS page
↑ Kim, PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J. Immunol. 177 6650-9 PubMed GONUTS page
↑ Marie, JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25 441-54 PubMed GONUTS page
↑ Takayanagi, S et al. (2006) Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood 107 4317-25 PubMed GONUTS page
↑ Bultman, SJ et al. (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 19 2849-61 PubMed GONUTS page
↑ Cheung, H et al. (2005) Accessory protein-like is essential for IL-18-mediated signaling. J. Immunol. 174 5351-7 PubMed GONUTS page
↑ Winkler, IG et al. (2005) Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J. Exp. Med. 201 1077-88 PubMed GONUTS page
↑ Mandal, M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J. Exp. Med. 201 603-14 PubMed GONUTS page
↑ Ye, Q et al. (2004) BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur. J. Immunol. 34 2750-9 PubMed GONUTS page
↑ García-Martínez, LF et al. (2004) A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J. Immunol. 173 2995-3001 PubMed GONUTS page
↑ Matsuzaki, J et al. (2003) Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell. Immunol. 224 98-105 PubMed GONUTS page
↑ Tamura, K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102 221-31 PubMed GONUTS page
↑ Kennedy, MK et al. (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191 771-80 PubMed GONUTS page
↑ Moriggl, R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10 249-59 PubMed GONUTS page
↑ Wilson, TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109 3786-93 PubMed GONUTS page
↑ Suzuki, M et al. (2003) Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J. Biol. Chem. 278 51448-53 PubMed GONUTS page
↑ ^53.0 ^53.1 Lidén, M et al. (2005) The C-terminal region of cis-retinol/androgen dehydrogenase 1 (CRAD1) confers ER localization and in vivo enzymatic function. Exp. Cell Res. 311 205-17 PubMed GONUTS page
↑ ^54.0 ^54.1 Blair, PJ et al. (1994) CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J. Immunol. 153 3764-74 PubMed GONUTS page

[PMID:23100516-1] Graw, F et al. (2012) Dynamics of CD4(+) T cell responses against Listeria monocytogenes. J. Immunol. 189 5250-6 PubMed GONUTS page

[PMID:2784195-2] Veillette, A et al. (1989) Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature 338 257-9 PubMed GONUTS page

[PMID:1832488-3] Rahemtulla, A et al. (1991) Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353 180-4 PubMed GONUTS page

[PMID:3262426-4] Veillette, A et al. (1988) The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 55 301-8 PubMed GONUTS page

[PMID:9551897-5] Frank, GD & Parnes, JR (1998) The level of CD4 surface protein influences T cell selection in the thymus. J. Immunol. 160 634-42 PubMed GONUTS page

[PMID:1533274-6] Seong, RH et al. (1992) Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356 718-20 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12421911-8] 8.0 ^8.1 Workman, CJ et al. (2002) Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J. Immunol. 169 5392-5 PubMed GONUTS page

[PMID:9208839-9] 9.0 ^9.1 ^9.2 ^9.3 Wiest, DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity 6 663-71 PubMed GONUTS page

[PMID:14688352-10] Bry, L & Brenner, MB (2004) Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J. Immunol. 172 433-41 PubMed GONUTS page

[PMID:15128768-11] 11.0 ^11.1 Balamuth, F et al. (2004) CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J. Immunol. 172 5887-92 PubMed GONUTS page

[PMID:8612131-12] Sant'Angelo, DB et al. (1996) The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4 367-76 PubMed GONUTS page

[PMID:9133426-13] Mendiratta, SK et al. (1997) CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6 469-77 PubMed GONUTS page

[PMID:8788039-14] Li, T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ. 7 107-14 PubMed GONUTS page

[PMID:8769481-15] Hazenbos, WL et al. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity 5 181-8 PubMed GONUTS page

[PMID:8755570-16] Bouvier, G et al. (1996) Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc. Natl. Acad. Sci. U.S.A. 93 7877-81 PubMed GONUTS page

[PMID:8524870-17] Chu, K et al. (1995) A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc. Natl. Acad. Sci. U.S.A. 92 11894-8 PubMed GONUTS page

[PMID:7688139-18] Shahinian, A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261 609-12 PubMed GONUTS page

[PMID:7630421-19] Negishi, I et al. (1995) Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376 435-8 PubMed GONUTS page

[PMID:7589135-20] Simpson, SJ et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur. J. Immunol. 25 2618-25 PubMed GONUTS page

[PMID:7477353-21] Cheng, AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378 303-6 PubMed GONUTS page

[PMID:7477352-22] Turner, M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378 298-302 PubMed GONUTS page

[PMID:22072979-23] Nowell, CS et al. (2011) Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet. 7 e1002348 PubMed GONUTS page

[PMID:21508411-24] Hu, MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood 117 6120-31 PubMed GONUTS page

[PMID:21460847-25] Motomura, Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12 450-9 PubMed GONUTS page

[PMID:20709950-26] Gartlan, KH et al. (2010) A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. J. Immunol. 185 3158-66 PubMed GONUTS page

[PMID:20706986-27] Wang, L et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur. J. Immunol. 40 2385-90 PubMed GONUTS page

[PMID:20399120-28] Yagi, R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 32 507-17 PubMed GONUTS page

[PMID:19934022-29] Hosoya, T et al. (2009) GATA-3 is required for early T lineage progenitor development. J. Exp. Med. 206 2987-3000 PubMed GONUTS page

[PMID:19838199-30] Du, C et al. (2009) MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 10 1252-9 PubMed GONUTS page

[PMID:19723499-31] Terauchi, M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab. 10 229-40 PubMed GONUTS page

[PMID:19349303-32] Stone, EL et al. (2009) Glycosyltransferase function in core 2-type protein O glycosylation. Mol. Cell. Biol. 29 3770-82 PubMed GONUTS page

[PMID:19008373-33] Abe, J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am. J. Pathol. 173 1682-92 PubMed GONUTS page

[PMID:18836449-34] Shiow, LR et al. (2008) The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat. Immunol. 9 1307-15 PubMed GONUTS page

[PMID:18776904-35] Wang, L et al. (2008) Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat. Immunol. 9 1122-30 PubMed GONUTS page

[PMID:18641307-36] Kisielow, J et al. (2008) SCART scavenger receptors identify a novel subset of adult gammadelta T cells. J. Immunol. 181 1710-6 PubMed GONUTS page

[PMID:17357106-37] Ling, KW et al. (2007) GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Eur. J. Immunol. 37 1043-52 PubMed GONUTS page

[PMID:17082577-38] Kim, PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J. Immunol. 177 6650-9 PubMed GONUTS page

[PMID:16973387-39] Marie, JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25 441-54 PubMed GONUTS page

[PMID:16455951-40] Takayanagi, S et al. (2006) Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood 107 4317-25 PubMed GONUTS page

[PMID:16287714-41] Bultman, SJ et al. (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 19 2849-61 PubMed GONUTS page

[PMID:15843532-42] Cheung, H et al. (2005) Accessory protein-like is essential for IL-18-mediated signaling. J. Immunol. 174 5351-7 PubMed GONUTS page

[PMID:15795238-43] Winkler, IG et al. (2005) Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J. Exp. Med. 201 1077-88 PubMed GONUTS page

[PMID:15728238-44] Mandal, M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J. Exp. Med. 201 603-14 PubMed GONUTS page

[PMID:15368291-45] Ye, Q et al. (2004) BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur. J. Immunol. 34 2750-9 PubMed GONUTS page

[PMID:15322158-46] García-Martínez, LF et al. (2004) A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J. Immunol. 173 2995-3001 PubMed GONUTS page

[PMID:14609575-47] Matsuzaki, J et al. (2003) Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell. Immunol. 224 98-105 PubMed GONUTS page

[PMID:10943842-48] Tamura, K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102 221-31 PubMed GONUTS page

[PMID:10704459-49] Kennedy, MK et al. (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191 771-80 PubMed GONUTS page

[PMID:10072077-50] Moriggl, R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10 249-59 PubMed GONUTS page

[PMID:17213291-51] Wilson, TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109 3786-93 PubMed GONUTS page

[PMID:14517216-52] Suzuki, M et al. (2003) Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J. Biol. Chem. 278 51448-53 PubMed GONUTS page

[PMID:16223484-53] 53.0 ^53.1 Lidén, M et al. (2005) The C-terminal region of cis-retinol/androgen dehydrogenase 1 (CRAD1) confers ER localization and in vivo enzymatic function. Exp. Cell Res. 311 205-17 PubMed GONUTS page

[PMID:7930593-54] 54.0 ^54.1 Blair, PJ et al. (1994) CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J. Immunol. 153 3764-74 PubMed GONUTS page

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