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PMID:15322158
| Citation |
García-Martínez, LF, Appleby, MW, Staehling-Hampton, K, Andrews, DM, Chen, Y, McEuen, M, Tang, P, Rhinehart, RL, Proll, S, Paeper, B, Brunkow, ME, Grandea, AG 3rd, Howard, ED, Walker, DE, Charmley, P, Jonas, M, Shaw, S, Latham, JA and Ramsdell, F (2004) A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J. Immunol. 173:2995-3001 |
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| Abstract |
Using a mouse mutagenesis screen, we have identified CD83 as being critical for the development of CD4(+) T cells and for their function postactivation. CD11c(+) dendritic cells develop and function normally in mice with a mutated CD83 gene but CD4(+) T cell development is substantially reduced. Additionally, we now show that those CD4(+) cells that develop in a CD83 mutant animal fail to respond normally following allogeneic stimulation. This is at least in part due to an altered cytokine expression pattern characterized by an increased production of IL-4 and IL-10 and diminished IL-2 production. Thus, in addition to its role in selection of CD4(+) T cells, absence of CD83 results in the generation of cells with an altered activation and cytokine profile. |
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| Keywords |
Amino Acid Sequence; Animals; Antigens, CD; Base Sequence; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; Cytokines/metabolism; Dendritic Cells/immunology; Female; Immunoglobulins/genetics; Immunoglobulins/immunology; Male; Membrane Glycoproteins/genetics; Membrane Glycoproteins/immunology; Mice; Molecular Sequence Data; Mutation; Pedigree |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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